ATE212358T1 - Unterdrückung der proliferation von t-zellen mittels peptidfragmenten des basischen proteins aus myelin - Google Patents

Unterdrückung der proliferation von t-zellen mittels peptidfragmenten des basischen proteins aus myelin

Info

Publication number: ATE212358T1
Authority: AT; Austria
Prior art keywords: myelin; suppression; cell proliferation; peptide fragments; basic protein
Prior art date: 1992-04-09

Application number

AT98102522T

Other languages

English (en)

Inventor

Howard M Weiner

Ariel Miller

David Allen Hafler

Ahmad Al-Sabbagh

Original Assignee

Autoimmune Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-04-09

Filing date

1993-04-09

Publication date

2002-02-15

1993-04-09 Application filed by Autoimmune Inc filed Critical Autoimmune Inc

2002-02-15 Application granted granted Critical

2002-02-15 Publication of ATE212358T1 publication Critical patent/ATE212358T1/de

Links

102000006386 Myelin Proteins Human genes 0.000 title 1
108010083674 Myelin Proteins Proteins 0.000 title 1
108010033276 Peptide Fragments Proteins 0.000 title 1
102000007079 Peptide Fragments Human genes 0.000 title 1
101710093543 Probable non-specific lipid-transfer protein Proteins 0.000 title 1
230000006052 T cell proliferation Effects 0.000 title 1
210000005012 myelin Anatomy 0.000 title 1
230000001629 suppression Effects 0.000 title 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
125000001433 C-terminal amino-acid group Chemical group 0.000 abstract 1
125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 abstract 1
125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 abstract 1
230000006472 autoimmune response Effects 0.000 abstract 1
239000012634 fragment Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Rheumatology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Zoology (AREA)
Biophysics (AREA)
Microbiology (AREA)
Rehabilitation Therapy (AREA)
Toxicology (AREA)
Hematology (AREA)
Diabetes (AREA)
Mycology (AREA)
Biomedical Technology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT98102522T 1992-04-09 1993-04-09 Unterdrückung der proliferation von t-zellen mittels peptidfragmenten des basischen proteins aus myelin ATE212358T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US86531892A	1992-04-09	1992-04-09

Publications (1)

Publication Number	Publication Date
ATE212358T1 true ATE212358T1 (de)	2002-02-15

Family

ID=25345228

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT93912176T ATE170874T1 (de)	1992-04-09	1993-04-09	Unterdrückung der t-zell proliferation mittels peptidfragmenten des myelin basischen protein
AT98102522T ATE212358T1 (de)	1992-04-09	1993-04-09	Unterdrückung der proliferation von t-zellen mittels peptidfragmenten des basischen proteins aus myelin

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT93912176T ATE170874T1 (de)	1992-04-09	1993-04-09	Unterdrückung der t-zell proliferation mittels peptidfragmenten des myelin basischen protein

Country Status (15)

Country	Link
EP (2)	EP0863155B1 (de)
JP (1)	JP3434510B2 (de)
KR (1)	KR950700934A (de)
AT (2)	ATE170874T1 (de)
AU (1)	AU680824B2 (de)
BR (1)	BR9306272A (de)
CA (1)	CA2133749A1 (de)
DE (2)	DE69331501T2 (de)
DK (1)	DK0863155T3 (de)
ES (1)	ES2172044T3 (de)
HU (1)	HU219306B (de)
IL (1)	IL105347A0 (de)
NO (1)	NO317049B1 (de)
PT (1)	PT863155E (de)
WO (1)	WO1993021222A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5869054A (en) *	1987-06-24	1999-02-09	Autoimmune Inc.	Treatment of multiple sclerosis by oral administration of autoantigens
US6252040B1 (en) *	1991-10-22	2001-06-26	The Governors Of The University Of Alberta	Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients
US5817629A (en) *	1991-10-22	1998-10-06	The Governors Of The University Of Alberta	Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients
EP0758902A1 (de) *	1994-05-10	1997-02-26	Immulogic Pharmaceutical Corporation	Zusammensetzungen und eine behandlung fuer multiple sklerose
SI9520118A (sl) *	1994-10-25	1998-08-31	Immulogic Pharmaceutical Corporation	Sestavki in zdravljenje multiple skleroze
US6251396B1 (en)	1994-11-18	2001-06-26	Neurocrine Biosciences, Inc.	Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein
US6379670B1 (en)	1994-11-18	2002-04-30	Neurocrine Biosciences, Inc.	Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein
US6329499B1 (en) *	1994-11-18	2001-12-11	Neurocrine Biosciences, Inc.	Methods for treatment of multiple sclerosis using peptide analogues of human myelin basic protein
EP1172376A1 (de) *	1994-11-18	2002-01-16	Neurocrine Biosciences, Inc.	Peptidanaloge des menschlichen, basischen myelinproteins mit substitution an position 91 zur behandlung der multiplen sklerose
AU5360796A (en) *	1995-03-09	1996-10-02	Neurocrine Biosciences, Inc.	Peptide analogues of human myelin basic protein useful in treating multiple sclerosis
US5856446A (en) *	1995-07-07	1999-01-05	Autoimmune Inc.	Method of treating rheumatoid arthritis with low dose type II collagen
IL116559A (en) *	1995-11-17	2005-11-20	Yissum Res Dev Co	Chimeric protein consisting of a bacterial toxin and a myelin basic protein sequence
US6274136B1 (en) *	1996-05-29	2001-08-14	University Of Southern California	Construction and use of genes encoding pathogenic epitopes for treatment of autoimmune disease
CA2494338C (en) *	1997-04-04	2007-07-17	The Governors Of The University Of Alberta	Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients
US20020072493A1 (en)	1998-05-19	2002-06-13	Yeda Research And Development Co. Ltd.	Activated T cells, nervous system-specific antigens and their uses
JP2003532618A (ja) *	1998-05-19	2003-11-05	イエダリサーチアンドデベロプメントカンパニイリミテッド	細胞、神経系−特異的抗原およびそれらの用途
JP4986361B2 (ja)	2000-05-24	2012-07-25	ザユナイテッドステイツオブアメリカアズリプレゼンティッドバイザシークレタリーデパートメントオブヘルスアンドヒューマンサービシーズ	Ｅ−セレクチンに対する寛容誘導による脳卒中防止法
EP1677821B1 (de)	2003-10-17	2013-02-27	Baylor College Of Medicine	Verfahren zur verstärkung der cd8+ zytotoxischen t-zell-antworten und zur behandlung von multipler sklerose

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0720622A1 (de) *	1993-09-22	1996-07-10	The Board Of Trustees Of The Leland Stanford Junior University	Wechselwirkung zwischen t-zellrezeptoren und antigen in autoimmunkrankheiten
EP1172376A1 (de) *	1994-11-18	2002-01-16	Neurocrine Biosciences, Inc.	Peptidanaloge des menschlichen, basischen myelinproteins mit substitution an position 91 zur behandlung der multiplen sklerose

1993
- 1993-04-09 DE DE69331501T patent/DE69331501T2/de not_active Expired - Lifetime
- 1993-04-09 DE DE69320967T patent/DE69320967T2/de not_active Expired - Lifetime
- 1993-04-09 AT AT93912176T patent/ATE170874T1/de not_active IP Right Cessation
- 1993-04-09 HU HU9402909A patent/HU219306B/hu not_active IP Right Cessation
- 1993-04-09 AU AU42824/93A patent/AU680824B2/en not_active Ceased
- 1993-04-09 EP EP98102522A patent/EP0863155B1/de not_active Expired - Lifetime
- 1993-04-09 BR BR9306272A patent/BR9306272A/pt not_active Application Discontinuation
- 1993-04-09 CA CA002133749A patent/CA2133749A1/en not_active Abandoned
- 1993-04-09 PT PT98102522T patent/PT863155E/pt unknown
- 1993-04-09 WO PCT/US1993/003369 patent/WO1993021222A1/en not_active Ceased
- 1993-04-09 EP EP93912176A patent/EP0650498B1/de not_active Expired - Lifetime
- 1993-04-09 DK DK98102522T patent/DK0863155T3/da active
- 1993-04-09 AT AT98102522T patent/ATE212358T1/de not_active IP Right Cessation
- 1993-04-09 JP JP51850993A patent/JP3434510B2/ja not_active Expired - Fee Related
- 1993-04-09 IL IL105347A patent/IL105347A0/xx unknown
- 1993-04-09 ES ES98102522T patent/ES2172044T3/es not_active Expired - Lifetime
1994
- 1994-10-06 NO NO19943755A patent/NO317049B1/no not_active IP Right Cessation
- 1994-10-08 KR KR1019940703571A patent/KR950700934A/ko active Granted

Also Published As

Publication number	Publication date
NO943755L (no)	1994-12-02
WO1993021222A1 (en)	1993-10-28
DE69320967T2 (de)	1999-05-12
IL105347A0 (en)	1993-08-18
DE69331501D1 (de)	2002-03-14
ATE170874T1 (de)	1998-09-15
CA2133749A1 (en)	1993-10-28
JP3434510B2 (ja)	2003-08-11
AU680824B2 (en)	1997-08-14
HU9402909D0 (en)	1995-01-30
PT863155E (pt)	2002-07-31
NO943755D0 (no)	1994-10-06
EP0650498A1 (de)	1995-05-03
DE69331501T2 (de)	2002-08-29
BR9306272A (pt)	1998-06-23
EP0650498A4 (de)	1995-06-21
DK0863155T3 (da)	2002-05-13
DE69320967D1 (de)	1998-10-15
JPH08500083A (ja)	1996-01-09
ES2172044T3 (es)	2002-09-16
KR950700934A (ko)	1995-02-20
AU4282493A (en)	1993-11-18
EP0863155A1 (de)	1998-09-09
EP0863155B1 (de)	2002-01-23
HU219306B (en)	2001-03-28
NO317049B1 (no)	2004-07-26
EP0650498B1 (de)	1998-09-09
HUT69169A (en)	1995-08-28
KR100295606B1 (de)	2001-10-22

Legal Events

Date	Code	Title	Description
2002-07-15	UEP	Publication of translation of european patent specification
2012-01-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE212358T1 (de)	2002-02-15	Unterdrückung der proliferation von t-zellen mittels peptidfragmenten des basischen proteins aus myelin
DE69333243D1 (de)	2003-11-13	Mutierte polypeptide des interleukin-3(il-3)
DE69532996D1 (de)	2004-06-09	Peptidanaloge des menschlichen basischen myelinproteins
ATE338121T1 (de)	2006-09-15	Von muc-1 abgeleitete peptide
PT662827E (pt)	2002-09-30	Metodos de diagnostico e composicoes farmaceuticas a base de proteinas notch e acidos nucleicos
EA200100465A1 (ru)	2001-10-22	Димерные тромбопоэтиновые пептидные миметики, связывающие mp1 рецептор и имеющие тромбопоэтичекую активность
ATE430801T1 (de)	2009-05-15	Von wd-40 abstammende peptide und ihre verwendung
IL89541A0 (en)	1989-09-10	Urethane-protected amino acid-n-carboxyanhydrides and their use in the synthesis of polypeptides
ATE368053T1 (de)	2007-08-15	Antimikrobielle peptide
GB8625435D0 (en)	1986-11-26	Human apolipoprotein ai
ES2112255T3 (es)	1998-04-01	Complejos proteicos que tienen actividad del factor viii:c y su produccion.
DE68927379D1 (de)	1996-11-28	Plättchen blockierende peptide
ATE223481T1 (de)	2002-09-15	Peptid der löslichen form von acetylcholinesterase mit aktivität als calciumkanalmodulator
DE69827262D1 (de)	2004-12-02	Penaeidine: antimikrobielle peptide aus krebstieren
DE69029377D1 (de)	1997-01-23	Substituierungsanaloge von magaininpeptiden
EP1132402A4 (de)	2005-12-21	Peptidfragmente mit den zelltod verhindernden aktivität