ATE211910T1 - Pharmazeutische zubereitungen enthaltend raloxifen, einen oberflächenaktiven stoff und ein wasserlösliches verdünnungsmittel - Google Patents

Pharmazeutische zubereitungen enthaltend raloxifen, einen oberflächenaktiven stoff und ein wasserlösliches verdünnungsmittel

Info

Publication number: ATE211910T1
Authority: AT; Austria
Prior art keywords: surfactant; water; pharmaceutical preparations; preparations containing; soluble diluent
Prior art date: 1994-03-02

Application number

AT95301291T

Other languages

English (en)

Inventor

Lowell Lee Gibson

Kerry John Hartauer

Julian Larry Stowers

Stephanie Ann Sweetana

Arvind Lavji Thakkar

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-02

Filing date

1995-02-28

Publication date

2002-02-15

1995-02-28 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2002-02-15 Application granted granted Critical

2002-02-15 Publication of ATE211910T1 publication Critical patent/ATE211910T1/de

Links

GZUITABIAKMVPG-UHFFFAOYSA-N raloxifene Chemical compound C1=CC(O)=CC=C1C1=C(C(=O)C=2C=CC(OCCN3CCCCC3)=CC=2)C2=CC=C(O)C=C2S1 GZUITABIAKMVPG-UHFFFAOYSA-N 0.000 title abstract 2
229960004622 raloxifene Drugs 0.000 title abstract 2
239000003085 diluting agent Substances 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
239000004094 surface-active agent Substances 0.000 title 1
150000002148 esters Chemical class 0.000 abstract 1
150000002170 ethers Chemical class 0.000 abstract 1
239000012052 hydrophilic carrier Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Biophysics (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Molecular Biology (AREA)
Obesity (AREA)
Hematology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)

AT95301291T 1994-03-02 1995-02-28 Pharmazeutische zubereitungen enthaltend raloxifen, einen oberflächenaktiven stoff und ein wasserlösliches verdünnungsmittel ATE211910T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US20491594A	1994-03-02	1994-03-02
SG1997000220A SG65636A1 (en)	1994-03-02	1997-01-30	Orally administrable pharmaceutical formulations

Publications (1)

Publication Number	Publication Date
ATE211910T1 true ATE211910T1 (de)	2002-02-15

Family

ID=26665140

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95301291T ATE211910T1 (de)	1994-03-02	1995-02-28	Pharmazeutische zubereitungen enthaltend raloxifen, einen oberflächenaktiven stoff und ein wasserlösliches verdünnungsmittel

Country Status (22)

Country	Link
EP (1)	EP0670162B1 (de)
JP (1)	JP3574210B2 (de)
CN (1)	CN1098684C (de)
AT (1)	ATE211910T1 (de)
AU (1)	AU684882B2 (de)
BR (1)	BR9500758A (de)
CA (1)	CA2143263C (de)
CZ (1)	CZ286119B6 (de)
DE (1)	DE69524981T2 (de)
DK (1)	DK0670162T3 (de)
ES (1)	ES2166799T3 (de)
FI (1)	FI117042B (de)
HU (1)	HU225418B1 (de)
IL (1)	IL112746A (de)
NO (1)	NO314286B1 (de)
NZ (1)	NZ270588A (de)
PL (1)	PL178858B1 (de)
PT (1)	PT670162E (de)
RU (1)	RU2118540C1 (de)
SG (1)	SG65636A1 (de)
SI (1)	SI0670162T1 (de)
ZA (1)	ZA951497B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5811447A (en)	1993-01-28	1998-09-22	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US6515009B1 (en)	1991-09-27	2003-02-04	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US6251920B1 (en)	1993-05-13	2001-06-26	Neorx Corporation	Prevention and treatment of cardiovascular pathologies
US6491938B2 (en)	1993-05-13	2002-12-10	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
ATE377418T1 (de)	1995-06-07	2007-11-15	Poniard Pharmaceuticals Inc	Vorbeugung und behandlung von kardiovaskulären beschwerden mit tamoxifen-analogen
BR9708248A (pt) *	1996-03-26	1999-07-27	Lilly Co Eli	Benzotiofenos formulações contendo os mesmos e metódos
US6458811B1 (en)	1996-03-26	2002-10-01	Eli Lilly And Company	Benzothiophenes formulations containing same and methods
CZ341297A3 (cs) *	1996-10-30	1998-05-13	Eli Lilly And Company	Způsob zlepšení léčby nebo profylaxe rakoviny prsu
ZA992858B (en)	1996-10-30	1999-07-29	Lilly Co Eli	Methods of preventing breast cancer.
US6117911A (en) *	1997-04-11	2000-09-12	Neorx Corporation	Compounds and therapies for the prevention of vascular and non-vascular pathologies
US6413533B1 (en) *	1998-05-07	2002-07-02	The University Of Tennessee Research Corporation	Method for chemoprevention of prostate cancer
JP3357356B2 (ja)	1999-12-13	2002-12-16	中外製薬株式会社	ヒドロキシカルボニル−ハロゲノアルキル側鎖を有する化合物
JP4798924B2 (ja) *	1999-12-13	2011-10-19	中外製薬株式会社	ヒドロキシカルボニル−ハロゲノアルキル側鎖を有する化合物
RU2247106C2 (ru) *	1999-12-13	2005-02-27	Чугаи Сейяку Кабусики Кайся	Соединения с гидроксикарбонильными-галогеналкильными боковыми цепями
AR029538A1 (es) *	2000-07-06	2003-07-02	Wyeth Corp	Composiciones farmaceuticas de agentes estrogenicos
WO2002085405A2 (en) *	2001-04-24	2002-10-31	Merck Patent Gmbh	COMBINATION THERAPY USING ANTI-ANGIOGENIC AGENTS AND TNF$g(a)
US6613083B2 (en)	2001-05-02	2003-09-02	Eckhard Alt	Stent device and method
EP1546138B1 (de)	2002-09-30	2012-01-18	A/S GEA Farmaceutisk Fabrik	Raloxifene-l-lactat oder ein hemihydrat davon, deren verwendungen, pharmazeutischen zusammensetzungen und herstellungsverfahren
US20050008704A1 (en) *	2003-07-11	2005-01-13	Ray Anup Kumar	Pharmaceutical composition for solubility enhancement of hydrophobic drugs
DK2054042T3 (da)	2006-06-30	2020-08-03	Iceutica Pty Ltd	Fremgangsmåder til fremstilling af biologisk aktive forbindelser i nanopartikelform
WO2009049643A1 (en) *	2007-10-16	2009-04-23	Pharmathen S.A.	Improved pharmaceutical composition containing a selective estrogen receptor modulator and method for the preparation thereof
EP2242483B1 (de) *	2007-12-21	2013-02-20	Synthon B.V.	Raloxifen-zusammensetzung
AU2010239081C1 (en)	2009-04-24	2014-11-06	Iceutica Pty Ltd	A novel formulation of indomethacin
WO2011000581A2 (en)	2009-07-02	2011-01-06	Synthon B.V.	Raloxifene composition
WO2011099942A1 (en)	2010-02-09	2011-08-18	Silverstone Pharma	New addition salts of raloxifene, process for the preparation thereof and use thereof in therapy
CN103006570B (zh) *	2012-10-08	2013-12-25	孙维会	一种阿佐昔芬速释微丸及其制备方法
DK2925320T3 (da) *	2012-11-30	2021-05-10	Pharmathen Sa	Hidtil ukendt fremgangsmåde til forbedring af bio-tilgængeligheden af lægemidler med lav vandopløselighed
CN103830197A (zh) *	2014-03-14	2014-06-04	崔书豪	一种盐酸雷洛昔芬分散片及其制备方法
US9526734B2 (en)	2014-06-09	2016-12-27	Iceutica Pty Ltd.	Formulation of meloxicam
WO2018062964A1 (ko) *	2016-09-30	2018-04-05	한미약품 주식회사	용출율이 향상된 라록시펜, 및 비타민 d 또는 그 유도체를 포함하는 복합 캡슐제 및 이의 제조방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4418068A (en) *	1981-04-03	1983-11-29	Eli Lilly And Company	Antiestrogenic and antiandrugenic benzothiophenes
TW366342B (en) *	1992-07-28	1999-08-11	Lilly Co Eli	The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss

1995
- 1995-02-23 ZA ZA951497A patent/ZA951497B/xx unknown
- 1995-02-23 BR BR9500758A patent/BR9500758A/pt not_active Application Discontinuation
- 1995-02-23 IL IL11274695A patent/IL112746A/xx not_active IP Right Cessation
- 1995-02-23 CA CA002143263A patent/CA2143263C/en not_active Expired - Lifetime
- 1995-02-24 RU RU95102924A patent/RU2118540C1/ru not_active IP Right Cessation
- 1995-02-24 CZ CZ1995499A patent/CZ286119B6/cs not_active IP Right Cessation
- 1995-02-27 CN CN95100822A patent/CN1098684C/zh not_active Expired - Lifetime
- 1995-02-28 NZ NZ270588A patent/NZ270588A/en unknown
- 1995-02-28 DK DK95301291T patent/DK0670162T3/da active
- 1995-02-28 PT PT95301291T patent/PT670162E/pt unknown
- 1995-02-28 ES ES95301291T patent/ES2166799T3/es not_active Expired - Lifetime
- 1995-02-28 SI SI9530581T patent/SI0670162T1/xx unknown
- 1995-02-28 EP EP95301291A patent/EP0670162B1/de not_active Expired - Lifetime
- 1995-02-28 DE DE69524981T patent/DE69524981T2/de not_active Expired - Lifetime
- 1995-02-28 AT AT95301291T patent/ATE211910T1/de active
- 1995-03-01 JP JP4177395A patent/JP3574210B2/ja not_active Expired - Lifetime
- 1995-03-01 PL PL95307491A patent/PL178858B1/pl not_active IP Right Cessation
- 1995-03-01 NO NO19950799A patent/NO314286B1/no not_active IP Right Cessation
- 1995-03-01 FI FI950947A patent/FI117042B/fi not_active IP Right Cessation
- 1995-03-01 AU AU13548/95A patent/AU684882B2/en not_active Expired
- 1995-03-01 HU HU9500635A patent/HU225418B1/hu not_active IP Right Cessation
1997
- 1997-01-30 SG SG1997000220A patent/SG65636A1/en unknown

Also Published As

Publication number	Publication date
JPH07277973A (ja)	1995-10-24
PL178858B1 (pl)	2000-06-30
NO314286B1 (no)	2003-03-03
CZ49995A3 (en)	1995-10-18
PL307491A1 (en)	1995-09-04
NZ270588A (en)	1996-01-26
EP0670162B1 (de)	2002-01-16
HU225418B1 (en)	2006-11-28
ES2166799T3 (es)	2002-05-01
CN1098684C (zh)	2003-01-15
DK0670162T3 (da)	2002-03-11
BR9500758A (pt)	1995-10-24
RU2118540C1 (ru)	1998-09-10
FI117042B (fi)	2006-05-31
SI0670162T1 (en)	2002-06-30
NO950799L (no)	1995-09-04
DE69524981T2 (de)	2002-08-29
HUT72661A (en)	1996-05-28
CN1112420A (zh)	1995-11-29
HU9500635D0 (en)	1995-04-28
AU684882B2 (en)	1998-01-08
FI950947A0 (fi)	1995-03-01
NO950799D0 (no)	1995-03-01
PT670162E (pt)	2002-06-28
DE69524981D1 (de)	2002-02-21
SG65636A1 (en)	1999-06-22
CA2143263A1 (en)	1995-09-03
IL112746A (en)	1999-12-31
CA2143263C (en)	2002-01-08
EP0670162A1 (de)	1995-09-06
AU1354895A (en)	1995-09-07
JP3574210B2 (ja)	2004-10-06
IL112746A0 (en)	1995-05-26
CZ286119B6 (cs)	2000-01-12
ZA951497B (en)	1996-08-23
FI950947L (fi)	1995-09-03

Legal Events

Date	Code	Title	Description
2002-06-15	UEP	Publication of translation of european patent specification

Publication	Publication Date	Title
DE69524981D1 (de)	2002-02-21	Pharmazeutische Zubereitungen enthaltend Raloxifen, einen oberflächenaktiven Stoff und ein wasserlösliches Verdünnungsmittel
DK0698393T3 (da)	2002-08-05	3-/-menthoxypropan-1,2-diol som solubiliseringsmiddel og præparat til udvortes brug, der indeholder samme
DK0948965T3 (da)	2004-07-05	Stabile medicinske præparater indeholdende 4,5-epoxymorphinanderivater
GB2341801B (en)	2003-10-29	Formulation
DE69115263D1 (de)	1996-01-18	Pharmazeutische zusammensetzungen.
IE901821L (en)	1990-11-24	Porous pharmaceutical form
ES8601698A1 (es)	1985-11-01	Procedimiento para producir preparados farmaceuticos a base de heparina y agentes tensioactivos.
DK0642530T3 (da)	1998-10-26	Dolastatinderivater
NO963113L (no)	1996-09-17	Farmasöytiske preparater omfattende hirudin
ATE149360T1 (de)	1997-03-15	Zahnseide mit chemotherapeutischen wirkstoffen
SE9101687L (sv)	1991-12-06	Dikloranilinfoerening
NO901169L (no)	1990-09-24	Azol-1-alkanamider som anti-arrytmiske midler og fremstilling derav.
MY117590A (en)	2004-07-31	Orally administerable pharmaceutical formulations
NO901200D0 (no)	1990-03-14	Azol-1-alkanamider som anti-arrytmiske midler og fremstilling derav.
ITPR910054A0 (it)	1991-12-09	Miscelatore per autorespiratore ad uso medicale,particolarmente per camera iperbarica.
ITMI931822A1 (it)	1995-02-12	Composizioni farmaceutiche a base di nimesulide, somministrabili per via orale, non gastrolesive e/o a rilascio controllato