ATE255086T1 - Verfahren zur herstellung von aceclofenac - Google Patents

Verfahren zur herstellung von aceclofenac

Info

Publication number: ATE255086T1
Authority: AT; Austria
Prior art keywords: compounds; aceclofenac; formula; alpha; producing
Prior art date: 1998-04-28

Application number

AT99918244T

Other languages

English (en)

Inventor

Helmut Schickaneder

Aggelos Nikolopoulos

Trevor Murphy

Original Assignee

Russinsky Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-28

Filing date

1999-04-22

Publication date

2003-12-15

1999-04-22 Application filed by Russinsky Ltd filed Critical Russinsky Ltd

2003-12-15 Application granted granted Critical

2003-12-15 Publication of ATE255086T1 publication Critical patent/ATE255086T1/de

Links

MNIPYSSQXLZQLJ-UHFFFAOYSA-N Biofenac Chemical compound OC(=O)COC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl MNIPYSSQXLZQLJ-UHFFFAOYSA-N 0.000 title abstract 3
229960004420 aceclofenac Drugs 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title 1
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
UAOMVDZJSHZZME-UHFFFAOYSA-N diisopropylamine Chemical compound CC(C)NC(C)C UAOMVDZJSHZZME-UHFFFAOYSA-N 0.000 abstract 3
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 2
150000001242 acetic acid derivatives Chemical class 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
229910021529 ammonia Inorganic materials 0.000 abstract 1
DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 abstract 1
229940043279 diisopropylamine Drugs 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
239000000041 non-steroidal anti-inflammatory agent Substances 0.000 abstract 1
229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C211/03—Monoamines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT99918244T 1998-04-28 1999-04-22 Verfahren zur herstellung von aceclofenac ATE255086T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IE980324		1998-04-28
PCT/IE1999/000028 WO1999055660A1 (en)	1998-04-28	1999-04-22	Process for the preparation of aceclofenac

Publications (1)

Publication Number	Publication Date
ATE255086T1 true ATE255086T1 (de)	2003-12-15

Family

ID=11041787

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99918244T ATE255086T1 (de)	1998-04-28	1999-04-22	Verfahren zur herstellung von aceclofenac

Country Status (7)

Country	Link
EP (1)	EP1082290B1 (de)
AT (1)	ATE255086T1 (de)
AU (1)	AU3625199A (de)
CA (1)	CA2330435A1 (de)
DE (1)	DE69913133T2 (de)
ES (1)	ES2211074T3 (de)
WO (1)	WO1999055660A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100348100B1 (ko) *	1998-07-31	2002-11-07	하나제약 주식회사	2-[(2,6-디클로로페닐)아미노]페닐아세톡시아세트산의제조방법
KR100524688B1 (ko) *	2002-10-16	2005-10-31	주식회사 한서켐	아세클로페낙의 제조방법
KR100397349B1 (en) *	2002-11-23	2003-09-13	Korea United Pharm Inc	Solubilized aceclofenac, soft capsule using the same and manufacturing method thereof
CN112250589A (zh) *	2020-10-23	2021-01-22	陕西恒诚制药有限公司	一种醋氯芬酸合成精制工艺

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69021511T2 (de) *	1989-11-14	1996-11-21	Beta Pharm Co	Entzündungshemmende Arzneimittel zur äusserlichen Anwendung.
US5235077A (en) *	1991-03-25	1993-08-10	E. I. Du Pont De Nemours And Company	Process for preparing phenyl esters of substituted acids
JP2523428B2 (ja) *	1992-12-04	1996-08-07	エスエス製薬株式会社	消炎鎮痛ゲル製剤
ES2065242B1 (es) *	1992-12-14	1995-10-01	Lepori Farma Sa	Derivados del acido fenilacetico, procedimiento para su obtencion y utilizacion correspondiente.

1999
- 1999-04-22 EP EP99918244A patent/EP1082290B1/de not_active Expired - Lifetime
- 1999-04-22 WO PCT/IE1999/000028 patent/WO1999055660A1/en not_active Ceased
- 1999-04-22 CA CA002330435A patent/CA2330435A1/en not_active Abandoned
- 1999-04-22 AU AU36251/99A patent/AU3625199A/en not_active Abandoned
- 1999-04-22 DE DE69913133T patent/DE69913133T2/de not_active Expired - Fee Related
- 1999-04-22 AT AT99918244T patent/ATE255086T1/de not_active IP Right Cessation
- 1999-04-22 ES ES99918244T patent/ES2211074T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP1082290B1 (de)	2003-11-26
ES2211074T3 (es)	2004-07-01
EP1082290A1 (de)	2001-03-14
AU3625199A (en)	1999-11-16
WO1999055660A1 (en)	1999-11-04
CA2330435A1 (en)	1999-11-04
DE69913133D1 (de)	2004-01-08
DE69913133T2 (de)	2004-08-26

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Legal Events

Date

Code

Title

Description

2004-06-15

UEP

Publication of translation of european patent specification

Ref document number: 1082290

Country of ref document: EP

2009-01-15

REN

Ceased due to non-payment of the annual fee