ATE212616T1 - 7-amino-2-heptenoate und ihre verwendung in der herstellung von methylphenidat - Google Patents
7-amino-2-heptenoate und ihre verwendung in der herstellung von methylphenidatInfo
- Publication number
- ATE212616T1 ATE212616T1 AT97908413T AT97908413T ATE212616T1 AT E212616 T1 ATE212616 T1 AT E212616T1 AT 97908413 T AT97908413 T AT 97908413T AT 97908413 T AT97908413 T AT 97908413T AT E212616 T1 ATE212616 T1 AT E212616T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- methylphenidate
- blocking group
- cooch3
- sec
- Prior art date
Links
- DUGOZIWVEXMGBE-UHFFFAOYSA-N Methylphenidate Chemical compound C=1C=CC=CC=1C(C(=O)OC)C1CCCCN1 DUGOZIWVEXMGBE-UHFFFAOYSA-N 0.000 title abstract 2
- 229960001344 methylphenidate Drugs 0.000 title abstract 2
- MEQZLBSYGZAXND-UHFFFAOYSA-N 7-aminohept-2-enoic acid Chemical compound NCCCCC=CC(O)=O MEQZLBSYGZAXND-UHFFFAOYSA-N 0.000 title 1
- 230000000903 blocking effect Effects 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000006845 Michael addition reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9606417.5A GB9606417D0 (en) | 1996-03-27 | 1996-03-27 | Asymmetric cyclisation |
| PCT/GB1997/000811 WO1997035836A1 (en) | 1996-03-27 | 1997-03-21 | 7-amino-2-heptenoates and their use in the preparation of methylphenidate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE212616T1 true ATE212616T1 (de) | 2002-02-15 |
Family
ID=10791096
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97908413T ATE212616T1 (de) | 1996-03-27 | 1997-03-21 | 7-amino-2-heptenoate und ihre verwendung in der herstellung von methylphenidat |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6031124A (de) |
| EP (1) | EP0889874B1 (de) |
| JP (1) | JP2000507263A (de) |
| KR (1) | KR100472753B1 (de) |
| AT (1) | ATE212616T1 (de) |
| AU (1) | AU703927B2 (de) |
| CA (1) | CA2243544C (de) |
| DE (1) | DE69710181T2 (de) |
| DK (1) | DK0889874T3 (de) |
| ES (1) | ES2172767T3 (de) |
| GB (1) | GB9606417D0 (de) |
| MX (1) | MX202731B (de) |
| PT (1) | PT889874E (de) |
| WO (1) | WO1997035836A1 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5922736A (en) * | 1995-12-04 | 1999-07-13 | Celegene Corporation | Chronic, bolus administration of D-threo methylphenidate |
| US5837284A (en) * | 1995-12-04 | 1998-11-17 | Mehta; Atul M. | Delivery of multiple doses of medications |
| US6486177B2 (en) * | 1995-12-04 | 2002-11-26 | Celgene Corporation | Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate |
| EP0860426A1 (de) * | 1997-02-19 | 1998-08-26 | Takasago International Corporation | 7-(N-Substituierte amino)-2-Phenylheptanoic Säure Derivaten, und Verfahren zur Herstellung |
| US5859249A (en) * | 1997-02-19 | 1999-01-12 | Takasago International Corporation | 2-phenyl-2-(2'-piperidinylidene)acetate derivative, process for manufacturing the same, and process for manufacturing optically active 2-phenyl-2-(2'-piperidinyl)acetate derivative by asymmetrically hydrogenating the same |
| US6962997B1 (en) | 1997-05-22 | 2005-11-08 | Celgene Corporation | Process and intermediates for resolving piperidyl acetamide steroisomers |
| US6100401A (en) * | 1998-04-20 | 2000-08-08 | Novartris Ag | Process for preparing the d-threo isomer of methylphenidate hydrochloride |
| US6025502A (en) * | 1999-03-19 | 2000-02-15 | The Trustees Of The University Of Pennsylvania | Enantopselective synthesis of methyl phenidate |
| US20050239830A1 (en) * | 2004-04-26 | 2005-10-27 | Vikram Khetani | Methods of diminishing co-abuse potential |
| US20060127421A1 (en) * | 2004-12-09 | 2006-06-15 | Celgene Corporation | Treatment using D-threo methylphenidate |
| US9603809B2 (en) | 2011-03-23 | 2017-03-28 | Ironshore Pharmaceuticals & Development, Inc. | Methods of treatment of attention deficit hyperactivity disorder |
| US8916588B2 (en) | 2011-03-23 | 2014-12-23 | Ironshore Pharmaceuticals & Development, Inc. | Methods for treatment of attention deficit hyperactivity disorder |
| US10292937B2 (en) | 2011-03-23 | 2019-05-21 | Ironshore Pharmaceuticals & Development, Inc. | Methods of treatment of attention deficit hyperactivity disorder |
| US9283214B2 (en) | 2011-03-23 | 2016-03-15 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
| US8927010B2 (en) | 2011-03-23 | 2015-01-06 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
| US11241391B2 (en) | 2011-03-23 | 2022-02-08 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
| US9498447B2 (en) | 2011-03-23 | 2016-11-22 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
| US10905652B2 (en) | 2011-03-23 | 2021-02-02 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
| AU2012230733B2 (en) | 2011-03-23 | 2016-10-20 | Ironshore Pharmaceuticals & Development, Inc. | Methods and compositions for treatment of attention deficit disorder |
| US9119809B2 (en) | 2011-03-23 | 2015-09-01 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2957880A (en) * | 1953-12-23 | 1960-10-25 | Ciba Pharm Prod Inc | Process for the conversion of stereoisomers |
| JPS537627A (en) * | 1976-07-07 | 1978-01-24 | Teijin Ltd | Optically active unsaturated esters and their preparation |
-
1996
- 1996-03-27 GB GBGB9606417.5A patent/GB9606417D0/en active Pending
-
1997
- 1997-03-21 CA CA002243544A patent/CA2243544C/en not_active Expired - Fee Related
- 1997-03-21 DK DK97908413T patent/DK0889874T3/da active
- 1997-03-21 US US09/155,322 patent/US6031124A/en not_active Expired - Fee Related
- 1997-03-21 ES ES97908413T patent/ES2172767T3/es not_active Expired - Lifetime
- 1997-03-21 DE DE69710181T patent/DE69710181T2/de not_active Expired - Fee Related
- 1997-03-21 AT AT97908413T patent/ATE212616T1/de not_active IP Right Cessation
- 1997-03-21 EP EP97908413A patent/EP0889874B1/de not_active Expired - Lifetime
- 1997-03-21 AU AU20386/97A patent/AU703927B2/en not_active Ceased
- 1997-03-21 KR KR10-1998-0707378A patent/KR100472753B1/ko not_active Expired - Fee Related
- 1997-03-21 JP JP9534133A patent/JP2000507263A/ja active Pending
- 1997-03-21 WO PCT/GB1997/000811 patent/WO1997035836A1/en not_active Ceased
- 1997-03-21 PT PT97908413T patent/PT889874E/pt unknown
-
1998
- 1998-09-25 MX MX9807879A patent/MX202731B/es not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0889874A1 (de) | 1999-01-13 |
| US6031124A (en) | 2000-02-29 |
| CA2243544C (en) | 2002-11-19 |
| AU703927B2 (en) | 1999-04-01 |
| DE69710181T2 (de) | 2002-08-14 |
| EP0889874B1 (de) | 2002-01-30 |
| DK0889874T3 (da) | 2002-05-06 |
| AU2038697A (en) | 1997-10-17 |
| MX9807879A (en) | 1999-02-28 |
| KR19990087826A (ko) | 1999-12-27 |
| ES2172767T3 (es) | 2002-10-01 |
| KR100472753B1 (ko) | 2005-07-07 |
| CA2243544A1 (en) | 1997-10-02 |
| GB9606417D0 (en) | 1996-06-05 |
| WO1997035836A1 (en) | 1997-10-02 |
| MX202731B (en) | 2001-06-29 |
| DE69710181D1 (de) | 2002-03-14 |
| JP2000507263A (ja) | 2000-06-13 |
| PT889874E (pt) | 2002-06-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |