ATE211766T1 - Gentechnologische herstellung von impfstoffen gegen aids und andere retrovirale krankheiten - Google Patents
Gentechnologische herstellung von impfstoffen gegen aids und andere retrovirale krankheitenInfo
- Publication number
- ATE211766T1 ATE211766T1 AT90914669T AT90914669T ATE211766T1 AT E211766 T1 ATE211766 T1 AT E211766T1 AT 90914669 T AT90914669 T AT 90914669T AT 90914669 T AT90914669 T AT 90914669T AT E211766 T1 ATE211766 T1 AT E211766T1
- Authority
- AT
- Austria
- Prior art keywords
- particles
- vaccines against
- production
- against aids
- retroviral diseases
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 208000030507 AIDS Diseases 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000002068 genetic effect Effects 0.000 title 1
- 230000001177 retroviral effect Effects 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
- 239000002245 particle Substances 0.000 abstract 4
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 3
- 108020004414 DNA Proteins 0.000 abstract 1
- 102000053602 DNA Human genes 0.000 abstract 1
- 230000002950 deficient Effects 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 108700004026 gag Genes Proteins 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002458 infectious effect Effects 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108700004029 pol Genes Proteins 0.000 abstract 1
- 238000003259 recombinant expression Methods 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15023—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16023—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/974—Aids related test
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/826—Viruses
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/788—Of specified organic or carbon-based composition
- Y10S977/802—Virus-based particle
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/788—Of specified organic or carbon-based composition
- Y10S977/802—Virus-based particle
- Y10S977/803—Containing biological material in its interior
- Y10S977/804—Containing nucleic acid
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/915—Therapeutic or pharmaceutical composition
- Y10S977/917—Vaccine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/918—Immunological
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/92—Detection of biochemical
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/924—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis using nanostructure as support of dna analysis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898923123A GB8923123D0 (en) | 1989-10-13 | 1989-10-13 | A vaccine for human immunodeficiency virus |
| PCT/CA1990/000350 WO1991005864A1 (en) | 1989-10-13 | 1990-10-12 | Production of genetically-engineered vaccines for aids and other retroviral diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE211766T1 true ATE211766T1 (de) | 2002-01-15 |
Family
ID=10664542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90914669T ATE211766T1 (de) | 1989-10-13 | 1990-10-12 | Gentechnologische herstellung von impfstoffen gegen aids und andere retrovirale krankheiten |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US5439809A (de) |
| EP (1) | EP0495811B1 (de) |
| JP (1) | JP2537570B2 (de) |
| AT (1) | ATE211766T1 (de) |
| CA (1) | CA2067333C (de) |
| DE (1) | DE69033896T2 (de) |
| DK (1) | DK0495811T3 (de) |
| ES (1) | ES2171156T3 (de) |
| GB (1) | GB8923123D0 (de) |
| WO (1) | WO1991005864A1 (de) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5861282A (en) * | 1989-10-16 | 1999-01-19 | Whitehead Institute For Biomedical Research | Non-infectious HIV particles and uses therefor |
| CA2068713A1 (en) * | 1989-11-20 | 1991-05-21 | Omar K. Haffar | Non-replicating recombinant-made retroviral particles used as antiviral agents and immunogens |
| WO1991019803A1 (en) * | 1990-06-19 | 1991-12-26 | Applied Biotechnology, Incorporated | Self assembled, defective, nonself-propagating viral particles |
| IL98845A0 (en) * | 1990-07-19 | 1992-07-15 | Merck & Co Inc | Coconjugate vaccines comprising immunogenic protein,hiv related peptides,and anionic moieties,their preparation and pharmaceutical compositions containing them |
| US5912338A (en) * | 1990-10-12 | 1999-06-15 | Benjamin Rovinski | Nucleic acids encoding self-assembled, non-infectious, non-replicating, immunogenic retrovirus-like particles comprising modified HIV genomes and chimeric envelope glycoproteins |
| US5863542A (en) * | 1991-03-07 | 1999-01-26 | Virogenetics Corporation | Recombinant attenuated ALVAC canaryopox virus containing heterologous HIV or SIV inserts |
| AU702634B2 (en) * | 1991-03-07 | 1999-02-25 | Virogenetics Corporation | Immunodeficiency recombinant poxvirus |
| FR2676071B1 (fr) * | 1991-05-02 | 1994-11-18 | Transgene Sa | Nouveau variant gp160 non-clivable, soluble, de forme hybride. |
| EP0588816A1 (de) * | 1991-05-15 | 1994-03-30 | Institut De Recherches Cliniques De Montreal | Nicht-ansteckendes hiv-genom enthaltendes nicht-menschliches transgenes tier |
| US6268211B1 (en) | 1991-08-20 | 2001-07-31 | L'institut De Recherches Cliniques De Montreal | Non-infectious HIV transgene |
| US5274122A (en) * | 1992-10-15 | 1993-12-28 | Merck & Co., Inc. | Acidic derivatives of homocysteine thiolactone |
| EP0611822B1 (de) * | 1993-02-17 | 2002-05-22 | Wisconsin Alumni Research Foundation | Retroviren vom Typ "more-complex", die LTR von gemischtem Typ enthalten und deren Anwendungen |
| US5470572A (en) * | 1993-07-16 | 1995-11-28 | University Of Puerto Rico | Non-infectious simian immunodeficiency virus particles produced by cell line CRL 11393 |
| AU7568794A (en) * | 1993-08-20 | 1995-03-21 | St. Luke's-Roosevelt Hospital Center | Hiv (vif)-related compositions, and prophylactic and therapeutic uses thereof |
| US6015661A (en) * | 1994-02-14 | 2000-01-18 | The Macfarlane Burnet Centre For Medical Research Limited | Methods for the detection of non-pathogenic HIV-1 strains containing deletions in the Nef coding region and U3 region of the LTR |
| US5955342A (en) * | 1994-08-15 | 1999-09-21 | Connaught Laboratories Limited | Non-infectious, replication-defective, self-assembling HIV-1 viral particles containing antigenic markers in the gag coding region |
| US6291157B1 (en) | 1998-02-23 | 2001-09-18 | Connaught Laboratories Limited | Antigenically-marked non-infectious retrovirus-like particles |
| US5858838A (en) | 1998-02-23 | 1999-01-12 | Taiwan Semiconductor Manufacturing Company, Ltd. | Method for increasing DRAM capacitance via use of a roughened surface bottom capacitor plate |
| US6080408A (en) * | 1994-08-22 | 2000-06-27 | Connaught Laboratories Limited | Human immunodeficiency virus type 1 nucleic acids devoid of long terminal repeats capable of encoding for non-infectious, immunogenic, retrovirus-like particles |
| DE69526260T2 (de) * | 1994-11-15 | 2002-10-17 | Powderject Vaccines, Inc. | Methode zur induktion der humoralen und zellulären immunantwort durch intrazelluläre zufuhr von peptidbeschichteten mikropartikeln |
| EP0817854A2 (de) * | 1995-03-31 | 1998-01-14 | Wolf, Hans, Prof. Dr. | Verfahren zur antigenpräsentation, aufbauend auf retrovirusähnlichen partikeln |
| US6242187B1 (en) * | 1996-01-29 | 2001-06-05 | Virologic, Inc. | Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening |
| KR100537153B1 (ko) * | 1996-01-29 | 2006-12-15 | 바이럴러직, 인코퍼레이티드 | 항바이러스약품감수성및내성그리고항바이러스약물의스크리닝을결정하는방법및조성물 |
| US6024965A (en) | 1996-10-18 | 2000-02-15 | Erasums University Rotterdam | Induction of REV and TAT specific cytotoxic T-cells for prevention and treatment of human immunodeficiency virus (HIV) infection |
| US6271354B1 (en) | 1997-04-03 | 2001-08-07 | Thomas Jefferson University | Chimeric viral proteins |
| BR9806084A (pt) * | 1997-08-07 | 2001-09-18 | Altwell Biotech Inc | Vetor de poliovirus sabin tipo i, recombinante ou quimérico de replicação competente, seus métodos de produção e célula hospedeira |
| US20050033022A1 (en) * | 1997-09-26 | 2005-02-10 | Smithkline Beecham Biologicals Sa | Fusion proteins comprising HIV-1 Tat and/or Nef proteins |
| US6121021A (en) * | 1997-12-16 | 2000-09-19 | Connaught Laboratories Limited | Constitutive expression of non-infectious HIV-like particles |
| FI105105B (fi) * | 1998-02-27 | 2000-06-15 | Finnish Immunotechnology Ltd O | Itsereplikoiva DNA-vektori immunisoimiseksi HIV:ta vastaan |
| US6218181B1 (en) | 1998-03-18 | 2001-04-17 | The Salk Institute For Biological Studies | Retroviral packaging cell line |
| EP1078105B1 (de) | 1998-05-12 | 2004-11-24 | Genecure LLC | Replikationsdefekter hiv impfstoff |
| US7090848B1 (en) * | 1998-08-04 | 2006-08-15 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | HIV-1 envelope protein associated with a broadly reactive neutralizing antibody response |
| EP1104310B1 (de) * | 1998-08-04 | 2009-07-01 | The Henry M. Jackson Foundation for the advancement of Military Medicine, Inc. | Expression und charakterisierung eines hiv-1 hüllproteins, das mit einer breitreaktiven neutralisierenden antikörperantwort assoziiert ist. |
| US6764676B1 (en) | 1998-08-24 | 2004-07-20 | Pfizer Inc. | Compositions and methods for protecting animals from lentivirus-associated disease such as feline immunodeficiency virus |
| US20040105871A1 (en) * | 2000-03-02 | 2004-06-03 | Robinson Harriet L. | Compositions and methods for generating an immune response |
| WO2002072754A2 (en) * | 2001-03-08 | 2002-09-19 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Mva expressing modified hiv envelope, gag, and pol genes |
| US8623379B2 (en) * | 2000-03-02 | 2014-01-07 | Emory University | Compositions and methods for generating an immune response |
| AU2002211948B2 (en) | 2000-03-02 | 2007-09-13 | Emory University | DNA expression vectors and methods of use |
| EP1776961A1 (de) * | 2000-04-27 | 2007-04-25 | Sanofi Pasteur Limited | Impfung gegen HIV |
| DK1280551T3 (da) * | 2000-04-27 | 2007-05-21 | Sanofi Pasteur Ltd | Vacciner mod HIV-infektion |
| US6585978B1 (en) * | 2000-09-09 | 2003-07-01 | Akzo Nobel | EIA vaccine and diagnostic |
| US6461616B1 (en) * | 2000-09-09 | 2002-10-08 | Akzo Nobel Nv | EIAV p26 deletion vaccine and diagnostic |
| US7122180B2 (en) * | 2000-10-23 | 2006-10-17 | Children's Medical Center Corporation | DNA vectors containing mutated HIV proviruses |
| FR2824072B1 (fr) * | 2001-04-27 | 2004-03-12 | Centre Nat Rech Scient | Procede de replication et de production du virus de l'hepatite c |
| US7943146B2 (en) * | 2001-12-21 | 2011-05-17 | Myrexis, Inc. | Immunizing compositions comprising HIV-1 proviral constructs with an inactive p6 gag TSG101 UEV binding domain capable of producing budding-defective viral particles that remain tethered to the cell surface |
| WO2004065575A2 (en) * | 2003-01-15 | 2004-08-05 | Research Institute For Genetic And Human Therapy (Right) | Dna compositon and uses thereof |
| CA2537953A1 (en) * | 2003-09-09 | 2005-03-17 | Virxsys Corporation | Lentivirus vector-based approaches for generating an immune response to hiv in humans |
| US20050222068A1 (en) | 2003-10-23 | 2005-10-06 | Mourich Dan V | Method and antisense composition for selective inhibition of HIV infection in hematopoietic cells |
| US8367805B2 (en) * | 2004-11-12 | 2013-02-05 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| DK1817340T3 (da) | 2004-11-12 | 2012-08-13 | Xencor Inc | Fc-varianter med ændret binding til fcrn |
| US20070135620A1 (en) * | 2004-11-12 | 2007-06-14 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| WO2006118615A2 (en) * | 2004-12-16 | 2006-11-09 | Brandeis University | Clonable tag for purification and electron microscopy labeling |
| US9216212B2 (en) * | 2005-08-05 | 2015-12-22 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
| US7951384B2 (en) * | 2005-08-05 | 2011-05-31 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
| EP2215231A4 (de) * | 2007-10-15 | 2010-12-01 | Univ Queensland | Expressionssystem zur modulation einer immunantwort |
| US12492253B1 (en) | 2008-02-25 | 2025-12-09 | Xencor, Inc. | Anti-human C5 antibodies |
| US8592386B2 (en) | 2008-12-17 | 2013-11-26 | Sarepta Therapeutics, Inc. | Antisense compositions and methods for modulating contact hypersensitivity or contact dermatitis |
| US9493578B2 (en) | 2009-09-02 | 2016-11-15 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
| CA2793959C (en) | 2010-03-25 | 2019-06-04 | Oregon Health & Science University | Cmv glycoproteins and recombinant vectors |
| US9795658B2 (en) | 2010-04-20 | 2017-10-24 | Admedus Vaccines Pty Ltd | Expression system for modulating an immune response |
| DK2694101T3 (en) | 2011-04-06 | 2017-01-09 | Biovaxim Ltd | Pharmaceutical compositions for the prevention and / or treatment of HIV disease in humans |
| DK2691530T3 (en) | 2011-06-10 | 2018-05-22 | Univ Oregon Health & Science | CMV GLYCOPROTEIN AND RECOMBINANT VECTORS |
| EP2568289A3 (de) | 2011-09-12 | 2013-04-03 | International AIDS Vaccine Initiative | Immunselektion von rekombinantem vesikulärem Stomatitisvirus mit Expression von HIV-1-Proteinen durch Breitbandneutralisierungs-Antikörper |
| US9402894B2 (en) | 2011-10-27 | 2016-08-02 | International Aids Vaccine Initiative | Viral particles derived from an enveloped virus |
| AU2013221187B9 (en) | 2012-02-16 | 2018-01-04 | Vlp Therapeutics, Inc. | Virus like particle composition |
| EP2679596B1 (de) | 2012-06-27 | 2017-04-12 | International Aids Vaccine Initiative | HIV-1 Env-proteinvariante |
| US9730996B2 (en) * | 2012-10-24 | 2017-08-15 | Texas Biomedical Research Institute | Involucrin-driven retroviral expression cassettes encoding human immunodeficiency virus envelope glycoproteins |
| TWI676636B (zh) | 2013-07-12 | 2019-11-11 | Vlp醫療股份有限公司 | 包含pd-1抗原或pd-1配體抗原的類病毒粒子 |
| US20150065381A1 (en) | 2013-09-05 | 2015-03-05 | International Aids Vaccine Initiative | Methods of identifying novel hiv-1 immunogens |
| US10058604B2 (en) | 2013-10-07 | 2018-08-28 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
| US10385101B2 (en) | 2014-08-08 | 2019-08-20 | Vlp Therapeutics, Llc | Virus like particle comprising modified envelope protein E3 |
| CN106795513B (zh) | 2014-08-08 | 2021-06-11 | Vlp治疗公司 | 包含修饰的包膜蛋白e3的病毒样颗粒 |
| CA2960102C (en) | 2014-09-11 | 2023-10-24 | Vlp Therapeutics, Llc | Flavivirus virus like particle |
| EP3069730A3 (de) | 2015-03-20 | 2017-03-15 | International Aids Vaccine Initiative | Lösliche hiv-1-hüllglykoproteintrimere |
| EP3072901A1 (de) | 2015-03-23 | 2016-09-28 | International Aids Vaccine Initiative | Lösliche hiv-1-hüllglykoproteintrimere |
| KR102895580B1 (ko) | 2015-12-09 | 2025-12-03 | 진강 메디신 (오스트레일리아) 피티와이 엘티디 | 치료를 위한 면역조절용 조성물 |
| JP2020531514A (ja) | 2017-08-22 | 2020-11-05 | モナシュ・ユニヴァーシティ | 終末糖化産物受容体(rage)の活性化のスクリーニングアッセイ、モジュレーター及び調節 |
| EP3676285B1 (de) * | 2017-09-01 | 2025-11-05 | InProTher ApS | Impfstoff zur verwendung bei der prophylaxe und/oder behandlung einer krankheit |
| WO2019124441A1 (en) | 2017-12-20 | 2019-06-27 | Vlp Therapeutics, Llc | Alphavirus replicon particle |
| US20210030795A1 (en) * | 2019-06-17 | 2021-02-04 | Enochian BioPharma, Inc. | Allogeneic t-cell-based hiv vaccine to induce cellular and humoral immunity |
| EP4135847A4 (de) | 2020-04-17 | 2024-05-15 | VLP Therapeutics, Inc. | Coronavirus-impfstoff |
| CA3174651A1 (en) | 2020-04-30 | 2021-11-04 | Vlp Therapeutics, Inc. | Cytokine immunotherapy |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59104325A (ja) * | 1982-12-07 | 1984-06-16 | Japan Found Cancer | ヒト白血病ウイルスの遺伝子rnaに相補性を示すdna |
| US4722840A (en) * | 1984-09-12 | 1988-02-02 | Chiron Corporation | Hybrid particle immunogens |
| GR862412B (en) * | 1985-09-25 | 1987-01-23 | Oncogen | Vaccines and immuinoassays for acquired immune deficiency syndrome |
| ZA867281B (en) * | 1985-09-25 | 1987-05-27 | Oncogen | Vaccines and immunoassays for acquired immune deficiency syndrome |
| US4925784A (en) * | 1986-04-04 | 1990-05-15 | Hoffmann-La Roche Inc. | Expression and purification of an HTLV-III gag/env gene protein |
| US4752565A (en) * | 1986-04-07 | 1988-06-21 | The United States Of America As Represented By The Department Of Health And Human Services | Cell line producing AIDS viral antigens without producing infectious virus particles |
| AU606627B2 (en) * | 1986-11-01 | 1991-02-14 | British Bio-Technology Limited | Particulate hybrid hiv antigens |
| JPH01120284A (ja) * | 1987-11-05 | 1989-05-12 | Shiro Kato | Hiv不完全粒子および該製造方法 |
| IL89567A0 (en) * | 1988-03-28 | 1989-09-10 | Univ Leland Stanford Junior | Mutated hiv envelope protein |
| WO1989012095A1 (en) * | 1988-06-10 | 1989-12-14 | Applied Biotechnology, Inc. | A method of evaluating recombinant vaccines against immunodeficiency virus |
| US5019752A (en) | 1988-06-16 | 1991-05-28 | Hughes Aircraft Company | Plasma switch with chrome, perturbated cold cathode |
| JPH02203783A (ja) * | 1989-02-02 | 1990-08-13 | Banyu Pharmaceut Co Ltd | 抗原性を有する非感染性エイズウイルス産生クローン化ヒトt細胞 |
| JP3140757B2 (ja) * | 1989-02-06 | 2001-03-05 | デイナ・フアーバー・キヤンサー・インステイテユート | パッケージング欠陥hivプロウイルス、細胞系及びその使用 |
| AU5848390A (en) * | 1989-06-01 | 1991-01-07 | Applied Biotechnology, Inc. | Self-assembled, defective, non-self-propagating viral particles |
| JP2897295B2 (ja) * | 1989-12-14 | 1999-05-31 | 味の素株式会社 | レトロウィルス高生産用dna構築物及びレトロウィルス高生産用細胞株 |
| WO1991019803A1 (en) * | 1990-06-19 | 1991-12-26 | Applied Biotechnology, Incorporated | Self assembled, defective, nonself-propagating viral particles |
-
1989
- 1989-10-13 GB GB898923123A patent/GB8923123D0/en active Pending
-
1990
- 1990-10-12 JP JP2513524A patent/JP2537570B2/ja not_active Expired - Lifetime
- 1990-10-12 EP EP90914669A patent/EP0495811B1/de not_active Expired - Lifetime
- 1990-10-12 ES ES90914669T patent/ES2171156T3/es not_active Expired - Lifetime
- 1990-10-12 DK DK90914669T patent/DK0495811T3/da active
- 1990-10-12 DE DE69033896T patent/DE69033896T2/de not_active Expired - Lifetime
- 1990-10-12 CA CA002067333A patent/CA2067333C/en not_active Expired - Lifetime
- 1990-10-12 WO PCT/CA1990/000350 patent/WO1991005864A1/en not_active Ceased
- 1990-10-12 AT AT90914669T patent/ATE211766T1/de not_active IP Right Cessation
-
1992
- 1992-06-15 US US07/839,751 patent/US5439809A/en not_active Expired - Lifetime
-
1994
- 1994-05-06 US US08/239,427 patent/US5571712A/en not_active Expired - Lifetime
-
1995
- 1995-03-09 US US08/401,355 patent/US6291227B1/en not_active Expired - Lifetime
- 1995-06-06 US US08/467,975 patent/US5985641A/en not_active Expired - Lifetime
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1999
- 1999-09-03 US US09/389,364 patent/US7008784B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6291227B1 (en) | 2001-09-18 |
| US5571712A (en) | 1996-11-05 |
| JP2537570B2 (ja) | 1996-09-25 |
| DE69033896T2 (de) | 2002-11-14 |
| GB8923123D0 (en) | 1989-11-29 |
| CA2067333C (en) | 2001-05-01 |
| CA2067333A1 (en) | 1991-04-14 |
| JPH04506301A (ja) | 1992-11-05 |
| EP0495811B1 (de) | 2002-01-09 |
| WO1991005864A1 (en) | 1991-05-02 |
| EP0495811A1 (de) | 1992-07-29 |
| US5985641A (en) | 1999-11-16 |
| ES2171156T3 (es) | 2002-09-01 |
| US7008784B1 (en) | 2006-03-07 |
| DE69033896D1 (de) | 2002-02-14 |
| US5439809A (en) | 1995-08-08 |
| DK0495811T3 (da) | 2002-02-11 |
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