ATE212355T1 - Synthetische peptide zur entgiftung von bakteriellen endotoxinen und verfahren zur behandlung von septischem schock - Google Patents

Synthetische peptide zur entgiftung von bakteriellen endotoxinen und verfahren zur behandlung von septischem schock

Info

Publication number
ATE212355T1
ATE212355T1 AT92910229T AT92910229T ATE212355T1 AT E212355 T1 ATE212355 T1 AT E212355T1 AT 92910229 T AT92910229 T AT 92910229T AT 92910229 T AT92910229 T AT 92910229T AT E212355 T1 ATE212355 T1 AT E212355T1
Authority
AT
Austria
Prior art keywords
amino acid
septic shock
synthetic peptides
bacterial endotoxins
treating septic
Prior art date
Application number
AT92910229T
Other languages
English (en)
Inventor
Massimo Porro
Original Assignee
Massimo Porro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massimo Porro filed Critical Massimo Porro
Application granted granted Critical
Publication of ATE212355T1 publication Critical patent/ATE212355T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT92910229T 1992-01-16 1992-05-14 Synthetische peptide zur entgiftung von bakteriellen endotoxinen und verfahren zur behandlung von septischem schock ATE212355T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/819,893 US5371186A (en) 1991-02-11 1992-01-16 Synthetic peptides for detoxification of bacterial endotoxins and for the prevention and treatment of septic shock
PCT/EP1992/001060 WO1993014115A1 (en) 1992-01-16 1992-05-14 Synthetic peptides for detoxification of bacterial endotoxins and treatment of septic shock

Publications (1)

Publication Number Publication Date
ATE212355T1 true ATE212355T1 (de) 2002-02-15

Family

ID=25229363

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92910229T ATE212355T1 (de) 1992-01-16 1992-05-14 Synthetische peptide zur entgiftung von bakteriellen endotoxinen und verfahren zur behandlung von septischem schock

Country Status (16)

Country Link
US (2) US5371186A (de)
EP (1) EP0623144B1 (de)
JP (1) JPH07505606A (de)
AT (1) ATE212355T1 (de)
AU (1) AU665945B2 (de)
CA (1) CA2123576A1 (de)
DE (1) DE69232378T2 (de)
DK (1) DK0623144T3 (de)
ES (1) ES2172506T3 (de)
FI (1) FI943396A0 (de)
HU (1) HUT69707A (de)
IE (1) IE920437A1 (de)
IL (1) IL100811A (de)
NZ (1) NZ241446A (de)
TW (1) TW215441B (de)
WO (1) WO1993014115A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5652211A (en) * 1991-02-11 1997-07-29 Biosynth S.R.L. Peptides for neutralizing the toxicity of Lipid A
US5371186A (en) * 1991-02-11 1994-12-06 Biosynth S.R.L. Synthetic peptides for detoxification of bacterial endotoxins and for the prevention and treatment of septic shock
US5733872A (en) * 1993-03-12 1998-03-31 Xoma Corporation Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof
US5610075A (en) * 1995-01-17 1997-03-11 Stahl-Rees; Marianne Competitive electrochemiluminescence assays for endotoxins using a ruthenium label
US5834430A (en) * 1995-05-31 1998-11-10 Biosynth S.R.L. Potentiation of antibiotics
WO1998035665A1 (fr) * 1997-02-14 1998-08-20 Ajinomoto Co., Inc. Antagonistes des endotoxines
CA2298101A1 (en) 1997-07-31 1999-02-11 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Novel synthetic peptides with antimicrobial and endotoxin neutralizing properties for management of the sepsis syndrome
WO1999011281A1 (en) * 1997-09-05 1999-03-11 Dana-Farber Cancer Institute The use of agents which bind g proteins for treating septic shock
US7078224B1 (en) * 1999-05-14 2006-07-18 Promega Corporation Cell concentration and lysate clearance using paramagnetic particles
US6194562B1 (en) 1998-04-22 2001-02-27 Promega Corporation Endotoxin reduction in nucleic acid purification
US6951652B2 (en) * 1998-07-29 2005-10-04 Biosynth S.R.L. Vaccine for prevention of gram-negative bacterial infections and endotoxin related diseases
US6116663A (en) * 1998-10-19 2000-09-12 Cercueils Vic Royal, Inc. Casket Lock
DE10117043A1 (de) * 2001-04-05 2002-11-07 Gerhard Puetz Verfahren zur Eliminierung von potentiell toxischen und/oder schädlichen Stoffen
WO2003094961A1 (en) * 2002-05-09 2003-11-20 Massimo Porro Improved polysaccharide and glycoconjugate vaccines_____________
CN1674933B (zh) 2002-08-02 2012-09-26 葛兰素史密丝克莱恩生物有限公司 疫苗组合物
WO2004052394A1 (en) * 2002-12-06 2004-06-24 Biosynth S.R.L. Broad-spectrum lps based vaccines of unencapsulated strains of haemophilus influenzae and other pathogenic species of gram-negative bacteria
GB2408263A (en) * 2003-11-14 2005-05-25 Pacgen Biopharmaceuticals Inc Antimicrobial peptides with reduced hemolysis and methods of their use.
US7628995B2 (en) 2003-12-23 2009-12-08 Glaxosmithkline Biologicals S.A. Outer membrane vesicles and uses thereof
BRPI0610701A2 (pt) * 2005-04-11 2010-07-20 Biosynth dìmero de peptìdeo saep ii, composição que o contém, seu uso, complexo de lps-peptìdeo, seu uso, composição farmacêutica e processo para a sua preparação, processo para a desintoxicação de um lps de bactérias gram-negativas e processo para a preparação de um dìmero de peptìdeo paralelo e antiparalelo saep ii
EP1712559A1 (de) * 2005-04-11 2006-10-18 Sanofi Pasteur Polymixin B Analoga zur LPS Enttoxifizierung
US7507718B2 (en) 2005-04-11 2009-03-24 Sanofi Pasteur Polymyxin B analogs for LPS detoxification
WO2007070381A2 (en) 2005-12-09 2007-06-21 Promega Corporation Nucleic acid purification with a binding matrix
ES2337309T5 (es) 2006-06-12 2013-07-30 Glaxosmithkline Biologicals S.A. Vacuna
ES2350430B1 (es) * 2009-05-28 2011-11-18 Fundacion De La Comunidad Valenciana Centro De Investigacion Principe Felipe,95%. Conjugado polimerico para el tratamiento de infecciones bacterianas
TWI548746B (zh) * 2009-08-06 2016-09-11 英特威特國際股份有限公司 防備豬胸膜肺炎之疫苗及製備該疫苗之方法
US8222397B2 (en) 2009-08-28 2012-07-17 Promega Corporation Methods of optimal purification of nucleic acids and kit for use in performing such methods
US8039613B2 (en) 2009-08-28 2011-10-18 Promega Corporation Methods of purifying a nucleic acid and formulation and kit for use in performing such methods
EP2544714A1 (de) 2010-03-10 2013-01-16 GlaxoSmithKline Biologicals S.A. Impfstoffzusammensetzung
KR101858840B1 (ko) * 2016-01-15 2018-05-16 단국대학교 천안캠퍼스 산학협력단 집먼지진드기 유래 알레르겐에 의한 과민반응 면역조절제
KR102604934B1 (ko) * 2021-10-27 2023-11-23 주식회사 베르티스 피분석물을 검출 또는 측정하기 위한 조성물
WO2026124814A1 (en) 2024-12-12 2026-06-18 Bachem Holding Ag Trichloroacetic acid based cleavage reagent for peptide synthesis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1340012C (en) * 1987-08-17 1998-08-25 Trustees Of Leland Stanford Jr. University Peptide determinant associated with immunity
US5593966A (en) * 1989-03-31 1997-01-14 The United States Of America As Represented By The Department Of Health And Human Services Peptide derivatives of cytochrome b558 and their use as medicaments
US5358932A (en) * 1989-12-29 1994-10-25 Zymogenetics, Inc. Hybrid protein C
ZA92943B (en) * 1991-02-11 1992-11-25 Porro Massimo Synthetic peptides for detoxification of bacterial endotoxins and for the prevention and treatment of septic shock
US5371186A (en) * 1991-02-11 1994-12-06 Biosynth S.R.L. Synthetic peptides for detoxification of bacterial endotoxins and for the prevention and treatment of septic shock

Also Published As

Publication number Publication date
HUT69707A (en) 1995-09-28
FI943396A7 (fi) 1994-07-15
NZ241446A (en) 1995-03-28
AU1691492A (en) 1993-08-03
IL100811A (en) 1999-07-14
FI943396L (fi) 1994-07-15
DE69232378T2 (de) 2002-10-31
JPH07505606A (ja) 1995-06-22
EP0623144A1 (de) 1994-11-09
IL100811A0 (en) 1992-09-06
IE920437A1 (en) 1992-08-12
FI943396A0 (fi) 1994-07-15
DE69232378D1 (de) 2002-03-14
US5371186A (en) 1994-12-06
ES2172506T3 (es) 2002-10-01
WO1993014115A1 (en) 1993-07-22
EP0623144B1 (de) 2002-01-23
AU665945B2 (en) 1996-01-25
TW215441B (de) 1993-11-01
US5589459A (en) 1996-12-31
CA2123576A1 (en) 1993-07-22
DK0623144T3 (da) 2002-05-13
HU9401970D0 (en) 1994-09-28

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