ATE212329T1 - Kontinuierliches verfahren zur herstellung von diazomethan - Google Patents
Kontinuierliches verfahren zur herstellung von diazomethanInfo
- Publication number
- ATE212329T1 ATE212329T1 AT98203800T AT98203800T ATE212329T1 AT E212329 T1 ATE212329 T1 AT E212329T1 AT 98203800 T AT98203800 T AT 98203800T AT 98203800 T AT98203800 T AT 98203800T AT E212329 T1 ATE212329 T1 AT E212329T1
- Authority
- AT
- Austria
- Prior art keywords
- organic
- phase
- continuously
- product mixture
- aqueous
- Prior art date
Links
- YXHKONLOYHBTNS-UHFFFAOYSA-N Diazomethane Chemical compound C=[N+]=[N-] YXHKONLOYHBTNS-UHFFFAOYSA-N 0.000 title abstract 5
- 238000010924 continuous production Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 abstract 8
- 239000012074 organic phase Substances 0.000 abstract 7
- 239000008346 aqueous phase Substances 0.000 abstract 6
- 150000007529 inorganic bases Chemical class 0.000 abstract 5
- 239000003960 organic solvent Substances 0.000 abstract 5
- 239000007864 aqueous solution Substances 0.000 abstract 4
- XGEGHDBEHXKFPX-UHFFFAOYSA-N N-methylthiourea Natural products CNC(N)=O XGEGHDBEHXKFPX-UHFFFAOYSA-N 0.000 abstract 3
- XGEGHDBEHXKFPX-NJFSPNSNSA-N methylurea Chemical compound [14CH3]NC(N)=O XGEGHDBEHXKFPX-NJFSPNSNSA-N 0.000 abstract 3
- 239000012071 phase Substances 0.000 abstract 3
- 239000002904 solvent Substances 0.000 abstract 3
- ZRKWMRDKSOPRRS-UHFFFAOYSA-N N-Methyl-N-nitrosourea Chemical compound O=NN(C)C(N)=O ZRKWMRDKSOPRRS-UHFFFAOYSA-N 0.000 abstract 2
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical group [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229940005654 nitrite ion Drugs 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 1
- -1 nitrite ions Chemical class 0.000 abstract 1
- 125000000018 nitroso group Chemical group N(=O)* 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
- C07C245/12—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom
- C07C245/14—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton
- C07C245/16—Diazomethane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/969,993 US5854405A (en) | 1997-11-13 | 1997-11-13 | Continuous process for diazomethane from an n-methyl-n-nitrosoamine and from methylurea through n-methyl-n-nitrosourea |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE212329T1 true ATE212329T1 (de) | 2002-02-15 |
Family
ID=25516271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98203800T ATE212329T1 (de) | 1997-11-13 | 1998-11-11 | Kontinuierliches verfahren zur herstellung von diazomethan |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5854405A (de) |
| EP (1) | EP0916648B1 (de) |
| JP (1) | JP3294560B2 (de) |
| AT (1) | ATE212329T1 (de) |
| BR (1) | BR9804629A (de) |
| DE (1) | DE69803537T2 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6605732B1 (en) * | 1999-05-03 | 2003-08-12 | Aerojet Fine Chemicals Llc | Clean, high-yield preparation of S,S and R,S amino acid isosteres |
| GB2357501B (en) * | 1999-12-23 | 2001-11-28 | Phoenix Chemicals Ltd | Generation of diazomethane |
| DE102004030371A1 (de) * | 2004-06-23 | 2006-01-19 | Dynamit Nobel Gmbh | Verfahren zur Herstellung von gasförmigen Diazoalkanen |
| CN101844063B (zh) * | 2010-06-24 | 2013-09-25 | 凯莱英医药集团（天津）股份有限公司 | 一种大批量连续安全生产重氮甲烷反应器及其工作方法 |
| DK2635548T3 (en) | 2010-11-01 | 2015-03-23 | Dpx Fine Chemicals Austria Gmbh & Co Kg | CONTINUOUS PRODUCTION AND TURNOVER OF A diazo compound |
| GB201318894D0 (en) | 2013-10-25 | 2013-12-11 | Givaudan Sa | Improvements in or relating to organic compounds |
| GB201318886D0 (en) * | 2013-10-25 | 2013-12-11 | Givaudan Sa | Improvements i or relating to organic compounds |
| US9233924B2 (en) | 2014-03-11 | 2016-01-12 | Ampac Fine Chemicals Llc | Methods for preparing D-threo methylphenidate using diazomethane, and compositions thereof |
| GB201516396D0 (en) | 2015-09-16 | 2015-10-28 | Givaudan Sa | Improvements in or relating to organic compounds |
| GB201810514D0 (en) | 2018-06-27 | 2018-08-15 | Givaudan Sa | Improvements in or relating to organic compounds |
| CN110078637B (zh) * | 2019-05-21 | 2022-08-30 | 凯莱英医药集团（天津）股份有限公司 | 重氮甲烷的制备工艺 |
| US12084402B2 (en) | 2019-05-21 | 2024-09-10 | Asymchem Laboratories (Tianjin) Co., Ltd. | Preparation process of diazomethane |
| EP3995477A4 (de) * | 2019-07-02 | 2022-09-14 | Asymchem Laboratories (Tianjin) Co., Ltd. | Verfahren und vorrichtung zur kontinuierlichen synthese von cyclopropanverbindungen |
| WO2022044038A1 (en) * | 2020-08-24 | 2022-03-03 | Council Of Scientific And Industrial Research | Automated diazomethane generator, reactor and solid phase quencher |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1033671B (de) * | 1957-04-02 | 1958-07-10 | Phrix Werke Ag | Verfahren zur Herstellung von Diazomethan |
| JPS54103803A (en) * | 1978-02-02 | 1979-08-15 | Minoru Sekiya | Nn**nnnitrosoalkylamino*methyl*carbamic acid ester*its manufacture and diazoalkane formation using said compound |
| JPS6178758A (ja) * | 1984-09-27 | 1986-04-22 | Taoka Chem Co Ltd | ジアゾメタン誘導体の製造方法 |
| JPS6351366A (ja) * | 1986-08-21 | 1988-03-04 | Kurita Water Ind Ltd | ジアゾメタンのエ−テル溶液の製造方法 |
| US5459253A (en) | 1991-07-19 | 1995-10-17 | Pharmacia P-L Biochemicals Inc. | M-RNA purification |
| US5459243A (en) * | 1994-03-10 | 1995-10-17 | Isis Pharmaceuticals, Inc. | Apparatus and processes for the large scale generation and transfer of diazomethane |
-
1997
- 1997-11-13 US US08/969,993 patent/US5854405A/en not_active Expired - Lifetime
-
1998
- 1998-11-11 AT AT98203800T patent/ATE212329T1/de not_active IP Right Cessation
- 1998-11-11 EP EP98203800A patent/EP0916648B1/de not_active Expired - Lifetime
- 1998-11-11 DE DE69803537T patent/DE69803537T2/de not_active Expired - Lifetime
- 1998-11-12 JP JP32241298A patent/JP3294560B2/ja not_active Expired - Fee Related
- 1998-11-12 BR BR9804629-2A patent/BR9804629A/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BR9804629A (pt) | 2001-03-20 |
| DE69803537D1 (de) | 2002-03-14 |
| JPH11209330A (ja) | 1999-08-03 |
| US5854405A (en) | 1998-12-29 |
| JP3294560B2 (ja) | 2002-06-24 |
| EP0916648B1 (de) | 2002-01-23 |
| DE69803537T2 (de) | 2002-08-08 |
| EP0916648A1 (de) | 1999-05-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |