ATE212546T1 - Behandlung von neurodegenerativen zuständen mittels nimesulide - Google Patents

Behandlung von neurodegenerativen zuständen mittels nimesulide

Info

Publication number: ATE212546T1
Authority: AT; Austria
Prior art keywords: nimesulide; treatment; neurodegenerative conditions; neurodegeneration; discovery
Prior art date: 1996-11-21

Application number

AT97950672T

Other languages

English (en)

Inventor

Sinai School Of Medicine Mount

Place Levy

Original Assignee

Sinai School Medicine

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-11-21

Filing date

1997-11-19

Publication date

2002-02-15

1997-11-19 Application filed by Sinai School Medicine filed Critical Sinai School Medicine

2002-02-15 Application granted granted Critical

2002-02-15 Publication of ATE212546T1 publication Critical patent/ATE212546T1/de

Links

HYWYRSMBCFDLJT-UHFFFAOYSA-N nimesulide Chemical compound CS(=O)(=O)NC1=CC=C([N+]([O-])=O)C=C1OC1=CC=CC=C1 HYWYRSMBCFDLJT-UHFFFAOYSA-N 0.000 title abstract 4
229960000965 nimesulide Drugs 0.000 title abstract 4
230000000626 neurodegenerative effect Effects 0.000 title abstract 2
102000013455 Amyloid beta-Peptides Human genes 0.000 abstract 1
108010090849 Amyloid beta-Peptides Proteins 0.000 abstract 1
230000030833 cell death Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000037456 inflammatory mechanism Effects 0.000 abstract 1
230000004770 neurodegeneration Effects 0.000 abstract 1
230000000324 neuroprotective effect Effects 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0083—Miscellaneous (1.14.99)
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0312—Animal model for Alzheimer's disease
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0318—Animal model for neurodegenerative disease, e.g. non- Alzheimer's
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2517/00—Cells related to new breeds of animals
- C12N2517/02—Cells from transgenic animals
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Biotechnology (AREA)
Organic Chemistry (AREA)
Environmental Sciences (AREA)
Animal Behavior & Ethology (AREA)
Wood Science & Technology (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Biochemistry (AREA)
Public Health (AREA)
Microbiology (AREA)
Animal Husbandry (AREA)
Biodiversity & Conservation Biology (AREA)
Molecular Biology (AREA)
Epidemiology (AREA)
Plant Pathology (AREA)
Neurosurgery (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Neurology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)

AT97950672T 1996-11-21 1997-11-19 Behandlung von neurodegenerativen zuständen mittels nimesulide ATE212546T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US3333296P	1996-11-21	1996-11-21
US08/831,402 US5985930A (en)	1996-11-21	1997-04-01	Treatment of neurodegenerative conditions with nimesulide
PCT/US1997/021484 WO1998022104A2 (en)	1996-11-21	1997-11-19	Treatment of neurodegenerative conditions with nimesulide

Publications (1)

Publication Number	Publication Date
ATE212546T1 true ATE212546T1 (de)	2002-02-15

Family

ID=26709565

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97950672T ATE212546T1 (de)	1996-11-21	1997-11-19	Behandlung von neurodegenerativen zuständen mittels nimesulide

Country Status (18)

Country	Link
US (3)	US5985930A (de)
EP (1)	EP0956009B9 (de)
JP (1)	JP2001505206A (de)
KR (1)	KR20000069061A (de)
AT (1)	ATE212546T1 (de)
AU (1)	AU725141B2 (de)
BR (1)	BR9714303A (de)
CA (1)	CA2272249A1 (de)
DE (1)	DE69710224T2 (de)
DK (1)	DK0956009T3 (de)
ES (1)	ES2172822T3 (de)
IL (1)	IL129949A (de)
NO (1)	NO992374L (de)
NZ (1)	NZ335726A (de)
PT (1)	PT956009E (de)
SK (1)	SK284334B6 (de)
TR (1)	TR199901120T2 (de)
WO (1)	WO1998022104A2 (de)

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KR20210122917A (ko)	2013-03-14	2021-10-12	샤이어 휴먼 지네틱 테라피즈 인크.	Cftr mrna 조성물 및 관련 방법 및 사용
JP6621747B2 (ja)	2013-08-14	2019-12-18	ザボードオブトラスティーズオブザレランドスタンフォードジュニアユニバーシティー	疼痛を制御するための組成物及び方法
EP3060303B1 (de)	2013-10-22	2018-11-14	Translate Bio, Inc.	Mrna-therapie für argininosuccinat-synthase-mangel
CN106459138A (zh)	2014-03-28	2017-02-22	斯坦福大学托管董事会	工程化的光激活阴离子通道蛋白及其使用方法
EP3636742B1 (de) *	2014-04-25	2025-11-05	Translate Bio, Inc.	Verfahren zur reinigung von messenger-rna
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1997
- 1997-04-01 US US08/831,402 patent/US5985930A/en not_active Expired - Lifetime
- 1997-11-19 JP JP52395698A patent/JP2001505206A/ja not_active Ceased
- 1997-11-19 DE DE69710224T patent/DE69710224T2/de not_active Expired - Fee Related
- 1997-11-19 AU AU53612/98A patent/AU725141B2/en not_active Ceased
- 1997-11-19 PT PT97950672T patent/PT956009E/pt unknown
- 1997-11-19 WO PCT/US1997/021484 patent/WO1998022104A2/en not_active Ceased
- 1997-11-19 NZ NZ335726A patent/NZ335726A/xx unknown
- 1997-11-19 SK SK671-99A patent/SK284334B6/sk unknown
- 1997-11-19 DK DK97950672T patent/DK0956009T3/da active
- 1997-11-19 AT AT97950672T patent/ATE212546T1/de not_active IP Right Cessation
- 1997-11-19 ES ES97950672T patent/ES2172822T3/es not_active Expired - Lifetime
- 1997-11-19 IL IL12994997A patent/IL129949A/xx not_active IP Right Cessation
- 1997-11-19 CA CA002272249A patent/CA2272249A1/en not_active Abandoned
- 1997-11-19 BR BR9714303-0A patent/BR9714303A/pt not_active Application Discontinuation
- 1997-11-19 TR TR1999/01120T patent/TR199901120T2/xx unknown
- 1997-11-19 EP EP97950672A patent/EP0956009B9/de not_active Expired - Lifetime
- 1997-11-19 US US09/308,424 patent/US6649811B2/en not_active Expired - Fee Related
- 1997-11-19 KR KR1019997004481A patent/KR20000069061A/ko not_active Ceased
1999
- 1999-05-18 NO NO992374A patent/NO992374L/no unknown
2002
- 2002-05-17 US US10/150,461 patent/US7226948B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US20020162130A1 (en)	2002-10-31
JP2001505206A (ja)	2001-04-17
TR199901120T2 (xx)	1999-07-21
PT956009E (pt)	2002-07-31
DE69710224T2 (de)	2002-10-02
IL129949A0 (en)	2000-02-29
ES2172822T3 (es)	2002-10-01
IL129949A (en)	2003-05-29
SK284334B6 (sk)	2005-02-04
EP0956009B9 (de)	2002-12-11
SK67199A3 (en)	2001-01-18
AU5361298A (en)	1998-06-10
CA2272249A1 (en)	1998-05-28
US6649811B2 (en)	2003-11-18
WO1998022104A3 (en)	1998-10-08
US5985930A (en)	1999-11-16
EP0956009B1 (de)	2002-01-30
US7226948B2 (en)	2007-06-05
US20060059576A1 (en)	2006-03-16
NZ335726A (en)	2000-10-27
BR9714303A (pt)	2000-04-25
NO992374D0 (no)	1999-05-18
DE69710224D1 (de)	2002-03-14
NO992374L (no)	1999-07-21
DK0956009T3 (da)	2002-05-21
AU725141B2 (en)	2000-10-05
EP0956009A1 (de)	1999-11-17
WO1998022104A2 (en)	1998-05-28
KR20000069061A (ko)	2000-11-25

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