PT686156E - Pirazolitriazinas com actividade inibidora de interleucina-1 e factor de necrose de tumor - Google Patents

Pirazolitriazinas com actividade inibidora de interleucina-1 e factor de necrose de tumor

Info

Publication number
PT686156E
PT686156E PT94906381T PT94906381T PT686156E PT 686156 E PT686156 E PT 686156E PT 94906381 T PT94906381 T PT 94906381T PT 94906381 T PT94906381 T PT 94906381T PT 686156 E PT686156 E PT 686156E
Authority
PT
Portugal
Prior art keywords
alkyl
suitable substituent
pct
pirazolitriazines
interleucin
Prior art date
Application number
PT94906381T
Other languages
English (en)
Inventor
Teruo Oku
Hirokazu Tanaka
Yoshio Kamikashiwada Kawai
Hitoshi Tsuchida Yamazki
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of PT686156E publication Critical patent/PT686156E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PT94906381T 1993-02-26 1994-02-09 Pirazolitriazinas com actividade inibidora de interleucina-1 e factor de necrose de tumor PT686156E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939303993A GB9303993D0 (en) 1993-02-26 1993-02-26 New heterocyclic derivatives

Publications (1)

Publication Number Publication Date
PT686156E true PT686156E (pt) 2002-12-31

Family

ID=10731142

Family Applications (1)

Application Number Title Priority Date Filing Date
PT94906381T PT686156E (pt) 1993-02-26 1994-02-09 Pirazolitriazinas com actividade inibidora de interleucina-1 e factor de necrose de tumor

Country Status (20)

Country Link
US (1) US5670503A (pt)
EP (1) EP0686156B1 (pt)
JP (1) JP3569917B2 (pt)
KR (1) KR100313615B1 (pt)
CN (1) CN1041929C (pt)
AT (1) ATE220677T1 (pt)
AU (1) AU681625B2 (pt)
CA (1) CA2156919A1 (pt)
DE (1) DE69430988T2 (pt)
DK (1) DK0686156T3 (pt)
ES (1) ES2176235T3 (pt)
GB (1) GB9303993D0 (pt)
HU (1) HUT70832A (pt)
IL (1) IL108562A (pt)
MX (1) MX9401408A (pt)
PT (1) PT686156E (pt)
RU (1) RU2124517C1 (pt)
TW (1) TW260669B (pt)
WO (1) WO1994019350A1 (pt)
ZA (1) ZA94787B (pt)

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AU736854B2 (en) 1996-04-25 2001-08-02 Nissan Chemical Industries Ltd. Ethylene derivatives and pesticides containing said derivatives
JP2002502380A (ja) 1997-05-22 2002-01-22 ジー．ディー．サール アンド カンパニー ｐ３８キナーゼ阻害剤としてのピラゾール誘導体
US6979686B1 (en) 2001-12-07 2005-12-27 Pharmacia Corporation Substituted pyrazoles as p38 kinase inhibitors
US6514977B1 (en) 1997-05-22 2003-02-04 G.D. Searle & Company Substituted pyrazoles as p38 kinase inhibitors
EP0988301B1 (en) 1997-06-12 2006-08-09 Aventis Pharma Limited Imidazolyl-cyclic acetals
WO1998056377A1 (en) 1997-06-13 1998-12-17 Smithkline Beecham Corporation Novel pyrazole and pyrazoline substituted compounds
ES2237850T3 (es) * 1997-10-14 2005-08-01 Mitsubishi Pharma Corporation Compuestos de piperazina y su uso medicinal.
US6335340B1 (en) 1997-12-19 2002-01-01 Smithkline Beecham Corporation compounds of heteroaryl substituted imidazole, their pharmaceutical compositons and uses
US6858617B2 (en) 1998-05-26 2005-02-22 Smithkline Beecham Corporation Substituted imidazole compounds
EP1112070B1 (en) * 1998-08-20 2004-05-12 Smithkline Beecham Corporation Novel substituted triazole compounds
US6548503B1 (en) 1998-11-04 2003-04-15 Smithkline Beecham Corporation Pyridin-4-yl or pyrimidin-4-yl substituted pyrazines
WO2001015525A1 (en) * 1999-08-31 2001-03-08 Fujisawa Pharmaceutical Co., Ltd. Organ preservatives
RU2264403C2 (ru) * 1999-11-10 2005-11-20 Орто-Макнейл Фармасьютикал, Инк. Замещенные 2-арил-3-(гетероарил) имидазо [1,2-а] пиримидины, содержащие их фармацевтические композиции и связанные с ними способы
US6417189B1 (en) * 1999-11-12 2002-07-09 Gpi Nil Holdings, Inc. AZA compounds, pharmaceutical compositions and methods of use
US7253169B2 (en) 1999-11-12 2007-08-07 Gliamed, Inc. Aza compounds, pharmaceutical compositions and methods of use
WO2001038314A1 (en) 1999-11-23 2001-05-31 Smithkline Beecham Corporation 3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p38 kinase inhibitors
US7053099B1 (en) 1999-11-23 2006-05-30 Smithkline Beecham Corporation 3,4-dihydro-(1H)quinazolin-2-one compounds as CSBP/p38 kinase inhibitors
JP2003528043A (ja) 1999-11-23 2003-09-24 スミスクライン・ビーチャム・コーポレイション ＣＳＢＰ／ｐ３８キナーゼ阻害剤としての３，４‐ジヒドロ−（１Ｈ）キナゾリン−２−オン化合物
US6759410B1 (en) 1999-11-23 2004-07-06 Smithline Beecham Corporation 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
US7235551B2 (en) 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
EP2404603A1 (en) 2000-10-23 2012-01-11 Glaxosmithkline LLC Novel trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds for the treatment of CSBP/p38 kinase mediated diseases
RU2316556C2 (ru) * 2000-11-17 2008-02-10 Бристол-Маерс Сквибб Компани СПОСОБЫ ЛЕЧЕНИЯ СОСТОЯНИЙ, ОБУСЛОВЛЕННЫХ p38 КИНАЗАМИ, И ПИРРОЛОТРИАЗИНОВЫЕ СОЕДИНЕНИЯ, ПРИМЕНИМЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ КИНАЗ
JP2004518731A (ja) * 2000-12-28 2004-06-24 ニューロクライン バイオサイエンシーズ， インコーポレイテッド 三環式ｃｒｆレセプターアンタゴニスト
HRP20030961B1 (en) * 2001-05-24 2012-01-31 Eli Lilly And Company Novel pyrrole derivatives as pharmaceutical agents
US6821971B2 (en) * 2001-09-20 2004-11-23 The Procter & Gamble Company Fused pyrazolone compounds which inhibit the release of inflammatory cytokines
MXPA04010267A (es) 2002-04-19 2005-02-03 Smithkline Beecham Corp Compuestos novedosos.
WO2004004725A2 (en) 2002-07-09 2004-01-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases
KR101050700B1 (ko) * 2002-08-26 2011-07-20 다케다 야쿠힌 고교 가부시키가이샤 칼슘 수용체 조절 화합물 및 이의 용도
US7572922B2 (en) 2003-01-27 2009-08-11 Merck & Co., Inc. Substituted pyrazoles, compositions containing such compounds and methods of use
CN1964947A (zh) * 2004-06-04 2007-05-16 默克公司 吡唑衍生物、包含其的组合物及其用法
US20060035893A1 (en) 2004-08-07 2006-02-16 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
PE20060777A1 (es) 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
US20090137550A1 (en) 2005-03-25 2009-05-28 Glaxo Group Limited Novel Compounds
EP1865959A2 (en) 2005-03-25 2007-12-19 Glaxo Group Limited Process for preparing pyridoý2,3-d¨pyrimidin-7-one and 3,4-dihydropyrimidoý4,5-d¨pyrimidin-2(1h)-one derivatives
TW200724142A (en) 2005-03-25 2007-07-01 Glaxo Group Ltd Novel compounds
PE20061351A1 (es) 2005-03-25 2007-01-14 Glaxo Group Ltd COMPUESTOS 8H-PIRIDO[2,3-d]PIRIMIDIN-7-ONA 2,4,8-TRISUSTITUIDOS COMO INHIBIDORES DE LA QUINASA CSBP/RK/p38
WO2007015999A2 (en) * 2005-07-26 2007-02-08 Merck & Co., Inc. Process for synthesizing a substituted pyrazole
EP1992344A1 (en) 2007-05-18 2008-11-19 Institut Curie P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation
US20110195962A1 (en) * 2007-08-16 2011-08-11 Alcon Research, Ltd. Use of multi-pharmacophore compounds to treat nasal disorders
WO2009039387A1 (en) * 2007-09-20 2009-03-26 Wyeth Pyrazolo[5, 1-c] [1,2,4] triazines, methods for preparation and use thereof
CN101441969B (zh) 2007-11-23 2010-07-28 清华大学 场发射像素管
CN101441972B (zh) 2007-11-23 2011-01-26 鸿富锦精密工业（深圳）有限公司 场发射像素管
EP2402344A1 (en) * 2010-06-29 2012-01-04 Basf Se Pyrazole fused bicyclic compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992012154A1 (en) * 1990-12-31 1992-07-23 Fujisawa Pharmaceutical Co., Ltd. Imidazotriazine derivatives
US5356897A (en) * 1991-09-09 1994-10-18 Fujisawa Pharmaceutical Co., Ltd. 3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines

Also Published As

Publication number Publication date
KR100313615B1 (ko) 2002-05-30
US5670503A (en) 1997-09-23
MX9401408A (es) 1994-08-31
DE69430988D1 (de) 2002-08-22
EP0686156B1 (en) 2002-07-17
HUT70832A (en) 1995-11-28
ES2176235T3 (es) 2002-12-01
JP3569917B2 (ja) 2004-09-29
ATE220677T1 (de) 2002-08-15
CN1041929C (zh) 1999-02-03
IL108562A (en) 1997-06-10
EP0686156A1 (en) 1995-12-13
HU9402459D0 (en) 1994-11-28
IL108562A0 (en) 1994-05-30
AU6010894A (en) 1994-09-14
JPH08507056A (ja) 1996-07-30
DK0686156T3 (da) 2002-11-11
KR960701055A (ko) 1996-02-24
AU681625B2 (en) 1997-09-04
TW260669B (pt) 1995-10-21
CN1120840A (zh) 1996-04-17
GB9303993D0 (en) 1993-04-14
DE69430988T2 (de) 2002-11-28
RU2124517C1 (ru) 1999-01-10
CA2156919A1 (en) 1994-09-01
ZA94787B (en) 1994-09-08
WO1994019350A1 (en) 1994-09-01

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