|
CU22545A1
(es)
*
|
1994-11-18 |
1999-03-31 |
Centro Inmunologia Molecular |
Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico
|
|
US7060808B1
(en)
*
|
1995-06-07 |
2006-06-13 |
Imclone Systems Incorporated |
Humanized anti-EGF receptor monoclonal antibody
|
|
EP1972194A1
(de)
*
|
1996-12-03 |
2008-09-24 |
Amgen Fremont Inc. |
Transgene Säugetiere mit menschlichen IG-Orten mit mehreren VH- und VK-Regionen und darin erzeugten Antikörpern
|
|
US6235883B1
(en)
*
|
1997-05-05 |
2001-05-22 |
Abgenix, Inc. |
Human monoclonal antibodies to epidermal growth factor receptor
|
|
US20020173629A1
(en)
|
1997-05-05 |
2002-11-21 |
Aya Jakobovits |
Human monoclonal antibodies to epidermal growth factor receptor
|
|
US20030224001A1
(en)
*
|
1998-03-19 |
2003-12-04 |
Goldstein Neil I. |
Antibody and antibody fragments for inhibiting the growth of tumors
|
|
ATE474849T1
(de)
|
1998-04-14 |
2010-08-15 |
Chugai Pharmaceutical Co Ltd |
Neues cytokinartiges protein
|
|
ZA200007412B
(en)
*
|
1998-05-15 |
2002-03-12 |
Imclone Systems Inc |
Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases.
|
|
US20030147882A1
(en)
|
1998-05-21 |
2003-08-07 |
Alan Solomon |
Methods for amyloid removal using anti-amyloid antibodies
|
|
AR022952A1
(es)
*
|
1999-03-19 |
2002-09-04 |
Smithkline Beecham Corp |
ANTICUERPO MONOCLONAL DE ROEDOR ESPECIFICAMENTE NEUTRALIZANTE PARA LA INTERLEUQUINA-18 HUMANA , UN FRAGMENTO FAB NEUTRALIZANTE o FRAGMENTO F(AB')2, UNA REGION DE COMPLEMENTARIEDAD DE CADENA LIGERA DE INMONOGLOBULINA(CDR), UNA MOLECULA DE ACIDO NUCLEICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE, EL
|
|
EP2275540B1
(de)
*
|
1999-04-09 |
2016-03-23 |
Kyowa Hakko Kirin Co., Ltd. |
Verfahren zur Steuerung der Aktivität von immunologisch funktionellen Molekülen
|
|
EE200100603A
(et)
*
|
1999-05-14 |
2003-02-17 |
Imclone Systems Incorporated |
Inimese refraktaarsete kasvajate ravi epidermaalse kasvufaktori retseptori antagonistidega
|
|
AR024464A1
(es)
|
1999-06-25 |
2002-10-02 |
Genentech Inc |
Anticuerpos anti-erbb2 humanizados.
|
|
GB0002952D0
(en)
*
|
2000-02-09 |
2000-03-29 |
Pharma Mar Sa |
Process for producing kahalalide F compounds
|
|
SI1270595T1
(sl)
|
2000-03-03 |
2008-12-31 |
Kyowa Hakko Kogyo Kk |
Protitelo proti CCR4 in njegov fragment
|
|
CA2409361A1
(en)
*
|
2000-05-19 |
2001-11-22 |
Scancell Limited |
Humanised antibodies to the epidermal growth factor receptor
|
|
AU2001295002B2
(en)
*
|
2000-08-09 |
2007-05-31 |
Imclone Systems Incorporated |
Treatment of hyperproliferative diseases with epidermal growth factor receptor antagonists
|
|
US6946292B2
(en)
*
|
2000-10-06 |
2005-09-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Cells producing antibody compositions with increased antibody dependent cytotoxic activity
|
|
KR100600550B1
(ko)
|
2000-10-20 |
2006-07-13 |
에자이 가부시키가이샤 |
질소 함유 방향환 유도체
|
|
CU22979A1
(es)
*
|
2000-12-08 |
2004-09-09 |
Centro Inmunologia Molecular |
Combinación inmunoterapéutica para el tratamiento de tumores que sobre-expresan receptores con actividad quinasa en residuos de tirosina
|
|
AU2002327164A1
(en)
|
2001-01-29 |
2002-12-09 |
Idec Pharmaceuticals Corporation |
Engineered tetravalent antibodies and methods of use
|
|
BR0206985A
(pt)
*
|
2001-01-29 |
2005-04-19 |
Idec Pharma Corp |
Anticorpos modificados e métodos de uso
|
|
WO2002066058A1
(en)
*
|
2001-02-19 |
2002-08-29 |
Merck Patent Gmbh |
Modified anti-egfr antibodies with reduced immunogenicity
|
|
US20080008704A1
(en)
*
|
2001-03-16 |
2008-01-10 |
Mark Rubin |
Methods of treating colorectal cancer with anti-epidermal growth factor antibodies
|
|
US20100056762A1
(en)
|
2001-05-11 |
2010-03-04 |
Old Lloyd J |
Specific binding proteins and uses thereof
|
|
DK1392359T4
(da)
|
2001-05-11 |
2013-06-10 |
Ludwig Inst For Cancer Res Ltd |
Specifikke bindingsproteiner og deres anvendelser.
|
|
US20100234570A1
(en)
*
|
2001-06-28 |
2010-09-16 |
Domantis Limited |
Ligand
|
|
US20050271663A1
(en)
*
|
2001-06-28 |
2005-12-08 |
Domantis Limited |
Compositions and methods for treating inflammatory disorders
|
|
JP4303105B2
(ja)
*
|
2001-06-28 |
2009-07-29 |
ドマンティス リミテッド |
二重特異性リガンドとその利用
|
|
US7951061B2
(en)
*
|
2001-07-25 |
2011-05-31 |
Allan Foreman |
Devices for targeted delivery of thermotherapy, and methods related thereto
|
|
US6997863B2
(en)
*
|
2001-07-25 |
2006-02-14 |
Triton Biosystems, Inc. |
Thermotherapy via targeted delivery of nanoscale magnetic particles
|
|
US7731648B2
(en)
*
|
2001-07-25 |
2010-06-08 |
Aduro Biotech |
Magnetic nanoscale particle compositions, and therapeutic methods related thereto
|
|
US7074175B2
(en)
|
2001-07-25 |
2006-07-11 |
Erik Schroeder Handy |
Thermotherapy via targeted delivery of nanoscale magnetic particles
|
|
US7241444B2
(en)
*
|
2002-01-18 |
2007-07-10 |
Pierre Fabre Medicament |
Anti-IGF-IR antibodies and uses thereof
|
|
US20080193445A1
(en)
*
|
2002-01-18 |
2008-08-14 |
Liliane Goetsch |
Novel anti-IGF-IR antibodies and uses thereof
|
|
US20080063639A1
(en)
*
|
2002-01-18 |
2008-03-13 |
Pierre Fabre Medicament |
Method for the treatment of psoriasis comprising novel anti-IGF-IR antibodies
|
|
ATE444308T1
(de)
*
|
2002-02-13 |
2009-10-15 |
Ludwig Inst Cancer Res |
Fusionsproteine humanisierter g250-spezifischer antikörper sowie verwendungen davon
|
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
|
US8093357B2
(en)
*
|
2002-03-01 |
2012-01-10 |
Xencor, Inc. |
Optimized Fc variants and methods for their generation
|
|
US20090042291A1
(en)
*
|
2002-03-01 |
2009-02-12 |
Xencor, Inc. |
Optimized Fc variants
|
|
US7332585B2
(en)
*
|
2002-04-05 |
2008-02-19 |
The Regents Of The California University |
Bispecific single chain Fv antibody molecules and methods of use thereof
|
|
CA2481920A1
(en)
|
2002-04-09 |
2003-10-16 |
Kyowa Hakko Kogyo Co., Ltd. |
Antibody composition-containing medicament
|
|
US7696320B2
(en)
|
2004-08-24 |
2010-04-13 |
Domantis Limited |
Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
|
|
US9321832B2
(en)
*
|
2002-06-28 |
2016-04-26 |
Domantis Limited |
Ligand
|
|
CN1678634A
(zh)
*
|
2002-06-28 |
2005-10-05 |
多曼蒂斯有限公司 |
免疫球蛋白单个变体抗原结合区及其特异性构建体
|
|
HUP0600340A3
(en)
|
2002-07-15 |
2011-06-28 |
Genentech Inc |
Methods for identifying tumors that are responsive to treatment with anti-erbb2 antibodies
|
|
CA2832136C
(en)
|
2002-09-27 |
2015-11-17 |
Xencor |
Optimized fc variants and methods for their generation
|
|
GB0304367D0
(en)
*
|
2003-02-26 |
2003-04-02 |
Pharma Mar Sau |
Methods for treating psoriasis
|
|
CU23097A1
(es)
*
|
2002-10-23 |
2005-11-18 |
Centro Inmunologia Molecular |
Método para la obtención de líneas celulares en medio libre de proteína y líneas celulares obtenidas por este método
|
|
US20060034845A1
(en)
*
|
2002-11-08 |
2006-02-16 |
Karen Silence |
Single domain antibodies directed against tumor necrosis factor alpha and uses therefor
|
|
NZ540194A
(en)
*
|
2002-11-08 |
2008-07-31 |
Ablynx Nv |
Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor
|
|
US20100003253A1
(en)
*
|
2002-11-08 |
2010-01-07 |
Ablynx N.V. |
Single domain antibodies directed against epidermal growth factor receptor and uses therefor
|
|
EP1558645B1
(de)
*
|
2002-11-08 |
2011-07-27 |
Ablynx N.V. |
Stabilisierte einzel-domänen-antikörper in einer pharmazeutischen zusammensetzung ausgestaltet für inhalation
|
|
US9320792B2
(en)
|
2002-11-08 |
2016-04-26 |
Ablynx N.V. |
Pulmonary administration of immunoglobulin single variable domains and constructs thereof
|
|
US20040147428A1
(en)
*
|
2002-11-15 |
2004-07-29 |
Pluenneke John D. |
Methods of treatment using an inhibitor of epidermal growth factor receptor
|
|
CA2511910A1
(en)
*
|
2002-12-27 |
2004-07-15 |
Domantis Limited |
Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand
|
|
US20040193752A1
(en)
*
|
2003-01-02 |
2004-09-30 |
Harpreet Singh |
System and method for providing fee-based data services
|
|
US20040156846A1
(en)
*
|
2003-02-06 |
2004-08-12 |
Triton Biosystems, Inc. |
Therapy via targeted delivery of nanoscale particles using L6 antibodies
|
|
ES2344645T3
(es)
*
|
2003-02-10 |
2010-09-02 |
Applied Molecular Evolution, Inc. |
Moleculas de union al abeta.
|
|
US8663650B2
(en)
|
2003-02-21 |
2014-03-04 |
Ac Immune Sa |
Methods and compositions comprising supramolecular constructs
|
|
US20090010920A1
(en)
*
|
2003-03-03 |
2009-01-08 |
Xencor, Inc. |
Fc Variants Having Decreased Affinity for FcyRIIb
|
|
US8388955B2
(en)
*
|
2003-03-03 |
2013-03-05 |
Xencor, Inc. |
Fc variants
|
|
EP1604665B1
(de)
|
2003-03-10 |
2011-05-11 |
Eisai R&D Management Co., Ltd. |
C-kit kinase-hemmer
|
|
EP1622941A2
(de)
*
|
2003-03-20 |
2006-02-08 |
ImClone Systems Incorporated |
Methode zur produktion von anti-egfr antikörpern
|
|
US20070036795A1
(en)
|
2003-06-09 |
2007-02-15 |
Samuel Waksal |
Method of inhibiting receptor tyrosine kinases with an extracellular antagonist and an intracellular agonist
|
|
GB0321066D0
(en)
*
|
2003-09-09 |
2003-10-08 |
Pharma Mar Sau |
New antitumoral compounds
|
|
US8101720B2
(en)
*
|
2004-10-21 |
2012-01-24 |
Xencor, Inc. |
Immunoglobulin insertions, deletions and substitutions
|
|
US9714282B2
(en)
|
2003-09-26 |
2017-07-25 |
Xencor, Inc. |
Optimized Fc variants and methods for their generation
|
|
ES2605443T3
(es)
|
2003-11-06 |
2017-03-14 |
Seattle Genetics, Inc. |
Conjugados de auristatina con anticuerpos anti-HER2 o anti-CD22 y su uso en terapia
|
|
PT1687338E
(pt)
*
|
2003-11-07 |
2011-01-20 |
Ablynx Nv |
Anticorpos de domínio único vhh de camelídeos direccionados para o receptor do factor de crescimento epidérmico e suas utilizações
|
|
JP4303726B2
(ja)
|
2003-11-11 |
2009-07-29 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
ウレア誘導体およびその製造方法
|
|
EP1759010A4
(de)
*
|
2004-01-07 |
2008-12-24 |
Bristol Myers Squibb Co |
Biomarker und verfahren zur bestimmung der empfindlichkeit gegenüber modulatoren des egf(epidermal growth factor)-rezeptors
|
|
TW200533339A
(en)
*
|
2004-03-16 |
2005-10-16 |
Bristol Myers Squibb Co |
Therapeutic synergy of anti-cancer compounds
|
|
ES2387809T3
(es)
*
|
2004-03-19 |
2012-10-02 |
Imclone Llc |
Anticuerpo frente al receptor del factor de crecimiento epidérmico humano
|
|
AU2005232657B2
(en)
|
2004-04-08 |
2010-12-16 |
David B. Agus |
ErbB antagonists for pain therapy
|
|
NZ551180A
(en)
|
2004-06-01 |
2009-10-30 |
Genentech Inc |
Antibody drug conjugates and methods
|
|
EP3342782B1
(de)
|
2004-07-15 |
2022-08-17 |
Xencor, Inc. |
Optimierte fc-varianten
|
|
FR2873699B1
(fr)
*
|
2004-07-29 |
2009-08-21 |
Pierre Fabre Medicament Sa |
Nouveaux anticorps anti igf ir rt leurs utilisations
|
|
US8969379B2
(en)
|
2004-09-17 |
2015-03-03 |
Eisai R&D Management Co., Ltd. |
Pharmaceutical compositions of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7=methoxy-6-quinolinecarboxide
|
|
TR201808537T4
(tr)
|
2004-09-23 |
2018-07-23 |
Genentech Inc |
Sistein değiştirilmiş antikorlar ve konjugatlar.
|
|
JO3000B1
(ar)
|
2004-10-20 |
2016-09-05 |
Genentech Inc |
مركبات أجسام مضادة .
|
|
US20070135620A1
(en)
*
|
2004-11-12 |
2007-06-14 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
|
US8802820B2
(en)
*
|
2004-11-12 |
2014-08-12 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
|
US8367805B2
(en)
*
|
2004-11-12 |
2013-02-05 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
|
US9200079B2
(en)
|
2004-11-12 |
2015-12-01 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
|
US8546543B2
(en)
|
2004-11-12 |
2013-10-01 |
Xencor, Inc. |
Fc variants that extend antibody half-life
|
|
EP3698807A1
(de)
|
2005-01-21 |
2020-08-26 |
Genentech, Inc. |
Fixe dosierung von her-antikörpern
|
|
BRPI0607315B1
(pt)
|
2005-02-07 |
2022-05-17 |
Roche Glycart Ag |
Molécula de ligação ao antígeno anti-egfr humanizada e seus usos, composição farmacêutica, e método para detectar a presença de egfr em uma amostra
|
|
RS53128B
(sr)
|
2005-02-23 |
2014-06-30 |
Genentech Inc. |
Produžavanje vremena progresije bolesti ili preživljavanja kod pacijenata obolelih od kancera jajnika korišćenjem pertuzumaba
|
|
PL1859793T3
(pl)
*
|
2005-02-28 |
2011-09-30 |
Eisai R&D Man Co Ltd |
Nowe połączone zastosowanie związku sulfonamidowego w leczeniu choroby nowotworowej
|
|
US20060204505A1
(en)
*
|
2005-03-08 |
2006-09-14 |
Sliwkowski Mark X |
Methods for identifying tumors responsive to treatment with HER dimerization inhibitors (HDIs)
|
|
US7635570B2
(en)
|
2005-04-01 |
2009-12-22 |
Salvatore Siena |
Epidermal growth factor receptor gene copy number
|
|
EP1888649A2
(de)
*
|
2005-05-09 |
2008-02-20 |
GlycArt Biotechnology AG |
Antigen-bindungsmoleküle mit modifizierten fc-regionen und veränderte bindung an fc-rezeptoren
|
|
AR053272A1
(es)
*
|
2005-05-11 |
2007-04-25 |
Hoffmann La Roche |
Determinacion de responsivos a la quimioterapia
|
|
JP4989476B2
(ja)
|
2005-08-02 |
2012-08-01 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
血管新生阻害物質の効果を検定する方法
|
|
KR20140053410A
(ko)
|
2005-08-19 |
2014-05-07 |
아보트 러보러터리즈 |
이원 가변 도메인 면역글로불린 및 이의 용도
|
|
US20090215992A1
(en)
*
|
2005-08-19 |
2009-08-27 |
Chengbin Wu |
Dual variable domain immunoglobulin and uses thereof
|
|
EP2500353A3
(de)
|
2005-08-19 |
2012-10-10 |
Abbott Laboratories |
Immunglobuline mit zweifacher variabler Domäne und ihre Verwendung
|
|
US7612181B2
(en)
*
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
|
WO2007025044A2
(en)
*
|
2005-08-24 |
2007-03-01 |
Bristol-Myers Squibb Company |
Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators
|
|
CN102716490A
(zh)
*
|
2005-09-01 |
2012-10-10 |
卫材R&D管理有限公司 |
药物组合物的崩解性的改善方法
|
|
DK1931709T3
(en)
|
2005-10-03 |
2017-03-13 |
Xencor Inc |
FC VARIETIES WITH OPTIMIZED FC RECEPTOR BINDING PROPERTIES
|
|
KR101353763B1
(ko)
|
2005-11-07 |
2014-01-21 |
에자이 알앤드디 매니지먼트 가부시키가이샤 |
혈관 신생 저해 물질과 ｃ―ｋｉｔ 키나아제 저해 물질의병용
|
|
US20090247576A1
(en)
*
|
2005-11-22 |
2009-10-01 |
Eisai R & D Management Co., Ltd. |
Anti-tumor agent for multiple myeloma
|
|
CA2632866A1
(en)
*
|
2005-12-01 |
2007-06-07 |
Domantis Limited |
Noncompetitive domain antibody formats that bind interleukin 1 receptor type 1
|
|
ES2368864T3
(es)
*
|
2006-02-06 |
2011-11-23 |
Metheresis Translational Research Sa |
Anticuerpos monoclonales anti-met, sus fragmentos y vectores para el tratamiento de tumores y productos correspondientes.
|
|
EP2004685A4
(de)
*
|
2006-03-22 |
2009-04-29 |
Genimmune N V |
Hepatitis-c-virus-neutralisierende antikörper
|
|
EP2010911A4
(de)
|
2006-03-31 |
2009-05-13 |
Massachusetts Inst Technology |
Behandlung von egf-rezeptormutanten exprimierenden tumoren
|
|
CN104706637A
(zh)
*
|
2006-05-18 |
2015-06-17 |
卫材R&D管理有限公司 |
针对甲状腺癌的抗肿瘤剂
|
|
MX2008014842A
(es)
|
2006-05-25 |
2009-02-17 |
Glaxo Group Ltd |
Anticuerpos humanizados contra interleuquina-18 modificados.
|
|
US20090203693A1
(en)
*
|
2006-06-29 |
2009-08-13 |
Eisai R & D Management Co., Ltd. |
Therapeutic agent for liver fibrosis
|
|
AR062223A1
(es)
*
|
2006-08-09 |
2008-10-22 |
Glycart Biotechnology Ag |
Moleculas de adhesion al antigeno que se adhieren a egfr, vectores que los codifican, y sus usos de estas
|
|
JP5368096B2
(ja)
|
2006-08-28 |
2013-12-18 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
未分化型胃癌に対する抗腫瘍剤
|
|
EP2061906B1
(de)
|
2006-09-12 |
2011-08-31 |
Genentech, Inc. |
Verfahren und zusammensetzungen zur diagnose und behandlung von lungenkrebs mittels pdgfra-, kit- oder kdg-gen als genmarker
|
|
CU23612A1
(es)
*
|
2006-09-29 |
2010-12-08 |
Centro Inmunologia Molecular |
Combinaciones terapéuticas para potenciar el efecto de la terapia con anticuerpos contra el receptor del factor de crecimiento epidérmico
|
|
JP2010513321A
(ja)
*
|
2006-12-22 |
2010-04-30 |
ノヴェリクス・セラピューティクス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング |
少なくとも一種の上皮細胞増殖因子受容体特異抗体またはその誘導体を用いる糖尿病の治療
|
|
WO2008079849A2
(en)
*
|
2006-12-22 |
2008-07-03 |
Genentech, Inc. |
Antibodies to insulin-like growth factor receptor
|
|
US9090693B2
(en)
*
|
2007-01-25 |
2015-07-28 |
Dana-Farber Cancer Institute |
Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease
|
|
WO2008093855A1
(ja)
|
2007-01-29 |
2008-08-07 |
Eisai R & D Management Co., Ltd. |
未分化型胃癌治療用組成物
|
|
BRPI0808551B1
(pt)
*
|
2007-03-01 |
2022-04-05 |
Symphogen A/S |
Composições de anticorpo para o receptor do fator de crescimento antiepidérmico recombinante, molécula de ligação bi-específica e composição farmacêutica que os compreende
|
|
MX2009008981A
(es)
|
2007-03-02 |
2009-09-02 |
Genentech Inc |
Prediccion de respuesta a un inhibidor her.
|
|
JP5618549B2
(ja)
*
|
2007-03-15 |
2014-11-05 |
ルードヴィッヒ インスティテュート フォー キャンサーリサーチ リミテッド |
Ｅｇｆｒ抗体及びｓｒｃ阻害剤を用いる治療方法及び関連製剤
|
|
CA2683801A1
(en)
*
|
2007-06-06 |
2008-12-11 |
Domantis Limited |
Polypeptides, antibody variable domains and antagonists
|
|
WO2008154249A2
(en)
|
2007-06-08 |
2008-12-18 |
Genentech, Inc. |
Gene expression markers of tumor resistance to her2 inhibitor treatment
|
|
JP5532486B2
(ja)
|
2007-08-14 |
2014-06-25 |
ルードヴィッヒ インスティテュート フォー キャンサー リサーチ |
Ｅｇｆ受容体を標的とするモノクローナル抗体１７５ならびにその誘導体および用途
|
|
CN101861159A
(zh)
*
|
2007-10-19 |
2010-10-13 |
马尔药品公司 |
改进的抗肿瘤治疗
|
|
CA2704000C
(en)
|
2007-11-09 |
2016-12-13 |
Eisai R&D Management Co., Ltd. |
Combination of anti-angiogenic substance and anti-tumor platinum complex
|
|
CN101918452A
(zh)
*
|
2007-11-15 |
2010-12-15 |
中外制药株式会社 |
与Anexelekto结合的单克隆抗体及其利用
|
|
KR101616758B1
(ko)
|
2007-12-26 |
2016-04-29 |
젠코어 인코포레이티드 |
ＦｃＲｎ에 대한 변경된 결합성을 갖는 Ｆｃ 변이체
|
|
WO2009096377A1
(ja)
*
|
2008-01-29 |
2009-08-06 |
Eisai R & D Management Co., Ltd. |
血管阻害物質とタキサンとの併用
|
|
TWI472339B
(zh)
|
2008-01-30 |
2015-02-11 |
Genentech Inc |
包含結合至ｈｅｒ２結構域ii之抗體及其酸性變異體的組合物
|
|
EP2252315A1
(de)
*
|
2008-01-30 |
2010-11-24 |
Pharma Mar, S.A. |
Verbesserte antitumorale behandlungen
|
|
US12492253B1
(en)
|
2008-02-25 |
2025-12-09 |
Xencor, Inc. |
Anti-human C5 antibodies
|
|
AU2009221120A1
(en)
*
|
2008-03-07 |
2009-09-11 |
Pharma Mar, S.A. |
Improved antitumoral treatments
|
|
US20100260668A1
(en)
*
|
2008-04-29 |
2010-10-14 |
Abbott Laboratories |
Dual Variable Domain Immunoglobulins and Uses Thereof
|
|
EP2282769A4
(de)
|
2008-04-29 |
2012-04-25 |
Abbott Lab |
Dual-variable- domain-immunglobuline und ihre verwendungen
|
|
KR20110016959A
(ko)
*
|
2008-06-03 |
2011-02-18 |
아보트 러보러터리즈 |
이원 가변 도메인 면역글로불린 및 이의 용도
|
|
EP2297209A4
(de)
*
|
2008-06-03 |
2012-08-01 |
Abbott Lab |
Dual-variable- domain-immunglobuline und ihre verwendungen
|
|
CN101602808B
(zh)
*
|
2008-06-12 |
2012-06-20 |
上海市肿瘤研究所 |
特异性结合蛋白及其使用
|
|
MX2010014543A
(es)
*
|
2008-06-20 |
2011-04-05 |
Centro Inmunologia Molecular |
Inhibidores del receptor del factor de crecimiento epidermico con accion citostatica y sus usos en la terapia de tumores.
|
|
US8822645B2
(en)
*
|
2008-07-08 |
2014-09-02 |
Abbvie Inc. |
Prostaglandin E2 dual variable domain immunoglobulins and uses thereof
|
|
MX2011001927A
(es)
*
|
2008-08-29 |
2011-04-21 |
Symphogen As |
Composiciones de anticuerpo recombinante anti-receptor de factor de crecimiento epidermico.
|
|
AU2009303526B2
(en)
|
2008-10-14 |
2015-01-15 |
Genentech, Inc. |
Immunoglobulin variants and uses thereof
|
|
RU2481824C2
(ru)
|
2008-10-29 |
2013-05-20 |
Аблинкс Н.В |
Препараты однодоменных антигенсвязывающих молекул
|
|
CN105646643A
(zh)
|
2008-10-29 |
2016-06-08 |
阿布林克斯公司 |
单域抗原结合性分子的纯化方法
|
|
SG171812A1
(en)
*
|
2008-12-04 |
2011-07-28 |
Abbott Lab |
Dual variable domain immunoglobulins and uses thereof
|
|
JP5818688B2
(ja)
*
|
2009-01-08 |
2015-11-18 |
バイオ−ラッド ラボラトリーズ インコーポレーティッド |
核酸増幅反応の効率を改善するための方法および組成物
|
|
EP2210903A1
(de)
*
|
2009-01-21 |
2010-07-28 |
Monoclonal Antibodies Therapeutics |
Monoklonale Antikörper gegen CD160 und Anwendungen davon
|
|
NZ594514A
(en)
|
2009-03-05 |
2013-06-28 |
Abbott Lab |
Interleukin-17 BINDING PROTEINS
|
|
KR20150036824A
(ko)
|
2009-03-20 |
2015-04-07 |
제넨테크, 인크. |
이중특이적 항-ｈｅｒ 항체
|
|
MX2011009620A
(es)
|
2009-03-31 |
2011-10-19 |
Roche Glycart Ag |
Tratamiento de cancer con un anticuerpo de inmunoglobulina g1 (igg1) humanizado anti receptor de factor de crecimiento epidermico (anti-egfr) e irinotecan.
|
|
AR075982A1
(es)
|
2009-03-31 |
2011-05-11 |
Roche Glycart Ag |
Terapia de combinacion de un anticuerpo afucosilado y una o mas de las citoquinas seleccionadas de gm- csf humano, m -csf humano y/o il-3 humano y composicion
|
|
CN102361884A
(zh)
|
2009-04-07 |
2012-02-22 |
罗氏格黎卡特股份公司 |
双特异性抗-ErbB-2/抗-c-Met抗体
|
|
CN102459344A
(zh)
|
2009-05-15 |
2012-05-16 |
中外制药株式会社 |
抗axl抗体
|
|
WO2010146059A2
(en)
|
2009-06-16 |
2010-12-23 |
F. Hoffmann-La Roche Ag |
Biomarkers for igf-1r inhibitor therapy
|
|
TW201109438A
(en)
*
|
2009-07-29 |
2011-03-16 |
Abbott Lab |
Dual variable domain immunoglobulins and uses thereof
|
|
US9345661B2
(en)
|
2009-07-31 |
2016-05-24 |
Genentech, Inc. |
Subcutaneous anti-HER2 antibody formulations and uses thereof
|
|
CA2771403C
(en)
|
2009-08-19 |
2015-02-24 |
Eisai R&D Management Co. Ltd. |
Quinoline derivative-containing pharmaceutical composition
|
|
MX2012002651A
(es)
|
2009-09-01 |
2012-05-22 |
Abbott Lab |
Inmunoglobulinas de dominio variable doble y usos de las mismas.
|
|
US9493578B2
(en)
|
2009-09-02 |
2016-11-15 |
Xencor, Inc. |
Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
|
|
ES2354922B1
(es)
|
2009-09-02 |
2012-02-07 |
Fundacion Institut De Recerca De L'hospital Universitari Vall D'hebron |
Marcadores para la selección de terapias personalizadas para el tratamiento del c�?ncer.
|
|
AR078161A1
(es)
|
2009-09-11 |
2011-10-19 |
Hoffmann La Roche |
Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento.
|
|
US20110076232A1
(en)
*
|
2009-09-29 |
2011-03-31 |
Ludwig Institute For Cancer Research |
Specific binding proteins and uses thereof
|
|
AR078651A1
(es)
|
2009-10-15 |
2011-11-23 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
|
UY32979A
(es)
*
|
2009-10-28 |
2011-02-28 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
|
US20120220594A1
(en)
|
2009-10-30 |
2012-08-30 |
Bristol-Meyers Squibb Company |
Methods for treating cancer in patients having igf-1r inhibitor resistance
|
|
CN101704891B
(zh)
*
|
2009-11-11 |
2011-11-09 |
中国人民解放军军事医学科学院生物工程研究所 |
一种针对表皮生长因子受体的抗体及其编码基因与应用
|
|
CN101875695B
(zh)
*
|
2009-11-11 |
2012-07-04 |
中国人民解放军军事医学科学院生物工程研究所 |
一种抗体及其编码基因与应用
|
|
CA2781682A1
(en)
|
2009-12-04 |
2011-06-09 |
Genentech, Inc. |
Multispecific antibodies, antibody analogs, compositions, and methods
|
|
CN102712640A
(zh)
|
2010-01-12 |
2012-10-03 |
弗·哈夫曼-拉罗切有限公司 |
三环杂环化合物、其组合物和应用方法
|
|
WO2011097527A2
(en)
|
2010-02-04 |
2011-08-11 |
Xencor, Inc. |
Immunoprotection of therapeutic moieties using enhanced fc regions
|
|
US20110189178A1
(en)
*
|
2010-02-04 |
2011-08-04 |
Xencor, Inc. |
Immunoprotection of Therapeutic Moieties Using Enhanced Fc Regions
|
|
ES2519348T3
(es)
|
2010-02-18 |
2014-11-06 |
Genentech, Inc. |
Antagonistas de neurregulina y uso de los mismos en el tratamiento del cáncer
|
|
US20110200595A1
(en)
|
2010-02-18 |
2011-08-18 |
Roche Glycart |
TREATMENT WITH A HUMANIZED IgG CLASS ANTI EGFR ANTIBODY AND AN ANTIBODY AGAINST INSULIN LIKE GROWTH FACTOR 1 RECEPTOR
|
|
CA2800230A1
(en)
|
2010-03-04 |
2011-09-09 |
Hospital District Of Southwest Finland |
Method for selecting patients for treatment with an egfr inhibitor
|
|
US20130096104A1
(en)
|
2010-03-17 |
2013-04-18 |
Genentech, Inc. |
Imidazopyridine compounds, compositions and methods of use
|
|
US20130108623A1
(en)
|
2010-03-29 |
2013-05-02 |
Zymeworks Inc |
Antibodies with Enhanced or Suppressed Effector Function
|
|
EP4450523A3
(de)
|
2010-04-02 |
2025-03-12 |
Amunix Pharmaceuticals, Inc. |
Bindungsfusionsproteine, bindungsfusionsprotein-arzneimittelkonjugate, xten-arzneimittelkonjugate sowie verfahren zur herstellung und verwendung davon
|
|
CN101875697B
(zh)
*
|
2010-04-15 |
2014-04-30 |
北京天广实生物技术股份有限公司 |
新型抗egfr人源抗体tgm10的设计及其应用
|
|
KR20130058672A
(ko)
|
2010-04-16 |
2013-06-04 |
제넨테크, 인크. |
ＰＩ3Ｋ/ＡＫＴ 키나제 경로 억제제 효능에 대한 예측 바이오마커로서의 ＦＯＸＯ３ａ
|
|
TWI500427B
(zh)
|
2010-05-14 |
2015-09-21 |
Abbvie Inc |
Ｉｌ－１結合蛋白
|
|
WO2011146568A1
(en)
|
2010-05-19 |
2011-11-24 |
Genentech, Inc. |
Predicting response to a her inhibitor
|
|
CN102958523B
(zh)
|
2010-06-25 |
2014-11-19 |
卫材R&D管理有限公司 |
使用具有激酶抑制作用的组合的抗肿瘤剂
|
|
US20120009196A1
(en)
|
2010-07-08 |
2012-01-12 |
Abbott Laboratories |
Monoclonal antibodies against hepatitis c virus core protein
|
|
UY33492A
(es)
|
2010-07-09 |
2012-01-31 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
|
EP2598530A2
(de)
|
2010-07-29 |
2013-06-05 |
Xencor, Inc. |
Antikörper mit modifizierten isoelektrischen punkten
|
|
KR20130100118A
(ko)
|
2010-08-03 |
2013-09-09 |
아비에 인코포레이티드 |
이원 가변 도메인 면역글로불린 및 이의 용도
|
|
US9046513B2
(en)
|
2010-08-26 |
2015-06-02 |
Abbvie Inc. |
Dual variable domain immunoglobulins and uses thereof
|
|
SG10201408229WA
(en)
|
2010-08-31 |
2015-02-27 |
Genentech Inc |
Biomarkers and methods of treatment
|
|
RU2013114352A
(ru)
|
2010-09-15 |
2014-10-20 |
Ф. Хоффманн-Ля Рош Аг |
Азабензотиазолы, композиции и способы применения
|
|
CA2815277A1
(en)
|
2010-10-29 |
2012-05-03 |
Immunogen, Inc. |
Novel egfr-binding molecules and immunoconjugates thereof
|
|
JP5828902B2
(ja)
|
2010-10-29 |
2015-12-09 |
イミュノジェン， インコーポレイテッド |
非拮抗性ｅｇｆｒ結合分子およびその免疫複合体
|
|
WO2012065161A2
(en)
|
2010-11-12 |
2012-05-18 |
Scott & White Healthcare |
Antibodies to tumor endothelial marker 8
|
|
KR20140009259A
(ko)
|
2010-11-19 |
2014-01-22 |
에프. 호프만-라 로슈 아게 |
피라졸로피리딘 및 tyk2 억제제로서 이의 용도
|
|
MX2013007332A
(es)
|
2010-12-21 |
2014-01-23 |
Abbvie Inc |
Inmunoglobulinas de dominio variable doble biespecificas de il-1 alfa y beta y su uso.
|
|
WO2012085176A1
(en)
|
2010-12-23 |
2012-06-28 |
F. Hoffmann-La Roche Ag |
Tricyclic pyrazinone compounds, compositions and methods of use thereof as janus kinase inhibitors
|
|
CN102153648B
(zh)
*
|
2011-01-27 |
2012-07-04 |
中国人民解放军军事医学科学院生物工程研究所 |
一种抗egfr人源化抗体l4-h3及其编码基因与应用
|
|
AU2012246490B2
(en)
|
2011-04-18 |
2016-08-04 |
Eisai R&D Management Co., Ltd. |
Therapeutic agent for tumor
|
|
GB201106870D0
(en)
|
2011-04-26 |
2011-06-01 |
Univ Belfast |
Marker
|
|
DK2714738T3
(en)
|
2011-05-24 |
2019-01-28 |
Zyngenia Inc |
MULTIVALENT AND MONOVALENT MULTISPECIFIC COMPLEXES AND THEIR APPLICATIONS
|
|
JP6038128B2
(ja)
|
2011-06-03 |
2016-12-07 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
レンバチニブ化合物に対する甲状腺癌対象及び腎臓癌対象の反応性を予測及び評価するためのバイオマーカー
|
|
AU2012274156A1
(en)
|
2011-06-20 |
2014-01-23 |
Traslational Cancer Drugs Pharma, S.L. |
Method for predicting the clinical response to chemotherapy in a subject with cancer
|
|
WO2019071023A1
(en)
|
2017-10-04 |
2019-04-11 |
Yale University |
COMPOSITIONS AND METHODS FOR MAKING POLYPEPTIDES CONTAINING SELENOCYSTEINE
|
|
WO2013009868A1
(en)
|
2011-07-11 |
2013-01-17 |
Yale University |
Compositions and methods for making selenocysteine containing polypeptides
|
|
WO2013007768A1
(en)
|
2011-07-13 |
2013-01-17 |
F. Hoffmann-La Roche Ag |
Tricyclic heterocyclic compounds, compositions and methods of use thereof as jak inhibitors
|
|
WO2013007765A1
(en)
|
2011-07-13 |
2013-01-17 |
F. Hoffmann-La Roche Ag |
Fused tricyclic compounds for use as inhibitors of janus kinases
|
|
WO2013022855A1
(en)
|
2011-08-05 |
2013-02-14 |
Xencor, Inc. |
Antibodies with modified isoelectric points and immunofiltering
|
|
RU2014105624A
(ru)
|
2011-08-12 |
2015-09-20 |
Ф. Хоффманн-Ля Рош Аг |
Соединения индазола, способ их применения и фармацевтическая композиция
|
|
BR112014003431A2
(pt)
|
2011-08-17 |
2017-06-13 |
Genentech Inc |
anticorpo, ácido nucleico, célula hospedeira, método de produção de um anticorpo, imunoconjugado, formulação farmacêutica, agente farmacêutico, uso do anticorpo, método de tratamento de um indivíduo que tem câncer e método de aumento de tempo para recorrência de tumor
|
|
BR112014006643A2
(pt)
|
2011-09-20 |
2017-04-04 |
Hoffmann La Roche |
compostos de imidazopiridina, composições e métodos de uso dos mesmos
|
|
US10851178B2
(en)
|
2011-10-10 |
2020-12-01 |
Xencor, Inc. |
Heterodimeric human IgG1 polypeptides with isoelectric point modifications
|
|
US12466897B2
(en)
|
2011-10-10 |
2025-11-11 |
Xencor, Inc. |
Heterodimeric human IgG1 polypeptides with isoelectric point modifications
|
|
DK2766392T3
(da)
|
2011-10-10 |
2019-10-07 |
Xencor Inc |
Fremgangsmåde til oprensning af antistoffer
|
|
US20140309229A1
(en)
|
2011-10-13 |
2014-10-16 |
Bristol-Myers Squibb Company |
Methods for selecting and treating cancer in patients with igf-1r/ir inhibitors
|
|
AR088513A1
(es)
|
2011-10-24 |
2014-06-18 |
Abbvie Inc |
Inmunoenlazantes dirigidos contra esclerostina
|
|
JP2014533954A
(ja)
|
2011-11-21 |
2014-12-18 |
イミュノジェン， インコーポレイテッド |
Ｅｇｆｒ抗体細胞傷害性薬物複合体による、ｅｇｆｒ療法に耐性である腫瘍の治療方法
|
|
WO2013078223A1
(en)
*
|
2011-11-23 |
2013-05-30 |
Children's Hospital & Research Center Oakland |
Anti-factor h binding protein antibodies and methods of use thereof
|
|
AU2012346540C1
(en)
|
2011-11-30 |
2019-07-04 |
Genentech, Inc. |
ErbB3 mutations in cancer
|
|
AR089529A1
(es)
|
2011-12-30 |
2014-08-27 |
Abbvie Inc |
Proteinas de union especificas duales dirigidas contra il-13 y/o il-17
|
|
WO2013148315A1
(en)
|
2012-03-27 |
2013-10-03 |
Genentech, Inc. |
Diagnosis and treatments relating to her3 inhibitors
|
|
CA2874407A1
(en)
|
2012-05-24 |
2013-11-28 |
Fundacio Institut D'investigacio Biomedica De Bellvitge (Idibell) |
Method for the identification of the origin of a cancer of unknown primary origin by methylation analysis
|
|
US9738724B2
(en)
|
2012-06-08 |
2017-08-22 |
Sutro Biopharma, Inc. |
Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use
|
|
AR091755A1
(es)
|
2012-07-12 |
2015-02-25 |
Abbvie Inc |
Proteinas de union a il-1
|
|
SI2890402T1
(sl)
|
2012-08-31 |
2019-07-31 |
Sutro Biopharma, Inc. |
Modificirane aminokisline vsebujoče acido skupino
|
|
DK2839860T3
(da)
|
2012-10-12 |
2019-06-17 |
Medimmune Ltd |
Pyrrolobenzodiazepiner og konjugater deraf
|
|
WO2014063205A1
(en)
|
2012-10-26 |
2014-05-01 |
The University Of Queensland |
Use of endocytosis inhibitors and antibodies for cancer therapy
|
|
TW201838651A
(zh)
|
2012-11-01 |
2018-11-01 |
美商艾伯維有限公司 |
穩定雙重可變區域免疫球蛋白蛋白質調配物
|
|
PE20151179A1
(es)
|
2012-11-01 |
2015-09-12 |
Abbvie Inc |
Inmunoglobulinas de dominio variable dual anti-vegf/dll4 y usos de las mismas
|
|
US20170275367A1
(en)
|
2012-11-21 |
2017-09-28 |
Janssen Biotech, Inc. |
Bispecific EGFR/C-Met Antibodies
|
|
KR102373193B1
(ko)
|
2012-11-21 |
2022-03-10 |
얀센 바이오테크 인코포레이티드 |
이중특이성 EGFR/c-Met 항체
|
|
JPWO2014098176A1
(ja)
|
2012-12-21 |
2017-01-12 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
キノリン誘導体のアモルファス及びその製造方法
|
|
US10487155B2
(en)
|
2013-01-14 |
2019-11-26 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US9605084B2
(en)
|
2013-03-15 |
2017-03-28 |
Xencor, Inc. |
Heterodimeric proteins
|
|
KR102391731B1
(ko)
|
2013-01-14 |
2022-04-27 |
젠코어 인코포레이티드 |
신규한 이형이량체 단백질
|
|
US11053316B2
(en)
|
2013-01-14 |
2021-07-06 |
Xencor, Inc. |
Optimized antibody variable regions
|
|
US9701759B2
(en)
|
2013-01-14 |
2017-07-11 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US10968276B2
(en)
|
2013-03-12 |
2021-04-06 |
Xencor, Inc. |
Optimized anti-CD3 variable regions
|
|
US10131710B2
(en)
|
2013-01-14 |
2018-11-20 |
Xencor, Inc. |
Optimized antibody variable regions
|
|
WO2014113510A1
(en)
|
2013-01-15 |
2014-07-24 |
Xencor, Inc. |
Rapid clearance of antigen complexes using novel antibodies
|
|
WO2014128235A1
(en)
|
2013-02-22 |
2014-08-28 |
F. Hoffmann-La Roche Ag |
Methods of treating cancer and preventing drug resistance
|
|
JP2016510751A
(ja)
|
2013-03-06 |
2016-04-11 |
ジェネンテック， インコーポレイテッド |
抗がん剤耐性を治療及び予防する方法
|
|
RU2015143517A
(ru)
|
2013-03-13 |
2017-04-19 |
Дженентек, Инк. |
Пиразолсодержащие соединения и их применения
|
|
ES2687439T3
(es)
|
2013-03-13 |
2018-10-25 |
Medimmune Limited |
Pirrolobenzodiazepinas y conjugados de las mismas
|
|
WO2014152358A2
(en)
|
2013-03-14 |
2014-09-25 |
Genentech, Inc. |
Combinations of a mek inhibitor compound with an her3/egfr inhibitor compound and methods of use
|
|
EP2968565A2
(de)
|
2013-03-14 |
2016-01-20 |
Genentech, Inc. |
Verfahren zur behandlung von krebs und prävention einer antikrebsmittelresistenz
|
|
MX2015013163A
(es)
|
2013-03-15 |
2016-04-04 |
Zyngenia Inc |
Complejos multiespecificos multivalente y monovalentes y sus usos.
|
|
US10519242B2
(en)
|
2013-03-15 |
2019-12-31 |
Xencor, Inc. |
Targeting regulatory T cells with heterodimeric proteins
|
|
US10106624B2
(en)
|
2013-03-15 |
2018-10-23 |
Xencor, Inc. |
Heterodimeric proteins
|
|
HK1214533A1
(zh)
|
2013-03-15 |
2016-07-29 |
基因泰克公司 |
治疗癌症和预防癌症耐药性的方法
|
|
AU2014227732A1
(en)
|
2013-03-15 |
2015-09-17 |
Abbvie Inc. |
Dual specific binding proteins directed against IL-1 beta and IL-17
|
|
EP3421495A3
(de)
|
2013-03-15 |
2019-05-15 |
Xencor, Inc. |
Modulation von t-zellen mit bispezifischen antikörpern und fc-fusionen
|
|
ES2699599T3
(es)
|
2013-03-15 |
2019-02-11 |
Abbvie Biotherapeutics Inc |
Variantes de Fc
|
|
US10858417B2
(en)
|
2013-03-15 |
2020-12-08 |
Xencor, Inc. |
Heterodimeric proteins
|
|
CA2912219C
(en)
|
2013-05-14 |
2021-11-16 |
Eisai R&D Management Co., Ltd. |
Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
|
|
WO2015006555A2
(en)
|
2013-07-10 |
2015-01-15 |
Sutro Biopharma, Inc. |
Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use
|
|
WO2015035044A2
(en)
|
2013-09-04 |
2015-03-12 |
Abbvie Biotherapeutics Inc. |
Fc VARIANTS WITH IMPROVED ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY
|
|
KR20160049003A
(ko)
|
2013-09-05 |
2016-05-04 |
제넨테크, 인크. |
항증식성 화합물
|
|
WO2015038984A2
(en)
|
2013-09-12 |
2015-03-19 |
Halozyme, Inc. |
Modified anti-epidermal growth factor receptor antibodies and methods of use thereof
|
|
EP3046588B1
(de)
|
2013-09-17 |
2022-03-02 |
OBI Pharma, Inc. |
Zusammensetzungen aus einem kohlenhydratimpfstoff zur induktion von immunreaktionen und verwendungen davon bei der krebsbehandlung
|
|
TW201605857A
(zh)
|
2013-10-03 |
2016-02-16 |
赫孚孟拉羅股份公司 |
Ｃｄｋ８之醫療性抑制劑及其用途
|
|
WO2015054658A1
(en)
|
2013-10-11 |
2015-04-16 |
Sutro Biopharma, Inc. |
Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use
|
|
US20150147333A1
(en)
|
2013-10-18 |
2015-05-28 |
Genentech, Inc. |
Anti-rspo antibodies and methods of use
|
|
EP3068892A4
(de)
|
2013-11-13 |
2017-05-31 |
Zymeworks Inc. |
Monovalente antigenbindende konstrukte zum targeting von egfr und/oder her2 und verwendungen davon
|
|
ES2763429T5
(es)
|
2013-12-17 |
2023-06-21 |
Hoffmann La Roche |
Procedimientos de tratamiento de cánceres usando antagonistas de la unión al eje de PD-1 y taxanos
|
|
MX2016007965A
(es)
|
2013-12-17 |
2016-10-28 |
Genentech Inc |
Terapia de combinacion que comprende agonistas de union a ox40 y antagonistas de union al eje pd-1.
|
|
AU2014372833B2
(en)
|
2013-12-23 |
2019-08-22 |
Bayer Pharma Aktiengesellschaft |
Antibody drug conjugates (ADCs) with kinesin spindel protein (KSP)
|
|
EP3122900A1
(de)
|
2014-03-24 |
2017-02-01 |
F. Hoffmann-La Roche AG |
Krebsbehandlung mit c-met-antagonisten und korrelation desselben mit hgf-expression
|
|
PL3122781T3
(pl)
|
2014-03-28 |
2020-06-15 |
Xencor, Inc. |
Dwuswoiste przeciwciała, które wiążą się z CD38 i CD3
|
|
SG11201607969XA
(en)
|
2014-03-31 |
2016-10-28 |
Genentech Inc |
Anti-ox40 antibodies and methods of use
|
|
KR20160146747A
(ko)
|
2014-03-31 |
2016-12-21 |
제넨테크, 인크. |
항혈관신생제 및 ox40 결합 효능제를 포함하는 조합 요법
|
|
US20170158749A1
(en)
*
|
2014-04-23 |
2017-06-08 |
Board Of Regents, The University Of Texas System |
Chimeric antigen receptors (car) and methods for making and using the same
|
|
CN104152415B
(zh)
*
|
2014-08-13 |
2015-09-30 |
百泰生物药业有限公司 |
获得高产稳定表达重组抗体的骨髓瘤细胞株的方法及应用
|
|
EP3187491A4
(de)
|
2014-08-28 |
2018-08-01 |
Eisai R&D Management Co., Ltd. |
Hochreines chinolinderivat und verfahren zur herstellung davon
|
|
CN107074823B
(zh)
|
2014-09-05 |
2021-05-04 |
基因泰克公司 |
治疗性化合物及其用途
|
|
EP3193940A1
(de)
|
2014-09-10 |
2017-07-26 |
Medimmune Limited |
Pyrrolobenzodiazepine und konjugate daraus
|
|
CN107073125A
(zh)
|
2014-09-19 |
2017-08-18 |
基因泰克公司 |
Cbp/ep300和bet抑制剂用于治疗癌症的用途
|
|
EP3204379B1
(de)
|
2014-10-10 |
2019-03-06 |
Genentech, Inc. |
Pyrrolidinamid-verbindungen als histondemethylase-inhibitoren
|
|
EP3209687A1
(de)
|
2014-10-23 |
2017-08-30 |
Innate Pharma |
Behandlung von krebs mit anti-nkg2a-mitteln
|
|
KR20170086540A
(ko)
|
2014-11-03 |
2017-07-26 |
제넨테크, 인크. |
T 세포 면역 하위세트를 검출하기 위한 검정 및 그의 사용 방법
|
|
CA2966507A1
(en)
|
2014-11-03 |
2016-05-12 |
Genentech, Inc. |
Methods and biomarkers for predicting efficacy and evaluation of an ox40 agonist treatment
|
|
CA2963974A1
(en)
|
2014-11-06 |
2016-05-12 |
Genentech, Inc. |
Combination therapy comprising ox40 binding agonists and tigit inhibitors
|
|
MA40940A
(fr)
|
2014-11-10 |
2017-09-19 |
Constellation Pharmaceuticals Inc |
Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines
|
|
JP6639497B2
(ja)
|
2014-11-10 |
2020-02-05 |
ジェネンテック， インコーポレイテッド |
ブロモドメインインヒビターおよびその使用
|
|
MA40943A
(fr)
|
2014-11-10 |
2017-09-19 |
Constellation Pharmaceuticals Inc |
Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines
|
|
CN106999583A
(zh)
|
2014-11-17 |
2017-08-01 |
豪夫迈·罗氏有限公司 |
包含ox40结合激动剂和pd‑1轴结合拮抗剂的组合疗法
|
|
HK1245171A1
(zh)
|
2014-11-26 |
2018-08-24 |
Xencor, Inc. |
结合cd3和cd38的异二聚体抗体
|
|
JP6696982B2
(ja)
|
2014-11-26 |
2020-05-20 |
ゼンコー・インコーポレイテッドＸｅｎｃｏｒ、 Ｉｎｃ． |
Ｃｄ３および腫瘍抗原に結合するヘテロ二量体抗体
|
|
US10259887B2
(en)
|
2014-11-26 |
2019-04-16 |
Xencor, Inc. |
Heterodimeric antibodies that bind CD3 and tumor antigens
|
|
EP3632915A1
(de)
|
2014-11-27 |
2020-04-08 |
Genentech, Inc. |
4,5,6,7-tetrahydro-1-h-pyrazolo[4,3-c]pyridin-3-amin-verbindungen als cbp- und/oder ep300-inhibitoren
|
|
EP3229836B1
(de)
|
2014-12-09 |
2019-11-13 |
Institut National de la Sante et de la Recherche Medicale (INSERM) |
Menschliche monoklonale antikörper gegen axl
|
|
US10093733B2
(en)
|
2014-12-11 |
2018-10-09 |
Abbvie Inc. |
LRP-8 binding dual variable domain immunoglobulin proteins
|
|
US10428155B2
(en)
|
2014-12-22 |
2019-10-01 |
Xencor, Inc. |
Trispecific antibodies
|
|
EP3237639A2
(de)
|
2014-12-23 |
2017-11-01 |
Genentech, Inc. |
Zusammensetzungen und verfahren zur behandlung und diagnostizierung von chemotherapieresistentem krebs
|
|
EP3240908A2
(de)
|
2014-12-30 |
2017-11-08 |
F. Hoffmann-La Roche AG |
Verfahren und zusammensetzungen zur diagnose und behandlung von krebs
|
|
EP3242875B1
(de)
|
2015-01-09 |
2022-02-23 |
Genentech, Inc. |
4,5-dihydroimidazol- derivate und ihre verwendung als histone demethylase (kdm2b) inhibitoren
|
|
CN107406429B
(zh)
|
2015-01-09 |
2021-07-06 |
基因泰克公司 |
哒嗪酮衍生物及其在治疗癌症中的用途
|
|
WO2016112284A1
(en)
|
2015-01-09 |
2016-07-14 |
Genentech, Inc. |
(piperidin-3-yl)(naphthalen-2-yl)methanone derivatives and related compounds as inhibitors of the histone demethylase kdm2b for the treatment of cancer
|
|
WO2016123391A1
(en)
|
2015-01-29 |
2016-08-04 |
Genentech, Inc. |
Therapeutic compounds and uses thereof
|
|
EP3250552B1
(de)
|
2015-01-30 |
2019-03-27 |
Genentech, Inc. |
Therapeutische verbindungen und verwendungen davon
|
|
US20180028662A1
(en)
|
2015-02-25 |
2018-02-01 |
Eisai R&D Management Co., Ltd. |
Method for Suppressing Bitterness of Quinoline Derivative
|
|
MA41598A
(fr)
|
2015-02-25 |
2018-01-02 |
Constellation Pharmaceuticals Inc |
Composés thérapeutiques de pyridazine et leurs utilisations
|
|
WO2016135041A1
(en)
|
2015-02-26 |
2016-09-01 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Fusion proteins and antibodies comprising thereof for promoting apoptosis
|
|
KR20240064733A
(ko)
|
2015-03-04 |
2024-05-13 |
머크 샤프 앤드 돔 코포레이션 |
암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
|
|
US10227411B2
(en)
|
2015-03-05 |
2019-03-12 |
Xencor, Inc. |
Modulation of T cells with bispecific antibodies and FC fusions
|
|
MX2017012805A
(es)
|
2015-04-07 |
2018-04-11 |
Genentech Inc |
Complejo de unión a antígenos con actividad agonista y métodos de uso.
|
|
DK3294770T4
(da)
|
2015-05-12 |
2024-05-21 |
Hoffmann La Roche |
Terapeutiske og diagnostiske fremgangsmåder til cancer
|
|
EP3303632B2
(de)
|
2015-05-29 |
2023-05-10 |
F. Hoffmann-La Roche AG |
Therapeutische und diagnostische verfahren für krebs
|
|
EP3303397A1
(de)
|
2015-06-08 |
2018-04-11 |
H. Hoffnabb-La Roche Ag |
Verfahren zur krebsbehandlung mit anti-ox40-antikörpern und pd-1-achsen-bindungsantagonisten
|
|
AU2016274585A1
(en)
|
2015-06-08 |
2017-12-14 |
Genentech, Inc. |
Methods of treating cancer using anti-OX40 antibodies
|
|
TW201710286A
(zh)
|
2015-06-15 |
2017-03-16 |
艾伯維有限公司 |
抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白
|
|
CA2988707C
(en)
|
2015-06-16 |
2023-10-10 |
Eisai R&D Management Co., Ltd. |
Combination of cbp/catenin inhibitor and immune checkpoint inhibitor for treating cancer
|
|
HRP20260689T1
(hr)
|
2015-06-17 |
2026-07-17 |
F. Hoffmann-La Roche Ag |
Postupci za liječenje lokalno uznapredovalog ili metastatskog raka dojke primjenom antagonista vezivanja osi pd-1 i taksana
|
|
SG11201710639YA
(en)
|
2015-06-22 |
2018-01-30 |
Bayer Pharma AG |
Antibody drug conjugates (adcs) and antibody prodrug conjugates (apdcs) with enzymatically cleavable groups
|
|
MX2017017138A
(es)
|
2015-06-23 |
2018-04-30 |
Bayer Pharma AG |
Conjugados homogeneos especificos de sitio con inhibidores de ksp.
|
|
RU2728571C2
(ru)
*
|
2015-07-27 |
2020-07-30 |
Инносимаб Пте Лтд |
Лечение пациентов с диагнозом аденокарцинома протоков поджелудочной железы с использованием моноклональных антител к рецептору эпидермального фактора роста (egfr)
|
|
CN108135894B
(zh)
|
2015-08-20 |
2021-02-19 |
卫材R&D管理有限公司 |
肿瘤治疗剂
|
|
AU2016313263B2
(en)
|
2015-08-26 |
2021-02-04 |
Fundación Del Sector Público Estatal Centro Nacional De Investigaciones Oncológicas Carlos III (F.S.P. CNIO) |
Condensed tricyclic compounds as protein kinase inhibitors
|
|
IL319047A
(en)
|
2015-08-28 |
2025-04-01 |
Amunix Operating Inc |
Chimeric polypeptide composition and methods for its preparation and use
|
|
EP3344806A4
(de)
|
2015-09-04 |
2019-03-20 |
OBI Pharma, Inc. |
Glycanarrays und verfahren zur verwendung
|
|
SG10202007764TA
(en)
|
2015-09-25 |
2020-09-29 |
Genentech Inc |
Anti-tigit antibodies and methods of use
|
|
WO2017060322A2
(en)
|
2015-10-10 |
2017-04-13 |
Bayer Pharma Aktiengesellschaft |
Ptefb-inhibitor-adc
|
|
CN105237638A
(zh)
*
|
2015-10-26 |
2016-01-13 |
无锡傲锐东源生物科技有限公司 |
抗egfr蛋白单克隆抗体杂交瘤细胞及其产生的抗egfr单克隆抗体和应用
|
|
EP3387013B1
(de)
|
2015-12-07 |
2022-06-08 |
Xencor, Inc. |
Cd3 und psma bindende heterodimere antikörper
|
|
HRP20220227T1
(hr)
|
2015-12-16 |
2022-04-29 |
Genentech, Inc. |
Postupak priprave tricikličnih spojeva inhibitora p13k i postupci upotrebe navedenih spojeva u liječenju raka
|
|
BR112018011029A2
(pt)
|
2016-01-08 |
2018-11-21 |
Hoffmann La Roche |
métodos para tratar ou atrasar a progressão do câncer e para melhorar a função imune em um indivíduo com câncer, usos de um antagonista de ligação e de um anticorpo biespecífico, composições e kits
|
|
WO2017151502A1
(en)
|
2016-02-29 |
2017-09-08 |
Genentech, Inc. |
Therapeutic and diagnostic methods for cancer
|
|
CN109071631B
(zh)
|
2016-03-14 |
2023-07-14 |
奥斯陆大学 |
具有改变的FcRn结合的工程化免疫球蛋白
|
|
WO2017161206A1
(en)
|
2016-03-16 |
2017-09-21 |
Halozyme, Inc. |
Conjugates containing conditionally active antibodies or antigen-binding fragments thereof, and methods of use
|
|
US10980894B2
(en)
|
2016-03-29 |
2021-04-20 |
Obi Pharma, Inc. |
Antibodies, pharmaceutical compositions and methods
|
|
AU2017239637A1
(en)
|
2016-03-29 |
2018-11-15 |
Obi Pharma, Inc. |
Antibodies, pharmaceutical compositions and methods
|
|
EP3443004A1
(de)
|
2016-04-14 |
2019-02-20 |
H. Hoffnabb-La Roche Ag |
Anti-rspo3-antikörper und verfahren zur verwendung
|
|
WO2017181079A2
(en)
|
2016-04-15 |
2017-10-19 |
Genentech, Inc. |
Methods for monitoring and treating cancer
|
|
AU2017249229A1
(en)
|
2016-04-15 |
2018-10-04 |
Genentech, Inc. |
Diagnostic and therapeutic methods for cancer
|
|
PL3443350T3
(pl)
|
2016-04-15 |
2021-05-31 |
F. Hoffmann-La Roche Ag |
Sposoby monitorowania i leczenia nowotworu
|
|
IL262296B2
(en)
|
2016-04-22 |
2024-09-01 |
Obi Pharma Inc |
Cancer immunotherapy by immune activation or immune modulation via globo series antigens
|
|
US20190151346A1
(en)
|
2016-05-10 |
2019-05-23 |
INSERM (Institute National de la Santé et de la Recherche Médicale) |
Combinations therapies for the treatment of cancer
|
|
MA45146A
(fr)
|
2016-05-24 |
2021-03-24 |
Constellation Pharmaceuticals Inc |
Dérivés de pyrazolopyridine pour le traitement du cancer
|
|
WO2017205536A2
(en)
|
2016-05-24 |
2017-11-30 |
Genentech, Inc. |
Therapeutic compounds and uses thereof
|
|
CN109312407A
(zh)
|
2016-06-08 |
2019-02-05 |
豪夫迈·罗氏有限公司 |
用于癌症的诊断和治疗方法
|
|
CA3026151A1
(en)
|
2016-06-14 |
2017-12-21 |
Xencor, Inc. |
Bispecific checkpoint inhibitor antibodies
|
|
WO2017216028A1
(en)
|
2016-06-15 |
2017-12-21 |
Bayer Pharma Aktiengesellschaft |
Specific antibody-drug-conjugates (adcs) with ksp inhibitors and anti-cd123-antibodies
|
|
WO2017218698A1
(en)
|
2016-06-15 |
2017-12-21 |
Sutro Biopharma, Inc. |
Antibodies with engineered ch2 domains, compositions thereof and methods of using the same
|
|
RU2019102008A
(ru)
|
2016-06-28 |
2020-07-28 |
Ксенкор, Инк. |
Гетеродимерные антитела, которые связывают рецептор соматостатина 2-го типа
|
|
TWI750194B
(zh)
*
|
2016-07-05 |
2021-12-21 |
大陸商江蘇恆瑞醫藥股份有限公司 |
Ｅｇｆｒ抗體-藥物偶聯物及其在醫藥上的應用
|
|
KR20190067765A
(ko)
|
2016-07-27 |
2019-06-17 |
오비아이 파머 인코퍼레이티드 |
면역원성/치료 글리칸 조성물 및 그의 용도
|
|
KR102528998B1
(ko)
|
2016-07-29 |
2023-05-03 |
오비아이 파머 인코퍼레이티드 |
인간 항체, 제약 조성물 및 방법
|
|
EP3494139B1
(de)
|
2016-08-05 |
2022-01-12 |
F. Hoffmann-La Roche AG |
Multivalente und multiepitopische anitikörper mit agonistischer wirkung und verfahren zur verwendung
|
|
WO2018029124A1
(en)
|
2016-08-08 |
2018-02-15 |
F. Hoffmann-La Roche Ag |
Therapeutic and diagnostic methods for cancer
|
|
US10793632B2
(en)
|
2016-08-30 |
2020-10-06 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
|
KR102804118B1
(ko)
|
2016-10-06 |
2025-05-09 |
제넨테크, 인크. |
암에 대한 치료 및 진단 방법
|
|
CN109862919A
(zh)
|
2016-10-11 |
2019-06-07 |
免疫医疗有限公司 |
抗体-药物缀合物联合免疫介导的治疗剂
|
|
MX2019004327A
(es)
|
2016-10-14 |
2019-10-14 |
Xencor Inc |
Proteinas de fusion heterodimericas biespecificas que contienen proteinas de fusion fc il-15/il-15ra y fragmentos de anticuerpo pd-1.
|
|
WO2018078143A1
(en)
|
2016-10-28 |
2018-05-03 |
MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. |
Means and methods for determining efficacy of anti-egfr inhibitors in colorectal cancer (crc) therapy
|
|
EP3532091A2
(de)
|
2016-10-29 |
2019-09-04 |
H. Hoffnabb-La Roche Ag |
Anti-mic-antikörper und verfahren zur verwendung
|
|
WO2018094414A1
(en)
|
2016-11-21 |
2018-05-24 |
Obi Pharma, Inc. |
Conjugated biological molecules, pharmaceutical compositions and methods
|
|
AU2017380871C1
(en)
|
2016-12-21 |
2025-05-15 |
Bayer Aktiengesellschaft |
Antibody drug conjugates (ADCs) having enzymatically cleavable groups
|
|
US11433140B2
(en)
|
2016-12-21 |
2022-09-06 |
Bayer Pharma Aktiengesellschaft |
Specific antibody drug conjugates (ADCs) having KSP inhibitors
|
|
CN110072528B
(zh)
|
2017-02-08 |
2022-04-26 |
卫材R&D管理有限公司 |
治疗肿瘤的药物组合物
|
|
MX2019010295A
(es)
|
2017-03-01 |
2019-11-21 |
Genentech Inc |
Métodos de diagnóstico y terapéuticos para el cáncer.
|
|
KR20190136076A
(ko)
|
2017-04-13 |
2019-12-09 |
에프. 호프만-라 로슈 아게 |
암 치료 방법에 사용하기 위한 인터루킨-2 면역접합체, cd40 작용제 및 임의적인 pd-1 축 결합 길항제
|
|
WO2018212202A1
(en)
|
2017-05-16 |
2018-11-22 |
Eisai R&D Management Co., Ltd. |
Treatment of hepatocellular carcinoma
|
|
AU2018291497A1
(en)
|
2017-06-30 |
2020-01-16 |
Xencor, Inc. |
Targeted heterodimeric Fc fusion proteins containing IL-15/IL-15Ra and antigen binding domains
|
|
AU2018304458B2
(en)
|
2017-07-21 |
2021-12-09 |
Foundation Medicine, Inc. |
Therapeutic and diagnostic methods for cancer
|
|
WO2019033043A2
(en)
|
2017-08-11 |
2019-02-14 |
Genentech, Inc. |
ANTI-CD8 ANTIBODIES AND USES THEREOF
|
|
KR102811888B1
(ko)
|
2017-09-08 |
2025-05-27 |
에프. 호프만-라 로슈 아게 |
암의 진단 및 치료 방법
|
|
KR20240017986A
(ko)
|
2017-09-26 |
2024-02-08 |
더 리전트 오브 더 유니버시티 오브 캘리포니아 |
암 치료를 위한 조성물 및 방법
|
|
WO2019084395A1
(en)
|
2017-10-27 |
2019-05-02 |
University Of Virginia Patent Foundation |
COMPOUNDS AND METHODS FOR REGULATING, LIMITING OR INHIBITING AVIL EXPRESSION
|
|
WO2019090263A1
(en)
|
2017-11-06 |
2019-05-09 |
Genentech, Inc. |
Diagnostic and therapeutic methods for cancer
|
|
US10981992B2
(en)
|
2017-11-08 |
2021-04-20 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
|
AU2018366199A1
(en)
|
2017-11-08 |
2020-05-28 |
Xencor, Inc. |
Bispecific and monospecific antibodies using novel anti-PD-1 sequences
|
|
CU24558B1
(es)
*
|
2017-11-28 |
2021-12-08 |
Ct Inmunologia Molecular |
Anticuerpos monoclonales que reconocen al receptor del factor de crecimiento epidérmico y sus fragmentos derivados
|
|
JP7765181B2
(ja)
|
2017-12-19 |
2025-11-06 |
ゼンコア インコーポレイテッド |
改変されたｉｌ－２ ｆｃ融合タンパク質
|
|
US12174193B2
(en)
|
2018-01-15 |
2024-12-24 |
Epiaxis Therapeutics Pty Ltd |
Agents and methods for predicting response to therapy
|
|
US20200399376A1
(en)
|
2018-02-26 |
2020-12-24 |
Genentech, Inc. |
Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies
|
|
CN112469477A
(zh)
|
2018-04-04 |
2021-03-09 |
Xencor股份有限公司 |
与成纤维细胞活化蛋白结合的异源二聚体抗体
|
|
CA3097593A1
(en)
|
2018-04-18 |
2019-10-24 |
Xencor, Inc. |
Pd-1 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and pd-1 antigen binding domains and uses thereof
|
|
KR20210003814A
(ko)
|
2018-04-18 |
2021-01-12 |
젠코어 인코포레이티드 |
IL-15/IL-15Rα Fc-융합 단백질 및 TIM-3 항원 결합 도메인을 함유하는 TIM-3 표적화 이종이량체 융합 단백질
|
|
US20210363590A1
(en)
|
2018-05-21 |
2021-11-25 |
Nanostring Technologies, Inc. |
Molecular gene signatures and methods of using same
|
|
CA3098103A1
(en)
|
2018-05-23 |
2019-11-28 |
Adc Therapeutics Sa |
Molecular adjuvant
|
|
TWI890148B
(zh)
|
2018-06-23 |
2025-07-11 |
美商建南德克公司 |
以pd-1軸結合拮抗劑、鉑劑及拓撲異構酶ii抑制劑治療肺癌之方法
|
|
TW202504930A
(zh)
|
2018-06-27 |
2025-02-01 |
台灣浩鼎生技股份有限公司 |
用於糖蛋白工程的糖苷合成酶變體及其使用方法
|
|
EP3823611A1
(de)
|
2018-07-18 |
2021-05-26 |
Genentech, Inc. |
Verfahren zur behandlung von lungenkrebs mit einem pd-1-achsen-bindenden antagonisten, einem antimetabolit und einem platinmittel
|
|
WO2020028909A1
(en)
|
2018-08-03 |
2020-02-06 |
Brown University |
Oral formulations with increased uptake
|
|
TW202024023A
(zh)
|
2018-09-03 |
2020-07-01 |
瑞士商赫孚孟拉羅股份公司 |
治療性化合物及其使用方法
|
|
CA3111401A1
(en)
|
2018-09-19 |
2020-03-26 |
Genentech, Inc. |
Therapeutic and diagnostic methods for bladder cancer
|
|
AU2019342133B8
(en)
|
2018-09-21 |
2025-08-07 |
Genentech, Inc. |
Diagnostic methods for triple-negative breast cancer
|
|
KR102884523B1
(ko)
|
2018-10-03 |
2025-11-10 |
젠코어 인코포레이티드 |
IL-12 이종이량체 Fc-융합 단백질
|
|
EP3863672A4
(de)
|
2018-10-11 |
2022-06-29 |
The Scripps Research Institute |
Antikörperverbindungen mit reaktivem arginin und verwandte antikörperarzneimittelkonjugate
|
|
EP3867405A4
(de)
|
2018-10-17 |
2022-07-20 |
The University of Queensland |
Epigenetischer biomarker und verwendungen dafür
|
|
EP3867646A1
(de)
|
2018-10-18 |
2021-08-25 |
F. Hoffmann-La Roche AG |
Diagnostische und therapeutische verfahren für sarkomatoiden nierenkrebs
|
|
KR20210116437A
(ko)
|
2018-11-20 |
2021-09-27 |
코넬 유니버시티 |
방사성핵종의 마크로사이클릭 복합체 및 암의 방사선 요법에서의 이의 용도
|
|
US12351571B2
(en)
|
2018-12-19 |
2025-07-08 |
Array Biopharma Inc. |
Substituted quinoxaline compounds as inhibitors of FGFR tyrosine kinases
|
|
WO2020131627A1
(en)
|
2018-12-19 |
2020-06-25 |
Array Biopharma Inc. |
Substituted pyrazolo[1,5-a]pyridine compounds as inhibitors of fgfr tyrosine kinases
|
|
CN113330033B
(zh)
|
2018-12-26 |
2024-11-29 |
先天制药公司 |
白细胞免疫球蛋白样受体2中和性抗体
|
|
CN113396230A
(zh)
|
2019-02-08 |
2021-09-14 |
豪夫迈·罗氏有限公司 |
癌症的诊断和治疗方法
|
|
SG11202108707WA
(en)
|
2019-02-27 |
2021-09-29 |
Epiaxis Therapeutics Pty Ltd |
Methods and agents for assessing t-cell function and predicting response to therapy
|
|
CN113710706A
(zh)
|
2019-02-27 |
2021-11-26 |
豪夫迈·罗氏有限公司 |
用于抗tigit抗体和抗cd20抗体或抗cd38抗体治疗的给药
|
|
EP3930850A1
(de)
|
2019-03-01 |
2022-01-05 |
Xencor, Inc. |
Enpp3 und cd3 bindende heterodimere antikörper
|
|
WO2020223233A1
(en)
|
2019-04-30 |
2020-11-05 |
Genentech, Inc. |
Prognostic and therapeutic methods for colorectal cancer
|
|
MX2021013222A
(es)
|
2019-05-03 |
2022-01-06 |
Genentech Inc |
Metodos para tratar el cancer con un anticuerpo anti-pd-l1.
|
|
EP3980423A1
(de)
|
2019-06-10 |
2022-04-13 |
Sutro Biopharma, Inc. |
5h-pyrrolo[3,2-d]pyrimidin-2,4-diaminverbindungen und ihre antikörper-konjugate
|
|
EP3983410A1
(de)
|
2019-06-17 |
2022-04-20 |
Sutro Biopharma, Inc. |
1-(4-(aminomethyl)benzyl)-2-butyl-2h-pyrazolo[3,4-c]quinolin-4-aminderivate und verwandte verbindungen als toll-like- rezeptor (tlr) 7/8-agonisten sowie antikörper-wirkstoff-konjugate davon zur verwendung in der krebstherapie und -diagnose
|
|
WO2020264200A1
(en)
|
2019-06-26 |
2020-12-30 |
Amunix Pharmceuticals, Inc. |
Cd3 antigen binding fragments and compositions comprising same
|
|
CN112300279A
(zh)
|
2019-07-26 |
2021-02-02 |
上海复宏汉霖生物技术股份有限公司 |
针对抗cd73抗体和变体的方法和组合物
|
|
TW202519557A
(zh)
|
2019-09-04 |
2025-05-16 |
美商建南德克公司 |
Cd8 結合劑及其用途
|
|
AU2020351734A1
(en)
|
2019-09-27 |
2022-04-14 |
Genentech, Inc. |
Dosing for treatment with anti-TIGIT and anti-PD-L1 antagonist antibodies
|
|
CN114728936A
(zh)
|
2019-10-29 |
2022-07-08 |
豪夫迈·罗氏有限公司 |
用于治疗癌症的双功能化合物
|
|
IL292458A
(en)
|
2019-11-06 |
2022-06-01 |
Genentech Inc |
Diagnostic and treatment methods for the treatment of hematological cancer
|
|
EP4058435A1
(de)
|
2019-11-13 |
2022-09-21 |
Genentech, Inc. |
Therapeutische verbindungen und verfahren zur verwendung
|
|
CN114981298B
(zh)
|
2019-12-12 |
2024-08-20 |
听治疗有限责任公司 |
用于预防和治疗听力损失的组合物和方法
|
|
CR20220330A
(es)
|
2019-12-13 |
2022-08-04 |
Genentech Inc |
Anticuerpos anti-ly6g6d y métodos de uso.
|
|
CA3164995A1
(en)
|
2019-12-20 |
2021-06-24 |
Erasca, Inc. |
Tricyclic pyridones and pyrimidones
|
|
WO2021194481A1
(en)
|
2020-03-24 |
2021-09-30 |
Genentech, Inc. |
Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies
|
|
US20230095053A1
(en)
|
2020-03-03 |
2023-03-30 |
Sutro Biopharma, Inc. |
Antibodies comprising site-specific glutamine tags, methods of their preparation and methods of their use
|
|
WO2021177980A1
(en)
|
2020-03-06 |
2021-09-10 |
Genentech, Inc. |
Combination therapy for cancer comprising pd-1 axis binding antagonist and il6 antagonist
|
|
CN115698717A
(zh)
|
2020-04-03 |
2023-02-03 |
基因泰克公司 |
癌症的治疗和诊断方法
|
|
JP2023524669A
(ja)
|
2020-04-26 |
2023-06-13 |
バイオサイトジェン ファーマシューティカルズ （ベイジン） カンパニー リミテッド |
改変免疫グロブリン
|
|
EP4143345A1
(de)
|
2020-04-28 |
2023-03-08 |
Genentech, Inc. |
Verfahren und zusammensetzungen zur immuntherapie gegen nicht-kleinzelligen lungenkrebs
|
|
WO2021231976A1
(en)
|
2020-05-14 |
2021-11-18 |
Xencor, Inc. |
Heterodimeric antibodies that bind prostate specific membrane antigen (psma) and cd3
|
|
EP4149632A1
(de)
|
2020-05-14 |
2023-03-22 |
Xencor, Inc. |
Msln und cd3 bindende heterodimere antikörper
|
|
EP3915576A1
(de)
|
2020-05-28 |
2021-12-01 |
Fundació Privada Institut d'Investigació Oncològica de Vall-Hebron |
Für p95her2 spezifische chimäre antigenrezeptoren und deren verwendung
|
|
WO2021257503A1
(en)
|
2020-06-16 |
2021-12-23 |
Genentech, Inc. |
Methods and compositions for treating triple-negative breast cancer
|
|
WO2021257124A1
(en)
|
2020-06-18 |
2021-12-23 |
Genentech, Inc. |
Treatment with anti-tigit antibodies and pd-1 axis binding antagonists
|
|
EP4172621A1
(de)
|
2020-06-30 |
2023-05-03 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Verfahren zur vorhersage des risikos des wiederauftretens und/oder tods von patienten mit solidem krebs nach präoperativen adjuvanten therapien
|
|
JP7741831B2
(ja)
|
2020-06-30 |
2025-09-18 |
アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル |
術前補助療法及び根治手術後の固形がんを患っている患者の再発及び／又は死亡のリスクを予測するための方法
|
|
EP3939999A1
(de)
|
2020-07-14 |
2022-01-19 |
Fundación del Sector Público Estatal Centro Nacional de Investigaciones Oncológicas Carlos III (F.S.P. CNIO) |
Antikörper zur neutralisierung der interleukin-11-rezeptor-alpha-unterheinheit (il11ra) und verwendungen davon
|
|
US11787775B2
(en)
|
2020-07-24 |
2023-10-17 |
Genentech, Inc. |
Therapeutic compounds and methods of use
|
|
JP7904195B2
(ja)
|
2020-08-03 |
2026-08-12 |
ジェネンテック， インコーポレイテッド |
リンパ腫のための診断及び治療方法
|
|
EP4196612A1
(de)
|
2020-08-12 |
2023-06-21 |
Genentech, Inc. |
Diagnostische und therapeutische verfahren für krebs
|
|
WO2022066805A1
(en)
|
2020-09-23 |
2022-03-31 |
Erasca, Inc. |
Tricyclic pyridones and pyrimidones
|
|
US20240307539A1
(en)
|
2020-09-30 |
2024-09-19 |
Institute Of Zoology, Chinese Academy Of Science |
Egfr-targeting chimeric antigen receptor
|
|
TW202446417A
(zh)
|
2020-10-05 |
2024-12-01 |
美商建南德克公司 |
用抗 fcrh5/抗 cd3 雙特異性抗體進行治療之給藥
|
|
US20230372528A1
(en)
|
2020-10-16 |
2023-11-23 |
University Of Georgia Research Foundation, Inc. |
Glycoconjugates
|
|
WO2022103983A2
(en)
|
2020-11-11 |
2022-05-19 |
Sutro Biopharma, Inc. |
Fluorenylmethyloxycarbonyl and fluorenylmethylaminocarbonyl compounds, protein conjugates thereof, and methods for their use
|
|
US20230107642A1
(en)
|
2020-12-18 |
2023-04-06 |
Erasca, Inc. |
Tricyclic pyridones and pyrimidones
|
|
MX2023009379A
(es)
|
2021-02-12 |
2023-10-10 |
Hoffmann La Roche |
Derivados de tetrahidroazepina biciclicos para el tratamiento del cancer.
|
|
GB202102396D0
(en)
|
2021-02-19 |
2021-04-07 |
Adc Therapeutics Sa |
Molecular adjuvant
|
|
EP4305067A1
(de)
|
2021-03-09 |
2024-01-17 |
Xencor, Inc. |
Cd3 und cldn6 bindende heterodimere antikörper
|
|
US11859012B2
(en)
|
2021-03-10 |
2024-01-02 |
Xencor, Inc. |
Heterodimeric antibodies that bind CD3 and GPC3
|
|
CA3221390A1
(en)
|
2021-05-25 |
2022-12-01 |
Erasca, Inc. |
Sulfur-containing heteroaromatic tricyclic kras inhibitors
|
|
JP7895372B2
(ja)
|
2021-06-14 |
2026-07-27 |
セントロ デ インミュノロヒア モレキュラル |
低酸素血症性急性呼吸不全患者の治療における上皮成長因子受容体に対するモノクローナル抗体の使用
|
|
WO2022266206A1
(en)
|
2021-06-16 |
2022-12-22 |
Erasca, Inc. |
Kras inhibitor conjugates
|
|
WO2023010060A2
(en)
|
2021-07-27 |
2023-02-02 |
Novab, Inc. |
Engineered vlrb antibodies with immune effector functions
|
|
EP4384522A1
(de)
|
2021-08-10 |
2024-06-19 |
Erasca, Inc. |
Selektive kras-hemmer
|
|
CN117980327A
(zh)
|
2021-11-03 |
2024-05-03 |
杭州多禧生物科技有限公司 |
抗体的特异性偶联
|
|
US12110276B2
(en)
|
2021-11-24 |
2024-10-08 |
Genentech, Inc. |
Pyrazolo compounds and methods of use thereof
|
|
US12275745B2
(en)
|
2021-11-24 |
2025-04-15 |
Genentech, Inc. |
Therapeutic compounds and methods of use
|
|
CU24763B1
(es)
|
2021-12-21 |
2025-07-09 |
Ct Inmunologia Molecular |
Proteínas de fusión compuestas por un anticuerpo y una muteína agonista de interleucina 2
|
|
US20250144042A1
(en)
|
2022-02-22 |
2025-05-08 |
Brown University |
Compositions and methods to achieve systemic uptake of particles following oral or mucosal administration
|
|
EP4253418A1
(de)
|
2022-03-29 |
2023-10-04 |
Fundació Privada Institut d'Investigació Oncològica de Vall-Hebron |
Immunzellen, die chimäre antigenrezeptoren exprimieren, und bispezifische antikörper und verwendungen davon
|
|
WO2023191816A1
(en)
|
2022-04-01 |
2023-10-05 |
Genentech, Inc. |
Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
|
|
JP2025517650A
(ja)
|
2022-05-11 |
2025-06-10 |
ジェネンテック， インコーポレイテッド |
抗ＦｃＲＨ５／抗ＣＤ３二重特異性抗体による処置のための投与
|
|
JP2025523387A
(ja)
|
2022-06-07 |
2025-07-23 |
ジェネンテック， インコーポレイテッド |
抗ｐｄ－ｌ１アンタゴニストおよび抗ｔｉｇｉｔアンタゴニスト抗体を含む、肺がん治療の有効性を判定するための方法
|
|
EP4543494A1
(de)
|
2022-06-27 |
2025-04-30 |
Sutro Biopharma, Inc. |
Beta-glucuronid-linker-payloads, proteinkonjugate davon und verfahren dafür
|
|
CN119585308A
(zh)
|
2022-07-13 |
2025-03-07 |
基因泰克公司 |
针对用抗fcrh5/抗cd3双特异性抗体进行的治疗的给药
|
|
CN119948030A
(zh)
|
2022-07-15 |
2025-05-06 |
苏特罗生物制药公司 |
蛋白酶/酶可切割连接体-有效载荷及蛋白质偶联物
|
|
KR20250040020A
(ko)
|
2022-07-19 |
2025-03-21 |
제넨테크, 인크. |
항-fcrh5/항-cd3 이중특이성 항체로 치료하기 위한 투약법
|
|
US20260035364A1
(en)
|
2022-08-11 |
2026-02-05 |
Hoffmann-La Roche Inc. |
Bicyclic tetrahydrothiazepine derivatives
|
|
WO2024033457A1
(en)
|
2022-08-11 |
2024-02-15 |
F. Hoffmann-La Roche Ag |
Bicyclic tetrahydrothiazepine derivatives
|
|
CN119677733A
(zh)
|
2022-08-11 |
2025-03-21 |
豪夫迈·罗氏有限公司 |
双环四氢硫氮杂䓬衍生物
|
|
WO2024033458A1
(en)
|
2022-08-11 |
2024-02-15 |
F. Hoffmann-La Roche Ag |
Bicyclic tetrahydroazepine derivatives
|
|
WO2024085242A2
(en)
|
2022-10-21 |
2024-04-25 |
Kawasaki Institute Of Industrial Promotion |
Non-fouling or super stealth vesicle
|
|
JP2026500084A
(ja)
|
2022-10-25 |
2026-01-06 |
ジェネンテック， インコーポレイテッド |
多発性骨髄腫の治療方法および診断方法
|
|
EP4406973A1
(de)
|
2023-01-27 |
2024-07-31 |
Fundació Privada Institut de Recerca de la SIDA-Caixa |
Antikörper und verwendungen davon zur behandlung von infektionen durch eingehüllte viren
|
|
WO2024173842A1
(en)
|
2023-02-17 |
2024-08-22 |
Erasca, Inc. |
Kras inhibitors
|
|
WO2024233341A1
(en)
|
2023-05-05 |
2024-11-14 |
Genentech, Inc. |
Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
|
|
WO2024254455A1
(en)
|
2023-06-08 |
2024-12-12 |
Genentech, Inc. |
Macrophage signatures for diagnostic and therapeutic methods for lymphoma
|
|
WO2025024257A1
(en)
|
2023-07-21 |
2025-01-30 |
Genentech, Inc. |
Diagnostic and therapeutic methods for cancer
|
|
AU2024315750A1
(en)
|
2023-07-31 |
2026-03-05 |
Sutro Biopharma, Inc. |
Sting agonist compounds and conjugates
|
|
EP4791439A1
(de)
|
2023-10-13 |
2026-08-19 |
Sutro Biopharma, Inc. |
Antikörper-wirkstoff-konjugate mit doppelter nutzlast
|
|
WO2025264647A1
(en)
|
2024-06-18 |
2025-12-26 |
Sutro Biopharma, Inc. |
Oxoadenine tlr7 agonist compounds and conjugates
|
|
WO2026030464A1
(en)
|
2024-07-30 |
2026-02-05 |
Genentech, Inc. |
Dosage regimen for reducing cytokine release syndrome (crs) with anti-fcrh5/anti-cd3 bispecific antibodies in multiple myeloma therapy
|
|
WO2026030476A1
(en)
|
2024-07-30 |
2026-02-05 |
Genentech, Inc. |
Precision medicine for optimal dosage of combined therapies systems and methods of use thereof
|
|
WO2026043823A2
(en)
|
2024-08-19 |
2026-02-26 |
Sutro Biopharma, Inc. |
Antibodies comprising site-specific non-natural amino acid residues, methods of preparation and uses thereof
|
|
WO2026080692A1
(en)
|
2024-10-09 |
2026-04-16 |
Sutro Biopharma, Inc. |
Branched beta-glucuronide linker-payloads, protein conjugates thereof, and methods thereof
|
|
WO2026080688A1
(en)
|
2024-10-09 |
2026-04-16 |
Sutro Biopharma, Inc. |
Dual mechanism of action payload antibody drug conjugates
|
|
WO2026080697A1
(en)
|
2024-10-09 |
2026-04-16 |
Sutro Biopharma, Inc. |
Antibody conjugates with high payload to antibody ratios, compositions comprising the same, and methods of their use
|
|
WO2026097015A1
(en)
|
2024-11-01 |
2026-05-07 |
Eindura Therapeutics, Inc. |
Targeted therapeutics with an electrophilic group for covalent attachment and methods of use and manufacture thereof
|
|
WO2026102349A1
(en)
|
2024-11-08 |
2026-05-15 |
Genentech, Inc. |
Anti-interleukin-23 receptor vhh antibodies and uses thereof
|