ATE214704T1 - 5h-thiazolo(3,2-a)pyrimidinderivate - Google Patents

5h-thiazolo(3,2-a)pyrimidinderivate

Info

Publication number: ATE214704T1
Authority: AT; Austria
Prior art keywords: thiazolo; pyrimidine derivatives; pyrimidine; derivatives
Prior art date: 1997-07-18

Application number

AT98112915T

Other languages

English (en)

Inventor

Geo Adam

Sabine Kolczewski

Vincent Mutel

Juergen Wichmann

Thomas Johannes Woltering

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-18

Filing date

1998-07-11

Publication date

2002-04-15

1998-07-11 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2002-04-15 Application granted granted Critical

2002-04-15 Publication of ATE214704T1 publication Critical patent/ATE214704T1/de

Links

CDUYCVWBLGEWSY-UHFFFAOYSA-N 5h-[1,3]thiazolo[3,2-a]pyrimidine Chemical class C1C=CN=C2SC=CN12 CDUYCVWBLGEWSY-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
- C07D239/40—One sulfur atom as doubly bound sulfur atom or as unsubstituted mercapto radical

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Addiction (AREA)
Ophthalmology & Optometry (AREA)
Anesthesiology (AREA)
Rheumatology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Otolaryngology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT98112915T 1997-07-18 1998-07-11 5h-thiazolo(3,2-a)pyrimidinderivate ATE214704T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP97112324		1997-07-18

Publications (1)

Publication Number	Publication Date
ATE214704T1 true ATE214704T1 (de)	2002-04-15

Family

ID=8227080

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98112915T ATE214704T1 (de)	1997-07-18	1998-07-11	5h-thiazolo(3,2-a)pyrimidinderivate

Country Status (32)

Country	Link
US (1)	US5958931A (de)
EP (1)	EP0891978B1 (de)
JP (1)	JP3100573B2 (de)
KR (1)	KR100296837B1 (de)
CN (1)	CN1102596C (de)
AR (1)	AR016129A1 (de)
AT (1)	ATE214704T1 (de)
AU (1)	AU738207B2 (de)
BR (1)	BR9802482A (de)
CA (1)	CA2243234C (de)
CO (1)	CO5210884A1 (de)
CZ (1)	CZ288944B6 (de)
DE (1)	DE69804273T2 (de)
DK (1)	DK0891978T3 (de)
ES (1)	ES2172840T3 (de)
HR (1)	HRP980398B1 (de)
HU (1)	HUP9801587A3 (de)
ID (1)	ID21824A (de)
IL (1)	IL125358A (de)
MA (1)	MA26520A1 (de)
NO (1)	NO310512B1 (de)
NZ (1)	NZ330988A (de)
PE (1)	PE97499A1 (de)
PL (1)	PL190218B1 (de)
PT (1)	PT891978E (de)
RU (1)	RU2197493C2 (de)
SI (1)	SI0891978T1 (de)
TR (1)	TR199801367A3 (de)
TW (1)	TW523518B (de)
UY (1)	UY25095A1 (de)
YU (1)	YU29798A (de)
ZA (1)	ZA986250B (de)

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CA2672805A1 (en) *	2001-01-31	2002-08-08	H. Lundbeck A/S	Pyrimidine derivatives
JPWO2002102807A1 (ja) *	2001-06-14	2004-09-30	萬有製薬株式会社	新規イソキサゾロピリドン誘導体及びその用途
US7329662B2 (en) *	2003-10-03	2008-02-12	Hoffmann-La Roche Inc.	Pyrazolo-pyridine
KR100847160B1 (ko) *	2004-06-21	2008-07-17	에프. 호프만-라 로슈 아게	피라졸로 피리미딘 유도체
WO2005123738A1 (en) *	2004-06-21	2005-12-29	F.Hoffmann-La Roche Ag	Pyrrazolo-pyrimidine derivatives
CN101115755B (zh)	2005-02-11	2013-01-16	弗·哈夫曼-拉罗切有限公司	作为mglur2拮抗剂的吡唑并-嘧啶衍生物
RU2412943C2 (ru)	2005-03-23	2011-02-27	Ф. Хоффманн-Ля Рош Аг	ПРОИЗВОДНЫЕ АЦЕТИЛЕНИЛ-ПИРАЗОЛО-ПИРИМИДИНА В КАЧЕСТВЕ АНТАГОНИСТОВ mGluR2
UA90707C2 (en) *	2005-04-06	2010-05-25	Астразенека Аб	Novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives
AR053347A1 (es) *	2005-04-06	2007-05-02	Astrazeneca Ab	Derivados de [1,3]tiazolo[4,5-d]pirimidin-2(3h)-ona 5,7-sustituidos
ES2340321T3 (es)	2005-09-27	2010-06-01	F.Hoffmann-La Roche Ag	Oxadiazolilpirazolo-pirimidinas, como antagonistas de mglur2.
TWI417095B (zh) *	2006-03-15	2013-12-01	Janssen Pharmaceuticals Inc	１，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途
TW200900065A (en)	2007-03-07	2009-01-01	Janssen Pharmaceutica Nv	3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) *	2007-03-07	2008-12-01	Janssen Pharmaceutica Nv	3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
KR20100065191A (ko)	2007-09-14	2010-06-15	오르토-맥닐-얀센 파마슈티칼스 인코포레이티드	１,３-이치환된 ４-(아릴-ｘ-페닐)-１ｈ-피리딘-２-온
CA2696948C (en) *	2007-09-14	2013-04-30	Jose Maria Cid-Nunez	1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h,1'h-[1,4']bipyridinyl-2'-ones
KR20100080597A (ko) *	2007-09-14	2010-07-09	오르토-맥닐-얀센 파마슈티칼스 인코포레이티드	１,３-이치환된-４-페닐-1ｈ-피리딘-2-온
EP2220083B1 (de) *	2007-11-14	2017-07-19	Janssen Pharmaceuticals, Inc.	Imidazo[1,2-a]-pyridin-derivate und ihre verwendung als positive allosterische modulatoren von mglur2-rezeptoren
CA2735764C (en)	2008-09-02	2016-06-14	Ortho-Mcneil-Janssen Pharmaceuticals, Inc.	3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
AU2009304293B2 (en)	2008-10-16	2012-04-26	Addex Pharma S.A.	Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
BRPI0921333A2 (pt)	2008-11-28	2015-12-29	Addex Pharmaceuticals Sa	derivados de indol e benzoxazina como moduladores de receptores de glutamato metabotrópicos
CN101503414B (zh) *	2009-03-04	2013-10-30	沈阳药科大学	噻唑并[3,2-b]-1,2,4-三嗪衍生物及其应用
MY153913A (en)	2009-05-12	2015-04-15	Janssen Pharmaceuticals Inc	7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
NZ596078A (en)	2009-05-12	2013-06-28	Janssen Pharmaceuticals Inc	1,2,4-TRIAZOLO [4,3-a] PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS
EA020671B1 (ru)	2009-05-12	2014-12-30	Янссен Фармасьютикалз, Инк.	ПРОИЗВОДНЫЕ 1,2,4-ТРИАЗОЛО[4,3-a]ПИРИДИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ПОЛОЖИТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2
CA2815002C (en)	2010-11-08	2019-10-22	Janssen Pharmaceuticals, Inc.	1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
CN103298810B (zh)	2010-11-08	2016-03-16	杨森制药公司	1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
EP2643320B1 (de)	2010-11-08	2015-03-04	Janssen Pharmaceuticals, Inc.	1,2,4-triazolo[4,3-a]pyridinderivate und ihre verwendung als positiv allosterische modulatoren des mglur2 receptors
JO3368B1 (ar)	2013-06-04	2019-03-13	Janssen Pharmaceutica Nv	مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar)	2013-09-06	2019-03-13	Janssen Pharmaceutica Nv	مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
BR112016007563B1 (pt)	2013-10-11	2022-12-20	F. Hoffmann-La Roche Ag	Tiazolopirimidinonas, seus usos, e composição farmacêutica
KR102414246B1 (ko)	2014-01-21	2022-06-27	얀센 파마슈티카 엔.브이.	대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도
LT3431106T (lt)	2014-01-21	2021-02-10	Janssen Pharmaceutica Nv	Deriniai, apimantys 2 potipio metabotropinio glutamaterginio receptoriaus teigiamus alosterinius moduliatorius arba ortosterinius agonistus, ir jų panaudojimas
MX2019011785A (es) *	2017-03-31	2019-11-18	Basf Se	Proceso para preparar compuestos de 2,3-dihidrotiazolo[3,2-a]pirim idin-4-io quirales.

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1998
- 1998-07-11 EP EP98112915A patent/EP0891978B1/de not_active Expired - Lifetime
- 1998-07-11 AT AT98112915T patent/ATE214704T1/de not_active IP Right Cessation
- 1998-07-11 DK DK98112915T patent/DK0891978T3/da active
- 1998-07-11 PT PT98112915T patent/PT891978E/pt unknown
- 1998-07-11 SI SI9830130T patent/SI0891978T1/xx unknown
- 1998-07-11 DE DE69804273T patent/DE69804273T2/de not_active Expired - Fee Related
- 1998-07-11 ES ES98112915T patent/ES2172840T3/es not_active Expired - Lifetime
- 1998-07-14 NO NO19983244A patent/NO310512B1/no not_active IP Right Cessation
- 1998-07-14 MA MA25167A patent/MA26520A1/fr unknown
- 1998-07-14 ID IDP981000A patent/ID21824A/id unknown
- 1998-07-14 ZA ZA986250A patent/ZA986250B/xx unknown
- 1998-07-14 US US09/115,191 patent/US5958931A/en not_active Expired - Fee Related
- 1998-07-14 TR TR1998/01367A patent/TR199801367A3/tr unknown
- 1998-07-14 NZ NZ330988A patent/NZ330988A/xx unknown
- 1998-07-15 JP JP10199363A patent/JP3100573B2/ja not_active Expired - Fee Related
- 1998-07-15 YU YU29798A patent/YU29798A/sh unknown
- 1998-07-15 CA CA002243234A patent/CA2243234C/en not_active Expired - Fee Related
- 1998-07-15 HU HU9801587A patent/HUP9801587A3/hu unknown
- 1998-07-15 IL IL12535898A patent/IL125358A/en not_active IP Right Cessation
- 1998-07-15 PE PE1998000625A patent/PE97499A1/es not_active Application Discontinuation
- 1998-07-15 CN CN98116063A patent/CN1102596C/zh not_active Expired - Fee Related
- 1998-07-16 PL PL98327532A patent/PL190218B1/pl unknown
- 1998-07-16 AR ARP980103469A patent/AR016129A1/es not_active Application Discontinuation
- 1998-07-16 KR KR1019980028788A patent/KR100296837B1/ko not_active Expired - Fee Related
- 1998-07-16 UY UY25095A patent/UY25095A1/es unknown
- 1998-07-16 HR HR980398A patent/HRP980398B1/xx not_active IP Right Cessation
- 1998-07-16 CZ CZ19982239A patent/CZ288944B6/cs not_active IP Right Cessation
- 1998-07-16 CO CO98040510A patent/CO5210884A1/es not_active Application Discontinuation
- 1998-07-16 BR BR9802482-5A patent/BR9802482A/pt not_active Application Discontinuation
- 1998-07-17 AU AU77302/98A patent/AU738207B2/en not_active Ceased
- 1998-07-17 RU RU98114683/04A patent/RU2197493C2/ru not_active IP Right Cessation
- 1998-07-21 TW TW087111834A patent/TW523518B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
ZA986250B (en)	1999-01-22
CZ288944B6 (cs)	2001-10-17
HUP9801587A2 (hu)	1999-11-29
MA26520A1 (fr)	2004-12-20
DK0891978T3 (da)	2002-07-01
TW523518B (en)	2003-03-11
PT891978E (pt)	2002-07-31
HK1018439A1 (en)	1999-12-24
EP0891978A2 (de)	1999-01-20
ES2172840T3 (es)	2002-10-01
JP3100573B2 (ja)	2000-10-16
RU2197493C2 (ru)	2003-01-27
PE97499A1 (es)	1999-10-12
TR199801367A2 (xx)	1999-02-22
PL190218B1 (pl)	2005-11-30
NO983244L (no)	1999-01-19
KR19990013919A (ko)	1999-02-25
NZ330988A (en)	1999-03-29
EP0891978A3 (de)	1999-02-03
AU738207B2 (en)	2001-09-13
ID21824A (id)	1999-07-29
YU29798A (sh)	2001-12-26
BR9802482A (pt)	2000-03-14
IL125358A0 (en)	1999-03-12
CA2243234C (en)	2007-09-18
CN1206010A (zh)	1999-01-27
NO983244D0 (no)	1998-07-14
NO310512B1 (no)	2001-07-16
AR016129A1 (es)	2001-06-20
CA2243234A1 (en)	1999-01-18
IL125358A (en)	2002-09-12
EP0891978B1 (de)	2002-03-20
HU9801587D0 (en)	1998-09-28
HRP980398B1 (en)	2002-06-30
HRP980398A2 (en)	1999-04-30
UY25095A1 (es)	2001-01-31
SI0891978T1 (en)	2002-06-30
AU7730298A (en)	1999-01-28
CO5210884A1 (es)	2002-10-30
CN1102596C (zh)	2003-03-05
US5958931A (en)	1999-09-28
DE69804273D1 (de)	2002-04-25
KR100296837B1 (ko)	2001-10-26
TR199801367A3 (tr)	1999-02-22
PL327532A1 (en)	1999-02-01
DE69804273T2 (de)	2002-10-31
CZ223998A3 (cs)	1999-02-17
HUP9801587A3 (en)	2001-09-28
JPH1171380A (ja)	1999-03-16

Legal Events

Date	Code	Title	Description
2002-09-15	UEP	Publication of translation of european patent specification
2009-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
TR199801367A3 (tr)	1999-02-22	5H- tiazol (3,2-a) pirimidin türevleri
ATE284404T1 (de)	2004-12-15	Pyrazolo(4,3-d)pyrimidinderivate
NO20006454D0 (no)	2000-12-18	Pyrrolo(2,3-d)pyrimidinforbindelser
NO20006453D0 (no)	2000-12-18	Pyrrolo(2,3-d)pyrimidinforbindelser
ATE261970T1 (de)	2004-04-15	Triazolo(4,5-d)pyrimidin-derivate
NO20022738D0 (no)	2002-06-07	Pyrrolo(2,3-d)pyrimidinforbindelser
ATE256123T1 (de)	2003-12-15	Pyrimidonderivate
ID19773A (id)	1998-07-30	Turunan-turunan 1,3,8-triaza-spiro (4,5) dekan-4-ona tersubtitusi-8
NO993658D0 (no)	1999-07-28	Sulfonylurea-derivater
ATE260243T1 (de)	2004-03-15	N-aroylphenylalaninderivate
DK1000048T3 (da)	2003-03-03	Substituerede 1,2,3,4-tetrahydronapthalenderivater
NL300150I1 (nl)	2004-08-02	4"-Gesubstitueerde 9-deoxo-9A-AZA-9A-homoërythromycine-A-derivaten.
TR199802520A3 (tr)	1999-06-21	1,3,8-Triaza-spiro(4,5) dekan -4-on türevleri.
ATE255098T1 (de)	2003-12-15	Substituierte chromanderivate
TR199800988A3 (tr)	1998-12-21	5' Deoksi-Sitidin türevleri.
BR9507666A (pt)	1997-09-23	Novos derivados de pirimidina
DE69716901D1 (de)	2002-12-12	2,4-diaminopyrimidin-derivate
ATE204279T1 (de)	2001-09-15	Diaza-spiro(3,5)nonan-derivate
FI972795A7 (fi)	1997-06-27	Pyrimidiinijohdannaisia
ATE292632T1 (de)	2005-04-15	Cis-disubstituierte aminocycloalkyl-pyrrolidin- derivate
NO995033D0 (no)	1999-10-15	6,7-disubstituerte-4-aminopyrido[2,3-D]pyrimidinforbindelser
NO995035D0 (no)	1999-10-15	5,6,7-trisubstituerte-4-aminopyrido[2,3-D]pyrimidinforbindelser
PT1010699E (pt)	2005-08-31	Derivados de 3-oxadiazolil-1,6-naftiridina-2(h)-ona substituido em 5
EP0954316A4 (de)	2002-02-13	Pyrimidine derivaten