ATE264913T1 - Protease-resistente analoge des thrombomodulin - Google Patents

Protease-resistente analoge des thrombomodulin

Info

Publication number
ATE264913T1
ATE264913T1 AT93905821T AT93905821T ATE264913T1 AT E264913 T1 ATE264913 T1 AT E264913T1 AT 93905821 T AT93905821 T AT 93905821T AT 93905821 T AT93905821 T AT 93905821T AT E264913 T1 ATE264913 T1 AT E264913T1
Authority
AT
Austria
Prior art keywords
thrombomodulin
protease
methods
resistant analogues
analogues
Prior art date
Application number
AT93905821T
Other languages
English (en)
Inventor
David Richard Light
William H Andrews
Jeffrey Homer Clarke
Robert Michael Wydro
Patricia Ann Young
Original Assignee
Paion Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paion Gmbh filed Critical Paion Gmbh
Application granted granted Critical
Publication of ATE264913T1 publication Critical patent/ATE264913T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/7455—Thrombomodulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Prostheses (AREA)
AT93905821T 1992-02-05 1993-02-05 Protease-resistente analoge des thrombomodulin ATE264913T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83057792A 1992-02-05 1992-02-05
PCT/US1993/001120 WO1993015755A1 (en) 1992-02-05 1993-02-05 Protease-resistant thrombomodulin analogs

Publications (1)

Publication Number Publication Date
ATE264913T1 true ATE264913T1 (de) 2004-05-15

Family

ID=25257242

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93905821T ATE264913T1 (de) 1992-02-05 1993-02-05 Protease-resistente analoge des thrombomodulin

Country Status (9)

Country Link
EP (2) EP0641215B1 (de)
JP (2) JP3517236B2 (de)
AT (1) ATE264913T1 (de)
AU (1) AU675422B2 (de)
CA (1) CA2129370A1 (de)
DE (1) DE69333491T2 (de)
ES (1) ES2220905T3 (de)
PT (1) PT641215E (de)
WO (1) WO1993015755A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7060484B1 (en) 1993-11-12 2006-06-13 Gilead Sciences, Inc. Polypeptides and coagulation therapy
US6110721A (en) * 1993-11-12 2000-08-29 Gilead Sciences, Inc. Polypeptides and coagulation therapy
ATE249234T1 (de) * 1993-12-17 2003-09-15 Mochida Pharm Co Ltd Lösliches thrombomodulin enthaltende zubereitung
JP2005511600A (ja) * 2001-11-09 2005-04-28 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト Ｖｉｉ因子ポリペプチドおよびトロンボモジュリンポリペプチドを含む薬学的組成物
PL1948216T3 (pl) * 2005-10-13 2011-10-31 Lilly Co Eli Leczenie ostrej niewydolności nerek za pomocą rozpuszczalnej trombomoduliny
MX2009003384A (es) 2006-10-06 2009-04-08 Asahi Kasei Pharma Corp Agente terapeutico y/o de mejoramiento para la coagulacion intravascular diseminada.
CA2681294C (en) 2007-03-23 2014-05-06 Asahi Kasei Pharma Corporation Method for producing high-purity soluble thrombomodulin
AR067345A1 (es) * 2007-07-10 2009-10-07 Paion Deutschland Gmbh Uso de trombomodulina para la preparacion de un medicamento trombolitico
EP2014296A1 (de) * 2007-07-10 2009-01-14 PAION Deutschland GmbH Neuartige Strategien zur Erhöhung der Reperfusion in einem verstopften Blutgefäß
EP2120049A1 (de) 2008-05-14 2009-11-18 PAION Deutschland GmbH Lösliches Thrombomodulin als Biomarker bei Therapien mit Gerinnungshemmern
EP2320936A1 (de) * 2008-07-16 2011-05-18 PAION Deutschland GmbH Prävention und behandlung von strahlenschäden
WO2010006635A1 (en) * 2008-07-16 2010-01-21 Paion Deutschland Gmbh Treatment of inflammatory bowel disease
CN102481344A (zh) 2009-06-12 2012-05-30 帕昂德国有限公司 具有纤溶亢进的凝血病的治疗
NZ602852A (en) 2010-04-30 2014-03-28 Asahi Kasei Pharma Corp Highly-purified soluble thrombomodulin and method for producing same
JP2013531651A (ja) 2010-06-14 2013-08-08 パイオン ドイチュラント ゲーエムベーハー 線溶亢進を伴う凝固障害の処置
PT2781221T (pt) 2011-11-15 2020-06-01 Asahi Kasei Pharma Corp Medicamento para tratamento e/ou melhoria de sepsia
WO2014004780A1 (en) * 2012-06-29 2014-01-03 Bristol-Myers Squibb Company Methods for reducing glycoprotein aggregation
BR112021007460A2 (pt) 2018-10-22 2021-11-03 Asahi Kasei Pharma Corp Medicamento para tratamento terapêutico e/ou melhora de um paciente com sepse

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK299087D0 (da) * 1987-06-12 1987-06-12 Novo Industri As Proteins and derivatives thereof
CA2046906A1 (en) * 1989-02-17 1990-08-18 Michael J. Morser Soluble analogs of thrombomodulin
US5256770A (en) * 1990-04-09 1993-10-26 Schering Ag Oxidation resistant thrombomodulin analogs
CA2022713A1 (en) * 1989-08-11 1991-02-12 Nils U. Bang Human thrombomodulin derivatives
JPH03259084A (ja) * 1990-03-06 1991-11-19 Kowa Co トロンビン結合性物質の製造法
US5702931A (en) * 1991-07-01 1997-12-30 Berlex Laboratories, Inc. Mutagenesis methods and compositions
WO1993025675A1 (en) * 1992-06-10 1993-12-23 Schering Aktiengesellschaft Mutants of the epidermal growth factor domains of human thrombomodulin

Also Published As

Publication number Publication date
EP0641215A4 (de) 1995-11-29
WO1993015755A1 (en) 1993-08-19
DE69333491D1 (en) 2004-05-27
ES2220905T3 (es) 2004-12-16
PT641215E (pt) 2004-09-30
EP0641215B1 (de) 2004-04-21
EP1449849A3 (de) 2006-01-25
AU675422B2 (en) 1997-02-06
EP1449849A2 (de) 2004-08-25
CA2129370A1 (en) 1993-08-19
AU3659393A (en) 1993-09-03
JP3517236B2 (ja) 2004-04-12
DE69333491T2 (de) 2005-03-31
EP0641215A1 (de) 1995-03-08
JPH07503849A (ja) 1995-04-27
JP2004105188A (ja) 2004-04-08

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