ATE102949T1 - Verfahren zur herstellung von retro-inversopeptiden und dessen zwischenprodukte. - Google Patents

Verfahren zur herstellung von retro-inversopeptiden und dessen zwischenprodukte.

Info

Publication number: ATE102949T1
Authority: AT; Austria
Prior art keywords: formula; amino acid; preparation; chain; iii
Prior art date: 1988-12-23

Application number

AT89203194T

Other languages

English (en)

Inventor

Massimo Pinori

Felice Centini

Antonio Silvio Verdini

Original Assignee

Sclavo Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-12-23

Filing date

1989-12-14

Publication date

1994-04-15

1989-12-14 Application filed by Sclavo Spa filed Critical Sclavo Spa

1994-04-15 Application granted granted Critical

1994-04-15 Publication of ATE102949T1 publication Critical patent/ATE102949T1/de

Links

238000000034 method Methods 0.000 title abstract 4
238000002360 preparation method Methods 0.000 title abstract 2
108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
239000013067 intermediate product Substances 0.000 title 1
238000003874 inverse correlation nuclear magnetic resonance spectroscopy Methods 0.000 title 1
102000004196 processed proteins & peptides Human genes 0.000 title 1
235000001014 amino acid Nutrition 0.000 abstract 2
150000001413 amino acids Chemical class 0.000 abstract 2
125000001721 carboxyacetyl group Chemical group 0.000 abstract 2
-1 5-substituted-2,2-dimethyl-1,3-dioxane-4,6-dione Chemical class 0.000 abstract 1
108010033276 Peptide Fragments Proteins 0.000 abstract 1
102000007079 Peptide Fragments Human genes 0.000 abstract 1
150000001370 alpha-amino acid derivatives Chemical class 0.000 abstract 1
235000008206 alpha-amino acids Nutrition 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000012634 fragment Substances 0.000 abstract 1
125000000524 functional group Chemical group 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
IESDGNYHXIOKRW-LEOABGAYSA-N tuftsin Chemical class C[C@@H](O)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](CCCNC(N)=N)C(O)=O IESDGNYHXIOKRW-LEOABGAYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0212—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -N-C-N-C(=0)-, e.g. retro-inverso peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Analytical Chemistry (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT89203194T 1988-12-23 1989-12-14 Verfahren zur herstellung von retro-inversopeptiden und dessen zwischenprodukte. ATE102949T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT8823098A IT1227907B (it)	1988-12-23	1988-12-23	Procedimento per la sintesi di peptidi retro-inversi e nuovi intermediin tale procedimento
EP89203194A EP0375040B1 (de)	1988-12-23	1989-12-14	Verfahren zur Herstellung von Retro-Inverso-Peptiden und dessen Zwischenprodukte

Publications (1)

Publication Number	Publication Date
ATE102949T1 true ATE102949T1 (de)	1994-04-15

Family

ID=11203765

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89203194T ATE102949T1 (de)	1988-12-23	1989-12-14	Verfahren zur herstellung von retro-inversopeptiden und dessen zwischenprodukte.

Country Status (8)

Country	Link
US (2)	US5061811A (de)
EP (1)	EP0375040B1 (de)
JP (1)	JPH02221294A (de)
AT (1)	ATE102949T1 (de)
CA (1)	CA2006560A1 (de)
DE (1)	DE68913935T2 (de)
ES (1)	ES2061956T3 (de)
IT (1)	IT1227907B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5200506A (en) *	1987-03-19	1993-04-06	Eniricerche S.P.A.	Process for preparing new thymopentin retro-inverso analogs and fragments thereof and the intermediates obtained therein
IT1227907B (it) *	1988-12-23	1991-05-14	Eniricerche S P A Milano Sclav	Procedimento per la sintesi di peptidi retro-inversi e nuovi intermediin tale procedimento
US5218089A (en) *	1988-12-23	1993-06-08	Sclavo S.P.A.	Retro-inverso analogues of thymopentin and the method for their synthesis
AU1194092A (en) *	1991-02-06	1992-09-07	Georgetown University	Receptor blocking peptides of fibroblast growth factor receptor
KR950702839A (ko) *	1992-08-27	1995-08-23	스티븐 딕	레트로, 인버소-, 및 레트로- 인버소 합성 펩티드 유사체(retro-, inverso-, and retro-inverso synthetic peptide analogues)
EP1052994A2 (de)	1998-02-02	2000-11-22	Trustees Of Tufts College	Verwendung von dipetidylpeptidasehemmer zur regulierung des glukosemetabolismus
US7396905B1 (en)	1999-05-21	2008-07-08	Mckeon Frank	Calcipressins: endogenous inhibitors of calcineurin, uses and reagents related thereto
US6610820B1 (en) *	1999-10-12	2003-08-26	University Of Lausanne	Cell-permeable peptide inhibitors of the JNK signal transduction pathway
US20040082509A1 (en)	1999-10-12	2004-04-29	Christophe Bonny	Cell-permeable peptide inhibitors of the JNK signal transduction pathway
US8183339B1 (en)	1999-10-12	2012-05-22	Xigen S.A.	Cell-permeable peptide inhibitors of the JNK signal transduction pathway
EP2769715A3 (de)	2001-11-26	2014-09-17	Trustees Of Tufts College	Verfahren zur Behandlung von Autoimmunkrankheiten und damit zusammenhängende Reagenzien
JP4771661B2 (ja) *	2001-11-26	2011-09-14	トラスティーズオブタフツカレッジ	Ｐｏｓｔ−プロリン開裂酵素の擬ペプチド性阻害剤
US7858297B2 (en) *	2001-12-18	2010-12-28	Centre National De La Recherche Scientifique Cnrs	Chemokine-binding protein and methods of use
WO2003051917A2 (en) *	2001-12-18	2003-06-26	Endocube Sas	Novel death associated proteins of the thap family and related par4 pathways involved in apoptosis control
EP1485408A2 (de)	2002-03-13	2004-12-15	Bayer CropScience S.A.	Mutagenese des pilzes aspergillus und identifikation von genen essentiell für das wachstum
US8080517B2 (en)	2005-09-12	2011-12-20	Xigen Sa	Cell-permeable peptide inhibitors of the JNK signal transduction pathway
WO2007031098A1 (en)	2005-09-12	2007-03-22	Xigen S.A.	Cell-permeable peptide inhibitors of the jnk signal transduction pathway
WO2009143864A1 (en)	2008-05-30	2009-12-03	Xigen S.A.	Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory digestive diseases
WO2009143865A1 (en)	2008-05-30	2009-12-03	Xigen S.A.	Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
WO2010072228A1 (en)	2008-12-22	2010-07-01	Xigen S.A.	Novel transporter constructs and transporter cargo conjugate molecules
WO2011160653A1 (en)	2010-06-21	2011-12-29	Xigen S.A.	Novel jnk inhibitor molecules
AU2010362444B2 (en)	2010-10-14	2015-08-06	Xigen Inflammation Ltd.	Use of cell-permeable peptide inhibitors of the JNK signal transduction pathway for the treatment of chronic or non-chronic inflammatory eye diseases
WO2013091670A1 (en)	2011-12-21	2013-06-27	Xigen S.A.	Novel jnk inhibitor molecules for treatment of various diseases
EA201501080A1 (ru)	2013-06-26	2016-07-29	Ксижен Инфлемейшн Лтд.	Новое применение обладающих способностью проникать в клетку пептидных ингибиторов пути трансдукции сигнала jnk для лечения различных заболеваний
WO2015197097A1 (en)	2014-06-26	2015-12-30	Xigen Inflammation Ltd.	New use for jnk inhibitor molecules for treatment of various diseases
WO2014206427A1 (en)	2013-06-26	2014-12-31	Xigen Inflammation Ltd.	New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2052517T3 (es) *	1986-07-16	1994-07-16	Eniricerche Spa	Analogos de tuftsina parcialmente retroinversos, metodo de preparacion de los mismos y composiciones farmaceuticas que los contienen.
IT1227907B (it) *	1988-12-23	1991-05-14	Eniricerche S P A Milano Sclav	Procedimento per la sintesi di peptidi retro-inversi e nuovi intermediin tale procedimento

1988
- 1988-12-23 IT IT8823098A patent/IT1227907B/it active
1989
- 1989-12-14 US US07/450,572 patent/US5061811A/en not_active Expired - Fee Related
- 1989-12-14 EP EP89203194A patent/EP0375040B1/de not_active Expired - Lifetime
- 1989-12-14 ES ES89203194T patent/ES2061956T3/es not_active Expired - Lifetime
- 1989-12-14 AT AT89203194T patent/ATE102949T1/de not_active IP Right Cessation
- 1989-12-14 DE DE68913935T patent/DE68913935T2/de not_active Expired - Fee Related
- 1989-12-22 CA CA002006560A patent/CA2006560A1/en not_active Abandoned
- 1989-12-25 JP JP1336182A patent/JPH02221294A/ja active Pending
1991
- 1991-08-09 US US07/742,873 patent/US5116947A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US5116947A (en)	1992-05-26
JPH02221294A (ja)	1990-09-04
CA2006560A1 (en)	1990-06-23
EP0375040B1 (de)	1994-03-16
DE68913935D1 (de)	1994-04-21
IT1227907B (it)	1991-05-14
IT8823098A0 (it)	1988-12-23
EP0375040A3 (de)	1991-07-03
DE68913935T2 (de)	1994-07-07
US5061811A (en)	1991-10-29
ES2061956T3 (es)	1994-12-16
EP0375040A2 (de)	1990-06-27

Legal Events

Date	Code	Title	Description
1994-11-15	UEP	Publication of translation of european patent specification
1996-03-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE68913935D1 (de)	1994-04-21	Verfahren zur Herstellung von Retro-Inverso-Peptiden und dessen Zwischenprodukte.
DK0792287T3 (da)	2004-08-30	Peptidanaloger af humant basisk myelinprotein
DE60041119D1 (de)	2009-01-29	Verfahren zur präsentation von (poly)peptiden/proteinen auf bakteriophagenpartikeln via disulfidbindungen
DE69627704D1 (en)	2003-05-28	Protegrine
NO911787D0 (no)	1991-05-07	Peptidaminer samt fremgangsmaate for fremstilling derav.
DE69429176D1 (en)	2002-01-03	Protegrine
ATE86964T1 (de)	1993-04-15	Malonsaeurederivate und ihre synthesemethoden.
ATE212355T1 (de)	2002-02-15	Synthetische peptide zur entgiftung von bakteriellen endotoxinen und verfahren zur behandlung von septischem schock
ATE6857T1 (de)	1984-04-15	Neue peptide und verfahren zu ihrer herstellung.
EP0498784A3 (en)	1993-03-31	Inhibitors of retroviral protease
DE60131733D1 (de)	2008-01-17	Verfahren zur herstellung von (2s,3r,4s)-4-hydroxyisoleucin und analoga
KR890013061A (ko)	1989-09-21	폴리펩티드 유도체
DE69315730D1 (de)	1998-01-29	Verfahren zur Herstellung von Peptiden und neue Zwischenverbindungen dazu
DE3782880D1 (de)	1993-01-14	Hemmende peptide.
ES2079054T3 (es)	1996-01-01	Peptidilhidroxiglicina n-c-liasa y adn codificante de la misma.
EP0934952A3 (de)	1999-12-29	N-substituiertes Glycine enthaltende Peptide
NO994929D0 (no)	1999-10-08	Syntetiske peptider, nyttige i biologiske tester, for paavisning av infeksjoner foraarsaket av gruppe 0 HIV-1 virus
DE60234843D1 (de)	2010-02-04	Modifizierte peptide und deren verwendung zur behandlung von autoimmunkrankheiten
DE68904578D1 (de)	1993-03-11	Enzym zur alpha-amidierung von c-termini und verfahren zu dessen herstellung.
EP0959895A4 (de)	2002-07-24	Peptide spezifisch für antikörper gegen peptidconcensussequenzen aus der cs4-cfa/iprpteinfamilie
DE69925911D1 (de)	2005-07-28	Immunodiagnostischer wirkstoff zum nachweiss von maedi-visna virus und caev infektionen
ATE212340T1 (de)	2002-02-15	Verfahren zur herstellung von n- carboxyanhydridaminosäuren aus n-(n'- nitrosocarbamoyl)-aminosäuren
DE69421849D1 (de)	2000-01-05	Verfahren zur Herstellung von alpha,omega-Diaminosäuren abgeleiteten Harnstoffen
DE69009224D1 (de)	1994-07-07	Gem-diamino-Derivate und ihre Verwendung bei der Herstellung von Retro-Inverso-Peptiden.