ATE214614T1 - Ein wachstumshormon und isoleucin enthaltende pharmazeutische formulierung - Google Patents

Ein wachstumshormon und isoleucin enthaltende pharmazeutische formulierung

Info

Publication number: ATE214614T1
Authority: AT; Austria
Prior art keywords: isoleucine; growth hormone; pharmaceutical formulation; formulation containing; containing growth
Prior art date: 1994-10-13

Application number

AT95933346T

Other languages

English (en)

Inventor

Hans Holmegaard Sorensen

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-13

Filing date

1995-10-13

Publication date

2002-04-15

1995-10-13 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

2002-04-15 Application granted granted Critical

2002-04-15 Publication of ATE214614T1 publication Critical patent/ATE214614T1/de

Links

102000018997 Growth Hormone Human genes 0.000 title abstract 2
108010051696 Growth Hormone Proteins 0.000 title abstract 2
AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 title abstract 2
239000000122 growth hormone Substances 0.000 title abstract 2
229960000310 isoleucine Drugs 0.000 title abstract 2
AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
239000000654 additive Substances 0.000 abstract 1
230000000996 additive effect Effects 0.000 abstract 1
239000006172 buffering agent Substances 0.000 abstract 1
238000003776 cleavage reaction Methods 0.000 abstract 1
230000006240 deamidation Effects 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000003647 oxidation Effects 0.000 abstract 1
238000007254 oxidation reaction Methods 0.000 abstract 1
230000007017 scission Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Endocrinology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT95933346T 1994-10-13 1995-10-13 Ein wachstumshormon und isoleucin enthaltende pharmazeutische formulierung ATE214614T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/322,837 US5631225A (en)	1994-10-13	1994-10-13	Pharmaceutical formulation
PCT/DK1995/000409 WO1996011703A1 (en)	1994-10-13	1995-10-13	A pharmaceutical formulation comprising a growth hormone and isoleucine

Publications (1)

Publication Number	Publication Date
ATE214614T1 true ATE214614T1 (de)	2002-04-15

Family

ID=23256650

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95933346T ATE214614T1 (de)	1994-10-13	1995-10-13	Ein wachstumshormon und isoleucin enthaltende pharmazeutische formulierung

Country Status (11)

Country	Link
US (1)	US5631225A (de)
EP (1)	EP0785796B1 (de)
JP (1)	JP4064454B2 (de)
KR (1)	KR970706839A (de)
AT (1)	ATE214614T1 (de)
AU (1)	AU699345B2 (de)
DE (1)	DE69525955T2 (de)
ES (1)	ES2173197T3 (de)
IL (1)	IL115590A (de)
WO (1)	WO1996011703A1 (de)
ZA (1)	ZA958604B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6022858A (en) *	1991-12-20	2000-02-08	Novo Nordisk A/S	Pharmaceutical formulation of human-growth hormone pretreated with zinc salt
US6582728B1 (en)	1992-07-08	2003-06-24	Inhale Therapeutic Systems, Inc.	Spray drying of macromolecules to produce inhaleable dry powders
US6673335B1 (en)	1992-07-08	2004-01-06	Nektar Therapeutics	Compositions and methods for the pulmonary delivery of aerosolized medicaments
DE69332105T2 (de) *	1992-09-29	2003-03-06	Inhale Therapeutic Systems, San Carlos	Pulmonale abgabe von aktiven fragmenten des parathormons
US20030113273A1 (en) *	1996-06-17	2003-06-19	Patton John S.	Methods and compositions for pulmonary delivery of insulin
EP0748213B1 (de)	1994-03-07	2004-04-14	Nektar Therapeutics	Verfahren und mittel zur verabreichung von insulin über die lunge
WO1995031479A1 (en) *	1994-05-18	1995-11-23	Inhale Therapeutic Systems, Inc.	Methods and compositions for the dry powder formulation of interferons
US6290991B1 (en) *	1994-12-02	2001-09-18	Quandrant Holdings Cambridge Limited	Solid dose delivery vehicle and methods of making same
US20030035778A1 (en) *	1997-07-14	2003-02-20	Robert Platz	Methods and compositions for the dry powder formulation of interferon
US6565885B1 (en)	1997-09-29	2003-05-20	Inhale Therapeutic Systems, Inc.	Methods of spray drying pharmaceutical compositions
US6309623B1 (en) *	1997-09-29	2001-10-30	Inhale Therapeutic Systems, Inc.	Stabilized preparations for use in metered dose inhalers
US20060165606A1 (en)	1997-09-29	2006-07-27	Nektar Therapeutics	Pulmonary delivery particles comprising water insoluble or crystalline active agents
HUP0204116A3 (en) *	1999-11-09	2005-07-28	Rappold Hoerbrand Gudrun	Methods of treating short stature disorders related to the short stature homeobox-containing (shox) gene
US8404217B2 (en)	2000-05-10	2013-03-26	Novartis Ag	Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
US7871598B1 (en)	2000-05-10	2011-01-18	Novartis Ag	Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
WO2001085136A2 (en)	2000-05-10	2001-11-15	Alliance Pharmaceutical Corporation	Phospholipid-based powders for drug delivery
KR20030038690A (ko) *	2000-08-07	2003-05-16	인헤일 테라퓨틱 시스템즈 인크.	응집이 최소화된, 흡입성 분무 건조 4-나선 다발 단백질분말
JP2005514393A (ja)	2001-12-19	2005-05-19	ネクターセラピューティクス	アミノグリコシドの肺への供給
WO2009002521A2 (en) *	2007-06-25	2008-12-31	Amgen Inc.	Compositions of specific binding agents to hepatocyte growth factor

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4056520A (en) *	1972-03-31	1977-11-01	Research Corporation	Clinically active bovine growth hormone fraction
US4563352A (en) *	1982-10-04	1986-01-07	The Salk Institute For Biological Studies	Human pancreatic GRF
JPS5967228A (ja) *	1982-10-07	1984-04-16	Green Cross Corp:The	寒冷不溶性グロブリンの凍結乾燥方法
US4917685A (en) *	1986-05-16	1990-04-17	International Minerals & Chem. Corp.	Delivery device for the administration of stabilized growth promoting hormones
EP0303746B2 (de) *	1987-08-21	1998-12-02	Mallinckrodt Group Inc.	Stabilisierung von Wachstumshormonen
US5096885A (en) *	1988-04-15	1992-03-17	Genentech, Inc.	Human growth hormone formulation
EP0374120A3 (de) *	1988-12-13	1991-07-31	Monsanto Company	Zusammensetzung mit kontrollierter Wirkstoffabgabe von Polypeptiden
US5137872A (en) *	1989-09-18	1992-08-11	Pitman-Moore, Inc.	Growth hormone-releasing factor analogs
DE69233704T2 (de) *	1991-12-20	2008-05-21	Novo Nordisk A/S	Stabilisierte pharmazeutische Formulierung, umfassend Wachstumshormon und Histidin
DK204791D0 (da) *	1991-12-20	1991-12-20	Novo Nordisk As	Hidtil ukendt farmaceutisk praeparat
SE9201073D0 (sv) *	1992-04-03	1992-04-03	Kabi Pharmacia Ab	Protein formulation
EP0652766B2 (de) *	1992-07-31	2008-03-19	Genentech, Inc.	Wässrige arzneizusammensetzung, welche das menschliche wachstumshormon enthält

1994
- 1994-10-13 US US08/322,837 patent/US5631225A/en not_active Expired - Lifetime
1995
- 1995-10-12 IL IL11559095A patent/IL115590A/xx not_active IP Right Cessation
- 1995-10-12 ZA ZA958604A patent/ZA958604B/xx unknown
- 1995-10-13 AT AT95933346T patent/ATE214614T1/de not_active IP Right Cessation
- 1995-10-13 DE DE69525955T patent/DE69525955T2/de not_active Expired - Lifetime
- 1995-10-13 EP EP95933346A patent/EP0785796B1/de not_active Expired - Lifetime
- 1995-10-13 AU AU36053/95A patent/AU699345B2/en not_active Ceased
- 1995-10-13 JP JP51286296A patent/JP4064454B2/ja not_active Expired - Fee Related
- 1995-10-13 KR KR1019970702430A patent/KR970706839A/ko not_active Abandoned
- 1995-10-13 WO PCT/DK1995/000409 patent/WO1996011703A1/en not_active Ceased
- 1995-10-13 ES ES95933346T patent/ES2173197T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0785796A1 (de)	1997-07-30
EP0785796B1 (de)	2002-03-20
KR970706839A (ko)	1997-12-01
IL115590A0 (en)	1996-01-19
JPH10507182A (ja)	1998-07-14
ZA958604B (en)	1996-05-14
DE69525955D1 (de)	2002-04-25
US5631225A (en)	1997-05-20
WO1996011703A1 (en)	1996-04-25
JP4064454B2 (ja)	2008-03-19
IL115590A (en)	2000-02-29
AU3605395A (en)	1996-05-06
AU699345B2 (en)	1998-12-03
DE69525955T2 (de)	2002-11-07
ES2173197T3 (es)	2002-10-16

Legal Events

Date	Code	Title	Description
2002-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE214614T1 (de)	2002-04-15	Ein wachstumshormon und isoleucin enthaltende pharmazeutische formulierung
ATE177645T1 (de)	1999-04-15	Stabilisierte pharmazeutische formulierung, die wachstumshormon und asparagin enthält
KR970706840A (ko)	1997-12-01	성장호르몬 및 발린으로 이루어진 약학적 조성물(a pharmaceutical formulation comprising a growth hormone and valine)
AU610636B2 (en)	1991-05-23	Stabilised human protein preparations
CA2125855A1 (en)	1993-07-08	A stabilized pharmaceutical formulation comprising growth hormone and histidine
AU694229B2 (en)	1998-07-16	A pharmaceutical preparation comprising glucagon
DK1086706T3 (da)	2004-03-08	Stabiliserede sammensætninger indeholdende nootropiske lægemidler
BG106046A (en)	2002-05-31	Pharmaceutical compositions of ertythropoietin
DK1014948T3 (da)	2007-09-24	Lyofiliseret farmaceutisk præparat som er beregnet til at efterligne et lægemiddel på basis af proteiner eller polypeptider
DE69525757D1 (de)	2002-04-11	Ein wachstumshormon und leucin enthaltende pharmazeutische formulierung
HUP9802286A2 (hu)	1999-02-01	Stabilizált gyógyszerkészítmény amely valamely növekedési hormont és legalább egy bázikus aminosavmaradékot és legalább egy savas aminosav maradékot tartalmazó peptidet foglal magában
DK0626173T3 (da)	1997-05-12	Aerosolpræparat indeholdende fusafungin
IT8720920A0 (it)	1987-06-16	Banco per l'esposizione e la conservazione di prodotti alimentari, in particolare diprodotti alimentari o di altri prodotti chimici e farmaceutici deperibili, provvisto di ripiani amovibili.
CO4230067A1 (es)	1995-10-19	Composicion cosmetica para el cuidado de la piel
ECSP992952A (es)	1999-07-08	Preparados efervescentes (caso lea 32842)