ATE212644T1 - Derivate und konjugete von mdp, eine von hämatopoitischer funktion stimulierende wirkung und deren enthaltende zusammensetzungen - Google Patents

Derivate und konjugete von mdp, eine von hämatopoitischer funktion stimulierende wirkung und deren enthaltende zusammensetzungen

Info

Publication number: ATE212644T1
Authority: AT; Austria
Prior art keywords: conjugets; mdp; derivatives; compositions containing; stimulating action
Prior art date: 1995-04-07

Application number

AT96912079T

Other languages

English (en)

Inventor

Georges Bahr

Pierre Lefrancier

Louis Chedid

Original Assignee

Vacsyn Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-07

Filing date

1996-04-05

Publication date

2002-02-15

1996-04-05 Application filed by Vacsyn Sa filed Critical Vacsyn Sa

2002-02-15 Application granted granted Critical

2002-02-15 Publication of ATE212644T1 publication Critical patent/ATE212644T1/de

Links

239000000203 mixture Substances 0.000 title 1
FKHUGQZRBPETJR-RXSRXONKSA-N (2r)-2-[[(4r)-4-[[(2s)-2-[[(2r)-2-[(3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxypropanoyl]amino]propanoyl]amino]-5-amino-5-oxopentanoyl]amino]-6-(octadecanoylamino)hexanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(=O)NCCCC[C@H](C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)OC(O)[C@@H]1NC(C)=O FKHUGQZRBPETJR-RXSRXONKSA-N 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000003394 haemopoietic effect Effects 0.000 abstract 1
229960005225 mifamurtide Drugs 0.000 abstract 1
JMUHBNWAORSSBD-WKYWBUFDSA-N mifamurtide Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCCCCCCCCCC)COP(O)(=O)OCCNC(=O)[C@H](C)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)OC(O)[C@@H]1NC(C)=O JMUHBNWAORSSBD-WKYWBUFDSA-N 0.000 abstract 1
125000001446 muramyl group Chemical group N[C@@H](C=O)[C@@H](O[C@@H](C(=O)*)C)[C@H](O)[C@H](O)CO 0.000 abstract 1
231100000052 myelotoxic Toxicity 0.000 abstract 1
230000002556 myelotoxic effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
229950003733 romurtide Drugs 0.000 abstract 1
230000004936 stimulating effect Effects 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
- C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Oil, Petroleum & Natural Gas (AREA)
Diabetes (AREA)
Hematology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Crystallography & Structural Chemistry (AREA)
Toxicology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Dermatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Detergent Compositions (AREA)

AT96912079T 1995-04-07 1996-04-05 Derivate und konjugete von mdp, eine von hämatopoitischer funktion stimulierende wirkung und deren enthaltende zusammensetzungen ATE212644T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9504194A FR2732604B1 (fr)	1995-04-07	1995-04-07	Derives et conjugues du mdp presentant une activite stimulatrice de la fonction hematopoietique et compositions les contenant
PCT/FR1996/000527 WO1996031533A1 (fr)	1995-04-07	1996-04-05	Derives et conjugues du mdp presentant une activite stimulatrice de la fonction hematopoietique et composition les contenant

Publications (1)

Publication Number	Publication Date
ATE212644T1 true ATE212644T1 (de)	2002-02-15

Family

ID=9477896

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96912079T ATE212644T1 (de)	1995-04-07	1996-04-05	Derivate und konjugete von mdp, eine von hämatopoitischer funktion stimulierende wirkung und deren enthaltende zusammensetzungen

Country Status (11)

Country	Link
EP (1)	EP0819136B1 (de)
JP (2)	JP3816522B2 (de)
AT (1)	ATE212644T1 (de)
AU (1)	AU5504696A (de)
CA (1)	CA2216599A1 (de)
DE (1)	DE69618942T2 (de)
DK (1)	DK0819136T3 (de)
ES (1)	ES2171665T3 (de)
FR (1)	FR2732604B1 (de)
PT (1)	PT819136E (de)
WO (1)	WO1996031533A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9618673D0 (en) *	1996-09-06	1996-10-16	Peptech Uk Ltd	The use of muramyl peptides
PE20100362A1 (es) *	2008-10-30	2010-05-27	Irm Llc	Derivados de purina que expanden las celulas madre hematopoyeticas
JP5805195B2 (ja) *	2010-08-23	2015-11-04	カンステムバイオテックカンパニーリミテッド	Ｎｏｄ２アゴニストで処理した幹細胞またはその培養物を含む免疫疾患および炎症性疾患の予防および治療用の薬学的組成物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2343483A1 (fr) *	1976-03-10	1977-10-07	Anvar	L'ester methylique de la 2- (2-acetamido-2-deoxy-3-o-d-glucopyranosyl) -d-propionyl-l-alanyl-d-isoglutamine et le diester methylique de l'acide 2- (2-acetamido-2-deoxy-3-o-d-glucopyranosyl) -d-propionyl-l-alanyl-d-glutamique et medicaments les contenant
FR2522967B1 (fr) *	1982-03-15	1986-03-07	Anvar	Conjugues d'haptenes et de muramyl-peptides, doues d'activite immunogene et compositions les contenant
DE3367596D1 (en) *	1982-07-23	1987-01-02	Ciba Geigy Ag	Muramyl peptides and method for their preparation
EP0192609A3 (de) *	1985-02-20	1988-04-27	Ciba-Geigy Ag	Acylierte Hexosederivate und Verfahren zu ihrer Herstellung
FR2715305B1 (fr) *	1994-01-25	1996-03-15	Vacsyn Sa	Diesters de muramyl peptides dans une forme orale.

1995
- 1995-04-07 FR FR9504194A patent/FR2732604B1/fr not_active Expired - Fee Related
1996
- 1996-04-05 ES ES96912079T patent/ES2171665T3/es not_active Expired - Lifetime
- 1996-04-05 DE DE69618942T patent/DE69618942T2/de not_active Expired - Fee Related
- 1996-04-05 DK DK96912079T patent/DK0819136T3/da active
- 1996-04-05 CA CA002216599A patent/CA2216599A1/fr not_active Abandoned
- 1996-04-05 AU AU55046/96A patent/AU5504696A/en not_active Abandoned
- 1996-04-05 JP JP53005296A patent/JP3816522B2/ja not_active Expired - Fee Related
- 1996-04-05 PT PT96912079T patent/PT819136E/pt unknown
- 1996-04-05 AT AT96912079T patent/ATE212644T1/de not_active IP Right Cessation
- 1996-04-05 WO PCT/FR1996/000527 patent/WO1996031533A1/fr not_active Ceased
- 1996-04-05 EP EP96912079A patent/EP0819136B1/de not_active Expired - Lifetime
2006
- 2006-02-15 JP JP2006037750A patent/JP2006182785A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
PT819136E (pt)	2002-07-31
WO1996031533A1 (fr)	1996-10-10
FR2732604B1 (fr)	1997-06-06
AU5504696A (en)	1996-10-23
JPH11503426A (ja)	1999-03-26
EP0819136B1 (de)	2002-01-30
JP2006182785A (ja)	2006-07-13
CA2216599A1 (fr)	1996-10-10
DE69618942D1 (de)	2002-03-14
FR2732604A1 (fr)	1996-10-11
JP3816522B2 (ja)	2006-08-30
ES2171665T3 (es)	2002-09-16
EP0819136A1 (de)	1998-01-21
DE69618942T2 (de)	2002-09-19
DK0819136T3 (da)	2002-05-21

Legal Events

Date	Code	Title	Description
2002-07-15	UEP	Publication of translation of european patent specification
2007-01-15	REN	Ceased due to non-payment of the annual fee

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