ES2173197T3 - Una formula farmaceutica que contiene hormona de crecimiento e isoleucina. - Google Patents

Una formula farmaceutica que contiene hormona de crecimiento e isoleucina.

Info

Publication number
ES2173197T3
ES2173197T3 ES95933346T ES95933346T ES2173197T3 ES 2173197 T3 ES2173197 T3 ES 2173197T3 ES 95933346 T ES95933346 T ES 95933346T ES 95933346 T ES95933346 T ES 95933346T ES 2173197 T3 ES2173197 T3 ES 2173197T3
Authority
ES
Spain
Prior art keywords
isoleucine
growth hormone
formula containing
containing growth
pharmaceutical formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95933346T
Other languages
English (en)
Inventor
Hans Sorensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Application granted granted Critical
Publication of ES2173197T3 publication Critical patent/ES2173197T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

FORMULACION FARMACEUTICA QUE INCLUYE UNA HORMONA DE CRECIMIENTO E ISOLEUCINA COMO SUSTANCIA ADITIVA O AMORTIGUANTE QUE MUESTRA UNA ESTABILIDAD MUY ALTA CONTRA LA DEAMIDACION, OXIDACION Y DISOCIACION DE ENLACES PEPTIDOS. LA ESTABILIDAD DEL PRODUCTO PERMITE EL ALMACENAMIENTO Y EMBALAJE DEL MISMO EN UN ESTADO LIOFILIZADO O EN LA FORMA DE UNA FORMULACION DISUELTA O REDISUELTA A TEMPERATURA AMBIENTE.
ES95933346T 1994-10-13 1995-10-13 Una formula farmaceutica que contiene hormona de crecimiento e isoleucina. Expired - Lifetime ES2173197T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/322,837 US5631225A (en) 1994-10-13 1994-10-13 Pharmaceutical formulation

Publications (1)

Publication Number Publication Date
ES2173197T3 true ES2173197T3 (es) 2002-10-16

Family

ID=23256650

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95933346T Expired - Lifetime ES2173197T3 (es) 1994-10-13 1995-10-13 Una formula farmaceutica que contiene hormona de crecimiento e isoleucina.

Country Status (11)

Country Link
US (1) US5631225A (es)
EP (1) EP0785796B1 (es)
JP (1) JP4064454B2 (es)
KR (1) KR970706839A (es)
AT (1) ATE214614T1 (es)
AU (1) AU699345B2 (es)
DE (1) DE69525955T2 (es)
ES (1) ES2173197T3 (es)
IL (1) IL115590A (es)
WO (1) WO1996011703A1 (es)
ZA (1) ZA958604B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6022858A (en) * 1991-12-20 2000-02-08 Novo Nordisk A/S Pharmaceutical formulation of human-growth hormone pretreated with zinc salt
US6582728B1 (en) * 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
US6673335B1 (en) 1992-07-08 2004-01-06 Nektar Therapeutics Compositions and methods for the pulmonary delivery of aerosolized medicaments
ES2179831T3 (es) * 1992-09-29 2003-02-01 Inhale Therapeutic Syst Liberacion en los pulmones de fragmentos activos de hormona paratiroidiana.
NZ281112A (en) 1994-03-07 1998-04-27 Inhale Therapeutic Syst Powdered insulin delivered as an aerosol
US20030113273A1 (en) * 1996-06-17 2003-06-19 Patton John S. Methods and compositions for pulmonary delivery of insulin
ES2245780T3 (es) * 1994-05-18 2006-01-16 Nektar Therapeutics Metodos y composiciones para la formulacion de interferones como un polvo seco.
US6290991B1 (en) * 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
US20030035778A1 (en) * 1997-07-14 2003-02-20 Robert Platz Methods and compositions for the dry powder formulation of interferon
US6309623B1 (en) * 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
AU1292201A (en) * 1999-11-09 2001-06-06 Gudrun Rappold-Hoerbrand Methods of treating short stature disorders related to the short stature homeobox-containing (shox) gene
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
ES2525087T5 (es) 2000-05-10 2018-06-28 Novartis Ag Polvos basados en fosfolípidos para administración de fármacos
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
TWI283182B (en) * 2000-08-07 2007-07-01 Nektar Therapeutics Inhalable spray dried 4-helix bundle protein powders having minimized aggregation
JP2005514393A (ja) 2001-12-19 2005-05-19 ネクター セラピューティクス アミノグリコシドの肺への供給
EP2170268A2 (en) * 2007-06-25 2010-04-07 Amgen, Inc. Compositions of specific binding agents to hepatocyte growth factor

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4056520A (en) * 1972-03-31 1977-11-01 Research Corporation Clinically active bovine growth hormone fraction
US4563352A (en) * 1982-10-04 1986-01-07 The Salk Institute For Biological Studies Human pancreatic GRF
JPS5967228A (ja) * 1982-10-07 1984-04-16 Green Cross Corp:The 寒冷不溶性グロブリンの凍結乾燥方法
US4917685A (en) * 1986-05-16 1990-04-17 International Minerals & Chem. Corp. Delivery device for the administration of stabilized growth promoting hormones
EP0303746B2 (en) * 1987-08-21 1998-12-02 Mallinckrodt Group Inc. Stabilization of growth promoting hormones
US5096885A (en) * 1988-04-15 1992-03-17 Genentech, Inc. Human growth hormone formulation
EP0374120A3 (en) * 1988-12-13 1991-07-31 Monsanto Company Comosition for controlled release of polypeptides
US5137872A (en) * 1989-09-18 1992-08-11 Pitman-Moore, Inc. Growth hormone-releasing factor analogs
DK0618807T3 (da) * 1991-12-20 2003-03-03 Novo Nordisk As Stabiliseret farmaceutisk formulering omfattende human væksthormon og histidin
DK204791D0 (da) * 1991-12-20 1991-12-20 Novo Nordisk As Hidtil ukendt farmaceutisk praeparat
SE9201073D0 (sv) * 1992-04-03 1992-04-03 Kabi Pharmacia Ab Protein formulation
ES2153385T5 (es) * 1992-07-31 2008-09-01 Genentech, Inc. Composicion acuosa a base de hormona del crecimiento humana.

Also Published As

Publication number Publication date
DE69525955T2 (de) 2002-11-07
WO1996011703A1 (en) 1996-04-25
EP0785796A1 (en) 1997-07-30
AU699345B2 (en) 1998-12-03
AU3605395A (en) 1996-05-06
DE69525955D1 (de) 2002-04-25
ZA958604B (en) 1996-05-14
IL115590A (en) 2000-02-29
IL115590A0 (en) 1996-01-19
US5631225A (en) 1997-05-20
ATE214614T1 (de) 2002-04-15
JP4064454B2 (ja) 2008-03-19
JPH10507182A (ja) 1998-07-14
EP0785796B1 (en) 2002-03-20
KR970706839A (ko) 1997-12-01

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