ATE212662T1 - Verfahren zur pharmakokinetischen studie der insulin-expression mit nicht-menschlichem transgen-säugetier - Google Patents

Verfahren zur pharmakokinetischen studie der insulin-expression mit nicht-menschlichem transgen-säugetier

Info

Publication number: ATE212662T1
Authority: AT; Austria
Prior art keywords: mice; gene; insulin; transgenic; transgenic mammal
Prior art date: 1986-05-20

Application number

AT93101772T

Other languages

English (en)

Inventor

Richard F Selden

Howard M Goodman

Original Assignee

Gen Hospital Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-05-20

Filing date

1987-05-19

Publication date

2002-02-15

1987-05-19 Application filed by Gen Hospital Corp filed Critical Gen Hospital Corp

2002-02-15 Application granted granted Critical

2002-02-15 Publication of ATE212662T1 publication Critical patent/ATE212662T1/de

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 6
108090001061 Insulin Proteins 0.000 title abstract 4
102000004877 Insulin Human genes 0.000 title abstract 3
229940125396 insulin Drugs 0.000 title abstract 3
241000124008 Mammalia Species 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
230000009261 transgenic effect Effects 0.000 title abstract 2
241000699670 Mus sp. Species 0.000 abstract 4
101000976075 Homo sapiens Insulin Proteins 0.000 abstract 3
238000011830 transgenic mouse model Methods 0.000 abstract 3
241000699660 Mus musculus Species 0.000 abstract 2
108090000623 proteins and genes Proteins 0.000 abstract 2
206010013710 Drug interaction Diseases 0.000 abstract 1
102000051325 Glucagon Human genes 0.000 abstract 1
108060003199 Glucagon Proteins 0.000 abstract 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
241000699666 Mus <mouse, genus> Species 0.000 abstract 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
230000004634 feeding behavior Effects 0.000 abstract 1
MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 abstract 1
229960004666 glucagon Drugs 0.000 abstract 1
239000008103 glucose Substances 0.000 abstract 1
230000014101 glucose homeostasis Effects 0.000 abstract 1
229940088597 hormone Drugs 0.000 abstract 1
239000005556 hormone Substances 0.000 abstract 1
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 1
238000011835 investigation Methods 0.000 abstract 1
210000000496 pancreas Anatomy 0.000 abstract 1
230000001105 regulatory effect Effects 0.000 abstract 1
230000001850 reproductive effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/89—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0325—Animal model for autoimmune diseases

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Veterinary Medicine (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Environmental Sciences (AREA)
Biodiversity & Conservation Biology (AREA)
Animal Behavior & Ethology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Animal Husbandry (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Investigating Or Analysing Biological Materials (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Sampling And Sample Adjustment (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)

AT93101772T 1986-05-20 1987-05-19 Verfahren zur pharmakokinetischen studie der insulin-expression mit nicht-menschlichem transgen-säugetier ATE212662T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US86512086A	1986-05-20	1986-05-20

Publications (1)

Publication Number	Publication Date
ATE212662T1 true ATE212662T1 (de)	2002-02-15

Family

ID=25344768

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT87107238T ATE140846T1 (de)	1986-05-20	1987-05-19	Methode zur bestimmung des effektes eines heterologen agens auf ein tier
AT93101772T ATE212662T1 (de)	1986-05-20	1987-05-19	Verfahren zur pharmakokinetischen studie der insulin-expression mit nicht-menschlichem transgen-säugetier

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT87107238T ATE140846T1 (de)	1986-05-20	1987-05-19	Methode zur bestimmung des effektes eines heterologen agens auf ein tier

Country Status (8)

Country	Link
US (1)	US6018097A (de)
EP (2)	EP0247494B1 (de)
JP (2)	JPH01502716A (de)
AT (2)	ATE140846T1 (de)
DE (2)	DE3752347T2 (de)
ES (2)	ES2171401T3 (de)
GR (1)	GR3021288T3 (de)
WO (1)	WO1987007298A1 (de)

Families Citing this family (30)

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US4873316A (en) *	1987-06-23	1989-10-10	Biogen, Inc.	Isolation of exogenous recombinant proteins from the milk of transgenic mammals
EP0370813A3 (de) *	1988-11-25	1991-06-19	Exemplar Corporation	Rascher Überprüfungstest der Mutagenesis und Tetratogenesis
FR2646438B1 (fr) *	1989-03-20	2007-11-02	Pasteur Institut	Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration
US6689610B1 (en)	1989-08-22	2004-02-10	University Of Utah Research Foundation	Cells and non-human organisms containing predetermined genomic modifications and positive-negative selection methods and vectors for making same
US5464764A (en) *	1989-08-22	1995-11-07	University Of Utah Research Foundation	Positive-negative selection methods and vectors
GB9003791D0 (en) *	1990-02-20	1990-04-18	Ludwig Inst Cancer Res	Transgenic animals,cell lines therefrom,and their use
US5744327A (en) *	1990-02-20	1998-04-28	Board Of Regents, The University Of Texas System	Methods for producing insulin in response to non-glucose secretagogues
US5427940A (en) *	1991-06-03	1995-06-27	Board Of Regents, The University Of Texas System	Engineered cells producing insulin in response to glucose
US5648597A (en) *	1990-04-20	1997-07-15	University Of South Carolina	Alpha-1-acid glycoprotein transgenic mice
US5614396A (en) *	1990-06-14	1997-03-25	Baylor College Of Medicine	Methods for the genetic modification of endogenous genes in animal cells by homologous recombination
US5569824A (en) *	1991-01-04	1996-10-29	Baylor College Of Medicine	Transgenic mice containing a disrupted p53 gene
US5866759A (en) *	1991-02-20	1999-02-02	Ludwig Institute For Cancer Research	Transgenic mice expressing TSSV40 large T antigen
US5792656A (en) *	1991-06-03	1998-08-11	Board Of Regents, The University Of Texas System	Methods of preparing genetically engineered cells that produce insulin in response to glucose
DE4126968A1 (de) *	1991-08-14	1993-02-18	Detlev Prof Dr Med Ganten	Transgene ratten, die in ihrem genom mindestens ein menschliches gen enthalten, das an der blutdruckregulation beteiligt ist
WO1993004171A1 (en) *	1991-08-19	1993-03-04	Symbicom Aktiebolag	Human beta-casein, process for producing it and use thereof
DK8892D0 (da)	1992-01-23	1992-01-23	Symbicom Ab	Humant proteingen
US5602307A (en) *	1992-08-12	1997-02-11	Baylor College Of Medicine	Non-human animal having predefined allele of a cellular adhesion gene
ATE221575T1 (de) *	1993-05-10	2002-08-15	Univ Michigan	Gentransfer zu den pankreatischen epithelzellen
US6310034B1 (en)	1993-05-21	2001-10-30	Ut-Battelle, Llc	Agouti polypeptide compositions
US5789651A (en) *	1993-05-21	1998-08-04	Martin Marietta Energy Systems, Inc.	Isolation and characterization of Agouti: a diabetes/obesity related gene
US5907080A (en) *	1995-11-30	1999-05-25	Nexia Biotechnologies, Inc.	Method for development of transgenic dwarf goats
US5891717A (en) *	1996-01-19	1999-04-06	Betagene, Inc.	Methods and compositions for inhibiting hexokinase
US5854067A (en) *	1996-01-19	1998-12-29	Board Of Regents, The University Of Texas System	Hexokinase inhibitors
US6077697A (en)	1996-04-10	2000-06-20	Chromos Molecular Systems, Inc.	Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US20030033617A1 (en)	1996-04-10	2003-02-13	Gyula Hadlaczky	Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US20030013081A1 (en)	2001-06-26	2003-01-16	Olson William C.	Uses of DC-SIGN and DC-SIGNR for inhibiting hepatitis C virus infection
US20090214482A1 (en) *	2005-04-13	2009-08-27	Ximerex, Inc.	Transgenic Mammals Expressing Human Preproinsulin
WO2014209553A1 (en)	2013-06-04	2014-12-31	Virginia Commonwealth University	Use of a truncated ccn1 promoter for cancer diagnostics, therapeutics and theranostics
WO2014197586A1 (en)	2013-06-04	2014-12-11	Virginia Commonwealth University	Mda-9/syntenin promoter to image and treat metastatic cancer cells
RU2020118342A (ru)	2017-11-07	2021-12-08	Дзе Юниверсити Оф Норт Каролина Эт Чепел Хилл	Оптимизированные гены aga и экспрессионные кластеры и их применение

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GR70279B (de) *	1979-09-12	1982-09-03	Univ California
US4431740A (en) *	1979-09-12	1984-02-14	The Regents Of The University Of California	DNA Transfer vector and transformed microorganism containing human proinsulin and pre-proinsulin genes
US4423829A (en) *	1980-08-28	1984-01-03	Container Industries Inc.	Apparatus for containing and dispensing fluids under pressure and method of manufacturing same
US4873191A (en) *	1981-06-12	1989-10-10	Ohio University	Genetic transformation of zygotes
WO1982004443A1 (en) *	1981-06-12	1982-12-23	Ohio Univ	Genetic transformation of zygotes
ZA824218B (en) *	1981-06-29	1983-04-27	Cetus Corp	Plasmid for producing human insulin
US4870009A (en) *	1982-11-22	1989-09-26	The Salk Institute For Biological Studies	Method of obtaining gene product through the generation of transgenic animals
US4564517A (en) *	1984-02-22	1986-01-14	Fudenberg Herman H	Method for evaluating parameters related to the therapeutic and/or prophylactic treatment of solid neoplasms in humans
US4736866B1 (en) *	1984-06-22	1988-04-12		Transgenic non-human mammals

1987
- 1987-05-19 DE DE3752347T patent/DE3752347T2/de not_active Expired - Fee Related
- 1987-05-19 ES ES93101772T patent/ES2171401T3/es not_active Expired - Lifetime
- 1987-05-19 ES ES87107238T patent/ES2090006T3/es not_active Expired - Lifetime
- 1987-05-19 EP EP87107238A patent/EP0247494B1/de not_active Expired - Lifetime
- 1987-05-19 AT AT87107238T patent/ATE140846T1/de not_active IP Right Cessation
- 1987-05-19 EP EP93101772A patent/EP0561140B1/de not_active Expired - Lifetime
- 1987-05-19 DE DE3751863T patent/DE3751863T2/de not_active Expired - Fee Related
- 1987-05-19 AT AT93101772T patent/ATE212662T1/de not_active IP Right Cessation
- 1987-05-20 WO PCT/US1987/001154 patent/WO1987007298A1/en not_active Ceased
- 1987-05-20 JP JP62503395A patent/JPH01502716A/ja active Pending
1995
- 1995-04-11 US US08/419,850 patent/US6018097A/en not_active Expired - Lifetime
1996
- 1996-10-09 GR GR960402659T patent/GR3021288T3/el unknown
1997
- 1997-07-07 JP JP9181034A patent/JPH10108587A/ja active Pending

Also Published As

Publication number	Publication date
DE3751863D1 (de)	1996-09-05
JPH01502716A (ja)	1989-09-21
DE3751863T2 (de)	1996-12-12
WO1987007298A1 (en)	1987-12-03
EP0247494B1 (de)	1996-07-31
EP0247494A3 (en)	1989-01-11
US6018097A (en)	2000-01-25
EP0247494A2 (de)	1987-12-02
EP0561140A1 (de)	1993-09-22
DE3752347T2 (de)	2002-09-26
ES2171401T3 (es)	2002-09-16
JPH10108587A (ja)	1998-04-28
GR3021288T3 (en)	1997-01-31
DE3752347D1 (de)	2002-03-14
ATE140846T1 (de)	1996-08-15
ES2090006T3 (es)	1996-10-16
EP0561140B1 (de)	2002-01-30

Legal Events

Date	Code	Title	Description
2002-06-15	UEP	Publication of translation of european patent specification
2004-02-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE212662T1 (de)	2002-02-15	Verfahren zur pharmakokinetischen studie der insulin-expression mit nicht-menschlichem transgen-säugetier
Sigg et al.	1982	Life history of hamadryas baboons: physical development, infant mortality, reproductive parameters and family relationships
Standen et al.	1989	Comparative socioecology
O'Connor	1987	Organization of avian assemblages--the influence of intraspecific habitat dynamics.
PT87363A (pt)	1989-05-31	Method of altering the concentration of a gene product
Miller et al.	2001	Behavioral plasticity of modern and Cenozoic burrowing thalassinidean shrimp
Woodward	1987	Interactions between Woodhouse's toad tadpoles (Bufo woodhousii) of mixed sizes
Calow et al.	1983	Physiological trade-offs and the evolution of life cycles
Kirkwood et al.	1985	Rearing a second generation of cotton-top tamarins (Saguinus oedipus oedipus) in captivity
Vance et al.	1988	The demographic meanings of the classical population growth models of ecology
Svare et al.	1984	Psychobiological determinants underlying infanticide in mice.
CN109897867B (zh)	2021-07-27	基因改造方法
Serns	1984	An 8-inch length limit on smallmouth bass: effects on the sport fisheries and populations of smallmouth bass and yellow perch in Nebish Lake, Wisconsin
Turner et al.	1972	The effect of unnatural day lengths on tail regeneration in the lizard Anolis carolinensis
Young	1977	Anomalies of limb regeneration in the adult salamander, Ambystoma annulatum
Rinne et al.	1988	Factors influencing salmonid populations in six headwater streams, central Arizona, USA.
Brushko et al.	1982	Horsfield’s tortoise (Agrionemys horsfieldii Gray, 1844) and the ways of its rational utilization in Kazakhstan
Strote	1985	Development of infective larvae of Onchocerca volvulus in diffusion chambers implanted into Mastomys natalensis.
Striegl et al.	1997	Fish Communities of Williams and Shingobee Lakes
Poli et al.	1983	Biological cycle under laboratory conditions of a planktonic copepod of the Gironde Estuary.
Stern et al.	1985	Occurrence of a breeding upland sandpiper at Sycan Marsh, Oregon.
Quigley et al.	1995	The Bogue Boops boops L. in Irish Waters: Further Records and a Review of Irish Records
Morath	1984	Competence of the baby in food-uptake
Du Buit et al.	1995	THE BOGUE BOOPS BOOPS L. IN IRISH WATERS: FURTHER RECORDS AND A REVIEW OF IRISH RECORDS
Lynch	1983	The rock elephant shrew