DK0956009T3 - Behandling af neurodegenerative tilstande med nimesulid - Google Patents

Behandling af neurodegenerative tilstande med nimesulid

Info

Publication number: DK0956009T3
Authority: DK; Denmark
Prior art keywords: nimesulide; treatment; neurodegenerative conditions; neurodegeneration; discovery
Prior art date: 1996-11-21

Application number

DK97950672T

Other languages

Danish (da)

English (en)

Inventor

Sinai School Of Medicine Mount

Original Assignee

Sinai School Medicine

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-11-21

Filing date

1997-11-19

Publication date

2002-05-21

1997-11-19 Application filed by Sinai School Medicine filed Critical Sinai School Medicine

2002-05-21 Application granted granted Critical

2002-05-21 Publication of DK0956009T3 publication Critical patent/DK0956009T3/da

Links

HYWYRSMBCFDLJT-UHFFFAOYSA-N nimesulide Chemical compound CS(=O)(=O)NC1=CC=C([N+]([O-])=O)C=C1OC1=CC=CC=C1 HYWYRSMBCFDLJT-UHFFFAOYSA-N 0.000 title abstract 4
229960000965 nimesulide Drugs 0.000 title abstract 4
230000000626 neurodegenerative effect Effects 0.000 title abstract 2
102000013455 Amyloid beta-Peptides Human genes 0.000 abstract 1
108010090849 Amyloid beta-Peptides Proteins 0.000 abstract 1
230000030833 cell death Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000037456 inflammatory mechanism Effects 0.000 abstract 1
230000004770 neurodegeneration Effects 0.000 abstract 1
230000000324 neuroprotective effect Effects 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0083—Miscellaneous (1.14.99)
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0312—Animal model for Alzheimer's disease
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0318—Animal model for neurodegenerative disease, e.g. non- Alzheimer's
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2517/00—Cells related to new breeds of animals
- C12N2517/02—Cells from transgenic animals
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Biotechnology (AREA)
Organic Chemistry (AREA)
Environmental Sciences (AREA)
Animal Behavior & Ethology (AREA)
Wood Science & Technology (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Biochemistry (AREA)
Public Health (AREA)
Microbiology (AREA)
Animal Husbandry (AREA)
Biodiversity & Conservation Biology (AREA)
Molecular Biology (AREA)
Epidemiology (AREA)
Plant Pathology (AREA)
Neurosurgery (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Neurology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)

DK97950672T 1996-11-21 1997-11-19 Behandling af neurodegenerative tilstande med nimesulid DK0956009T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US3333296P	1996-11-21	1996-11-21
US08/831,402 US5985930A (en)	1996-11-21	1997-04-01	Treatment of neurodegenerative conditions with nimesulide
PCT/US1997/021484 WO1998022104A2 (en)	1996-11-21	1997-11-19	Treatment of neurodegenerative conditions with nimesulide

Publications (1)

Publication Number	Publication Date
DK0956009T3 true DK0956009T3 (da)	2002-05-21

Family

ID=26709565

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97950672T DK0956009T3 (da)	1996-11-21	1997-11-19	Behandling af neurodegenerative tilstande med nimesulid

Country Status (18)

Country	Link
US (3)	US5985930A (de)
EP (1)	EP0956009B9 (de)
JP (1)	JP2001505206A (de)
KR (1)	KR20000069061A (de)
AT (1)	ATE212546T1 (de)
AU (1)	AU725141B2 (de)
BR (1)	BR9714303A (de)
CA (1)	CA2272249A1 (de)
DE (1)	DE69710224T2 (de)
DK (1)	DK0956009T3 (de)
ES (1)	ES2172822T3 (de)
IL (1)	IL129949A (de)
NO (1)	NO992374L (de)
NZ (1)	NZ335726A (de)
PT (1)	PT956009E (de)
SK (1)	SK284334B6 (de)
TR (1)	TR199901120T2 (de)
WO (1)	WO1998022104A2 (de)

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US20040063752A1 (en) *	2002-05-31	2004-04-01	Pharmacia Corporation	Monotherapy for the treatment of amyotrophic lateral sclerosis with cyclooxygenase-2 (COX-2) inhibitor(s)
AU2003237988A1 (en) *	2002-06-13	2003-12-31	Mount Sinai School Of Medicine Of New York University	Inhibiting progressive cognitive impairment
EP1562570A4 (de) *	2002-11-06	2007-09-05	Sinai School Medicine	Behandlung von amyotropher lateralsklerose mit nimesulid
US20060041022A1 (en) *	2002-11-06	2006-02-23	Pasinetti Giulio M	Treatment of amyotrophic lateral sclerosis with nimesulide
CN101274926A (zh)	2003-03-31	2008-10-01	惠氏公司	β淀粉样蛋白生成抑制剂含氟和三氟烷基杂环磺酰胺及其衍生物
US20090155903A1 (en) *	2004-03-19	2009-06-18	Myriad Genetics, Incorporated	Pharmaceutical composition and method
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CN102395359A (zh) *	2009-03-16	2012-03-28	Ipintl有限责任公司	治疗阿尔茨海默病和骨质疏松症以及减缓衰老
US8324450B2 (en)	2009-06-02	2012-12-04	Academia Sinica	Non-human animal model for frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U)
SMT201900445T1 (it)	2011-06-08	2019-09-09	Translate Bio Inc	Composizione di nanoparticelle lipidiche e metodi per il rilascio di mrna
WO2013090356A2 (en)	2011-12-16	2013-06-20	The Board Of Trustees Of The Leland Stanford Junior University	Opsin polypeptides and methods of use thereof
EP3536787A1 (de)	2012-06-08	2019-09-11	Translate Bio, Inc.	Nukleaseresistente polynukleotide und verwendungen davon
EP4446413A3 (de)	2013-03-14	2024-12-18	Translate Bio, Inc.	Verfahren zur reinigung von messenger-rna
KR20210122917A (ko)	2013-03-14	2021-10-12	샤이어 휴먼 지네틱 테라피즈 인크.	Cftr mrna 조성물 및 관련 방법 및 사용
JP6621747B2 (ja)	2013-08-14	2019-12-18	ザボードオブトラスティーズオブザレランドスタンフォードジュニアユニバーシティー	疼痛を制御するための組成物及び方法
EP3060303B1 (de)	2013-10-22	2018-11-14	Translate Bio, Inc.	Mrna-therapie für argininosuccinat-synthase-mangel
CN106459138A (zh)	2014-03-28	2017-02-22	斯坦福大学托管董事会	工程化的光激活阴离子通道蛋白及其使用方法
EP3636742B1 (de) *	2014-04-25	2025-11-05	Translate Bio, Inc.	Verfahren zur reinigung von messenger-rna
US11168369B2 (en)	2014-11-25	2021-11-09	The Brigham And Women's Hospital, Inc.	Method of identifying and treating a person having a predisposition to or afflicted with a cardiometabolic disease
WO2016085876A1 (en)	2014-11-25	2016-06-02	The Broad Institute Inc.	Clonal haematopoiesis
CA2995019C (en)	2015-08-31	2024-02-13	The Board Of Trustees Of The Leland Stanford Junior University	Compressed sensing high resolution functional magnetic resonance imaging
KR102893860B1 (ko) *	2015-12-09	2025-12-03	더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티	기능적 뇌 회로 분석법
WO2017136285A1 (en)	2016-02-01	2017-08-10	The Board Of Trustees Of The Leland Stanford Junior University	Method and systems for analyzing functional imaging data
AU2018224326B2 (en)	2017-02-27	2024-01-04	Translate Bio, Inc.	Novel codon-optimized CFTR mRNA
US11173190B2 (en)	2017-05-16	2021-11-16	Translate Bio, Inc.	Treatment of cystic fibrosis by delivery of codon-optimized mRNA encoding CFTR
US11174500B2 (en)	2018-08-24	2021-11-16	Translate Bio, Inc.	Methods for purification of messenger RNA
AU2019384557B2 (en)	2018-11-21	2025-07-17	Translate Bio, Inc.	Treatment of cystic fibrosis by delivery of nebulized mRNA encoding CFTR
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US5985930A (en) *	1996-11-21	1999-11-16	Pasinetti; Giulio M.	Treatment of neurodegenerative conditions with nimesulide

1997
- 1997-04-01 US US08/831,402 patent/US5985930A/en not_active Expired - Lifetime
- 1997-11-19 JP JP52395698A patent/JP2001505206A/ja not_active Ceased
- 1997-11-19 DE DE69710224T patent/DE69710224T2/de not_active Expired - Fee Related
- 1997-11-19 AU AU53612/98A patent/AU725141B2/en not_active Ceased
- 1997-11-19 PT PT97950672T patent/PT956009E/pt unknown
- 1997-11-19 WO PCT/US1997/021484 patent/WO1998022104A2/en not_active Ceased
- 1997-11-19 NZ NZ335726A patent/NZ335726A/xx unknown
- 1997-11-19 SK SK671-99A patent/SK284334B6/sk unknown
- 1997-11-19 DK DK97950672T patent/DK0956009T3/da active
- 1997-11-19 AT AT97950672T patent/ATE212546T1/de not_active IP Right Cessation
- 1997-11-19 ES ES97950672T patent/ES2172822T3/es not_active Expired - Lifetime
- 1997-11-19 IL IL12994997A patent/IL129949A/xx not_active IP Right Cessation
- 1997-11-19 CA CA002272249A patent/CA2272249A1/en not_active Abandoned
- 1997-11-19 BR BR9714303-0A patent/BR9714303A/pt not_active Application Discontinuation
- 1997-11-19 TR TR1999/01120T patent/TR199901120T2/xx unknown
- 1997-11-19 EP EP97950672A patent/EP0956009B9/de not_active Expired - Lifetime
- 1997-11-19 US US09/308,424 patent/US6649811B2/en not_active Expired - Fee Related
- 1997-11-19 KR KR1019997004481A patent/KR20000069061A/ko not_active Ceased
1999
- 1999-05-18 NO NO992374A patent/NO992374L/no unknown
2002
- 2002-05-17 US US10/150,461 patent/US7226948B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US20020162130A1 (en)	2002-10-31
JP2001505206A (ja)	2001-04-17
TR199901120T2 (xx)	1999-07-21
PT956009E (pt)	2002-07-31
DE69710224T2 (de)	2002-10-02
IL129949A0 (en)	2000-02-29
ES2172822T3 (es)	2002-10-01
IL129949A (en)	2003-05-29
SK284334B6 (sk)	2005-02-04
EP0956009B9 (de)	2002-12-11
SK67199A3 (en)	2001-01-18
ATE212546T1 (de)	2002-02-15
AU5361298A (en)	1998-06-10
CA2272249A1 (en)	1998-05-28
US6649811B2 (en)	2003-11-18
WO1998022104A3 (en)	1998-10-08
US5985930A (en)	1999-11-16
EP0956009B1 (de)	2002-01-30
US7226948B2 (en)	2007-06-05
US20060059576A1 (en)	2006-03-16
NZ335726A (en)	2000-10-27
BR9714303A (pt)	2000-04-25
NO992374D0 (no)	1999-05-18
DE69710224D1 (de)	2002-03-14
NO992374L (no)	1999-07-21
AU725141B2 (en)	2000-10-05
EP0956009A1 (de)	1999-11-17
WO1998022104A2 (en)	1998-05-28
KR20000069061A (ko)	2000-11-25

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