ATE211390T1 - Überlegende thrombomodulinanaloga zur pharmazeutischen verwendung - Google Patents

Überlegende thrombomodulinanaloga zur pharmazeutischen verwendung

Info

Publication number
ATE211390T1
ATE211390T1 AT91918117T AT91918117T ATE211390T1 AT E211390 T1 ATE211390 T1 AT E211390T1 AT 91918117 T AT91918117 T AT 91918117T AT 91918117 T AT91918117 T AT 91918117T AT E211390 T1 ATE211390 T1 AT E211390T1
Authority
AT
Austria
Prior art keywords
thrombin
analogs
superior
pharmaceutical use
methods
Prior art date
Application number
AT91918117T
Other languages
English (en)
Inventor
Charles B Glaser
Michael John Morser
David Richard Light
Original Assignee
Paion Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paion Gmbh filed Critical Paion Gmbh
Application granted granted Critical
Publication of ATE211390T1 publication Critical patent/ATE211390T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/7455—Thrombomodulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT91918117T 1990-08-15 1991-08-15 Überlegende thrombomodulinanaloga zur pharmazeutischen verwendung ATE211390T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56845690A 1990-08-15 1990-08-15
PCT/US1991/005806 WO1992003149A1 (en) 1990-08-15 1991-08-15 Superior thrombomodulin analogs for pharmaceutical use

Publications (1)

Publication Number Publication Date
ATE211390T1 true ATE211390T1 (de) 2002-01-15

Family

ID=24271371

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91918117T ATE211390T1 (de) 1990-08-15 1991-08-15 Überlegende thrombomodulinanaloga zur pharmazeutischen verwendung

Country Status (8)

Country Link
EP (1) EP0544826B1 (de)
AT (1) ATE211390T1 (de)
AU (2) AU8723391A (de)
CA (2) CA2648350A1 (de)
DE (1) DE69132889T2 (de)
DK (1) DK0544826T3 (de)
ES (1) ES2170747T3 (de)
WO (1) WO1992003149A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063763A (en) * 1989-04-28 2000-05-16 Schering Aktiengesellschaft Protease-resistant thrombomodulin analogs
FR2689640B1 (fr) * 1992-04-06 1997-08-08 Bio Merieux Procede pour la determination d'une activite proteine c et/ou proteine s dans un echantillon plasmatique.
EP0965597A4 (de) * 1996-12-27 2003-01-08 Mochida Pharm Co Ltd Zellmembran-wirksame medikamente
DE19749197A1 (de) * 1997-11-07 1999-05-12 Dade Behring Marburg Gmbh Verfahren zur Bestimmung des antikoagulatorischen Potentials einer Probe
AU2003301332B2 (en) * 2002-10-17 2008-06-12 Pharming Intellectual Property B.V. Protein modification
US7553930B2 (en) 2003-01-06 2009-06-30 Xencor, Inc. BAFF variants and methods thereof
WO2008044631A1 (en) 2006-10-06 2008-04-17 Asahi Kasei Pharma Corporation Therapeutic and/or ameliorating agent for disseminated intravascular coagulation
ES2496596T3 (es) 2007-03-23 2014-09-19 Asahi Kasei Pharma Corporation Método para producir trombomodulina soluble de gran pureza
EP2120049A1 (de) 2008-05-14 2009-11-18 PAION Deutschland GmbH Lösliches Thrombomodulin als Biomarker bei Therapien mit Gerinnungshemmern
JP2012529445A (ja) 2009-06-12 2012-11-22 パイオン ドイチュラント ゲーエムベーハー 線溶亢進を伴う凝固障害の処置
NZ602852A (en) 2010-04-30 2014-03-28 Asahi Kasei Pharma Corp Highly-purified soluble thrombomodulin and method for producing same
JP2013531651A (ja) 2010-06-14 2013-08-08 パイオン ドイチュラント ゲーエムベーハー 線溶亢進を伴う凝固障害の処置
DK2781221T3 (da) 2011-11-15 2020-06-02 Asahi Kasei Pharma Corp Medicin til behandling og/eller forbedring af sepsis
WO2020084853A1 (ja) 2018-10-22 2020-04-30 旭化成ファーマ株式会社 凝固異常を伴う敗血症の治療及び／又は改善のための医薬

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4912207A (en) * 1987-05-06 1990-03-27 Washington University DNA clone of human thrombomodulin and portions thereof
DK299087D0 (da) * 1987-06-12 1987-06-12 Novo Industri As Proteins and derivatives thereof
CA2046906A1 (en) * 1989-02-17 1990-08-18 Michael J. Morser Soluble analogs of thrombomodulin
US5256770A (en) * 1990-04-09 1993-10-26 Schering Ag Oxidation resistant thrombomodulin analogs

Also Published As

Publication number Publication date
ES2170747T3 (es) 2002-08-16
AU8723391A (en) 1992-03-17
DK0544826T3 (da) 2002-04-22
CA2087271C (en) 2009-03-24
DE69132889T2 (de) 2002-08-29
AU4554396A (en) 1996-04-26
DE69132889D1 (de) 2002-02-07
EP0544826B1 (de) 2002-01-02
CA2087271A1 (en) 1992-02-16
AU692988B2 (en) 1998-06-18
WO1992003149A1 (en) 1992-03-05
CA2648350A1 (en) 1992-03-05
EP0544826A1 (de) 1993-06-09
EP0544826A4 (de) 1994-04-27

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee