ATE211386T1 - 7-(5-substituiertes zyklopentyl) und (5- substituiertes zyklopentyl) heptyl-alkohol, heptylamine und heptan-säure-amide und das verfahren zur senkung des augeninnendrucks bei säugetieren durch anwendung dieser neuen verbindungen - Google Patents

7-(5-substituiertes zyklopentyl) und (5- substituiertes zyklopentyl) heptyl-alkohol, heptylamine und heptan-säure-amide und das verfahren zur senkung des augeninnendrucks bei säugetieren durch anwendung dieser neuen verbindungen

Info

Publication number
ATE211386T1
ATE211386T1 AT93924387T AT93924387T ATE211386T1 AT E211386 T1 ATE211386 T1 AT E211386T1 AT 93924387 T AT93924387 T AT 93924387T AT 93924387 T AT93924387 T AT 93924387T AT E211386 T1 ATE211386 T1 AT E211386T1
Authority
AT
Austria
Prior art keywords
substituted cyclopentyl
lower alkyl
heptylamines
mammals
acid amides
Prior art date
Application number
AT93924387T
Other languages
English (en)
Inventor
Michael E Garst
Robert Burk
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Application granted granted Critical
Publication of ATE211386T1 publication Critical patent/ATE211386T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
AT93924387T 1992-10-21 1993-10-20 7-(5-substituiertes zyklopentyl) und (5- substituiertes zyklopentyl) heptyl-alkohol, heptylamine und heptan-säure-amide und das verfahren zur senkung des augeninnendrucks bei säugetieren durch anwendung dieser neuen verbindungen ATE211386T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/964,223 US5385945A (en) 1992-10-21 1992-10-21 7-(5-substituted cyclopentyl) and (5-substituted cyclopentenyl) heptyl alcohols, heptylamines and heptanoic acid amides, and method of lowering intraocular pressure in the eye of a mammal by administration of these novel compounds
PCT/US1993/010061 WO1994008587A1 (en) 1992-10-21 1993-10-20 Novel 7-(5-substituted cyclopentyl) and (5-substituted cyclopentenyl) heptyl alcohols, heptylamines and heptanoic acid amines, and method of lowering intraocular pressure in the eye of a mammal by administration of these novel compounds

Publications (1)

Publication Number Publication Date
ATE211386T1 true ATE211386T1 (de) 2002-01-15

Family

ID=25508274

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93924387T ATE211386T1 (de) 1992-10-21 1993-10-20 7-(5-substituiertes zyklopentyl) und (5- substituiertes zyklopentyl) heptyl-alkohol, heptylamine und heptan-säure-amide und das verfahren zur senkung des augeninnendrucks bei säugetieren durch anwendung dieser neuen verbindungen

Country Status (9)

Country Link
US (4) US5385945A (de)
EP (1) EP0665751B1 (de)
JP (1) JPH08502495A (de)
AT (1) ATE211386T1 (de)
AU (1) AU669957B2 (de)
CA (1) CA2147502C (de)
DE (1) DE69331417T2 (de)
ES (1) ES2170076T3 (de)
WO (1) WO1994008587A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5268387A (en) * 1992-04-24 1993-12-07 Allergan, Inc. Pharmaceutical compositions and method for administering 3 and 4-substituted 2(5H)-furanones to a mammal for inhibiting bone loss
US5385945A (en) * 1992-10-21 1995-01-31 Allergan, Inc. 7-(5-substituted cyclopentyl) and (5-substituted cyclopentenyl) heptyl alcohols, heptylamines and heptanoic acid amides, and method of lowering intraocular pressure in the eye of a mammal by administration of these novel compounds
US5698733A (en) * 1994-09-30 1997-12-16 Alcon Laboratories, Inc. Use of 9-deoxy prostaglandin derivatives to treat glaucoma
WO1998021180A1 (en) 1995-06-07 1998-05-22 Alcon Laboratories, Inc. Conformationally rigid aryl- or heteroaryl prostaglandins for use in glaucoma therapy
US6441047B2 (en) 1995-11-17 2002-08-27 Alcon Manufacturing Ltd.. Combination therapy for treating glaucoma
WO2000039194A1 (fr) * 1998-12-25 2000-07-06 Mitsui Chemicals, Incorporated Procedes servant a preparer une resine absorbant l'eau
US6864282B2 (en) 2002-08-05 2005-03-08 Allergan, Inc. 9,11-cycloendoperoxide pro-drugs of prostaglandin analogues for treatment of ocular hypertension and glaucoma
US20040216749A1 (en) * 2003-01-23 2004-11-04 Hosheng Tu Vasomodulation during glaucoma surgery
US7179820B2 (en) * 2003-06-06 2007-02-20 Allergan, Inc. Piperidinyl prostaglandin E analogs
US7101904B2 (en) * 2004-08-10 2006-09-05 Allergan, Inc. Cyclopentane heptan(ENE)OIC acid, 2-heteroarylalkenyl derivatives as therapeutic agents
WO2006041875A1 (en) 2004-10-06 2006-04-20 Allergan, Inc. Novel prostamides for the treatment of glaucoma and related diseases
PL2084124T3 (pl) * 2006-10-02 2014-08-29 Techfields Biochem Co Ltd Dodatnio naładowane rozpuszczalne w wodzie proleki prostaglandyn i związków pokrewnych o bardzo dużych szybkościach przenikania przez skórę
US12478503B2 (en) 2009-05-18 2025-11-25 Glaukos Corporation Implants with controlled drug delivery features and methods of using same
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
JP5925158B2 (ja) * 2013-06-04 2016-05-25 テックフィールズ バイオケム カンパニー リミテッド 非常に高い皮膚浸透率を有するプロスタグランジン及び関連化合物の正荷電水溶性プロドラッグ
JP6030168B2 (ja) * 2015-03-09 2016-11-24 テックフィールズ バイオケム カンパニー リミテッド 非常に高い皮膚浸透率を有するプロスタグランジン及び関連化合物の正荷電水溶性プロドラッグ
JP6306067B2 (ja) * 2016-01-08 2018-04-04 テックフィールズ バイオケム カンパニー リミテッド 非常に高い皮膚浸透率を有するプロスタグランジン及び関連化合物の正荷電水溶性プロドラッグ

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Publication number Priority date Publication date Assignee Title
US3935261A (en) * 1970-01-23 1976-01-27 May & Baker Limited Cyclopentane derivatives
US4054604A (en) * 1974-01-10 1977-10-18 American Cyanamid Company Amide derivatives of 9-oxo-13-trans-prostenoic acid
NL7605381A (nl) * 1975-05-26 1976-11-30 Schering Ag Werkwijze voor het bereiden van prostaanderi- vaten en werkwijze voor het bereiden van een geneesmiddel met prostaglandinewerking.
DE2629834A1 (de) * 1976-06-30 1978-01-12 Schering Ag Neue prostansaeurederivate und verfahren zu ihrer herstellung
US4058564A (en) * 1976-07-26 1977-11-15 The Upjohn Company Aliphatic 2-decarboxy-2-hydroxymethyl-13,14-didehydro-PG compounds
DE2715838A1 (de) * 1977-04-05 1978-10-19 Schering Ag Neue prostanderivate und verfahren zu ihrer herstellung
DE3126924A1 (de) * 1981-07-03 1983-01-20 Schering Ag, 1000 Berlin Und 4619 Bergkamen 9-fluor-prostaglandinderivate, verfahren zur herstellung und verwendung als arzneimittel
US4599353A (en) * 1982-05-03 1986-07-08 The Trustees Of Columbia University In The City Of New York Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma
EP0242580B1 (de) * 1986-03-13 1993-04-28 The Trustees Of Columbia University In The City Of New York Verwendung von A-, B- und C-Prostaglandinen und deren Derivaten zur Behandlung von Augen-Hypertension und Glaukom
IT1205183B (it) * 1987-06-25 1989-03-15 Istituto Biochimico Italiano Derivati prostaglandinici,procedimenti per prepararli e composizioni farmaceutiche che li contengono
WO1990002553A1 (en) * 1988-09-06 1990-03-22 Pharmacia Ab Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
EP0425584A1 (de) * 1988-09-20 1991-05-08 IBI- Istituto Biochimico Italiano Giovanni Lorenzini S.p.A. Prostaglandin-derivate mit antithrombotischer wirkung
US4994274A (en) * 1989-07-27 1991-02-19 Allergan, Inc. Intraocular pressure reducing 11,15-diacyl prostaglandins and method of using
US5034413A (en) * 1989-07-27 1991-07-23 Allergan, Inc. Intraocular pressure reducing 9,11-diacyl prostaglandins
KR0178542B1 (ko) * 1991-01-30 1999-05-15 모찌즈끼 노부히꼬 디티오카르밤산의 염류, 그 제조방법 및 그 디티오카르밤산의 염류를 사용하는 이소티오시아네이트류의 제조방법
IE920397A1 (en) * 1991-02-07 1992-08-12 Allergan Inc 2-decarboxyl-2-hydroxyalkyl-5-trans prostaglandin f¹derivatives
US5385945A (en) * 1992-10-21 1995-01-31 Allergan, Inc. 7-(5-substituted cyclopentyl) and (5-substituted cyclopentenyl) heptyl alcohols, heptylamines and heptanoic acid amides, and method of lowering intraocular pressure in the eye of a mammal by administration of these novel compounds

Also Published As

Publication number Publication date
JPH08502495A (ja) 1996-03-19
US5385945A (en) 1995-01-31
DE69331417D1 (de) 2002-02-07
US5773654A (en) 1998-06-30
AU5409494A (en) 1994-05-09
CA2147502A1 (en) 1994-04-28
WO1994008587A1 (en) 1994-04-28
DE69331417T2 (de) 2002-08-29
EP0665751A1 (de) 1995-08-09
US5552434A (en) 1996-09-03
US5674910A (en) 1997-10-07
ES2170076T3 (es) 2002-08-01
EP0665751B1 (de) 2002-01-02
CA2147502C (en) 2005-05-17
AU669957B2 (en) 1996-06-27

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