ATE214397T1 - Kristallisierung von alpha-l-aspartyl-l- phenylalaninmethylester aus wässerigen lösungen - Google Patents

Kristallisierung von alpha-l-aspartyl-l- phenylalaninmethylester aus wässerigen lösungen

Info

Publication number: ATE214397T1
Authority: AT; Austria
Prior art keywords: crystallization; aspartyl; alpha; methyl ester; phenylalanine methyl
Prior art date: 1995-06-30

Application number

AT95201794T

Other languages

English (en)

Inventor

Marinus Petrus Wilhelm Rijkers

Alexander Peter Marie Vrinzen

Original Assignee

Holland Sweetener Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-30

Filing date

1995-06-30

Publication date

2002-03-15

1995-06-30 Application filed by Holland Sweetener Co filed Critical Holland Sweetener Co

2002-03-15 Application granted granted Critical

2002-03-15 Publication of ATE214397T1 publication Critical patent/ATE214397T1/de

Links

IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 title abstract 4
238000002425 crystallisation Methods 0.000 title abstract 4
230000008025 crystallization Effects 0.000 title abstract 4
239000007864 aqueous solution Substances 0.000 title abstract 2
150000002576 ketones Chemical class 0.000 abstract 3
108010011485 Aspartame Proteins 0.000 abstract 2
229960003438 aspartame Drugs 0.000 abstract 2
235000010357 aspartame Nutrition 0.000 abstract 2
239000000605 aspartame Substances 0.000 abstract 2
238000001816 cooling Methods 0.000 abstract 2
239000013078 crystal Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT95201794T 1995-06-30 1995-06-30 Kristallisierung von alpha-l-aspartyl-l- phenylalaninmethylester aus wässerigen lösungen ATE214397T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP95201794A EP0751146B1 (de)	1995-06-30	1995-06-30	Kristallisierung von alpha-L-aspartyl-L-phenylalaninmethylester aus wässerigen Lösungen

Publications (1)

Publication Number	Publication Date
ATE214397T1 true ATE214397T1 (de)	2002-03-15

Family

ID=8220443

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95201794T ATE214397T1 (de)	1995-06-30	1995-06-30	Kristallisierung von alpha-l-aspartyl-l- phenylalaninmethylester aus wässerigen lösungen

Country Status (9)

Country	Link
US (1)	US5733883A (de)
EP (1)	EP0751146B1 (de)
KR (1)	KR100426247B1 (de)
CN (1)	CN1135237C (de)
AT (1)	ATE214397T1 (de)
CA (1)	CA2180207A1 (de)
DE (1)	DE69525839T2 (de)
RU (1)	RU2155771C2 (de)
TW (1)	TW323270B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5728862A (en) *	1997-01-29	1998-03-17	The Nutrasweet Company	Method for preparing and purifying an N-alkylated aspartame derivative
IL122068A (en) *	1997-10-29	2001-01-28	Yissum Res Dev Co	Process for the preparation of crystal form of aspartame
US6657073B1 (en)	1999-08-18	2003-12-02	Daesang Corporation	Crystallization of α-L-aspartyl-L-phenylalanine methyl ester
US8956677B2 (en) *	2005-11-23	2015-02-17	The Coca-Cola Company	High-potency sweetener composition with glucosamine and compositions sweetened therewith
US20070116836A1 (en) *	2005-11-23	2007-05-24	The Coca-Cola Company	High-Potency Sweetener Composition for Treatment and/or Prevention of Osteoporosis and Compositions Sweetened Therewith
US9101160B2 (en)	2005-11-23	2015-08-11	The Coca-Cola Company	Condiments with high-potency sweetener
US20070116831A1 (en) *	2005-11-23	2007-05-24	The Coca-Cola Company	Dental Composition with High-Potency Sweetener
US20070116825A1 (en) *	2005-11-23	2007-05-24	The Coca-Cola Company	Confection with High-Potency Sweetener
US8993027B2 (en) *	2005-11-23	2015-03-31	The Coca-Cola Company	Natural high-potency tabletop sweetener compositions with improved temporal and/or flavor profile, methods for their formulation, and uses
US9144251B2 (en) *	2005-11-23	2015-09-29	The Coca-Cola Company	High-potency sweetener composition with mineral and compositions sweetened therewith
US20070134391A1 (en) *	2005-11-23	2007-06-14	The Coca-Cola Company	High-Potency Sweetener Composition for Treatment and/or Prevention of Autoimmune Disorders and Compositions Sweetened Therewith
CA2629556A1 (en) *	2005-11-23	2007-07-19	The Coca Cola Company	Synthetic sweetener compositions with improved temporal profile and/or flavor profile, methods for their formulation, and uses
US8956678B2 (en) *	2005-11-23	2015-02-17	The Coca-Cola Company	High-potency sweetener composition with preservative and compositions sweetened therewith
US20070116822A1 (en) *	2005-11-23	2007-05-24	The Coca-Cola Company	High-potency sweetener composition with saponin and compositions sweetened therewith
US20080107787A1 (en) *	2006-11-02	2008-05-08	The Coca-Cola Company	Anti-Diabetic Composition with High-Potency Sweetener
US9101161B2 (en) *	2006-11-02	2015-08-11	The Coca-Cola Company	High-potency sweetener composition with phytoestrogen and compositions sweetened therewith
US8017168B2 (en)	2006-11-02	2011-09-13	The Coca-Cola Company	High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0101755A1 (de) *	1982-08-31	1984-03-07	Chimicasa Gmbh	Wassarlösliche, durch Pressen verfestigte Süssungstablette
AT394854B (de) *	1986-06-12	1992-07-10	Biochemie Gmbh	Verfahren zur herstellung von n-l-alpha-aspartyl-l-phenylalanin(nieder)alkylestern
JPH0832719B2 (ja) *	1986-12-19	1996-03-29	三井東圧化学株式会社	吸湿性の小さいα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造法
DE68925450T2 (de) *	1988-10-03	1996-09-19	Ajinomoto Kk	Verfahren zur Herstellung von trockenen IB Kristallen des alpha-L-Aspartyl-L-phenylalaninmethylesters, die eine verbesserte Löslichkeit besitzen
JP2946853B2 (ja) *	1991-05-09	1999-09-06	味の素株式会社	アスパルテームの晶析法
JP2970107B2 (ja) *	1991-05-23	1999-11-02	味の素株式会社	α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステルの製造方法
ATE145650T1 (de) *	1991-07-19	1996-12-15	Holland Sweetener Co	Verfahren zur kristallisation von alpha-l- aspartyl-l-phenylalaninmethylester
RU2092490C1 (ru) *	1991-07-19	1997-10-10	Тосох корпорейшн	Способ кристаллизации метилового эфира альфа-l-аспартил-l-фенилаланина
BR9205373A (pt) *	1991-07-19	1994-03-08	Tosoh Corp	Processo para cristalizacao de ester alfa-i-aspartil-i-fenilalanina metilico
ATE145920T1 (de) *	1991-07-19	1996-12-15	Holland Sweetener Co	Verfahren zur kristallisation von alpha-l- aspartyl-l-phenylalaninmethylester
JP3094684B2 (ja) *	1992-09-04	2000-10-03	味の素株式会社	ジペプチド甘味料顆粒の製造法
RU2083585C1 (ru) *	1994-12-13	1997-07-10	Волгоградское акционерное общество открытого типа "Химпром"	Способ получения метилового эфира n-бензилоксикарбонил-l-аспартил-l-фенилаланина

1995
- 1995-06-30 AT AT95201794T patent/ATE214397T1/de active
- 1995-06-30 DE DE69525839T patent/DE69525839T2/de not_active Expired - Fee Related
- 1995-06-30 EP EP95201794A patent/EP0751146B1/de not_active Expired - Lifetime
1996
- 1996-06-03 TW TW085106688A patent/TW323270B/zh active
- 1996-06-28 US US08/672,924 patent/US5733883A/en not_active Expired - Fee Related
- 1996-06-28 RU RU96112765/04A patent/RU2155771C2/ru not_active IP Right Cessation
- 1996-06-28 CA CA002180207A patent/CA2180207A1/en not_active Abandoned
- 1996-06-28 CN CNB961088621A patent/CN1135237C/zh not_active Expired - Fee Related
- 1996-06-29 KR KR1019960027004A patent/KR100426247B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69525839D1 (de)	2002-04-18
RU2155771C2 (ru)	2000-09-10
KR970001370A (ko)	1997-01-24
CN1143649A (zh)	1997-02-26
KR100426247B1 (ko)	2004-06-30
CA2180207A1 (en)	1996-12-31
DE69525839T2 (de)	2002-10-31
TW323270B (de)	1997-12-21
US5733883A (en)	1998-03-31
EP0751146A1 (de)	1997-01-02
EP0751146B1 (de)	2002-03-13
CN1135237C (zh)	2004-01-21

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