ATE264913T1 - Protease-resistente analoge des thrombomodulin - Google Patents

Protease-resistente analoge des thrombomodulin

Info

Publication number: ATE264913T1
Authority: AT; Austria
Prior art keywords: thrombomodulin; protease; methods; resistant analogues; analogues
Prior art date: 1992-02-05

Application number

AT93905821T

Other languages

English (en)

Inventor

David Richard Light

William H Andrews

Jeffrey Homer Clarke

Robert Michael Wydro

Patricia Ann Young

Original Assignee

Paion Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-02-05

Filing date

1993-02-05

Publication date

2004-05-15

1993-02-05 Application filed by Paion Gmbh filed Critical Paion Gmbh

2004-05-15 Application granted granted Critical

2004-05-15 Publication of ATE264913T1 publication Critical patent/ATE264913T1/de

Links

102000012607 Thrombomodulin Human genes 0.000 title abstract 3
108010079274 Thrombomodulin Proteins 0.000 title abstract 3
238000000034 method Methods 0.000 abstract 2
108090000623 proteins and genes Proteins 0.000 abstract 2
102000035195 Peptidases Human genes 0.000 abstract 1
108091005804 Peptidases Proteins 0.000 abstract 1
239000004365 Protease Substances 0.000 abstract 1
230000002785 anti-thrombosis Effects 0.000 abstract 1
239000003146 anticoagulant agent Substances 0.000 abstract 1
230000004071 biological effect Effects 0.000 abstract 1
238000003776 cleavage reaction Methods 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
102000039446 nucleic acids Human genes 0.000 abstract 1
108020004707 nucleic acids Proteins 0.000 abstract 1
150000007523 nucleic acids Chemical class 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
230000007017 scission Effects 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1
230000001732 thrombotic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/7455—Thrombomodulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Diabetes (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
General Chemical & Material Sciences (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Enzymes And Modification Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Prostheses (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT93905821T 1992-02-05 1993-02-05 Protease-resistente analoge des thrombomodulin ATE264913T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US83057792A	1992-02-05	1992-02-05
PCT/US1993/001120 WO1993015755A1 (en)	1992-02-05	1993-02-05	Protease-resistant thrombomodulin analogs

Publications (1)

Publication Number	Publication Date
ATE264913T1 true ATE264913T1 (de)	2004-05-15

Family

ID=25257242

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93905821T ATE264913T1 (de)	1992-02-05	1993-02-05	Protease-resistente analoge des thrombomodulin

Country Status (9)

Country	Link
EP (2)	EP1449849A3 (de)
JP (2)	JP3517236B2 (de)
AT (1)	ATE264913T1 (de)
AU (1)	AU675422B2 (de)
CA (1)	CA2129370A1 (de)
DE (1)	DE69333491T2 (de)
ES (1)	ES2220905T3 (de)
PT (1)	PT641215E (de)
WO (1)	WO1993015755A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU1096595A (en) *	1993-11-12	1995-05-29	Gilead Sciences, Inc.	Thrombin mutants
US7060484B1 (en)	1993-11-12	2006-06-13	Gilead Sciences, Inc.	Polypeptides and coagulation therapy
EP0689843B1 (de) *	1993-12-17	2003-09-10	Mochida Pharmaceutical Co., Ltd.	Lösliches thrombomodulin enthaltende zubereitung
JP2005511600A (ja) *	2001-11-09	2005-04-28	ノボノルディスクヘルスケアアクチェンゲゼルシャフト	Ｖｉｉ因子ポリペプチドおよびトロンボモジュリンポリペプチドを含む薬学的組成物
ES2360610T3 (es) *	2005-10-13	2011-06-07	Eli Lilly And Company	Tratamiento de la insuficiencia renal aguda con trombomodulina soluble.
RU2433829C2 (ru)	2006-10-06	2011-11-20	Асахи Касеи Фарма Корпорейшн	Средство для лечения и/или улучшения состояния при диссеминированном внутрисосудистом свертывании
CA2681294C (en)	2007-03-23	2014-05-06	Asahi Kasei Pharma Corporation	Method for producing high-purity soluble thrombomodulin
EP2014296A1 (de) *	2007-07-10	2009-01-14	PAION Deutschland GmbH	Neuartige Strategien zur Erhöhung der Reperfusion in einem verstopften Blutgefäß
AR067345A1 (es) *	2007-07-10	2009-10-07	Paion Deutschland Gmbh	Uso de trombomodulina para la preparacion de un medicamento trombolitico
EP2120049A1 (de)	2008-05-14	2009-11-18	PAION Deutschland GmbH	Lösliches Thrombomodulin als Biomarker bei Therapien mit Gerinnungshemmern
EP2320936A1 (de) *	2008-07-16	2011-05-18	PAION Deutschland GmbH	Prävention und behandlung von strahlenschäden
WO2010006635A1 (en) *	2008-07-16	2010-01-21	Paion Deutschland Gmbh	Treatment of inflammatory bowel disease
AU2009347614A1 (en)	2009-06-12	2012-01-19	Paion Deutschland Gmbh	Treatment of coagulopathy with hyperfibrinolysis
SG10201500036WA (en)	2010-04-30	2015-02-27	Asahi Kasei Pharma Corp	Highly-purified soluble thrombomodulin and method for producing same
WO2011157283A1 (en)	2010-06-14	2011-12-22	Paion Deutschland Gmbh	Treatment of coagulopathy with hyperfibrinolysis
DK2781221T3 (da)	2011-11-15	2020-06-02	Asahi Kasei Pharma Corp	Medicin til behandling og/eller forbedring af sepsis
US9926365B2 (en) *	2012-06-29	2018-03-27	Bristol-Myers Squibb Company	Methods for reducing glycoprotein aggregation
EP3871684B1 (de)	2018-10-22	2024-06-26	Asahi Kasei Pharma Corporation	Arzneimittel zur behandlung und/oder verbesserung der septikämie in zusammenhang mit einer gerinnungsstörung

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK299087D0 (da) *	1987-06-12	1987-06-12	Novo Industri As	Proteins and derivatives thereof
WO1990010081A1 (en) *	1989-02-17	1990-09-07	Codon	Soluble analogs of thrombomodulin
US5256770A (en) *	1990-04-09	1993-10-26	Schering Ag	Oxidation resistant thrombomodulin analogs
CA2022713A1 (en) *	1989-08-11	1991-02-12	Nils U. Bang	Human thrombomodulin derivatives
JPH03259084A (ja) *	1990-03-06	1991-11-19	Kowa Co	トロンビン結合性物質の製造法
US5702931A (en) *	1991-07-01	1997-12-30	Berlex Laboratories, Inc.	Mutagenesis methods and compositions
AU4533093A (en) *	1992-06-10	1994-01-04	Michael John Morser	Mutants of the epidermal growth factor domains of human thrombomodulin

1993
- 1993-02-05 AT AT93905821T patent/ATE264913T1/de not_active IP Right Cessation
- 1993-02-05 DE DE69333491T patent/DE69333491T2/de not_active Expired - Fee Related
- 1993-02-05 EP EP04009293A patent/EP1449849A3/de not_active Withdrawn
- 1993-02-05 EP EP93905821A patent/EP0641215B1/de not_active Expired - Lifetime
- 1993-02-05 ES ES93905821T patent/ES2220905T3/es not_active Expired - Lifetime
- 1993-02-05 WO PCT/US1993/001120 patent/WO1993015755A1/en not_active Ceased
- 1993-02-05 CA CA002129370A patent/CA2129370A1/en not_active Abandoned
- 1993-02-05 PT PT93905821T patent/PT641215E/pt unknown
- 1993-02-05 JP JP51424193A patent/JP3517236B2/ja not_active Expired - Fee Related
- 1993-02-05 AU AU36593/93A patent/AU675422B2/en not_active Ceased
2003
- 2003-10-15 JP JP2003355493A patent/JP2004105188A/ja active Pending

Also Published As

Publication number	Publication date
EP0641215B1 (de)	2004-04-21
AU3659393A (en)	1993-09-03
EP1449849A2 (de)	2004-08-25
AU675422B2 (en)	1997-02-06
JP2004105188A (ja)	2004-04-08
EP0641215A1 (de)	1995-03-08
CA2129370A1 (en)	1993-08-19
JPH07503849A (ja)	1995-04-27
ES2220905T3 (es)	2004-12-16
JP3517236B2 (ja)	2004-04-12
DE69333491D1 (en)	2004-05-27
PT641215E (pt)	2004-09-30
EP0641215A4 (de)	1995-11-29
DE69333491T2 (de)	2005-03-31
WO1993015755A1 (en)	1993-08-19
EP1449849A3 (de)	2006-01-25

Legal Events

Date	Code	Title	Description
2004-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE264913T1 (de)	2004-05-15	Protease-resistente analoge des thrombomodulin
ATE75483T1 (de)	1992-05-15	Oligonukleotides heilmittel und dessen herstellungsverfahren.
MX9602993A (es)	1997-05-31	Hormona del crecimiento humano.
DK0409472T3 (da)	1995-01-16	Knoglemorfogenetisk protein
ES2130177T3 (es)	1999-07-01	Tratamiento de poblaciones de celulas.
HU9601448D0 (en)	1996-07-29	Novel apoptosis-modulating proteins, dna encoding the proteins and methods of use thereof
JPS6485096A (en)	1989-03-30	Hybrid human protein c and biotechnological synthesis thereof
DE69333346T2 (de)	2004-10-07	Neuartiges p- selectin ligandenprotein
EP0205475A4 (de)	1990-06-27	Rekombinantverfahren zur herstellung von serinproteaseinhibitoren, sowie dns-sequenzen dazu.
CA2170515A1 (en)	1995-03-09	Nucleotide sequences for novel protein tyrosine phosphatases
AU692988B2 (en)	1998-06-18	Superior thrombomodulin analogs for pharmaceutical use
IL98273A0 (en)	1992-06-21	Dna sequences,proteins having esterase activity coded by them,and use of such proteins
ES2124694T3 (es)	1999-02-16	Clonacion de la n-metil-hidantoinasa.
EP0238275A3 (en)	1989-05-10	Recombinant product
DE58909692D1 (de)	1996-07-25	Verfahren zur selektiven Spaltung von Fusionsproteinen
DE69636737D1 (de)	2007-01-11	Neues immunoregulatorisches protein lst-1
KR970009339B1 (en)	1997-06-10	Tpa from scolopendra subepinpes multilans and its purification method
ATE98953T1 (de)	1994-01-15	Verfahren und zwischenprodukte zur herstellung von isopropylestern von 3s-amino-2rhydroxyalkans\|uren.