ATE214067T1 - Pyrido (2,3-b) pyrazinderivate - Google Patents

Pyrido (2,3-b) pyrazinderivate

Info

Publication number: ATE214067T1
Authority: AT; Austria
Prior art keywords: alkenyl; pyridyl; phenyl; amino; alkenoyl
Prior art date: 1995-12-27

Application number

AT96941882T

Other languages

English (en)

Inventor

Norihiko Shimazaki

Akihiko Sawada

Shinya Watanabe

Original Assignee

Fujisawa Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-27

Filing date

1996-12-13

Publication date

2002-03-15

1996-12-13 Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co

2002-03-15 Application granted granted Critical

2002-03-15 Publication of ATE214067T1 publication Critical patent/ATE214067T1/de

Links

YEYHFKBVNARCNE-UHFFFAOYSA-N pyrido[2,3-b]pyrazine Chemical class N1=CC=NC2=CC=CN=C21 YEYHFKBVNARCNE-UHFFFAOYSA-N 0.000 title 1
125000003342 alkenyl group Chemical group 0.000 abstract 14
125000004076 pyridyl group Chemical group 0.000 abstract 9
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 6
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 6
125000000217 alkyl group Chemical group 0.000 abstract 5
-1 aminophenyl Chemical group 0.000 abstract 4
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
125000002883 imidazolyl group Chemical group 0.000 abstract 2
125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
125000005236 alkanoylamino group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000005059 halophenyl group Chemical group 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Hematology (AREA)
Dermatology (AREA)
Diabetes (AREA)
Immunology (AREA)
Heart & Thoracic Surgery (AREA)
Neurology (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Toxicology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)

AT96941882T 1995-12-27 1996-12-13 Pyrido (2,3-b) pyrazinderivate ATE214067T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9526558.3A GB9526558D0 (en)	1995-12-27	1995-12-27	Heterobicyclic derivatives
PCT/JP1996/003666 WO1997024355A1 (en)	1995-12-27	1996-12-13	Pyrido (2,3-b) pyrazine derivatives

Publications (1)

Publication Number	Publication Date
ATE214067T1 true ATE214067T1 (de)	2002-03-15

Family

ID=10786098

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96941882T ATE214067T1 (de)	1995-12-27	1996-12-13	Pyrido (2,3-b) pyrazinderivate

Country Status (18)

Country	Link
US (1)	US6117875A (de)
EP (1)	EP0874845B1 (de)
JP (1)	JP2000502699A (de)
KR (1)	KR19990072053A (de)
CN (1)	CN1066732C (de)
AT (1)	ATE214067T1 (de)
AU (1)	AU720301B2 (de)
CA (1)	CA2241690A1 (de)
DE (1)	DE69619702T2 (de)
DK (1)	DK0874845T3 (de)
EA (1)	EA001324B1 (de)
ES (1)	ES2170286T3 (de)
GB (1)	GB9526558D0 (de)
HU (1)	HUP9901038A3 (de)
IL (1)	IL124673A (de)
MX (1)	MX9805129A (de)
PT (1)	PT874845E (de)
WO (1)	WO1997024355A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9413975D0 (en)	1994-07-11	1994-08-31	Fujisawa Pharmaceutical Co	New heterobicyclic derivatives
CA2715683A1 (en)	1999-08-21	2001-03-01	Nycomed Gmbh	Synergistic combination
US6906072B1 (en)	2000-01-20	2005-06-14	Eisai Co., Ltd.	Piperazine compound and pharmaceutical composition containing the compound
DK1302461T3 (da) *	2000-05-31	2008-01-28	Santen Pharmaceutical Co Ltd	TNF-alfa-produktionsinhibitorer
SE0102299D0 (sv)	2001-06-26	2001-06-26	Astrazeneca Ab	Compounds
SE0102764D0 (sv)	2001-08-17	2001-08-17	Astrazeneca Ab	Compounds
CA2504820C (en) *	2002-11-06	2011-08-23	Grelan Pharmaceutical Co., Ltd.	Pyrazolonaphthyridine derivatives
US7153824B2 (en)	2003-04-01	2006-12-26	Applied Research Systems Ars Holding N.V.	Inhibitors of phosphodiesterases in infertility
US7504401B2 (en)	2003-08-29	2009-03-17	Locus Pharmaceuticals, Inc.	Anti-cancer agents and uses thereof
DE602005017129D1 (de) *	2004-03-22	2009-11-26	Lilly Co Eli	Pyridyl-derivate und ihre verwendung als mglu5-rezeptorantagonisten
WO2006126081A2 (en) *	2005-05-24	2006-11-30	Pharmacia & Upjohn Company Llc	Pyridino [2 , 3-b] pyrazinones as pde-5 inhibitors
KR101346902B1 (ko)	2005-07-09	2014-01-02	아스트라제네카 아베	당뇨병 치료에 있어 ｇｌｋ 활성화제로서 사용하기 위한헤테로아릴 벤즈아미드 유도체
US20080280891A1 (en) *	2006-06-27	2008-11-13	Locus Pharmaceuticals, Inc.	Anti-cancer agents and uses thereof
PT2247292T (pt)	2008-03-05	2017-07-17	Merck Patent Gmbh	Derivados de piridopirazinonas como estimulantes da secreção de insulina, procedimentos para a sua obtenção e a sua utilização no tratamento da diabetes
US8551996B2 (en) *	2009-02-20	2013-10-08	Emory University	Compounds, compositions, methods of synthesis, and methods of treatment
CN101875627B (zh) *	2009-04-30	2014-01-15	凯惠科技发展(上海)有限公司	一种1-烷氧羰基-2h-异吲哚衍生物及其制备方法和中间体
CN112566905B (zh) *	2019-05-10	2024-07-30	上海海雁医药科技有限公司	取代的苯基丙烯基吡啶类衍生物，其制法与医药上的用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0008864A1 (de) *	1978-08-15	1980-03-19	FISONS plc	Pyridopyrazin- und Chinoxalinderivate, Verfahren zu ihrer Herstellung, und sie enthaltende pharmazeutische Zusammensetzungen
GB9413975D0 (en) *	1994-07-11	1994-08-31	Fujisawa Pharmaceutical Co	New heterobicyclic derivatives

1995
- 1995-12-27 GB GBGB9526558.3A patent/GB9526558D0/en active Pending
1996
- 1996-12-13 WO PCT/JP1996/003666 patent/WO1997024355A1/en not_active Ceased
- 1996-12-13 DK DK96941882T patent/DK0874845T3/da active
- 1996-12-13 AT AT96941882T patent/ATE214067T1/de not_active IP Right Cessation
- 1996-12-13 EA EA199800599A patent/EA001324B1/ru not_active IP Right Cessation
- 1996-12-13 JP JP9524170A patent/JP2000502699A/ja active Pending
- 1996-12-13 KR KR1019980704348A patent/KR19990072053A/ko not_active Ceased
- 1996-12-13 ES ES96941882T patent/ES2170286T3/es not_active Expired - Lifetime
- 1996-12-13 IL IL12467396A patent/IL124673A/en not_active IP Right Cessation
- 1996-12-13 DE DE69619702T patent/DE69619702T2/de not_active Expired - Fee Related
- 1996-12-13 HU HU9901038A patent/HUP9901038A3/hu unknown
- 1996-12-13 CA CA002241690A patent/CA2241690A1/en not_active Abandoned
- 1996-12-13 US US09/091,361 patent/US6117875A/en not_active Expired - Fee Related
- 1996-12-13 AU AU11112/97A patent/AU720301B2/en not_active Ceased
- 1996-12-13 EP EP96941882A patent/EP0874845B1/de not_active Expired - Lifetime
- 1996-12-13 CN CN96199282A patent/CN1066732C/zh not_active Expired - Fee Related
- 1996-12-13 PT PT96941882T patent/PT874845E/pt unknown
1998
- 1998-06-24 MX MX9805129A patent/MX9805129A/es not_active IP Right Cessation

Also Published As

Publication number	Publication date
PT874845E (pt)	2002-08-30
US6117875A (en)	2000-09-12
DK0874845T3 (da)	2002-07-01
MX9805129A (es)	1998-10-31
ES2170286T3 (es)	2002-08-01
EP0874845A1 (de)	1998-11-04
JP2000502699A (ja)	2000-03-07
EP0874845B1 (de)	2002-03-06
GB9526558D0 (en)	1996-02-28
CA2241690A1 (en)	1997-07-10
HUP9901038A2 (hu)	1999-07-28
EA001324B1 (ru)	2001-02-26
KR19990072053A (ko)	1999-09-27
DE69619702T2 (de)	2002-08-14
CN1205702A (zh)	1999-01-20
IL124673A0 (en)	1998-12-06
EA199800599A1 (ru)	1998-12-24
IL124673A (en)	2002-07-25
AU1111297A (en)	1997-07-28
HUP9901038A3 (en)	2000-04-28
WO1997024355A1 (en)	1997-07-10
CN1066732C (zh)	2001-06-06
DE69619702D1 (de)	2002-04-11
AU720301B2 (en)	2000-05-25

Legal Events

Date	Code	Title	Description
2002-07-15	UEP	Publication of translation of european patent specification
2004-09-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DK0874845T3 (da)	2002-07-01	Pyrido[2,3-b]pyrazinderivater
AU4954097A (en)	1998-05-22	2-pyrimidineamine derivatives and processes for their preparation
EP0349949A3 (de)	1991-09-04	Benzodiazepin-Derivate
AU7453498A (en)	1998-12-30	Sulfonamide derivatives, their production and use
GR3034542T3 (en)	2001-01-31	4,5-diaryloxazole derivatives
ATE195117T1 (de)	2000-08-15	1-amdinophenyl-pyrrolidone/piperidinone als blutblättchen-aggregations inhibitoren
KR960701055A (ko)	1996-02-24	인터로이킨-1 및 종양 괴사 인자 억제 활성을 지닌 피라졸로트리아진 (pyrazol itriazines with interleukin-1 and tumour necrosis factor in-hibitory actvity)
BG103195A (en)	1999-09-30	Substituted indazole derivatives and their application as inhibitors of phosphodiesterase (pde) type iv and of the production of a tumournecrotic factor (tnf)
NO2005019I1 (no)	2005-09-26	Metylaminolevulina, eventuelt i form av et salt, fortinnsvis metylaminolevulinat-hydroklorid
AU4064597A (en)	1998-03-06	Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof
IE901799L (en)	1990-11-20	Anti inflammatory aminophenol derivatives
IL122737A (en)	2003-01-12	Salts of amidine derivatives and cyclooxygenase inhibitors, their preparation and pharmaceutical compositions containing them
IT1250749B (it)	1995-04-21	Composti eterociclici ad attivita' a ii antagonista
AU1556997A (en)	1997-08-22	Chinoline and benzimidazole derivatives as bradykinin agonists
NZ332310A (en)	1999-08-30	Optionally condensed pyrimidine substituted hexahydro-pyrido[4,3-b]indole derivatives and medicaments
DE69613385D1 (de)	2001-07-19	Cephemverbindungen
TW333525B (en)	1998-06-11	New perhydroisoindole derivatives, their preparation and the pharmaceutical compositions which contain them the invention relates to perhydroisoindole derivatives of general formula (I), and their salts when they exist advantageously as neurokinin A antagonists.
ZA941334B (en)	1995-08-25	Amide derivative .