ATE215081T1 - Gonadotropin releasing hormon- antagonisten - Google Patents

Gonadotropin releasing hormon- antagonisten

Info

Publication number: ATE215081T1
Authority: AT; Austria
Prior art keywords: releasing hormone; gonadotropin releasing; hormone antagonists; useful; antagonists
Prior art date: 1995-12-14

Application number

AT96944249T

Other languages

English (en)

Inventor

Mark Goulet

Wallace T Ashton

Lin Chu

Michael H Fisher

Narindar N Girotra

Peter Lin

Matthew J Wyvratt

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-14

Filing date

1996-12-10

Publication date

2002-04-15

1996-02-16 Priority claimed from GBGB9603242.0A external-priority patent/GB9603242D0/en

1996-12-10 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2002-04-15 Application granted granted Critical

2002-04-15 Publication of ATE215081T1 publication Critical patent/ATE215081T1/de

Links

101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 title abstract 2
239000005557 antagonist Substances 0.000 title abstract 2
239000000579 Gonadotropin-Releasing Hormone Substances 0.000 title 1
XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 title 1
229940035638 gonadotropin-releasing hormone Drugs 0.000 title 1
NMJREATYWWNIKX-UHFFFAOYSA-N GnRH Chemical compound C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CC(C)C)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 NMJREATYWWNIKX-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003163 gonadal steroid hormone Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Gynecology & Obstetrics (AREA)
Dermatology (AREA)
Anesthesiology (AREA)
Immunology (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Steroid Compounds (AREA)

AT96944249T 1995-12-14 1996-12-10 Gonadotropin releasing hormon- antagonisten ATE215081T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US863395P	1995-12-14	1995-12-14
GBGB9603242.0A GB9603242D0 (en)	1996-02-16	1996-02-16	Antagonists of gonadotropin releasing hormone
PCT/US1996/019444 WO1997021704A1 (en)	1995-12-14	1996-12-10	Antagonists of gonadotropin releasing hormone

Publications (1)

Publication Number	Publication Date
ATE215081T1 true ATE215081T1 (de)	2002-04-15

Family

ID=26308721

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96944249T ATE215081T1 (de)	1995-12-14	1996-12-10	Gonadotropin releasing hormon- antagonisten

Country Status (19)

Country	Link
EP (1)	EP0873336B1 (de)
JP (2)	JP3230818B2 (de)
KR (1)	KR19990072101A (de)
CN (1)	CN1208412A (de)
AT (1)	ATE215081T1 (de)
AU (1)	AU707641B2 (de)
CA (1)	CA2240108A1 (de)
CZ (1)	CZ183998A3 (de)
DE (1)	DE69620241T2 (de)
EA (1)	EA000992B1 (de)
EE (1)	EE9800173A (de)
ES (1)	ES2174129T3 (de)
HU (1)	HUP9903671A3 (de)
IL (1)	IL124459A0 (de)
NO (1)	NO982729L (de)
NZ (1)	NZ325569A (de)
PL (1)	PL327146A1 (de)
SK (1)	SK77298A3 (de)
WO (1)	WO1997021704A1 (de)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1950200B1 (de)	1994-04-01	2012-01-11	Eli Lilly And Company	[[3-(2-amino-1,2-dioxoethyl)-2-ethyl-1-(phenylmethyl)-11H-indol-4-yl]oxy]essigsäure methyl ester als sPLA2 inhibitor
WO1997021435A1 (en) *	1995-12-14	1997-06-19	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone
US6200957B1 (en)	1995-12-14	2001-03-13	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone
KR19990072124A (ko) *	1995-12-14	1999-09-27	애쉬톤 왈레이스 티	고나도트로핀 방출 호르몬의 길항제
EP0986385A4 (de) *	1997-06-05	2001-05-16	Merck & Co Inc	Antagonisten des gonadorelins
AU729663B2 (en) *	1997-06-05	2001-02-08	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone
WO1998055123A1 (en) *	1997-06-05	1998-12-10	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone
EP1027046A4 (de) *	1997-10-28	2002-04-03	Merck & Co Inc	Antagonisten des gonadotropin freisetzenden hormons
US6017944A (en) *	1997-10-28	2000-01-25	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone
AU1197299A (en) *	1997-10-28	1999-05-17	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone
CA2318957A1 (en) *	1998-02-11	1999-08-19	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone
US5972898A (en) *	1998-03-27	1999-10-26	Abbott Laboratories	3',3-N-bis-substituted macrolide LHRH antagonists
US5955440A (en) *	1998-03-27	1999-09-21	Abbott Laboratories	Macrolide LHRH antagonists
EP1067930A4 (de) *	1998-04-02	2002-09-18	Merck & Co Inc	Antagonisten des gonadoliberins
DE19815060A1 (de) *	1998-04-03	1999-10-14	Jenapharm Gmbh	Pharmazeutische Präparate zur Therapie von Nebenwirkungen während und/oder nach einer GnRHa-Therapie
US6020521A (en) *	1998-08-26	2000-02-01	Abbott Laboratories	Macrolide LHRH antagonists
US6387885B1 (en) *	1998-08-26	2002-05-14	Abbott Laboratories	3′,3′-N-bis-desmethyl-3′-N-cycloalkyl erythromycin derivatives as LHRH antagonists
US6346534B1 (en)	1998-09-23	2002-02-12	Neurocrine Biosciences, Inc.	Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
US5981521A (en) *	1998-11-13	1999-11-09	Abbott Laboratories	Tetrahydroisoquinoline derivatives as LHRH antagonists
US6537998B1 (en)	1999-10-15	2003-03-25	Neurocrine Biosciences, Inc.	Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
US6608197B2 (en)	2000-01-25	2003-08-19	Neurocrine Biosciences, Inc.	Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
GB0022670D0 (en)	2000-09-15	2000-11-01	Astrazeneca Ab	Molecules
SE0100566D0 (sv)	2001-02-20	2001-02-20	Astrazeneca Ab	Compounds
SE0101692D0 (sv)	2001-05-14	2001-05-14	Astrazeneca Ab	Compounds
AU2002324586B2 (en)	2001-08-02	2008-04-24	Neurocrine Biosciences, Inc.	1,3,5-triazine-2,4,6-triones, preparation and use as gonadotropin-releasing hormone receptor antagonists
JP2005505525A (ja)	2001-08-02	2005-02-24	ニューロクラインバイオサイエンシーズ，インコーポレイテッド	性腺刺激ホルモン放出ホルモンレセプターアンタゴニストおよびそれに関連する方法
EP1412363A1 (de)	2001-08-02	2004-04-28	Neurocrine Biosciences, Inc.	Rezeptor antagonisten für gonadotropin-freisetzende hormone
JP2005504034A (ja)	2001-08-02	2005-02-10	ニューロクラインバイオサイエンシーズ，インコーポレイテッド	ゴナドトロピン放出性ホルモンレセプターアンタゴニストとしてのピリジノン誘導体およびピリダジノン誘導体
EP1414808A1 (de)	2001-08-02	2004-05-06	Neurocrine Biosciences, Inc.	1,2,4-triazin-3,5-dione als antagonisten des gonadotropin freisetzenden hormons
WO2003068769A1 (en)	2002-02-12	2003-08-21	Pfizer Inc.	Non-peptide compounds affecting the action of gonadotropin-releasing hormone (gnrh)
JP2005538064A (ja)	2002-06-13	2005-12-15	ファイザー・インク	非ペプチドＧｎＲＨ剤、医薬組成物、およびそれらの使用方法
KR100378891B1 (ko)	2002-08-09	2003-04-08	에스케이 텔레콤주식회사	플렉시블 페이징시의 가입자 기반 링백톤 서비스 방법
KR100392768B1 (ko)	2002-08-09	2003-07-28	에스케이 텔레콤주식회사	발신 교환기를 이용한 가입자 기반 링백톤 서비스 방법
DE60318716T2 (de)	2002-08-21	2009-01-08	Astrazeneca Ab	Thieno-pyrrole verbindungen als antagonisten der gonadotropin-freisetzenden hormonrezeptoren
TW200413351A (en)	2002-08-21	2004-08-01	Astrazeneca Ab	Chemical compounds
TW200407127A (en)	2002-08-21	2004-05-16	Astrazeneca Ab	Chemical compounds
GB0219472D0 (en)	2002-08-21	2002-10-02	Astrazeneca Ab	Chemical compounds
AU2003255811A1 (en)	2002-08-21	2004-03-11	Astrazeneca Ab	Pyrazole derivatives as gnrh inhibitors
AU2003251189A1 (en) *	2002-09-05	2004-03-29	Sk Telecom Co., Ltd.	Method of managing trunk and querying and ascertaining ring-back sound to provide ring-back sound in subscriber-based ring-back sound service
US7045527B2 (en)	2002-09-24	2006-05-16	Amgen Inc.	Piperidine derivatives
WO2004032547A1 (en) *	2002-10-01	2004-04-15	Sk Telecom Co., Ltd	Method for providing a subscriber-based ringback tone sound
KR100393552B1 (ko) *	2002-10-01	2003-08-02	에스케이 텔레콤주식회사	교환기 음원 송출을 통한 가입자 기반 링백톤 서비스 방법
KR100393553B1 (ko) *	2002-10-18	2003-08-02	에스케이 텔레콤주식회사	착신 미가입자에 대한 발신시 가입자 기반 링백톤 서비스방법
WO2004056744A1 (en)	2002-12-23	2004-07-08	Janssen Pharmaceutica N.V.	Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors
BRPI0412327A (pt)	2003-07-07	2006-09-05	Neurocrine Biosciences Inc	derivados de pirimidina-2,4-diona como antagonistas de receptor de hormÈnio liberador de gonadotropina
EP1646389B1 (de) *	2003-07-07	2008-09-10	Neurocrine Biosciences, Inc.	Pyrimidin-2,4-dion-derivate als gonadotropin freisetzende hormon-rezeptor-antagonisten
JP4673847B2 (ja)	2003-07-07	2011-04-20	ニューロクラインバイオサイエンシーズ，インコーポレイテッド	性腺刺激ホルモン放出ホルモンレセプターアンタゴニストおよびそれに関連する方法
CA2565630C (en)	2004-05-07	2013-05-28	Janssen Pharmaceutica N.V.	Pyrrolidin-2-one and piperidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
CN101300005B (zh)	2004-08-30	2013-05-01	詹森药业有限公司	作为11-β羟类固醇脱氢酶抑制剂的N-2金刚烷基-2-苯氧基-乙酰胺衍生物
DE602005017159D1 (de)	2004-08-30	2009-11-26	Janssen Pharmaceutica Nv	Oxysteroid-dehydrogenase-inhibitoren
MY141198A (en)	2004-08-30	2010-03-31	Janssen Pharmaceutica Nv	Tricyclic adamantylamide derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
CN101547923A (zh)	2006-12-07	2009-09-30	弗·哈夫曼-拉罗切有限公司	作为via受体拮抗剂的螺环-哌啶衍生物
CN101563324A (zh) *	2006-12-22	2009-10-21	弗·哈夫曼-拉罗切有限公司	螺-哌啶衍生物
KR101524817B1 (ko)	2007-04-18	2015-06-01	깃세이 야쿠힌 고교 가부시키가이샤	질소 함유 축합환 유도체, 그것을 함유하는 의약 조성물 및 그 의약 용도
KR101247840B1 (ko)	2008-02-22	2013-03-26	에프. 호프만-라 로슈 아게	아밀로이드 베타 조절제
JP5502089B2 (ja)	2008-10-09	2014-05-28	エフ．ホフマン−ラロシュアーゲー	アミロイドβのモジュレーター
CN102209537A (zh)	2008-11-10	2011-10-05	弗·哈夫曼-拉罗切有限公司	杂环γ分泌酶调节剂
TW201130854A (en)	2009-12-22	2011-09-16	Bayer Schering Pharma Ag	Pyridinone derivatives and pharmaceutical compositions thereof
US8486967B2 (en)	2010-02-17	2013-07-16	Hoffmann-La Roche Inc.	Heteroaryl substituted piperidines
WO2012175514A1 (en)	2011-06-21	2012-12-27	Bayer Intellectual Property Gmbh	Pyridinone derivatives and pharmaceutical compositions thereof
CN102260208A (zh) *	2011-07-28	2011-11-30	海门慧聚药业有限公司	4-吡啶丁醇的制备新工艺
US20140315881A1 (en) *	2011-07-29	2014-10-23	Tempero Pharmaceuticals, Inc.	Compounds and methods
AU2015308987B2 (en)	2014-08-26	2021-02-18	Kaass Discovery As	Methods, agents and compositions for treatment of inflammatory conditions
WO2019113693A1 (en) *	2017-12-12	2019-06-20	Queen's University At Kingston	Compounds and methods for inhibiting cyp26 enzymes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA795239B (en) *	1978-10-12	1980-11-26	Glaxo Group Ltd	Heterocyclic compounds
US4544663A (en) *	1984-05-07	1985-10-01	Sandoz, Inc.	Indolamine derivatives as anti-fertility agents
US5030640A (en) *	1989-01-05	1991-07-09	Merck & Co., Inc.	Novel β-adrenergic agonists and pharmaceutical compositions thereof
TW449600B (en) *	1994-04-19	2001-08-11	Takeda Chemical Industries Ltd	Condensed-ring thiophene derivatives, their production and use

1996
- 1996-12-10 PL PL96327146A patent/PL327146A1/xx unknown
- 1996-12-10 SK SK772-98A patent/SK77298A3/sk unknown
- 1996-12-10 HU HU9903671A patent/HUP9903671A3/hu unknown
- 1996-12-10 NZ NZ325569A patent/NZ325569A/xx unknown
- 1996-12-10 CZ CZ981839A patent/CZ183998A3/cs unknown
- 1996-12-10 AT AT96944249T patent/ATE215081T1/de not_active IP Right Cessation
- 1996-12-10 ES ES96944249T patent/ES2174129T3/es not_active Expired - Lifetime
- 1996-12-10 DE DE69620241T patent/DE69620241T2/de not_active Expired - Fee Related
- 1996-12-10 CN CN96199872A patent/CN1208412A/zh active Pending
- 1996-12-10 IL IL12445996A patent/IL124459A0/xx unknown
- 1996-12-10 EA EA199800563A patent/EA000992B1/ru not_active IP Right Cessation
- 1996-12-10 JP JP52212497A patent/JP3230818B2/ja not_active Expired - Fee Related
- 1996-12-10 CA CA002240108A patent/CA2240108A1/en not_active Abandoned
- 1996-12-10 EP EP96944249A patent/EP0873336B1/de not_active Expired - Lifetime
- 1996-12-10 WO PCT/US1996/019444 patent/WO1997021704A1/en not_active Ceased
- 1996-12-10 AU AU14106/97A patent/AU707641B2/en not_active Ceased
- 1996-12-10 KR KR1019980704413A patent/KR19990072101A/ko not_active Withdrawn
- 1996-12-10 EE EE9800173A patent/EE9800173A/xx unknown
1998
- 1998-06-12 NO NO982729A patent/NO982729L/no not_active Application Discontinuation
2000
- 2000-08-28 JP JP2000257791A patent/JP2001106685A/ja active Pending

Also Published As

Publication number	Publication date
HUP9903671A2 (hu)	2001-10-28
CN1208412A (zh)	1999-02-17
SK77298A3 (en)	1999-01-11
DE69620241T2 (de)	2002-10-02
JP3230818B2 (ja)	2001-11-19
EP0873336B1 (de)	2002-03-27
ES2174129T3 (es)	2002-11-01
JP2001106685A (ja)	2001-04-17
EE9800173A (et)	1998-12-15
CA2240108A1 (en)	1997-06-19
JPH11506471A (ja)	1999-06-08
NO982729D0 (no)	1998-06-12
AU1410697A (en)	1997-07-03
EA199800563A1 (ru)	1998-12-24
IL124459A0 (en)	1998-12-06
MX9804765A (es)	1998-10-31
DE69620241D1 (de)	2002-05-02
CZ183998A3 (cs)	1998-10-14
NO982729L (no)	1998-08-13
WO1997021704A1 (en)	1997-06-19
HUP9903671A3 (en)	2001-11-28
EA000992B1 (ru)	2000-08-28
EP0873336A1 (de)	1998-10-28
KR19990072101A (ko)	1999-09-27
NZ325569A (en)	2000-05-26
AU707641B2 (en)	1999-07-15
PL327146A1 (en)	1998-11-23

Legal Events

Date	Code	Title	Description
2002-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69620241D1 (de)	2002-05-02	Gonadotropin releasing hormon- antagonisten
MX9804850A (es)	1998-09-30	Antagonistas de hormona liberadora de gonadotropina.
NZ325060A (en)	2000-02-28	Non peptide indole derivative and their use as antagonists of gonadotropin releasing hormone
DE69911023D1 (de)	2003-10-09	Antagonisten des gonadotropin freisetzenden hormons
BR0112160A (pt)	2003-10-07	Agentes antiinflamatórios seletivos para glicocorticóides
SE9504661D0 (sv)	1995-12-22	New compounds
TR199801679T2 (xx)	2001-06-21	Osteoporoz i�in birle�tirme terapisi.
UA41879C2 (uk)	2001-10-15	Засіб для лікування мотонейронових захворювань
FI963036A0 (fi)	1996-08-01	Munasarjan estrogeenista riippuvaisten tilojen hoito
YU5399A (sh)	2002-03-18	Supstituisani pirido-ili pirimido-derivati koji sadrže 6,6- ili 6,7-biciklične prstenove
DK1053239T3 (da)	2003-04-22	Gluccocorticoid-selektive, anti-inflammatoriske midler
NO20025450D0 (no)	2002-11-14	Ny farmasöytisk sammensetning
BR9811099A (pt)	2002-05-14	Inibidores de urocinase
UA37259C2 (uk)	2001-05-15	Активна речовина для одержання лікарських засобів при лікуванні дисфункціональних маткових кровотеч
EP1067930A4 (de)	2002-09-18	Antagonisten des gonadoliberins
ATE353224T1 (de)	2007-02-15	Abgabeeinrichtung für eine zusammensetzung einer pharmazeutisch wirksamen substanz
HU9700661D0 (en)	1997-05-28	Use of alpha-1-adrenoreceptor antagonists for profilacting and treating cancer
MX9708557A (es)	1997-12-31	Nuevo uso farmacologico de los antagonistas del receptor aii.
SE9504662D0 (sv)	1995-12-22	New compounds
MX9804120A (es)	1998-09-30	Nuevos antagonistas de la lh-rh con efectividad mejorada.
NZ516209A (en)	2004-01-30	Indoloazepines as vasopressin receptor antagonists
SE9902596D0 (sv)	1999-07-06	Pharmaceutically active compounds
IT1307866B1 (it)	2001-11-19	Composizioni farmaceutiche contenenti inibitori dell'ormone dellacrescita o loro frammenti biologicamente attivi per il trattamento
MX9701529A (es)	1998-06-28	Uso de (e)-1-[4'-(2-alquilaminoetoxi)fenil]-1-(3'-hidroxifenil)-2-f enilbut-1-enos para inhibir trastornos patologicos.
MX9701526A (es)	1998-06-28	Terapia combinada para tratar la osteoporosis.