ATE213231T1 - Michellamine zur verwendung als antivirale wirkstoffe, zusammensetzung und behandlungsverfahren - Google Patents

Michellamine zur verwendung als antivirale wirkstoffe, zusammensetzung und behandlungsverfahren

Info

Publication number: ATE213231T1
Authority: AT; Austria
Prior art keywords: antiviral compounds; antiviral; michellamine; treatment; composition
Prior art date: 1991-04-12

Application number

AT92922789T

Other languages

English (en)

Inventor

Michael R Boyd

John H Ii Cardellina

Kirk P Manfredi

John W Blunt

Lewis K Pannell

James B Mcmahon

Robert J Gulakowski

Gordon M Cragg

Original Assignee

Us Secretary United States Dep

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-04-12

Filing date

1992-04-10

Publication date

2002-02-15

1992-04-10 Application filed by Us Secretary United States Dep filed Critical Us Secretary United States Dep

2002-02-15 Application granted granted Critical

2002-02-15 Publication of ATE213231T1 publication Critical patent/ATE213231T1/de

Links

230000000840 anti-viral effect Effects 0.000 title abstract 7
229930188095 michellamine Natural products 0.000 title abstract 2
239000000203 mixture Substances 0.000 title abstract 2
239000004615 ingredient Substances 0.000 title 1
GMLBVLXDRNJFGR-MOUTVQLLSA-N michellamine c Chemical compound C[C@H]1N[C@H](C)CC2=C1C(O)=CC(O)=C2C1=C2C=C(C)C=C(OC)C2=C(O)C(C=2C(=C3C(OC)=CC(C)=CC3=C(C=3C=4C[C@@H](C)N[C@H](C)C=4C(O)=CC=3O)C=2)O)=C1 GMLBVLXDRNJFGR-MOUTVQLLSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 5
208000029483 Acquired immunodeficiency Diseases 0.000 abstract 1
241000893025 Ancistrocladus Species 0.000 abstract 1
241000196324 Embryophyta Species 0.000 abstract 1
208000036142 Viral infection Diseases 0.000 abstract 1
241000700605 Viruses Species 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000009385 viral infection Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Virology (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Plant Substances (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Other In-Based Heterocyclic Compounds (AREA)

AT92922789T 1991-04-12 1992-04-10 Michellamine zur verwendung als antivirale wirkstoffe, zusammensetzung und behandlungsverfahren ATE213231T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US68419791A	1991-04-12	1991-04-12
PCT/US1992/002805 WO1992018125A1 (en)	1991-04-12	1992-04-10	Michellamines useful as antiviral agents, composition and method of treatment

Publications (1)

Publication Number	Publication Date
ATE213231T1 true ATE213231T1 (de)	2002-02-15

Family

ID=24747059

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92922789T ATE213231T1 (de)	1991-04-12	1992-04-10	Michellamine zur verwendung als antivirale wirkstoffe, zusammensetzung und behandlungsverfahren

Country Status (7)

Country	Link
US (2)	US5455251A (de)
EP (1)	EP0594795B1 (de)
JP (1)	JPH0676383B2 (de)
AT (1)	ATE213231T1 (de)
CA (1)	CA2100066C (de)
DE (1)	DE69232417T2 (de)
WO (1)	WO1992018125A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0676383B2 (ja) *	1991-04-12	1994-09-28	アメリカ合衆国	抗ウイルス剤として有用なミシェルアミン、組成物および治療方法
AU4290993A (en) *	1993-04-19	1994-11-08	United States Of America, Represented By The Secretary, Department Of Health And Human Services, The	Michellamines useful as antiviral agents
US5552550A (en) *	1994-07-22	1996-09-03	The United States Of America, As Represented By The Department Of Health And Human Services	Monomeric Naphthylisoquinoline alkaloids and synthesis methods thereof
US5578729A (en) *	1994-07-22	1996-11-26	The United States Of America As Represented By The Department Of Health And Human Services	Dimeric arylisoquinoline alkaloid compounds
US5639761A (en)	1994-02-14	1997-06-17	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Antimalarial naphthylisoquinoline alkaloids and pharmaceutical compositions and medical uses thereof
US6140339A (en)	1994-02-14	2000-10-31	The United States Of America As Represented By The Department Of Health And Human Services	Monomeric and dimeric arylisoquinoline alkaloids and derivatives thereof
US5571919A (en) *	1994-07-22	1996-11-05	The United States Of America As Represented By The Department Of Health And Human Services	Dimeric naphthylisoquinoline alkaloids and synthesis methods thereof
DE69530209T2 (de) *	1994-07-22	2004-03-04	The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services	Monomer und dimer naphthylisochinoline alkaloide und verfahren zu deren synthese
US5543523A (en) *	1994-11-15	1996-08-06	Regents Of The University Of Minnesota	Method and intermediates for the synthesis of korupensamines
CN102532018A (zh) *	2011-12-20	2012-07-04	苏州宝泽堂医药科技有限公司	一种纯化米歇尔胺c的方法
CN110368407B (zh) *	2019-08-20	2021-07-13	大连民族大学	一种钩枝藤枝叶有效部位及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH541609A (de) *	1970-02-03	1973-09-15	Ciba Geigy Ag	Verfahren zur Herstellung von Bi-isochinolinonen und deren Verwendung als Fluoreszenzfarbstoffe in Kunststoffen
JPH0676383B2 (ja) *	1991-04-12	1994-09-28	アメリカ合衆国	抗ウイルス剤として有用なミシェルアミン、組成物および治療方法

1992
- 1992-04-10 JP JP4510252A patent/JPH0676383B2/ja not_active Expired - Fee Related
- 1992-04-10 WO PCT/US1992/002805 patent/WO1992018125A1/en not_active Ceased
- 1992-04-10 DE DE69232417T patent/DE69232417T2/de not_active Expired - Fee Related
- 1992-04-10 EP EP92922789A patent/EP0594795B1/de not_active Expired - Lifetime
- 1992-04-10 AT AT92922789T patent/ATE213231T1/de not_active IP Right Cessation
- 1992-04-10 CA CA002100066A patent/CA2100066C/en not_active Expired - Fee Related
1993
- 1993-04-19 US US08/049,824 patent/US5455251A/en not_active Expired - Lifetime
1995
- 1995-06-01 US US08/457,677 patent/US5654432A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69232417D1 (de)	2002-03-21
AU1880592A (en)	1992-11-17
JPH06502186A (ja)	1994-03-10
CA2100066C (en)	1996-08-13
EP0594795B1 (de)	2002-02-13
JPH0676383B2 (ja)	1994-09-28
US5654432A (en)	1997-08-05
EP0594795A1 (de)	1994-05-04
AU657549B2 (en)	1995-03-16
EP0594795A4 (de)	1993-12-07
US5455251A (en)	1995-10-03
WO1992018125A1 (en)	1992-10-29
CA2100066A1 (en)	1992-10-13
DE69232417T2 (de)	2002-10-24

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Legal Events

Date	Code	Title	Description
2002-10-15	UEP	Publication of translation of european patent specification
2009-01-15	REN	Ceased due to non-payment of the annual fee