ATE145650T1 - Verfahren zur kristallisation von alpha-l- aspartyl-l-phenylalaninmethylester - Google Patents

Verfahren zur kristallisation von alpha-l- aspartyl-l-phenylalaninmethylester

Info

Publication number: ATE145650T1
Authority: AT; Austria
Prior art keywords: aspartyl; methyl ester; phenylalanine methyl; apm; crystallizing
Prior art date: 1991-07-19

Application number

AT92202213T

Other languages

English (en)

Inventor

Kengo Okajima

Winfried Johannes Wout Vermijs

Tsuguo Murakami

Hidetaka Egashira

Yukio Takeshima

Original Assignee

Holland Sweetener Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-07-19

Filing date

1992-07-17

Publication date

1996-12-15

1992-07-17 Application filed by Holland Sweetener Co filed Critical Holland Sweetener Co

1996-12-15 Application granted granted Critical

1996-12-15 Publication of ATE145650T1 publication Critical patent/ATE145650T1/de

Links

IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 title abstract 6
238000000034 method Methods 0.000 title abstract 4
238000001816 cooling Methods 0.000 abstract 2
239000013078 crystal Substances 0.000 abstract 2
238000001914 filtration Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT92202213T 1991-07-19 1992-07-17 Verfahren zur kristallisation von alpha-l- aspartyl-l-phenylalaninmethylester ATE145650T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP20370391		1991-07-19

Publications (1)

Publication Number	Publication Date
ATE145650T1 true ATE145650T1 (de)	1996-12-15

Family

ID=16478456

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92202213T ATE145650T1 (de)	1991-07-19	1992-07-17	Verfahren zur kristallisation von alpha-l- aspartyl-l-phenylalaninmethylester

Country Status (8)

Country	Link
EP (1)	EP0523813B1 (de)
KR (1)	KR930702384A (de)
AT (1)	ATE145650T1 (de)
CA (1)	CA2089359A1 (de)
DE (1)	DE69215444T2 (de)
ES (1)	ES2096708T3 (de)
MX (1)	MX9204243A (de)
WO (1)	WO1993002100A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE201694T1 (de) *	1994-12-22	2001-06-15	Holland Sweetener Co	Crystallisierung vom alpha-l-aspartyl-l- phenylalanylmethylester aus wässrigen lösungen
EP0751146B1 (de) *	1995-06-30	2002-03-13	Holland Sweetener Company V.o.F.	Kristallisierung von alpha-L-aspartyl-L-phenylalaninmethylester aus wässerigen Lösungen
KR20000009984A (ko) *	1998-07-29	2000-02-15	고두모	알파-엘-아스파틸-엘-페닐알라닌 메틸 에스테르의 결정화 방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2017137A1 (en) *	1989-05-22	1990-11-22	Shigeaki Irino	Method for crystallizing &-l-aspartyl-l-phenylalanine methyl ester
JPH0327398A (ja) *	1989-06-26	1991-02-05	Mitsui Toatsu Chem Inc	α―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステルの晶析方法

1992
- 1992-07-17 ES ES92202213T patent/ES2096708T3/es not_active Expired - Lifetime
- 1992-07-17 EP EP92202213A patent/EP0523813B1/de not_active Expired - Lifetime
- 1992-07-17 AT AT92202213T patent/ATE145650T1/de not_active IP Right Cessation
- 1992-07-17 DE DE69215444T patent/DE69215444T2/de not_active Expired - Fee Related
- 1992-07-20 WO PCT/JP1992/000923 patent/WO1993002100A1/en not_active Ceased
- 1992-07-20 CA CA002089359A patent/CA2089359A1/en not_active Abandoned
- 1992-07-20 MX MX9204243A patent/MX9204243A/es not_active IP Right Cessation
- 1992-07-20 KR KR1019930700746A patent/KR930702384A/ko not_active Withdrawn

Also Published As

Publication number	Publication date
MX9204243A (es)	1994-02-28
ES2096708T3 (es)	1997-03-16
KR930702384A (ko)	1993-09-08
WO1993002100A1 (en)	1993-02-04
CA2089359A1 (en)	1993-01-20
EP0523813B1 (de)	1996-11-27
DE69215444D1 (de)	1997-01-09
EP0523813A1 (de)	1993-01-20
DE69215444T2 (de)	1997-06-12

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Legal Events

Date	Code	Title	Description
1997-06-15	UEP	Publication of translation of european patent specification
1999-04-15	REN	Ceased due to non-payment of the annual fee