ATE211727T1 - 5-hydroxymethyl-2-aminotetraline als cardiovasculäre mittel - Google Patents

5-hydroxymethyl-2-aminotetraline als cardiovasculäre mittel

Info

Publication number: ATE211727T1
Authority: AT; Austria
Prior art keywords: pct; aminotetraline; hydroxymethyl; cardiovascular agents; sec
Prior art date: 1997-02-26

Application number

AT98908052T

Other languages

English (en)

Inventor

Stefania Montanari

Paolo Cavalleri

Francesco Santangelo

Francesco Marchini

Original Assignee

Zambon Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-02-26

Filing date

1998-02-04

Publication date

2002-01-15

1998-02-04 Application filed by Zambon Spa filed Critical Zambon Spa

2002-01-15 Application granted granted Critical

2002-01-15 Publication of ATE211727T1 publication Critical patent/ATE211727T1/de

Links

MCZDRSDRUYHKCH-UHFFFAOYSA-N (6-amino-5,6,7,8-tetrahydronaphthalen-1-yl)methanol Chemical compound C1=CC=C2CC(N)CCC2=C1CO MCZDRSDRUYHKCH-UHFFFAOYSA-N 0.000 title 1
229940125692 cardiovascular agent Drugs 0.000 title 1
239000002327 cardiovascular agent Substances 0.000 title 1
IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
230000002526 effect on cardiovascular system Effects 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT98908052T 1997-02-26 1998-02-04 5-hydroxymethyl-2-aminotetraline als cardiovasculäre mittel ATE211727T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT97MI000414A IT1289979B1 (it)	1997-02-26	1997-02-26	5-idrossimetil-6-idrossi-2-amminotetraline attive come agenti cardiovascolari
PCT/EP1998/000589 WO1998038155A1 (en)	1997-02-26	1998-02-04	5-hydroxymethyl-2-aminotetralins as cardiovascular agents

Publications (1)

Publication Number	Publication Date
ATE211727T1 true ATE211727T1 (de)	2002-01-15

Family

ID=11376182

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98908052T ATE211727T1 (de)	1997-02-26	1998-02-04	5-hydroxymethyl-2-aminotetraline als cardiovasculäre mittel

Country Status (16)

Country	Link
US (1)	US6063964A (de)
EP (1)	EP0970042B1 (de)
JP (1)	JP2001513763A (de)
KR (1)	KR20000075736A (de)
AT (1)	ATE211727T1 (de)
AU (1)	AU733001B2 (de)
CA (1)	CA2282388A1 (de)
DE (1)	DE69803445T2 (de)
DK (1)	DK0970042T3 (de)
ES (1)	ES2169909T3 (de)
HU (1)	HUP0001058A3 (de)
IT (1)	IT1289979B1 (de)
NO (1)	NO994104L (de)
NZ (1)	NZ336680A (de)
PT (1)	PT970042E (de)
WO (1)	WO1998038155A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR113908A1 (es)	2017-11-24	2020-06-24	H Lundbeck As	Profármacos de catecolamina para uso en el tratamiento de la enfermedad de parkinson
US11111263B2 (en)	2019-05-20	2021-09-07	H. Lundbeck A/S	Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11104697B2 (en)	2019-05-20	2021-08-31	H. Lundbeck A/S	Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11130775B2 (en)	2019-05-20	2021-09-28	H. Lundbeck A/S	Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11168056B2 (en)	2019-05-20	2021-11-09	H. Lundbeck A/S	Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol
US12391650B2 (en)	2019-05-21	2025-08-19	H. Lundbeck A/S	Catecholamine prodrugs for use in the treatment of Parkinson's disease
CN113677675B (zh)	2019-05-21	2024-07-26	H.隆德贝克有限公司	用于治疗帕金森病的新儿茶酚胺前药
CN113727979B (zh)	2019-05-21	2024-09-20	H.隆德贝克有限公司	用于治疗帕金森病的新儿茶酚胺前药
EP3972600B1 (de)	2019-05-21	2026-02-18	H. Lundbeck A/S	Catecholamin-carbamat-prodrugs zur verwendung bei der behandlung von morbus parkinson

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2803582A1 (de) *	1978-01-27	1979-08-02	Sandoz Ag	Neue tetralinderivate, ihre herstellung und verwendung
IT1271411B (it) *	1993-09-14	1997-05-28	Zambon Spa	Derivati del 2-ammino-1,2,3,4-tetraidro-naftalene attivi sul sistema cardiovascolare

1997
- 1997-02-26 IT IT97MI000414A patent/IT1289979B1/it active IP Right Grant
1998
- 1998-02-04 JP JP53721898A patent/JP2001513763A/ja active Pending
- 1998-02-04 WO PCT/EP1998/000589 patent/WO1998038155A1/en not_active Ceased
- 1998-02-04 US US09/341,673 patent/US6063964A/en not_active Expired - Fee Related
- 1998-02-04 AT AT98908052T patent/ATE211727T1/de not_active IP Right Cessation
- 1998-02-04 KR KR1019997007805A patent/KR20000075736A/ko not_active Withdrawn
- 1998-02-04 AU AU66198/98A patent/AU733001B2/en not_active Ceased
- 1998-02-04 HU HU0001058A patent/HUP0001058A3/hu unknown
- 1998-02-04 EP EP98908052A patent/EP0970042B1/de not_active Expired - Lifetime
- 1998-02-04 DK DK98908052T patent/DK0970042T3/da active
- 1998-02-04 PT PT98908052T patent/PT970042E/pt unknown
- 1998-02-04 ES ES98908052T patent/ES2169909T3/es not_active Expired - Lifetime
- 1998-02-04 CA CA002282388A patent/CA2282388A1/en not_active Abandoned
- 1998-02-04 DE DE69803445T patent/DE69803445T2/de not_active Expired - Fee Related
- 1998-02-04 NZ NZ336680A patent/NZ336680A/en unknown
1999
- 1999-08-25 NO NO994104A patent/NO994104L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
ES2169909T3 (es)	2002-07-16
IT1289979B1 (it)	1998-10-19
DE69803445T2 (de)	2002-08-29
US6063964A (en)	2000-05-16
WO1998038155A1 (en)	1998-09-03
AU733001B2 (en)	2001-05-03
DE69803445D1 (en)	2002-02-28
PT970042E (pt)	2002-06-28
CA2282388A1 (en)	1998-09-03
NO994104D0 (no)	1999-08-25
NO994104L (no)	1999-10-26
HUP0001058A3 (en)	2001-07-30
HUP0001058A2 (hu)	2001-06-28
JP2001513763A (ja)	2001-09-04
DK0970042T3 (da)	2002-04-29
ITMI970414A1 (it)	1998-08-26
NZ336680A (en)	2000-02-28
EP0970042A1 (de)	2000-01-12
AU6619898A (en)	1998-09-18
EP0970042B1 (de)	2002-01-09
KR20000075736A (ko)	2000-12-26

Legal Events

Date	Code	Title	Description
2002-06-15	UEP	Publication of translation of european patent specification
2006-11-15	REN	Ceased due to non-payment of the annual fee

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DK0882021T3 (da)	2003-06-23	Nye phenanthridiner
NO20025821L (no)	2003-02-04	2-aminokarbonyl-9H-purinderivater
DE60230127D1 (de)	2009-01-15	Inhibitoren von integrin alpha-v-beta-6
MXPA02012076A (es)	2003-06-06	Compuestos quimicos.
MXPA03002911A (es)	2003-09-10	Compuestos quimicos.
AU2001266575A1 (en)	2002-01-08	Chemical compounds
ATE308529T1 (de)	2005-11-15	Arylsulfonamide als antivirale mittel
ATE211727T1 (de)	2002-01-15	5-hydroxymethyl-2-aminotetraline als cardiovasculäre mittel
MXPA02012470A (es)	2004-01-26	Inhibidores de fosfodiesterasa especificos para gmp ciclico.
DE60121048D1 (de)	2006-08-03	PYRAZINOi1'2':1,6öPYRIDOi3,4-BöINDOLDERIVATE
DK1204659T3 (da)	2004-04-05	Serotonerge benzofuraner
TR200100133T2 (tr)	2001-06-21	FKBP İnhibitörleri
IL114968A0 (en)	1995-12-08	1,4-dihydropyridine compounds
HRP20010885B1 (en)	2010-07-31	Ethanesulfonyl-piperidine derivatives
MXPA02011234A (es)	2004-10-15	Nuevas bases de oxidacion 2,5-diaminopiridina utiles para el tinte de las fibras queratinicas.
IT1292155B1 (it)	1999-01-25	Derivati naftotiazolonici attivi sul recettore dopaminergico d 3
SE9402241L (sv)	1995-12-24	Inhibitor
TR199800958A2 (xx)	1998-12-21	Herbisidal 3,5-Difloropridinleri.
ATE380178T1 (de)	2007-12-15	Anthranilsäure diamide derivate, ihre herstellung und pharmazeutische verwendung als antigastrin mittel
SE9603284D0 (sv)	1996-09-10	New compounds
TR199701011A2 (xx)	1998-04-21	1-karba-(detia)-sefalosforin t�revleri.
DK0914129T3 (da)	2002-01-28	Anvendelse af aspirochlor eller derivater deraf som immunosuppresive midler
AU758194C (en)	2004-04-08	Novel benzimidazoles and benzoxazoles