EP1027046A4 - Antagonisten des gonadotropin freisetzenden hormons - Google Patents

Antagonisten des gonadotropin freisetzenden hormons

Info

Publication number
EP1027046A4
EP1027046A4 EP98954019A EP98954019A EP1027046A4 EP 1027046 A4 EP1027046 A4 EP 1027046A4 EP 98954019 A EP98954019 A EP 98954019A EP 98954019 A EP98954019 A EP 98954019A EP 1027046 A4 EP1027046 A4 EP 1027046A4
Authority
EP
European Patent Office
Prior art keywords
gonadothrophin
hormone antagonists
release hormone
release
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98954019A
Other languages
English (en)
French (fr)
Other versions
EP1027046A1 (de
Inventor
Lin Chu
Mark T Goulet
Thomas F Walsh
Stephanie L Witkin
Matthew J Wyvratt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9809789.2A external-priority patent/GB9809789D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1027046A1 publication Critical patent/EP1027046A1/de
Publication of EP1027046A4 publication Critical patent/EP1027046A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
EP98954019A 1997-10-28 1998-10-27 Antagonisten des gonadotropin freisetzenden hormons Withdrawn EP1027046A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6330597P 1997-10-28 1997-10-28
US63305P 1997-10-28
GB9809789 1998-05-07
GBGB9809789.2A GB9809789D0 (en) 1998-05-07 1998-05-07 Antagonists of gonadotropin releasing hormone
PCT/US1998/022799 WO1999021553A1 (en) 1997-10-28 1998-10-27 Antagonists of gonadotropin releasing hormone

Publications (2)

Publication Number Publication Date
EP1027046A1 EP1027046A1 (de) 2000-08-16
EP1027046A4 true EP1027046A4 (de) 2002-04-03

Family

ID=26313619

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98954019A Withdrawn EP1027046A4 (de) 1997-10-28 1998-10-27 Antagonisten des gonadotropin freisetzenden hormons

Country Status (5)

Country Link
EP (1) EP1027046A4 (de)
JP (1) JP2001520996A (de)
AU (1) AU1124399A (de)
CA (1) CA2308454A1 (de)
WO (1) WO1999021553A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0017256D0 (en) 2000-07-13 2000-08-30 Merck Sharp & Dohme Therapeutic agents
GB0022670D0 (en) 2000-09-15 2000-11-01 Astrazeneca Ab Molecules
SE0100566D0 (sv) 2001-02-20 2001-02-20 Astrazeneca Ab Compounds
SE0101692D0 (sv) * 2001-05-14 2001-05-14 Astrazeneca Ab Compounds
TW200413351A (en) 2002-08-21 2004-08-01 Astrazeneca Ab Chemical compounds
TW200407127A (en) 2002-08-21 2004-05-16 Astrazeneca Ab Chemical compounds
GB0219472D0 (en) 2002-08-21 2002-10-02 Astrazeneca Ab Chemical compounds
DE60318716T2 (de) 2002-08-21 2009-01-08 Astrazeneca Ab Thieno-pyrrole verbindungen als antagonisten der gonadotropin-freisetzenden hormonrezeptoren
AU2003255811A1 (en) 2002-08-21 2004-03-11 Astrazeneca Ab Pyrazole derivatives as gnrh inhibitors
DE602005020280D1 (de) 2004-06-01 2010-05-12 Hoffmann La Roche 3-amino-1-arylpropyl-indole als monoamin-wiederaufnahmehemmer
DE102004033902A1 (de) 2004-07-14 2006-02-16 Zentaris Gmbh Neue Tetrahydrocarbazolderivate mit verbesserter biologischer Wirkung und verbesserter Löslichkeit als Liganden für G-Protein gekoppelte Rezeptoren (GPCR's)
JP2009523705A (ja) 2005-11-30 2009-06-25 エフ．ホフマン−ラ ロシュ アーゲー ３−アミノ−１−アリールプロピルインドールの合成方法
BRPI0619263A2 (pt) 2005-11-30 2011-09-27 Hoffmann La Roche indóis de 3-amino-1-arilpropila e indóis aza-substituìdos, métodos para prepará-los, composição farmacêutica e uso dos referidos indóis
EP1957488B1 (de) 2005-11-30 2009-09-09 F.Hoffmann-La Roche Ag 3-amino-2-arylpropylazaindole und anwendungen davon
EP2095818A1 (de) 2008-02-29 2009-09-02 AEterna Zentaris GmbH Verwendung von LHRH-Antagonisten in nicht-kastrierenden Dosen
WO2010039977A2 (en) 2008-10-01 2010-04-08 Amira Pharmaceuticals, Inc. Heteroaryl antagonists of prostaglandin d2 receptors
EP4223298A3 (de) * 2013-03-15 2023-08-16 AbbVie Inc. Zusammensetzungen zur verwendung bei der behandlung von schweren menstruationsblutungen
US20170158702A1 (en) * 2015-12-02 2017-06-08 Kyras Therapeutics, Inc. Multivalent ras binding compounds
LT3860998T (lt) 2018-10-05 2024-06-25 Annapurna Bio Inc. Junginiai ir kompozicijos, skirti gydyti būkles, susijusias su apj receptoriaus aktyvumu

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2181559A1 (en) * 1972-04-28 1973-12-07 Aec Chimie Organique Bio N-Phenylalkyl-N-3-indolylalkyl-alkylamines - with sedative, neuroleptic, analgesic, hypotensive, antiserotonin, adrenolytic activity
GB1562825A (en) * 1975-10-29 1980-03-19 Lilly Co Eli N-(2-(5-methoxa-6-halo-indol-3-yl)-ethyl)-amides methods for their preparation and their use
US4544663A (en) * 1984-05-07 1985-10-01 Sandoz, Inc. Indolamine derivatives as anti-fertility agents
US5030640A (en) * 1989-01-05 1991-07-09 Merck & Co., Inc. Novel β-adrenergic agonists and pharmaceutical compositions thereof
WO1998055119A1 (en) * 1997-06-05 1998-12-10 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
PL327146A1 (en) * 1995-12-14 1998-11-23 Merck & Co Inc Antagonists of the gonadotrophin liberating hormone
US5756507A (en) * 1995-12-14 1998-05-26 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2181559A1 (en) * 1972-04-28 1973-12-07 Aec Chimie Organique Bio N-Phenylalkyl-N-3-indolylalkyl-alkylamines - with sedative, neuroleptic, analgesic, hypotensive, antiserotonin, adrenolytic activity
GB1562825A (en) * 1975-10-29 1980-03-19 Lilly Co Eli N-(2-(5-methoxa-6-halo-indol-3-yl)-ethyl)-amides methods for their preparation and their use
US4544663A (en) * 1984-05-07 1985-10-01 Sandoz, Inc. Indolamine derivatives as anti-fertility agents
US5030640A (en) * 1989-01-05 1991-07-09 Merck & Co., Inc. Novel β-adrenergic agonists and pharmaceutical compositions thereof
WO1998055119A1 (en) * 1997-06-05 1998-12-10 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9921553A1 *

Also Published As

Publication number Publication date
AU1124399A (en) 1999-05-17
JP2001520996A (ja) 2001-11-06
WO1999021553A1 (en) 1999-05-06
EP1027046A1 (de) 2000-08-16
CA2308454A1 (en) 1999-05-06

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