ATE215228T1 - Gerät zur untersuchung von verbindungssammlungen - Google Patents

Gerät zur untersuchung von verbindungssammlungen

Info

Publication number
ATE215228T1
ATE215228T1 AT98401525T AT98401525T ATE215228T1 AT E215228 T1 ATE215228 T1 AT E215228T1 AT 98401525 T AT98401525 T AT 98401525T AT 98401525 T AT98401525 T AT 98401525T AT E215228 T1 ATE215228 T1 AT E215228T1
Authority
AT
Austria
Prior art keywords
library
compound
compound collections
target receptor
examining
Prior art date
Application number
AT98401525T
Other languages
English (en)
Inventor
Ole Hindsgaul
David C Schriemer
Original Assignee
Ole Hindsgaul
David C Schriemer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ole Hindsgaul, David C Schriemer filed Critical Ole Hindsgaul
Application granted granted Critical
Publication of ATE215228T1 publication Critical patent/ATE215228T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/466—Flow patterns using more than one column with separation columns in parallel
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G01N30/724—Nebulising, aerosol formation or ionisation
    • G01N30/7266—Nebulising, aerosol formation or ionisation by electric field, e.g. electrospray
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/538—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by sorbent column, particles or resin strip, i.e. sorbent materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00704—Processes involving means for analysing and characterising the products integrated with the reactor apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00731—Saccharides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00738—Organic catalysts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/00745—Inorganic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/00745—Inorganic compounds
    • B01J2219/00747—Catalysts
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/08—Methods of screening libraries by measuring catalytic activity
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/12—Libraries containing saccharides or polysaccharides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/18—Libraries containing only inorganic compounds or inorganic materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N2030/628—Multiplexing, i.e. several columns sharing a single detector
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Mobile Radio Communication Systems (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Tests Of Electronic Circuits (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT98401525T 1998-03-27 1998-06-22 Gerät zur untersuchung von verbindungssammlungen ATE215228T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7962298P 1998-03-27 1998-03-27
US09/069,890 US6054047A (en) 1998-03-27 1998-04-29 Apparatus for screening compound libraries

Publications (1)

Publication Number Publication Date
ATE215228T1 true ATE215228T1 (de) 2002-04-15

Family

ID=26750531

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98401525T ATE215228T1 (de) 1998-03-27 1998-06-22 Gerät zur untersuchung von verbindungssammlungen

Country Status (12)

Country Link
US (5) US6054047A (de)
EP (1) EP0886143B1 (de)
JP (2) JP3101607B2 (de)
AT (1) ATE215228T1 (de)
AU (1) AU2918499A (de)
CA (1) CA2240380C (de)
DE (2) DE69804379T2 (de)
DK (1) DK0886143T3 (de)
ES (1) ES2174404T3 (de)
IL (1) IL137009A0 (de)
PT (1) PT886143E (de)
WO (1) WO1999050668A1 (de)

Families Citing this family (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6342160B2 (en) * 1998-01-09 2002-01-29 Christopher J. Welch Method for screening chromatographic adsorbents
CA2240325A1 (en) * 1998-03-27 1998-11-14 Synsorb Biotech, Inc. Methods for screening compound libraries
US6720190B1 (en) 1998-03-27 2004-04-13 Ole Hindsgaul Methods for screening compound libraries
US6054047A (en) 1998-03-27 2000-04-25 Synsorb Biotech, Inc. Apparatus for screening compound libraries
US6613575B1 (en) * 1998-03-27 2003-09-02 Ole Hindsgaul Methods for screening compound libraries
US6416663B1 (en) 1998-04-03 2002-07-09 Symyx Technologies, Inc. Chromatographic column for rapid characterizations of polymers
US6866786B2 (en) * 1998-04-03 2005-03-15 Symyx Technologies, Inc. Rapid characterization of polymers
US6406632B1 (en) 1998-04-03 2002-06-18 Symyx Technologies, Inc. Rapid characterization of polymers
US6979728B2 (en) * 1998-05-04 2005-12-27 Baylor College Of Medicine Articles of manufacture and methods for array based analysis of biological molecules
US6998233B2 (en) 1998-06-26 2006-02-14 Sunesis Pharmaceuticals, Inc. Methods for ligand discovery
US6919178B2 (en) 2000-11-21 2005-07-19 Sunesis Pharmaceuticals, Inc. Extended tethering approach for rapid identification of ligands
US6432651B1 (en) * 1998-07-10 2002-08-13 Cetek Corporation Method to detect and analyze tight-binding ligands in complex biological samples using capillary electrophoresis and mass spectrometry
US6309541B1 (en) * 1999-10-29 2001-10-30 Ontogen Corporation Apparatus and method for multiple channel high throughput purification
US6458273B1 (en) 1999-10-29 2002-10-01 Ontogen Corporation Sample separation apparatus and method for multiple channel high throughput purification
AU2486100A (en) * 1998-12-23 2000-07-12 Admetric Biochem Inc. High throughput method for measuring physicochemical values
GB9904038D0 (en) * 1999-02-22 1999-04-14 Isis Innovation Improvements in or related to microfluidic sample preparation and mass spectrometry
US7150994B2 (en) 1999-03-03 2006-12-19 Symyx Technologies, Inc. Parallel flow process optimization reactor
US6296771B1 (en) 1999-04-02 2001-10-02 Symyx Technologies, Inc. Parallel high-performance liquid chromatography with serial injection
US6436292B1 (en) 1999-04-02 2002-08-20 Symyx Technologies, Inc. Parallel high-performance liquid chromatography with post-separation treatment
US6855258B2 (en) * 1999-04-02 2005-02-15 Symyx Technologies, Inc. Methods for characterization of polymers using multi-dimensional liquid chromatography with parallel second-dimension sampling
WO2000066155A1 (en) 1999-04-30 2000-11-09 La Jolla Institute For Allergy And Immunology Methods for preventing reactivation of latent virus and controlling virus replication
US6579720B1 (en) * 1999-05-13 2003-06-17 Bdc Pharma Llc Method for activity profiling compound mixtures
US6413431B1 (en) * 1999-08-10 2002-07-02 Scynexis Chemistry & Automation, Inc. HPLC method for purifying organic compounds
US6358414B1 (en) * 1999-10-29 2002-03-19 Ontogen Corporation Pressure regulation apparatus and method for multiple channel high throughput purification
US6355164B1 (en) * 1999-10-29 2002-03-12 Ontogen Corporation Sample collection apparatus and method for multiple channel high throughput purification
US6406604B1 (en) * 1999-11-08 2002-06-18 Norberto A. Guzman Multi-dimensional electrophoresis apparatus
US7329388B2 (en) * 1999-11-08 2008-02-12 Princeton Biochemicals, Inc. Electrophoresis apparatus having staggered passage configuration
DE60108482T2 (de) 2000-03-07 2006-02-16 Symyx Technologies, Inc., Santa Clara Prozessoptimierungsreaktor mit parallelem durchfluss
JP2003532117A (ja) * 2000-04-13 2003-10-28 サーモ フィニガン リミテッド ライアビリティ カンパニー 並列質量分析によるプロテオミクス解析
AU2001261392A1 (en) * 2000-05-12 2001-11-26 Admetric Biochem Inc. High throughput chromatographic systems
US6697454B1 (en) 2000-06-29 2004-02-24 X-Ray Optical Systems, Inc. X-ray analytical techniques applied to combinatorial library screening
CA2419238A1 (en) * 2000-08-16 2002-02-21 University Of Alberta Non-pressurized methods for the preparation of conjugated solid supports for boronic acids
US6919382B2 (en) 2000-08-31 2005-07-19 The Governors Of The University Of Alberta Preparation and uses of conjugated solid supports for boronic acids
US6743356B1 (en) * 2000-10-27 2004-06-01 Johnson & Johnson High throughput high performance chromatography system
US7118710B2 (en) * 2000-10-30 2006-10-10 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US6841774B1 (en) 2000-11-28 2005-01-11 Mds Inc. Sample introduction device for mass spectrometry using a fast fluidic system to synchronize multiple parallel liquid sample streams
ATE502391T1 (de) * 2000-11-28 2011-04-15 Dh Technologies Dev Pte Ltd Vorrichtung zur einführung von flüssigen proben in ein massenspektrometer unter verwendung eines schnellen ventilsystems zur synchronisation mehrerer paraleller probenströmen
US6635173B2 (en) * 2000-12-28 2003-10-21 Cohesive Technologies, Inc. Multi column chromatography system
US20020139751A1 (en) * 2001-02-20 2002-10-03 Sheng Zhang Microchip electrospray device and column with affinity adsorbents and use of the same
US7118917B2 (en) 2001-03-07 2006-10-10 Symyx Technologies, Inc. Parallel flow reactor having improved thermal control
US20050123970A1 (en) * 2001-04-25 2005-06-09 Can Ozbal High throughput autosampler
US8414774B2 (en) * 2001-04-25 2013-04-09 Agilent Technologies, Inc. Systems and methods for high-throughput screening of fluidic samples
US7588725B2 (en) * 2001-04-25 2009-09-15 Biotrove, Inc. High throughput autosampler
US9157875B2 (en) * 2001-05-16 2015-10-13 Benjamin P. Warner Drug development and manufacturing
US6858148B2 (en) * 2003-07-16 2005-02-22 The Regents Of The University Of California Method and apparatus for detecting chemical binding
US20040017884A1 (en) * 2002-07-25 2004-01-29 Havrilla George J. Flow method and apparatus for screening chemicals using micro x-ray fluorescence
US20080220441A1 (en) * 2001-05-16 2008-09-11 Birnbaum Eva R Advanced drug development and manufacturing
DE10125258A1 (de) * 2001-05-23 2003-01-09 November Ag Molekulare Medizin Verfahren zur Bestimmung des Bindeverhaltens von an Ziel-Molekülen spezifisch bindenden Liganden
US20020190204A1 (en) * 2001-06-04 2002-12-19 Bruker Daltonics, Inc. Systems and method of a gated electrospray interface with variable flow rate for high throughput mass spectrometric analysis
US7066011B2 (en) * 2001-06-07 2006-06-27 Nano Solution, Inc. Liquid chromatograph and analysis system
AU2002316372A1 (en) 2001-06-22 2003-01-08 Symyx Technologies, Inc. Inverse chromatography methods and apparatus for evaluation of interactions between modifying agents and receptors
JP2003028849A (ja) * 2001-07-10 2003-01-29 Hiromasa Tojo 自動化脂質組成一斉分析装置
US6703137B2 (en) * 2001-08-02 2004-03-09 Siemens Westinghouse Power Corporation Segmented thermal barrier coating and method of manufacturing the same
WO2003021251A1 (en) * 2001-08-28 2003-03-13 Symyx Technologies, Inc. Methods for characterization of polymers using multi-dimentional liquid chromatography
US20050032060A1 (en) * 2001-08-31 2005-02-10 Shishir Shah Arrays comprising pre-labeled biological molecules and methods for making and using these arrays
KR100414157B1 (ko) * 2001-09-28 2004-01-13 삼성전자주식회사 유체 샘플링 장치 및 이를 갖는 분석 장치
AU2002347777A1 (en) * 2001-10-01 2003-04-14 Massachussetts Institute Of Technology Methods for determining oligosaccharide binding
JP3868267B2 (ja) * 2001-10-31 2007-01-17 株式会社荏原製作所 マルチカラム・アフィニティー検出システム
EP1451350A4 (de) * 2001-11-05 2006-05-10 Transgenomic Inc Verfahren, systeme und kits zur analyse von polynukleotiden
DE10155692A1 (de) * 2001-11-07 2003-05-22 Florian Schweigert Verfahren zum Nachweis von endogenen und exogenen Stoffen im Organismus
WO2003050540A2 (en) * 2001-12-05 2003-06-19 Large Scale Biology Corporation Flexible method and apparatus for high throughput production and purification of multiple proteins
US20030141253A1 (en) * 2001-12-07 2003-07-31 Bihan Thierry Le Apparatus for efficient liquid chromatography/mass spectrometry processing
US20030150812A1 (en) * 2001-12-19 2003-08-14 Irving Wainer Novel parallel throughput system
US7261812B1 (en) * 2002-02-13 2007-08-28 Nanostream, Inc. Multi-column separation devices and methods
GB0205186D0 (en) * 2002-03-06 2002-04-17 Molecularnature Ltd Method for monitoring the quality of a herbal medicine
US6916621B2 (en) * 2002-03-27 2005-07-12 Spectral Genomics, Inc. Methods for array-based comparitive binding assays
US6621076B1 (en) 2002-04-30 2003-09-16 Agilent Technologies, Inc. Flexible assembly for transporting sample fluids into a mass spectrometer
US20030224531A1 (en) * 2002-05-29 2003-12-04 Brennen Reid A. Microplate with an integrated microfluidic system for parallel processing minute volumes of fluids
CA2387316A1 (en) * 2002-05-31 2003-11-30 The University Of Western Ontario Method and apparatus for the detection of noncovalent interactions by mass spectrometry - based diffusion measurements
US7519145B2 (en) * 2002-07-25 2009-04-14 Los Alamos National Security, Llc Flow method and apparatus for screening chemicals using micro x-ray fluorescence
US7214320B1 (en) 2002-08-08 2007-05-08 Nanostream, Inc. Systems and methods for high throughput sample analysis
US6812458B2 (en) * 2002-08-08 2004-11-02 Nanostream, Inc. Systems and methods for high-throughput microfluidic sample analysis
JPWO2004029079A1 (ja) * 2002-09-25 2006-01-26 農工大ティー・エル・オー株式会社 タンパク質複合体の精製方法、アッセイ方法、精製装置およびアッセイ装置
JP3917052B2 (ja) * 2002-10-16 2007-05-23 信和化工株式会社 コポリマー、これを用いた吸着剤又は濃縮媒体、固相マイクロ抽出用注射針
CA2515213A1 (en) * 2003-02-11 2004-08-26 University Of Washington Stimuli-responsive polymer conjugates and related methods
DE10322893A1 (de) * 2003-05-19 2004-12-16 Hans-Knöll-Institut für Naturstoff-Forschung e.V. Vorrichtung und Verfahren zum Zudosieren von Reaktionsflüssigkeiten zu in Separationsmedium eingebetteten Flüssigkeitskompartimenten
DE10322942A1 (de) * 2003-05-19 2004-12-09 Hans-Knöll-Institut für Naturstoff-Forschung e.V. Vorrichtung zum Positionieren und Ausschleusen von in Separationsmedium eingebetteten Fluidkompartimenten
US8242254B2 (en) 2003-09-11 2012-08-14 Ibis Biosciences, Inc. Compositions for use in identification of bacteria
US8546082B2 (en) 2003-09-11 2013-10-01 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US8097416B2 (en) 2003-09-11 2012-01-17 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
JP2007510935A (ja) * 2003-11-07 2007-04-26 プリンストン・バイオケミカルズ・インコーポレーテッド 多次元電気泳動装置
US8007724B2 (en) * 2003-11-07 2011-08-30 Princeton Biochemicals, Inc. Electrophoresis apparatus having at least one auxiliary buffer passage
DE10361003B3 (de) * 2003-12-23 2005-07-28 Hte Ag The High Throughput Experimentation Company Vorrichtung und Verfahren zur Druck- und Flusskontrolle in Parallelreaktoren
JP4515387B2 (ja) * 2003-12-25 2010-07-28 独立行政法人産業技術総合研究所 糖鎖構造プロファイリング技術
WO2005064333A1 (ja) * 2003-12-25 2005-07-14 National Institute Of Advanced Industrial Science And Technology タンパク質と糖鎖との相互作用を分析する方法
US7318900B2 (en) * 2004-02-25 2008-01-15 Varian, Inc. Chromatography system and method
US7317187B2 (en) * 2004-05-20 2008-01-08 Davidson William R Frontal affinity chromatography/MALDI tandem mass spectrometry
CA2566815A1 (en) * 2004-05-21 2005-12-01 Mds Inc., Doing Business Through Its Mds Sciex Division Frontal affinity chromatography/maldi tandem mass spectrometry
CA2496481A1 (en) * 2005-02-08 2006-08-09 Mds Inc., Doing Business Through It's Mds Sciex Division Method and apparatus for sample deposition
US20060226082A1 (en) * 2005-03-15 2006-10-12 Mcmaster University Methods for substrate and modulator screening using enzyme-reactor chromatography/tandem mass spectrometry
WO2006116064A2 (en) * 2005-04-22 2006-11-02 Waters Investments Limited Apparatus and methods for mass-spectrometric directed purification of biopolymers
EP1929282A4 (de) * 2005-08-31 2009-06-03 Affymax Inc Derivatisierung und nachweis von arzneimitteln in niedrigen konzentrationen in biologischen flüssigkeiten und anderen lösungsmatrizen mittels proxy-marker
DK2084519T3 (da) 2006-10-10 2012-08-20 Los Alamos Nat Security Llc Røntgenfluorescens-analysefremgangsmåde
US7981688B2 (en) 2007-03-08 2011-07-19 University Of Washington Stimuli-responsive magnetic nanoparticles and related methods
GB0713187D0 (en) * 2007-07-06 2007-08-15 Cambridge Entpr biomolecule binding ligands
EP2217903B1 (de) * 2007-11-02 2019-04-03 Biocius Life Sciences, Inc. Probeninjektionssystem
US20090162845A1 (en) * 2007-12-20 2009-06-25 Elazar Rabbani Affinity tag nucleic acid and protein compositions, and processes for using same
US7884318B2 (en) * 2008-01-16 2011-02-08 Metabolon, Inc. Systems, methods, and computer-readable medium for determining composition of chemical constituents in a complex mixture
US20100227414A1 (en) * 2009-03-05 2010-09-09 Trex Enterprises Corp. Affinity capture mass spectroscopy with a porous silicon biosensor
US8426214B2 (en) * 2009-06-12 2013-04-23 University Of Washington System and method for magnetically concentrating and detecting biomarkers
PL3702775T3 (pl) * 2009-06-26 2026-03-30 Cytiva Sweden Ab Sposób oznaczania zdolności wiązania w układzie chromatograficznym
US9080933B2 (en) 2009-11-09 2015-07-14 University Of Washington Through Its Center For Commercialization Stimuli-responsive polymer diagnostic assay comprising magnetic nanoparticles and capture conjugates
US20110117668A1 (en) * 2009-11-09 2011-05-19 University Of Washington Through Its Center For Commercialization Self-powered smart diagnostic devices
US20120296403A1 (en) 2010-02-10 2012-11-22 Novartis Ag Methods and compounds for muscle growth
JP5632316B2 (ja) 2011-03-18 2014-11-26 株式会社日立ハイテクノロジーズ 質量分析装置及びそれに用いられるイオン源
CN103854949B (zh) * 2012-11-30 2016-12-21 中国科学院大连化学物理研究所 热解析进样器离子迁移谱气路
JP6510747B2 (ja) * 2013-08-02 2019-05-08 東洋ビーネット株式会社 プロテアーゼ活性測定法
US9803192B2 (en) * 2013-10-04 2017-10-31 Cornell University Programmable and reconfigurable microcolumn affinity chromatography device, system, and methods of use thereof
EP2944955A1 (de) * 2014-05-13 2015-11-18 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Bezugspunkt für LC-MS-Systeme
US20170234865A1 (en) 2016-02-16 2017-08-17 Gerald F. Swiss Methods, Compositions and Devices for Improving the Sensitivity of Assays
CN107331597B (zh) * 2017-06-23 2019-01-01 江苏天瑞仪器股份有限公司福建分公司 基质辅助激光解析电离飞行时间质谱仪的离子推斥方法
JP2019068869A (ja) * 2019-02-18 2019-05-09 東洋ビーネット株式会社 プロテアーゼ活性測定法
JP7349104B2 (ja) * 2019-11-13 2023-09-22 株式会社島津製作所 ベロ毒素の検出方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5106756A (en) * 1984-03-02 1992-04-21 The United States Of America As Represented By The United States Department Of Energy Method and system for gathering a library of response patterns for sensor arrays
US4842701A (en) * 1987-04-06 1989-06-27 Battelle Memorial Institute Combined electrophoretic-separation and electrospray method and system
US4869093A (en) * 1988-05-18 1989-09-26 Rutgers, The State University Methods and apparatus for determining sorption isotherms
US5324820A (en) * 1988-07-15 1994-06-28 Central Sydney Area Health Service Acid-labile subunit (ALS) of insulin-like growth factor binding protein complex
US4896093A (en) 1988-08-22 1990-01-23 American Telephone And Telegraph Company Electronic inductor
US4970085A (en) * 1989-10-19 1990-11-13 The Procter & Gamble Company Process for making improved citrus aqueous essence and product produced therefrom
US5646046A (en) * 1989-12-01 1997-07-08 Akzo Nobel N.V. Method and instrument for automatically performing analysis relating to thrombosis and hemostasis
WO1991019183A1 (en) * 1990-06-04 1991-12-12 Eastman Kodak Company Method for interactive self-modeling mixture analysis
WO1992002815A2 (en) * 1990-08-10 1992-02-20 Perseptive Biosystems, Inc. Quantitative analysis and monitoring of protein structure by subtractive chromatography
JP2950697B2 (ja) * 1993-01-08 1999-09-20 株式会社日立製作所 高速液体クロマトグラフ・質量分析計の直結方法およびその装置
US5503805A (en) * 1993-11-02 1996-04-02 Affymax Technologies N.V. Apparatus and method for parallel coupling reactions
WO1995025737A1 (en) * 1994-03-23 1995-09-28 The Penn State Research Foundation Method for identifying members of combinatorial libraries
WO1995032425A1 (en) * 1994-05-23 1995-11-30 Smithkline Beecham Corporation Encoded combinatorial libraries
GB9507366D0 (en) * 1995-04-08 1995-05-31 Zeneca Ltd Assay
US5834318A (en) * 1995-05-10 1998-11-10 Bayer Corporation Screening of combinatorial peptide libraries for selection of peptide ligand useful in affinity purification of target proteins
WO1997029508A2 (en) 1996-02-08 1997-08-14 Perseptive Biosystems, Inc. Interface between liquid flow and mass spectrometer
US5872015A (en) * 1996-05-10 1999-02-16 Board Of Trustees Of The University Of Illinois Molecular diversity screening method
WO1997043301A2 (en) * 1996-05-10 1997-11-20 Novartis Ag Identification of members of combinatorial libraries by mass spectrometry
US5792431A (en) * 1996-05-30 1998-08-11 Smithkline Beecham Corporation Multi-reactor synthesizer and method for combinatorial chemistry
US5917185A (en) * 1997-06-26 1999-06-29 Iowa State University Research Foundation, Inc. Laser vaporization/ionization interface for coupling microscale separation techniques with mass spectrometry
US6054047A (en) * 1998-03-27 2000-04-25 Synsorb Biotech, Inc. Apparatus for screening compound libraries

Also Published As

Publication number Publication date
JPH11304786A (ja) 1999-11-05
DK0886143T3 (da) 2002-07-08
IL137009A0 (en) 2001-06-14
AU2918499A (en) 1999-10-18
ES2174404T3 (es) 2002-11-01
US6355163B2 (en) 2002-03-12
CA2240380A1 (en) 1998-07-11
US6723235B2 (en) 2004-04-20
US6387257B1 (en) 2002-05-14
DE886143T1 (de) 1999-09-16
JP2001013125A (ja) 2001-01-19
EP0886143B1 (de) 2002-03-27
EP0886143A1 (de) 1998-12-23
DE69804379D1 (de) 2002-05-02
US6054047A (en) 2000-04-25
US20020134718A1 (en) 2002-09-26
CA2240380C (en) 2007-03-13
PT886143E (pt) 2002-09-30
US6395169B1 (en) 2002-05-28
JP3242392B2 (ja) 2001-12-25
US20010003328A1 (en) 2001-06-14
DE69804379T2 (de) 2002-09-12
WO1999050668A1 (en) 1999-10-07
JP3101607B2 (ja) 2000-10-23

Similar Documents

Publication Publication Date Title
ATE215228T1 (de) Gerät zur untersuchung von verbindungssammlungen
IL137010A0 (en) Methods for screening compound libraries
DE69230318D1 (de) Reagenzzusammensetzungen für analytische testungen
DK1199569T3 (da) Pröveanalysesystem
DE69632447D1 (de) Analysator zur Analyse von Urinbestandteilen
DE69434857D1 (de) Instrument zum Sammeln von mehreren Biopsieproben
DE69620870D1 (de) Affinitäts-selektion von liganden mittels massenspektroskopie
DE69232833D1 (de) Prüfung von alloantigenen durch bindungstest
FR2651157B1 (fr) Appareil de tamisage pour analyses.
DK0868427T3 (da) Fremgangsmåder til at idenficere forbindelser, der binder til et mål
DE69608277D1 (de) Probenanalysegerät
ATE475092T1 (de) Schnelle und quantitative proteomanalyse und entsprechende verfahren
WO1997012039A3 (en) Sh2-containing inositol-phosphatase
DE69622978D1 (de) Analysator zur Analyse von Urinbestandteilen
WO1997043301A3 (en) Identification of members of combinatorial libraries by mass spectrometry
NO933325D0 (no) Analyse for bestemmelse av estersubstrater
DE59713051D1 (de) Probe
DE69617715D1 (de) Materialanalyse
DE69118303D1 (de) Trockenanalytisches Element zur Analyse von Eisenionen
ATA36797A (de) Vorrichtung zum analysieren gasförmiger proben
CA2329818A1 (en) Method for analyzing total reactive sulfur
DK0687910T3 (da) Testsæt og fremgangsmåde til en bestemmelse ved kompetitiv specifik binding
BR9508258A (pt) Haste de imersão analítica e aparelho para teste de analito
DK0934527T3 (da) Ikke-radioaktivt receptor-assay, der er egnet til kvantitativ og kvalitativ analyse af spormængder af receptorbindende analysand
NO900840D0 (no) Anordning og fremgangsmaate for aa gjoere substansflekker paaskiktkromatogrammer synlige.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee