ATE214803T1 - Stabilisierte standards und kalibratoren - Google Patents

Stabilisierte standards und kalibratoren

Info

Publication number: ATE214803T1
Authority: AT; Austria
Prior art keywords: calibrators; stabilized; standards; rapamycin; drug
Prior art date: 1995-06-07

Application number

AT96916602T

Other languages

English (en)

Inventor

Frank Grenier

Thomas F Holzman

Allan H Smith

Alan C Tsurutani

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-07

Filing date

1996-05-24

Publication date

2002-04-15

1996-05-24 Application filed by Abbott Lab filed Critical Abbott Lab

2002-04-15 Application granted granted Critical

2002-04-15 Publication of ATE214803T1 publication Critical patent/ATE214803T1/de

Links

QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 abstract 2
229940079593 drug Drugs 0.000 abstract 2
239000003814 drug Substances 0.000 abstract 2
ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 abstract 2
QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 abstract 2
229960002930 sirolimus Drugs 0.000 abstract 2
229960001967 tacrolimus Drugs 0.000 abstract 2
QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 abstract 2
102000014914 Carrier Proteins Human genes 0.000 abstract 1
108091008324 binding proteins Proteins 0.000 abstract 1
238000000338 in vitro Methods 0.000 abstract 1
239000011159 matrix material Substances 0.000 abstract 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9493—Immunosupressants
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general
- G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/101666—Particle count or volume standard or control [e.g., platelet count standards, etc.]
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/102499—Blood gas standard or control
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/106664—Blood serum or blood plasma standard or control
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/107497—Preparation composition [e.g., lysing or precipitation, etc.]
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/108331—Preservative, buffer, anticoagulant or diluent

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Food Science & Technology (AREA)
General Physics & Mathematics (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Pathology (AREA)
Cell Biology (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Peptides Or Proteins (AREA)
Investigating Or Analysing Biological Materials (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Polymerisation Methods In General (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT96916602T 1995-06-07 1996-05-24 Stabilisierte standards und kalibratoren ATE214803T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/474,589 US5635406A (en)	1995-06-07	1995-06-07	Stabilized standards and calibrators containing rapamycin and tacrolimus bound to anti-rapamycin and anti-tacrolimus antibodies
PCT/US1996/007617 WO1996041184A1 (en)	1995-06-07	1996-05-24	Stabilized standards and calibrators

Publications (1)

Publication Number	Publication Date
ATE214803T1 true ATE214803T1 (de)	2002-04-15

Family

ID=23884190

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96916602T ATE214803T1 (de)	1995-06-07	1996-05-24	Stabilisierte standards und kalibratoren

Country Status (8)

Country	Link
US (2)	US5635406A (de)
EP (1)	EP0832433B1 (de)
JP (1)	JP3863564B2 (de)
AT (1)	ATE214803T1 (de)
CA (1)	CA2219931C (de)
DE (1)	DE69619982T2 (de)
ES (1)	ES2176459T3 (de)
WO (1)	WO1996041184A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6709873B1 (en)	1997-04-09	2004-03-23	Isodiagnostika Inc.	Method for production of antibodies to specific sites of rapamycin
US7078495B1 (en) *	1999-08-03	2006-07-18	Dade Behring Inc.	Monoclonal antibodies to tacrolimus and immunoassay methods for tacrolimus
US6613083B2 (en) *	2001-05-02	2003-09-02	Eckhard Alt	Stent device and method
US20030054042A1 (en) *	2001-09-14	2003-03-20	Elaine Liversidge	Stabilization of chemical compounds using nanoparticulate formulations
US7186518B2 (en) *	2003-11-21	2007-03-06	Dade Behring Inc.	Method and composition useful for determining FK 506
US8022188B2 (en) *	2006-04-24	2011-09-20	Abbott Laboratories	Immunosuppressant binding antibodies and methods of obtaining and using same
US7642338B2 (en) *	2006-06-20	2010-01-05	Siemens Healthcare Diagnostics Inc.	Tacrolimus standard and methods of using same
US8329424B2 (en)	2010-06-25	2012-12-11	Siemens Healthcare Diagnostics	Reduction in false results in assay measurements
US8809003B2 (en)	2010-06-25	2014-08-19	Siemens Healthcare Diagnostics Inc.	Reduction in false results in assay measurements
US8563298B2 (en)	2010-10-22	2013-10-22	T2 Biosystems, Inc.	NMR systems and methods for the rapid detection of analytes
US8409807B2 (en)	2010-10-22	2013-04-02	T2 Biosystems, Inc.	NMR systems and methods for the rapid detection of analytes
EP3974831A1 (de)	2010-10-22	2022-03-30	T2 Biosystems, Inc.	Verfahren zum nachweis eines bakteriums in einer vollblutprobe
WO2013158281A1 (en)	2012-04-20	2013-10-24	T2 Biosystems, Inc.	Compositions and methods for detection of candida species
GB201309376D0 (en) *	2013-05-24	2013-07-10	Chronos Therapeutics Ltd	Medical methods and compounds for medical use
US11519016B2 (en)	2016-01-21	2022-12-06	T2 Biosystems, Inc.	NMR methods and systems for the rapid detection of bacteria
CN110849694B (zh) *	2019-12-02	2022-03-18	北京丹大生物技术有限公司	一种他克莫司全血样本前处理液及其使用方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2060621T3 (es) *	1987-06-05	1994-12-01	Fujisawa Pharmaceutical Co	Anticuerpos anti-sustancia fr-900506 y metodo de inmunoensayo enzimatico altamente sensible.
US5322772A (en) *	1991-04-09	1994-06-21	Children's Research Institute	Rapamycin assay
WO1994024568A1 (en) *	1993-04-20	1994-10-27	Abbott Laboratories	Stable aqueous fk506 standards
AU4400593A (en) *	1992-06-05	1994-01-04	Abbott Laboratories	Methods and reagents for the determination of immunosuppressive agents
GB9307491D0 (en) *	1993-04-08	1993-06-02	Sandoz Ltd	Organic compounds
GB9313163D0 (en) *	1993-06-25	1993-08-11	Health Lab Service Board	Storage of antibodies

1995
- 1995-06-07 US US08/474,589 patent/US5635406A/en not_active Expired - Lifetime
1996
- 1996-05-24 EP EP96916602A patent/EP0832433B1/de not_active Expired - Lifetime
- 1996-05-24 JP JP50070597A patent/JP3863564B2/ja not_active Expired - Lifetime
- 1996-05-24 AT AT96916602T patent/ATE214803T1/de not_active IP Right Cessation
- 1996-05-24 ES ES96916602T patent/ES2176459T3/es not_active Expired - Lifetime
- 1996-05-24 CA CA2219931A patent/CA2219931C/en not_active Expired - Lifetime
- 1996-05-24 DE DE69619982T patent/DE69619982T2/de not_active Expired - Lifetime
- 1996-05-24 WO PCT/US1996/007617 patent/WO1996041184A1/en not_active Ceased
- 1996-09-27 US US08/723,203 patent/US5736401A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2219931C (en)	2012-05-15
JP3863564B2 (ja)	2006-12-27
EP0832433A1 (de)	1998-04-01
DE69619982T2 (de)	2002-11-21
US5635406A (en)	1997-06-03
US5736401A (en)	1998-04-07
ES2176459T3 (es)	2002-12-01
WO1996041184A1 (en)	1996-12-19
EP0832433B1 (de)	2002-03-20
JP2001515581A (ja)	2001-09-18
DE69619982D1 (de)	2002-04-25
CA2219931A1 (en)	1996-12-19

Legal Events

Date	Code	Title	Description
2002-09-15	UEP	Publication of translation of european patent specification
2006-02-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69619982D1 (de)	2002-04-25	Stabilisierte standards und kalibratoren
AR004357A1 (es)	1998-11-04	Compuestos de 1-fenil-2-dimetilaminometil-ciclohexan-1-ol, y procedimiento de preparacion para dichos compuestos.
DE69838323D1 (de)	2007-10-11	Dieselzusatz zur cetan-,schmiereigenschaft- und stabilitätverbesserung
TR199903331T2 (xx)	2000-06-21	Farnesil protein transferas engelleyicileri.
FI955319A7 (fi)	1995-12-22	2-pyridyylimetyleenipolyatsamakrosyklofosfonihappoja, niiden komplekse ja ja johdannaisia käytettäväksi vasta-aineina
ATE339507T1 (de)	2006-10-15	Erythropoietin-analog-menschliches serum-albumin fusionsprotein
ZA200006312B (en)	2003-02-26	Antibodies to CD23, derivatives thereof, and their therapeutic uses.
UA43348C2 (uk)	2001-12-17	Водна фармацевтична композиція, що включає фактор росту нерва (варіанти) та ліофілізований фармацевтичний склад
KR100547921B1 (ko)	2006-10-19	설폰아미드-치환된크로만,이의제조방법및이를포함하는약제학적조성물
DK0960127T3 (da)	2010-03-29	Isoleret dimert fibroblastaktiverende protein-alfa og anvendelser deraf
ATE243708T1 (de)	2003-07-15	Substituierte imidazolidinderivate, ihre herstellung, ihre verwendung und sie enthaltende pharmazeutische präparate
EE04526B1 (et)	2005-08-15	Halogeenasendatud tetratsklilise tetrahdrofuraani derivaadid, nende valmistamismeetod, kasutamineja farmatseutiline kompositsioon
EP0875567A3 (de)	1999-12-22	Myc-bindende Zinkfinger-Proteine, ihre Herstellung und ihre Verwendung
ATE449786T1 (de)	2009-12-15	Imidazolidinderivate, ihre herstellung, ihre verwendung und sie enthaltende pharmazeutische präparate
DE68915112D1 (de)	1994-06-09	Spiro-isochinolin-pyrrolidin-tetrone und Analoge davon, verwendbar als Aldosereduktase-Inhibitoren.
ATE252096T1 (de)	2003-11-15	Prolylendopeptidase-inhibitoren, ihre herstellung und ihre pharmazeutische verwendung
FI972988L (fi)	1997-09-11	Menetelmiä ja farmaseuttisia koostumuksia, joissa käytetään desmetyyliselegiliiniä
AUPQ712000A0 (en)	2000-05-18	Antigenic peptide fragments of VapA protein, and uses thereof
FI952738L (fi)	1995-07-31	Stabiiliproteiini, fosfolipidikoostumuksia ja menetelmiä
WO1998031712A3 (en)	1998-09-11	Chitosan-conjugates with acidic chelate-complex forming agents
EP1038958A4 (de)	2002-10-09	Menschliches nap1-protein
BR9802803A (pt)	2000-03-21	ação e composições farmacêuticas contendo os mesmos.
DE59608611D1 (de)	2002-02-28	Topische aciclovir-zubereitung
DE69014115D1 (de)	1994-12-15	Stabilisierte, starke grf-analoga.
DE69834057D1 (de)	2006-05-18	Echinocandinderivate, deren herstellung und deren verwendung zur bekämpfung von pilzen