ATE29496T1 - Tetrahydro-beta-carbolin-derivate und verfahren fuer ihre herstellung. - Google Patents
Tetrahydro-beta-carbolin-derivate und verfahren fuer ihre herstellung.Info
- Publication number
- ATE29496T1 ATE29496T1 AT84303685T AT84303685T ATE29496T1 AT E29496 T1 ATE29496 T1 AT E29496T1 AT 84303685 T AT84303685 T AT 84303685T AT 84303685 T AT84303685 T AT 84303685T AT E29496 T1 ATE29496 T1 AT E29496T1
- Authority
- AT
- Austria
- Prior art keywords
- tetrahydro
- beta
- group
- processes
- production
- Prior art date
Links
- CFTOTSJVQRFXOF-UHFFFAOYSA-N 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole Chemical class N1C2=CC=CC=C2C2=C1CNCC2 CFTOTSJVQRFXOF-UHFFFAOYSA-N 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 206010067125 Liver injury Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 231100000234 hepatic damage Toxicity 0.000 abstract 1
- 230000008818 liver damage Effects 0.000 abstract 1
- 208000019423 liver disease Diseases 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G67/00—Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing oxygen or oxygen and carbon, not provided for in groups C08G2/00 - C08G65/00
- C08G67/02—Copolymers of carbon monoxide and aliphatic unsaturated compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Polymers & Plastics (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB08315403A GB2140797A (en) | 1983-06-04 | 1983-06-04 | Tetrahydro-b-carboline derivatives |
| EP84303685A EP0128021B1 (de) | 1983-06-04 | 1984-06-01 | Tetrahydro-beta-Carbolin-Derivate und Verfahren für ihre Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE29496T1 true ATE29496T1 (de) | 1987-09-15 |
Family
ID=10543822
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT84303685T ATE29496T1 (de) | 1983-06-04 | 1984-06-01 | Tetrahydro-beta-carbolin-derivate und verfahren fuer ihre herstellung. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4612317A (de) |
| EP (1) | EP0128021B1 (de) |
| JP (1) | JPS59225187A (de) |
| KR (1) | KR870001239B1 (de) |
| AT (1) | ATE29496T1 (de) |
| AU (1) | AU563923B2 (de) |
| CA (1) | CA1251449A (de) |
| DE (1) | DE3465995D1 (de) |
| DK (1) | DK272684A (de) |
| ES (1) | ES8702909A1 (de) |
| GB (1) | GB2140797A (de) |
| HU (1) | HU198928B (de) |
| SU (1) | SU1382401A3 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040253891A1 (en) * | 2000-09-12 | 2004-12-16 | Schierenbeck Alan W. | Composite structure for protective garment |
| US20050137220A1 (en) * | 2003-07-23 | 2005-06-23 | Pharmacia Corporation | Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors |
| FR2869540B1 (fr) * | 2004-04-30 | 2008-05-16 | Centre Nat Rech Scient Cnrse | Compositions pharmaceutiques contenant des derives de b-carboline, et leur utilisation pour le traitement des cancers |
| JP5649170B2 (ja) * | 2010-11-26 | 2015-01-07 | 国立大学法人 千葉大学 | テトラヒドロ−β−カルボリン誘導体及びその製造方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA668301A (en) * | 1963-08-06 | Leonard Frederick | PROCESS FOR THE PREPARATION OF NEW .beta.-CARBOLINE DERIVATIVES | |
| DD20923A (de) * | ||||
| DE20923C (de) * | H. LAMPRECHT In Gnarrenburg und G. HlRDES in Bremen | Neuerungen an Tropfenzählern | ||
| US2187719A (en) * | 1938-06-10 | 1940-01-23 | Du Pont | Derivative of hexamethylene-di-thio-carbamic acid |
| ES273769A1 (es) * | 1961-01-18 | 1962-06-01 | Geigy Ag J R | Procedimiento para la preparaciën de nuevos derivados de amidas de acido beta-carbolin-carboxilico |
| JPS5826755B2 (ja) * | 1975-09-01 | 1983-06-04 | オオキ サダオ | 3− ヒドロキシメチル − ベ−タ − カルボリンユウドウタイノ セイゾウホウ |
-
1983
- 1983-06-04 GB GB08315403A patent/GB2140797A/en not_active Withdrawn
-
1984
- 1984-05-18 US US06/611,965 patent/US4612317A/en not_active Expired - Fee Related
- 1984-05-28 JP JP59109300A patent/JPS59225187A/ja active Pending
- 1984-05-29 KR KR1019840002970A patent/KR870001239B1/ko not_active Expired
- 1984-05-31 CA CA000455559A patent/CA1251449A/en not_active Expired
- 1984-05-31 AU AU28874/84A patent/AU563923B2/en not_active Ceased
- 1984-06-01 SU SU843749299A patent/SU1382401A3/ru active
- 1984-06-01 ES ES533080A patent/ES8702909A1/es not_active Expired
- 1984-06-01 EP EP84303685A patent/EP0128021B1/de not_active Expired
- 1984-06-01 DE DE8484303685T patent/DE3465995D1/de not_active Expired
- 1984-06-01 DK DK272684A patent/DK272684A/da not_active Application Discontinuation
- 1984-06-01 AT AT84303685T patent/ATE29496T1/de not_active IP Right Cessation
- 1984-06-04 HU HU842165A patent/HU198928B/hu not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HU198928B (en) | 1989-12-28 |
| CA1251449A (en) | 1989-03-21 |
| GB2140797A (en) | 1984-12-05 |
| DK272684A (da) | 1984-12-05 |
| KR850000034A (ko) | 1985-02-25 |
| HUT34191A (en) | 1985-02-28 |
| DE3465995D1 (en) | 1987-10-15 |
| ES8702909A1 (es) | 1987-01-16 |
| EP0128021A1 (de) | 1984-12-12 |
| DK272684D0 (da) | 1984-06-01 |
| AU563923B2 (en) | 1987-07-30 |
| EP0128021B1 (de) | 1987-09-09 |
| ES533080A0 (es) | 1987-01-16 |
| KR870001239B1 (ko) | 1987-06-26 |
| SU1382401A3 (ru) | 1988-03-15 |
| US4612317A (en) | 1986-09-16 |
| AU2887484A (en) | 1984-12-06 |
| JPS59225187A (ja) | 1984-12-18 |
| GB8315403D0 (en) | 1983-07-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |