ATE215060T1 - Verfahren zur herstellung von rhein und seinen diacylderivaten - Google Patents

Verfahren zur herstellung von rhein und seinen diacylderivaten

Info

Publication number: ATE215060T1
Authority: AT; Austria
Prior art keywords: rhine; producing; diacyl derivatives; derivatives; rhein
Prior art date: 1997-12-30

Application number

AT98124607T

Other languages

English (en)

Inventor

Napoli Guido Di

Original Assignee

Medidom Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-30

Filing date

1998-12-23

Publication date

2002-04-15

1998-12-23 Application filed by Medidom Lab filed Critical Medidom Lab

2002-04-15 Application granted granted Critical

2002-04-15 Publication of ATE215060T1 publication Critical patent/ATE215060T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
YDQWDHRMZQUTBA-UHFFFAOYSA-N Aloe emodin Chemical compound C1=CC=C2C(=O)C3=CC(CO)=CC(O)=C3C(=O)C2=C1O YDQWDHRMZQUTBA-UHFFFAOYSA-N 0.000 abstract 2
TYNLGDBUJLVSMA-UHFFFAOYSA-N 4,5-diacetyloxy-9,10-dioxo-2-anthracenecarboxylic acid Chemical compound O=C1C2=CC(C(O)=O)=CC(OC(C)=O)=C2C(=O)C2=C1C=CC=C2OC(=O)C TYNLGDBUJLVSMA-UHFFFAOYSA-N 0.000 abstract 1
IOVCWXUNBOPUCH-UHFFFAOYSA-N Nitrous acid Chemical class ON=O IOVCWXUNBOPUCH-UHFFFAOYSA-N 0.000 abstract 1
230000010933 acylation Effects 0.000 abstract 1
238000005917 acylation reaction Methods 0.000 abstract 1
229960004590 diacerein Drugs 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000003647 oxidation Effects 0.000 abstract 1
238000007254 oxidation reaction Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
- C07C51/27—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with oxides of nitrogen or nitrogen-containing mineral acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
- C07C2603/24—Anthracenes; Hydrogenated anthracenes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Plant Substances (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT98124607T 1997-12-30 1998-12-23 Verfahren zur herstellung von rhein und seinen diacylderivaten ATE215060T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT97MI002899A IT1297038B1 (it)	1997-12-30	1997-12-30	Procedimento per la preparazione di reina e suoi diacilderivati

Publications (1)

Publication Number	Publication Date
ATE215060T1 true ATE215060T1 (de)	2002-04-15

Family

ID=11378477

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98124607T ATE215060T1 (de)	1997-12-30	1998-12-23	Verfahren zur herstellung von rhein und seinen diacylderivaten

Country Status (5)

Country	Link
EP (1)	EP0928781B1 (de)
AT (1)	ATE215060T1 (de)
DE (1)	DE69804421T2 (de)
ES (1)	ES2172857T3 (de)
IT (1)	IT1297038B1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR026801A1 (es)	2000-01-12	2003-02-26	Medidom Lab	Sustancias para uso en el tratamiento de la psoriasis
IT1318574B1 (it) *	2000-06-13	2003-08-27	Synteco Spa	Procedimento per la purificazione di diacereina.
EP1666446A1 (de) *	2004-11-12	2006-06-07	Laboratoire Medidom S.A.	Verfahren zur Herstellung von Rhein und Diacerhein
CN100351222C (zh) *	2006-02-16	2007-11-28	江阴南极星生物制品有限公司	大黄酸的制备方法
CN101104583B (zh) *	2006-07-13	2010-06-02	上海朴颐化学科技有限公司	两步氧化法制备双醋瑞因的工艺
ITMI20080011A1 (it) *	2008-01-04	2009-07-05	Chimico Internaz S P A	Procedimento per la preparazione di diacereina
WO2009106910A1 (en)	2008-02-29	2009-09-03	Laboratoire Medidom S.A.	Process for the preparation of aloe-emodin
WO2009106908A1 (en)	2008-02-29	2009-09-03	Laboratoire Medidom S.A.	Process for preparing rhein
EP2218707A1 (de) *	2009-02-16	2010-08-18	Evultis S.A.	Verfahren zur Herstellung eines nicht genotoxischen Diacetylrheins (Diacerein)
BRPI0917627A2 (pt) *	2008-12-09	2015-11-17	Evultis Sa	"processo para produzir diacereína não genotóxica, diacereína não genotíxica, cápsulas e formulações farmacêuticas"
ITTO20110120A1 (it)	2011-02-11	2012-08-12	Icrom Spa	Un nuovo processo di purificazione per derivati antrachinonici
CN103360250B (zh) *	2012-03-30	2016-06-01	常州靶点医药科技有限公司	一种高收率的双醋瑞因合成方法
CN103127252B (zh) *	2013-03-13	2015-03-11	四川省中医药科学院	用于男性性功能保健的组合物
CN103694114A (zh) *	2013-12-09	2014-04-02	台州海辰药业有限公司	一种大黄酸的合成方法
CN104262147A (zh) *	2014-08-25	2015-01-07	台州海辰药业有限公司	4,5-二乙酰氧-9,10-二氧-9,10-二氢-2-蒽羧酸的晶型及其制备方法
CN104292101A (zh) *	2014-09-18	2015-01-21	上海慈瑞医药科技有限公司	一种二乙酰大黄酸的制备方法
CN104897839B (zh) *	2015-06-12	2017-02-08	中国人民解放军第三〇二医院	一种多组分综合量化的中药质量评控方法及应用
CN105044300B (zh) *	2015-06-18	2017-07-07	中国人民解放军第三〇二医院	一种基于抗痢疾杆菌效应当量因子调节黄连药材用量的方法
CN110105202B (zh) *	2019-05-16	2021-09-03	北京中医药大学	一种高效、快速分离制备大黄酸衍生物的方法
CN114874171B (zh) *	2022-05-17	2023-05-23	华南理工大学	一种芦荟苷酯及其制备方法与应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3678107A (en) *	1969-03-15	1972-07-18	Mitsubishi Edogawa Kagaku Kk	Process for the production of oxalic acid
GB1503649A (en) *	1974-06-28	1978-03-15	Glaxo Lab Ltd	Process for the preparation of alpha-keto acids
IT1264545B1 (it) *	1993-07-30	1996-10-02	Medidom Lab	Procedimento per la preparazione della diacereina

1997
- 1997-12-30 IT IT97MI002899A patent/IT1297038B1/it active IP Right Grant
1998
- 1998-12-23 AT AT98124607T patent/ATE215060T1/de active
- 1998-12-23 EP EP98124607A patent/EP0928781B1/de not_active Expired - Lifetime
- 1998-12-23 ES ES98124607T patent/ES2172857T3/es not_active Expired - Lifetime
- 1998-12-23 DE DE69804421T patent/DE69804421T2/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE69804421T2 (de)	2002-11-07
ITMI972899A1 (it)	1999-06-30
ES2172857T3 (es)	2002-10-01
DE69804421D1 (de)	2002-05-02
IT1297038B1 (it)	1999-08-03
EP0928781A1 (de)	1999-07-14
EP0928781B1 (de)	2002-03-27

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Legal Events

Date	Code	Title	Description
2002-09-15	UEP	Publication of translation of european patent specification