DK0670162T3 - Farmaceutiske formuleringer indeholdende raloxifen, et overfladeaktivt middel og et vandopløseligt fortyndingsmiddel - Google Patents

Farmaceutiske formuleringer indeholdende raloxifen, et overfladeaktivt middel og et vandopløseligt fortyndingsmiddel

Info

Publication number: DK0670162T3
Authority: DK; Denmark
Prior art keywords: pharmaceutical formulations; surfactant; water; formulations containing; soluble diluent
Prior art date: 1994-03-02

Application number

DK95301291T

Other languages

English (en)

Inventor

Arvind Lavji Thakkar

Stephanie Ann Sweetana

Lowell Lee Gibson

Kerry John Hartauer

Julian Larry Stowers

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-02

Filing date

1995-02-28

Publication date

2002-03-11

1995-02-28 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2002-03-11 Application granted granted Critical

2002-03-11 Publication of DK0670162T3 publication Critical patent/DK0670162T3/da

Links

239000008194 pharmaceutical composition Substances 0.000 title abstract 2
GZUITABIAKMVPG-UHFFFAOYSA-N raloxifene Chemical compound C1=CC(O)=CC=C1C1=C(C(=O)C=2C=CC(OCCN3CCCCC3)=CC=2)C2=CC=C(O)C=C2S1 GZUITABIAKMVPG-UHFFFAOYSA-N 0.000 title abstract 2
229960004622 raloxifene Drugs 0.000 title abstract 2
239000003085 diluting agent Substances 0.000 title 1
239000004094 surface-active agent Substances 0.000 title 1
150000002148 esters Chemical class 0.000 abstract 1
150000002170 ethers Chemical class 0.000 abstract 1
239000012052 hydrophilic carrier Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Endocrinology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Rheumatology (AREA)
Obesity (AREA)
Hematology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)

DK95301291T 1994-03-02 1995-02-28 Farmaceutiske formuleringer indeholdende raloxifen, et overfladeaktivt middel og et vandopløseligt fortyndingsmiddel DK0670162T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US20491594A	1994-03-02	1994-03-02
SG1997000220A SG65636A1 (en)	1994-03-02	1997-01-30	Orally administrable pharmaceutical formulations

Publications (1)

Publication Number	Publication Date
DK0670162T3 true DK0670162T3 (da)	2002-03-11

Family

ID=26665140

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95301291T DK0670162T3 (da)	1994-03-02	1995-02-28	Farmaceutiske formuleringer indeholdende raloxifen, et overfladeaktivt middel og et vandopløseligt fortyndingsmiddel

Country Status (22)

Country	Link
EP (1)	EP0670162B1 (da)
JP (1)	JP3574210B2 (da)
CN (1)	CN1098684C (da)
AT (1)	ATE211910T1 (da)
AU (1)	AU684882B2 (da)
BR (1)	BR9500758A (da)
CA (1)	CA2143263C (da)
CZ (1)	CZ286119B6 (da)
DE (1)	DE69524981T2 (da)
DK (1)	DK0670162T3 (da)
ES (1)	ES2166799T3 (da)
FI (1)	FI117042B (da)
HU (1)	HU225418B1 (da)
IL (1)	IL112746A (da)
NO (1)	NO314286B1 (da)
NZ (1)	NZ270588A (da)
PL (1)	PL178858B1 (da)
PT (1)	PT670162E (da)
RU (1)	RU2118540C1 (da)
SG (1)	SG65636A1 (da)
SI (1)	SI0670162T1 (da)
ZA (1)	ZA951497B (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6515009B1 (en)	1991-09-27	2003-02-04	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en)	1993-01-28	1998-09-22	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US6251920B1 (en)	1993-05-13	2001-06-26	Neorx Corporation	Prevention and treatment of cardiovascular pathologies
US6491938B2 (en)	1993-05-13	2002-12-10	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
JPH11510479A (ja)	1995-06-07	1999-09-14	ネオルックスコーポレイション	タモキシフェン類似体による心臓血管疾病の予防及び治療
UA57596C2 (uk) *	1996-03-26	2003-06-16	Елі Ліллі Енд Компані	Похідне бензотіофену, фармацевтична лікарська форма, фармацевтична композиція, спосіб лікування остеопорозу та спосіб зниження рівнів ліпідів
US6458811B1 (en)	1996-03-26	2002-10-01	Eli Lilly And Company	Benzothiophenes formulations containing same and methods
CZ341297A3 (cs) *	1996-10-30	1998-05-13	Eli Lilly And Company	Způsob zlepšení léčby nebo profylaxe rakoviny prsu
ZA979720B (en)	1996-10-30	1999-04-29	Lilly Co Eli	Prophylaxis of breast cancer
WO1998046588A2 (en)	1997-04-11	1998-10-22	Neorx Corporation	Compounds and therapies for the prevention of vascular and non-vascular pathologies
US6413533B1 (en) *	1998-05-07	2002-07-02	The University Of Tennessee Research Corporation	Method for chemoprevention of prostate cancer
RU2247106C2 (ru) *	1999-12-13	2005-02-27	Чугаи Сейяку Кабусики Кайся	Соединения с гидроксикарбонильными-галогеналкильными боковыми цепями
US6737417B2 (en)	1999-12-13	2004-05-18	Chugai Seiyaku Kabushiki Kaisha	Compounds with hydroxycarbonyl-halogenoalkyl side chain
JP4798924B2 (ja) *	1999-12-13	2011-10-19	中外製薬株式会社	ヒドロキシカルボニル−ハロゲノアルキル側鎖を有する化合物
AR029538A1 (es) *	2000-07-06	2003-07-02	Wyeth Corp	Composiciones farmaceuticas de agentes estrogenicos
ES2366775T3 (es) *	2001-04-24	2011-10-25	Merck Patent Gmbh	POLITERAPIA UTILIZANDO AGENTES ANTIANGIOGÉNICOS Y TNF(alfa).
US6613083B2 (en)	2001-05-02	2003-09-02	Eckhard Alt	Stent device and method
ATE541840T1 (de)	2002-09-30	2012-02-15	Gea Farmaceutisk Fabrik As	Raloxifene-l-lactat oder ein hemihydrat davon, deren verwendungen, pharmazeutischen zusammensetzungen und herstellungsverfahren
US20050008704A1 (en) *	2003-07-11	2005-01-13	Ray Anup Kumar	Pharmaceutical composition for solubility enhancement of hydrophobic drugs
WO2008000042A1 (en)	2006-06-30	2008-01-03	Iceutica Pty Ltd	Methods for the preparation of biologically active compounds in nanoparticulate form
US20110065751A1 (en) *	2007-10-16	2011-03-17	Pharmathen S.A.	Improved pharmaceutical composition containing a selective estrogen receptor modulator and method for the preparation thereof
WO2009080364A1 (en) *	2007-12-21	2009-07-02	Synthon B.V.	Raloxifene composition
UA106231C2 (uk)	2009-04-24	2014-08-11	Айсьютика Пти Лтд	Разова доза фармацевтичної композиції індометацину (варіанти)
ES2437916T3 (es)	2009-07-02	2014-01-15	Synthon B.V.	Composición de raloxifeno
WO2011099942A1 (en)	2010-02-09	2011-08-18	Silverstone Pharma	New addition salts of raloxifene, process for the preparation thereof and use thereof in therapy
CN103006570B (zh) *	2012-10-08	2013-12-25	孙维会	一种阿佐昔芬速释微丸及其制备方法
ES2864096T3 (es) *	2012-11-30	2021-10-13	Pharmathen Sa	Método nuevo para mejorar la biodisponibilidad de fármacos de baja solubilidad acuosa
CN103830197A (zh) *	2014-03-14	2014-06-04	崔书豪	一种盐酸雷洛昔芬分散片及其制备方法
US9526734B2 (en)	2014-06-09	2016-12-27	Iceutica Pty Ltd.	Formulation of meloxicam
WO2018062964A1 (ko) *	2016-09-30	2018-04-05	한미약품 주식회사	용출율이 향상된 라록시펜, 및 비타민 d 또는 그 유도체를 포함하는 복합 캡슐제 및 이의 제조방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4418068A (en) *	1981-04-03	1983-11-29	Eli Lilly And Company	Antiestrogenic and antiandrugenic benzothiophenes
TW366342B (en) *	1992-07-28	1999-08-11	Lilly Co Eli	The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss

1995
- 1995-02-23 ZA ZA951497A patent/ZA951497B/xx unknown
- 1995-02-23 IL IL11274695A patent/IL112746A/xx not_active IP Right Cessation
- 1995-02-23 BR BR9500758A patent/BR9500758A/pt not_active Application Discontinuation
- 1995-02-23 CA CA002143263A patent/CA2143263C/en not_active Expired - Lifetime
- 1995-02-24 CZ CZ1995499A patent/CZ286119B6/cs not_active IP Right Cessation
- 1995-02-24 RU RU95102924A patent/RU2118540C1/ru not_active IP Right Cessation
- 1995-02-27 CN CN95100822A patent/CN1098684C/zh not_active Expired - Lifetime
- 1995-02-28 DK DK95301291T patent/DK0670162T3/da active
- 1995-02-28 AT AT95301291T patent/ATE211910T1/de active
- 1995-02-28 EP EP95301291A patent/EP0670162B1/en not_active Expired - Lifetime
- 1995-02-28 DE DE69524981T patent/DE69524981T2/de not_active Expired - Lifetime
- 1995-02-28 ES ES95301291T patent/ES2166799T3/es not_active Expired - Lifetime
- 1995-02-28 NZ NZ270588A patent/NZ270588A/en unknown
- 1995-02-28 PT PT95301291T patent/PT670162E/pt unknown
- 1995-02-28 SI SI9530581T patent/SI0670162T1/xx unknown
- 1995-03-01 AU AU13548/95A patent/AU684882B2/en not_active Expired
- 1995-03-01 NO NO19950799A patent/NO314286B1/no not_active IP Right Cessation
- 1995-03-01 PL PL95307491A patent/PL178858B1/pl not_active IP Right Cessation
- 1995-03-01 HU HU9500635A patent/HU225418B1/hu not_active IP Right Cessation
- 1995-03-01 FI FI950947A patent/FI117042B/fi not_active IP Right Cessation
- 1995-03-01 JP JP4177395A patent/JP3574210B2/ja not_active Expired - Lifetime
1997
- 1997-01-30 SG SG1997000220A patent/SG65636A1/en unknown

Also Published As

Publication number	Publication date
ZA951497B (en)	1996-08-23
SI0670162T1 (en)	2002-06-30
ATE211910T1 (de)	2002-02-15
AU1354895A (en)	1995-09-07
EP0670162B1 (en)	2002-01-16
CZ49995A3 (en)	1995-10-18
DE69524981D1 (de)	2002-02-21
IL112746A0 (en)	1995-05-26
FI117042B (fi)	2006-05-31
NO314286B1 (no)	2003-03-03
CZ286119B6 (cs)	2000-01-12
RU2118540C1 (ru)	1998-09-10
EP0670162A1 (en)	1995-09-06
CA2143263C (en)	2002-01-08
NO950799D0 (no)	1995-03-01
PT670162E (pt)	2002-06-28
DE69524981T2 (de)	2002-08-29
JPH07277973A (ja)	1995-10-24
AU684882B2 (en)	1998-01-08
FI950947L (fi)	1995-09-03
IL112746A (en)	1999-12-31
BR9500758A (pt)	1995-10-24
CA2143263A1 (en)	1995-09-03
ES2166799T3 (es)	2002-05-01
HUT72661A (en)	1996-05-28
NO950799L (no)	1995-09-04
SG65636A1 (en)	1999-06-22
PL307491A1 (en)	1995-09-04
FI950947A0 (fi)	1995-03-01
JP3574210B2 (ja)	2004-10-06
HU9500635D0 (en)	1995-04-28
NZ270588A (en)	1996-01-26
CN1112420A (zh)	1995-11-29
HU225418B1 (en)	2006-11-28
CN1098684C (zh)	2003-01-15
PL178858B1 (pl)	2000-06-30

Publication	Publication Date	Title
DE69524981D1 (de)	2002-02-21	Pharmazeutische Zubereitungen enthaltend Raloxifen, einen oberflächenaktiven Stoff und ein wasserlösliches Verdünnungsmittel
DK0698393T3 (da)	2002-08-05	3-/-menthoxypropan-1,2-diol som solubiliseringsmiddel og præparat til udvortes brug, der indeholder samme
DK0948965T3 (da)	2004-07-05	Stabile medicinske præparater indeholdende 4,5-epoxymorphinanderivater
ES2052809T3 (es)	1994-07-16	Agente desinfectante tuberculocida.
DK0425016T3 (da)	1996-05-06	Antimikrobiel fremgangsmåde og formulering med anvendelse af type II endoglycosidase og antimikrobielt middel
DK0396404T3 (da)	1994-03-14	Farmaceutisk middel indeholdende loratadin, ibuprofen og pseudoephedrin
NO902280D0 (no)	1990-05-23	Ny poroes farmasoeytisk form og fremstilling derav.
NO950315L (no)	1995-03-30	Orale preparater
MA23136A1 (fr)	1994-10-01	Composition de nettoyage comprenant des tensio- actifs a courte chaine .
NO913035D0 (no)	1991-08-05	(2r)-2-(di(2-propyl)fosfonylmetoksy)-3-p-toluensulfonyloksy-1-trimetylacetoksypropan, fremgangsmaate for fremstilling og anvendelse derav.
NO902277L (no)	1990-11-30	Baere- eller foeringsvalse og anordning som anvender slike.
FI952540L (fi)	1995-05-24	Puhdistuskoostumukset, joissa on hyvin hydrofiilisiä ja hyvin hydrofobisia ei-ionisia pinta-aktiivisia aineita
ES2129108T3 (es)	1999-06-01	Procedimiento para una preparacion estabilizadora para lentes de contacto.
NO900564D0 (no)	1990-02-06	Overflateaktivt middel.
NO901169D0 (no)	1990-03-13	Azol-1-alkanamider som anti-arrytmiske midler og fremstilling derav.
EP0615695A3 (en)	1995-02-08	Sterilizer with reduced surface pollution.
ATE149360T1 (de)	1997-03-15	Zahnseide mit chemotherapeutischen wirkstoffen
MY117590A (en)	2004-07-31	Orally administerable pharmaceutical formulations
NO901200D0 (no)	1990-03-14	Azol-1-alkanamider som anti-arrytmiske midler og fremstilling derav.
IT9022245A0 (it)	1990-11-29	Composizioni e metodo per la disinfezione e la pulizia delle lenti a contatto rigide, semirigide e morbide.
IT8620095A0 (it)	1986-04-15	Apparecchiatura per sterilizzare lenti a contatto, in particolare lenti morbide.
NO913561D0 (no)	1991-09-10	Brannhemmende middel.