ATE178886T1 - 1-aryl-2-acylamino-ethan-verbindungen und ihre verwendung als neurokinin- insbesondere als neurokinin-1-antagonisten - Google Patents

1-aryl-2-acylamino-ethan-verbindungen und ihre verwendung als neurokinin- insbesondere als neurokinin-1-antagonisten

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Publication number
ATE178886T1
ATE178886T1 AT96901800T AT96901800T ATE178886T1 AT E178886 T1 ATE178886 T1 AT E178886T1 AT 96901800 T AT96901800 T AT 96901800T AT 96901800 T AT96901800 T AT 96901800T AT E178886 T1 ATE178886 T1 AT E178886T1
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Austria
Prior art keywords
neurokinin
antagonists
aryl
pct
acylamino
Prior art date
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AT96901800T
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English (en)
Inventor
Marc Gerspacher
Sprecher Andreas Von
Silvio Roggo
Robert Mah
Silvio Ofner
Siem Jacob Veenstra
Claudia Betschart
Yves Auberson
Walter Schilling
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Novartis Erfind Verwalt Gmbh
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Publication of ATE178886T1 publication Critical patent/ATE178886T1/de

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    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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AT96901800T 1995-02-22 1996-02-09 1-aryl-2-acylamino-ethan-verbindungen und ihre verwendung als neurokinin- insbesondere als neurokinin-1-antagonisten ATE178886T1 (de)

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EP0912178A4 (de) * 1996-05-24 2000-08-16 Lilly Co Eli Verfahren zur behandlung des bluthochdrucks
MY132550A (en) 1996-08-22 2007-10-31 Novartis Ag Acylaminoalkenylene-amide derivatives as nk1 and nk2 antogonists
GB0010958D0 (en) * 2000-05-05 2000-06-28 Novartis Ag Organic compounds
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GB0224788D0 (en) * 2002-10-24 2002-12-04 Novartis Ag Organic compounds
GB2394417A (en) * 2002-10-24 2004-04-28 Novartis Ag Solid dispersion comprising a piperidine substance P antagonist and a carrier
JP5248779B2 (ja) * 2003-12-01 2013-07-31 ケンブリッジ エンタープライズ リミティド 抗炎症剤
US20090156465A1 (en) 2005-12-30 2009-06-18 Sattigeri Jitendra A Derivatives of beta-amino acid as dipeptidyl peptidase-iv inhibitors
JO2630B1 (en) * 2006-04-13 2012-06-17 نوفارتيس ايه جي Organic compounds
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JP4983616B2 (ja) 2008-01-16 2012-07-25 ソニー株式会社 熱転写記録媒体
WO2013004766A1 (en) 2011-07-04 2013-01-10 Ferrari Giulio Nk-1 receptor antagonists for treating corneal neovascularisation
MX2016009939A (es) * 2014-02-18 2017-01-23 Daiichi Sankyo Co Ltd Derivado de aminopirazolona.
RU2020131446A (ru) 2018-02-26 2022-03-28 Оспедале Сан Раффаэле С.Р.Л. Антагонисты nk-1 для применения в лечении глазной боли
RU2697414C1 (ru) * 2018-05-11 2019-08-14 Общество с ограниченной ответственностью "АЙ БИ ДИ Терапевтикс" Новый антагонист тахикининовых рецепторов и его применение
EP3917509A4 (de) * 2019-01-28 2022-11-09 Mitochondria Emotion, Inc. Trans-4-hydroxycyclohexylphenylamid-mitofusinaktivatoren und verfahren zu deren verwendung
WO2021150499A1 (en) 2020-01-20 2021-07-29 Monomer Software LLC Optical device field of view cleaning apparatus
EP4117673A1 (de) 2020-03-11 2023-01-18 Ospedale San Raffaele S.r.l. Behandlung von stammzellenmangel

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EA199900385A1 (ru) 1999-10-28
AU4623396A (en) 1996-09-11
FI120304B (fi) 2009-09-15
FI973221A0 (fi) 1997-08-04
HUP9800051A3 (en) 1998-08-28
ES2132882T3 (es) 1999-08-16
IL117209A (en) 2001-01-11
IL117209A0 (en) 1996-06-18
MX9706394A (es) 1997-11-29
EA002348B1 (ru) 2002-04-25
SK113997A3 (en) 1998-02-04
EP0810991A1 (de) 1997-12-10
US5929067A (en) 1999-07-27
NO325605B1 (no) 2008-06-23
BR9607335A (pt) 1997-11-25
KR19980702391A (ko) 1998-07-15
PL322001A1 (en) 1998-01-05
CY2198B1 (en) 2002-11-08
CZ266297A3 (en) 1997-11-12
KR100389253B1 (ko) 2003-08-19
FI973221L (fi) 1997-10-20
CA2213080A1 (en) 1996-08-29
DE69602087T2 (de) 1999-09-09
NZ300942A (en) 1998-12-23
NO973857D0 (no) 1997-08-21
GR3030626T3 (en) 1999-10-29
NO973857L (no) 1997-10-01
EP0810991B1 (de) 1999-04-14
HUP9800051A2 (hu) 1998-05-28
PL184226B1 (pl) 2002-09-30
WO1996026183A1 (en) 1996-08-29
CN1081625C (zh) 2002-03-27
CA2213080C (en) 2007-11-13
DE69602087D1 (de) 1999-05-20
TR199700834T1 (xx) 1998-01-21
DK0810991T3 (da) 1999-10-25
ZA961364B (en) 1996-08-22
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CN1175944A (zh) 1998-03-11
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