ATE215993T1 - Nachweis von nukleinsäuren mit breitem dynamikbereich unter verwendung von aggregat- primer-reihen - Google Patents
Nachweis von nukleinsäuren mit breitem dynamikbereich unter verwendung von aggregat- primer-reihenInfo
- Publication number
- ATE215993T1 ATE215993T1 AT96920266T AT96920266T ATE215993T1 AT E215993 T1 ATE215993 T1 AT E215993T1 AT 96920266 T AT96920266 T AT 96920266T AT 96920266 T AT96920266 T AT 96920266T AT E215993 T1 ATE215993 T1 AT E215993T1
- Authority
- AT
- Austria
- Prior art keywords
- target sequence
- aggregate
- detection
- nucleic acids
- dynamic range
- Prior art date
Links
- 238000001514 detection method Methods 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- 230000003321 amplification Effects 0.000 abstract 2
- 238000003199 nucleic acid amplification method Methods 0.000 abstract 2
- 230000001351 cycling effect Effects 0.000 abstract 1
- 230000035945 sensitivity Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6851—Quantitative amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6862—Ligase chain reaction [LCR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/702—Specific hybridization probes for retroviruses
- C12Q1/703—Viruses associated with AIDS
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/706—Specific hybridization probes for hepatitis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44461595A | 1995-05-19 | 1995-05-19 | |
| PCT/US1996/007138 WO1996036736A2 (en) | 1995-05-19 | 1996-05-17 | Wide dynamic range nucleic acid detection using an aggregate primer series |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE215993T1 true ATE215993T1 (de) | 2002-04-15 |
Family
ID=23765635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96920266T ATE215993T1 (de) | 1995-05-19 | 1996-05-17 | Nachweis von nukleinsäuren mit breitem dynamikbereich unter verwendung von aggregat- primer-reihen |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5858732A (de) |
| EP (1) | EP0826069B1 (de) |
| JP (1) | JPH11505126A (de) |
| AT (1) | ATE215993T1 (de) |
| CA (1) | CA2221454A1 (de) |
| DE (1) | DE69620596T2 (de) |
| WO (1) | WO1996036736A2 (de) |
Families Citing this family (85)
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| JPH1059817A (ja) * | 1996-08-20 | 1998-03-03 | Shiseido Co Ltd | 水中油型乳化化粧料 |
| EP1164203B1 (de) | 1996-11-06 | 2007-10-10 | Sequenom, Inc. | DNA-Diagnostik mittels Massenspektrometrie |
| US6327410B1 (en) | 1997-03-14 | 2001-12-04 | The Trustees Of Tufts College | Target analyte sensors utilizing Microspheres |
| US7622294B2 (en) | 1997-03-14 | 2009-11-24 | Trustees Of Tufts College | Methods for detecting target analytes and enzymatic reactions |
| US20030027126A1 (en) * | 1997-03-14 | 2003-02-06 | Walt David R. | Methods for detecting target analytes and enzymatic reactions |
| US6143496A (en) | 1997-04-17 | 2000-11-07 | Cytonix Corporation | Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly |
| US7348181B2 (en) | 1997-10-06 | 2008-03-25 | Trustees Of Tufts College | Self-encoding sensor with microspheres |
| US7115884B1 (en) | 1997-10-06 | 2006-10-03 | Trustees Of Tufts College | Self-encoding fiber optic sensor |
| EP1090293B2 (de) | 1998-06-24 | 2019-01-23 | Illumina, Inc. | Dekodierung von matrixartig-angeordneten Sensoren durch Mikropartikel |
| US6245511B1 (en) | 1999-02-22 | 2001-06-12 | Vialogy Corp | Method and apparatus for exponentially convergent therapy effectiveness monitoring using DNA microarray based viral load measurements |
| US20040111219A1 (en) * | 1999-02-22 | 2004-06-10 | Sandeep Gulati | Active interferometric signal analysis in software |
| US6235479B1 (en) * | 1999-04-13 | 2001-05-22 | Bio Merieux, Inc. | Methods and devices for performing analysis of a nucleic acid sample |
| US20060275782A1 (en) * | 1999-04-20 | 2006-12-07 | Illumina, Inc. | Detection of nucleic acid reactions on bead arrays |
| US6355431B1 (en) * | 1999-04-20 | 2002-03-12 | Illumina, Inc. | Detection of nucleic acid amplification reactions using bead arrays |
| EP1190100B1 (de) | 1999-05-20 | 2012-07-25 | Illumina, Inc. | Kombinatorische entschlüsselung von zufallsnukleinsäurearrays |
| US6544732B1 (en) | 1999-05-20 | 2003-04-08 | Illumina, Inc. | Encoding and decoding of array sensors utilizing nanocrystals |
| US8481268B2 (en) | 1999-05-21 | 2013-07-09 | Illumina, Inc. | Use of microfluidic systems in the detection of target analytes using microsphere arrays |
| US8080380B2 (en) * | 1999-05-21 | 2011-12-20 | Illumina, Inc. | Use of microfluidic systems in the detection of target analytes using microsphere arrays |
| CA2382157C (en) | 1999-08-18 | 2012-04-03 | Illumina, Inc. | Compositions and methods for preparing oligonucleotide solutions |
| US7361488B2 (en) * | 2000-02-07 | 2008-04-22 | Illumina, Inc. | Nucleic acid detection methods using universal priming |
| US6913884B2 (en) * | 2001-08-16 | 2005-07-05 | Illumina, Inc. | Compositions and methods for repetitive use of genomic DNA |
| US8076063B2 (en) * | 2000-02-07 | 2011-12-13 | Illumina, Inc. | Multiplexed methylation detection methods |
| US7582420B2 (en) * | 2001-07-12 | 2009-09-01 | Illumina, Inc. | Multiplex nucleic acid reactions |
| DK1259643T3 (da) * | 2000-02-07 | 2009-02-23 | Illumina Inc | Fremgangsmåde til detektion af nukleinsyre ved anvendelse af universel priming |
| US7955794B2 (en) * | 2000-09-21 | 2011-06-07 | Illumina, Inc. | Multiplex nucleic acid reactions |
| US20050214825A1 (en) * | 2000-02-07 | 2005-09-29 | John Stuelpnagel | Multiplex sample analysis on universal arrays |
| US7611869B2 (en) * | 2000-02-07 | 2009-11-03 | Illumina, Inc. | Multiplexed methylation detection methods |
| WO2001057268A2 (en) | 2000-02-07 | 2001-08-09 | Illumina, Inc. | Nucleic acid detection methods using universal priming |
| AU2001239760B2 (en) * | 2000-02-10 | 2005-11-24 | Illumina, Inc. | Array of individual arrays as substrate for bead-based simultaneous processing of samples and manufacturing method therefor |
| US6770441B2 (en) * | 2000-02-10 | 2004-08-03 | Illumina, Inc. | Array compositions and methods of making same |
| ATE412774T1 (de) | 2000-02-16 | 2008-11-15 | Illumina Inc | Parallele genotypisierung mehrerer patientenproben |
| AU2001254670A1 (en) * | 2000-03-02 | 2001-09-12 | Akzo Nobel N.V. | Detection of hepatitis b virus rna |
| US20040018491A1 (en) * | 2000-10-26 | 2004-01-29 | Kevin Gunderson | Detection of nucleic acid reactions on bead arrays |
| EP1440311B1 (de) * | 2001-08-31 | 2009-01-07 | Gen-Probe Incorporated | Sonden mit affinitätsverschiebung zur quantifizierung von analytenpolynukleotiden |
| DE60238699D1 (de) * | 2001-09-17 | 2011-02-03 | Phadia Ab | Mehrfachanalytassay-vorrichtung mit multi-spot-nachweiszone |
| SE0103072D0 (sv) * | 2001-09-17 | 2001-09-17 | Pharmacia Diagnostics Ab | Multi-analyte assay device with multi-spot detection zone |
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| ATE519861T1 (de) | 2002-06-14 | 2011-08-15 | Gen Probe Inc | Zusammensetzungen zum nachweis von hepatitis-b- virus |
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| CN100354298C (zh) * | 2002-06-28 | 2007-12-12 | 兰华生物科技公司 | 使用单核苷酸多态性组分析受损样品的方法和组合物 |
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| US20040259105A1 (en) * | 2002-10-03 | 2004-12-23 | Jian-Bing Fan | Multiplex nucleic acid analysis using archived or fixed samples |
| WO2004065000A1 (en) * | 2003-01-21 | 2004-08-05 | Illumina Inc. | Chemical reaction monitor |
| US6943768B2 (en) | 2003-02-21 | 2005-09-13 | Xtellus Inc. | Thermal control system for liquid crystal cell |
| EP1737985B1 (de) * | 2004-04-07 | 2015-12-30 | Access Bio, Inc. | System für den nachweis von nukleinsäuren |
| FR2869045A1 (fr) * | 2004-04-16 | 2005-10-21 | Bioalliance Pharma Sa | Methode d'etude de la variabilite genetique et fonctionnelle du vih et kit pour sa mise en oeuvre |
| EP1792263A2 (de) * | 2004-09-02 | 2007-06-06 | Vialogy Corporation | Erkennung von interessensereignissen unter verwendung von quantenresonanzinterferometrie |
| US11111544B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
| US11111543B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US7624808B2 (en) * | 2006-03-13 | 2009-12-01 | Western Well Tool, Inc. | Expandable ramp gripper |
| US20080274458A1 (en) * | 2007-05-01 | 2008-11-06 | Latham Gary J | Nucleic acid quantitation methods |
| EP3584324A1 (de) | 2008-11-24 | 2019-12-25 | Sequenom, Inc. | Produkte und verfahren zur nukleinsäuresequenzierung |
| AU2010276236B2 (en) | 2009-07-21 | 2014-03-20 | Gen-Probe Incorporated | Methods and compositions for quantitative detection of nucleic acid sequences over an extended dynamic range |
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12221653B2 (en) | 2010-05-18 | 2025-02-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11326208B2 (en) | 2010-05-18 | 2022-05-10 | Natera, Inc. | Methods for nested PCR amplification of cell-free DNA |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11332785B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11339429B2 (en) | 2010-05-18 | 2022-05-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US12152275B2 (en) | 2010-05-18 | 2024-11-26 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11332793B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
| WO2011146632A1 (en) | 2010-05-18 | 2011-11-24 | Gene Security Network Inc. | Methods for non-invasive prenatal ploidy calling |
| CN103608466B (zh) | 2010-12-22 | 2020-09-18 | 纳特拉公司 | 非侵入性产前亲子鉴定方法 |
| WO2012106385A2 (en) | 2011-01-31 | 2012-08-09 | Apprise Bio, Inc. | Methods of identifying multiple epitopes in cells |
| RU2671980C2 (ru) | 2011-02-09 | 2018-11-08 | Натера, Инк. | Способы неинвазивного пренатального установления плоидности |
| EP2882868B1 (de) | 2012-08-08 | 2019-07-31 | H. Hoffnabb-La Roche Ag | Dynamikbereichssteigerung zur identifikation mehrerer epitope in zellen |
| US20140100126A1 (en) | 2012-08-17 | 2014-04-10 | Natera, Inc. | Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data |
| CA2945962C (en) | 2014-04-21 | 2023-08-29 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| US20180173846A1 (en) | 2014-06-05 | 2018-06-21 | Natera, Inc. | Systems and Methods for Detection of Aneuploidy |
| US11479812B2 (en) | 2015-05-11 | 2022-10-25 | Natera, Inc. | Methods and compositions for determining ploidy |
| EP3106876B1 (de) | 2015-06-19 | 2022-12-07 | F. Hoffmann-La Roche AG | Feststoffabfallentsorgung |
| RU2760913C2 (ru) | 2016-04-15 | 2021-12-01 | Натера, Инк. | Способы выявления рака легкого |
| WO2018067517A1 (en) | 2016-10-04 | 2018-04-12 | Natera, Inc. | Methods for characterizing copy number variation using proximity-litigation sequencing |
| GB201618485D0 (en) | 2016-11-02 | 2016-12-14 | Ucl Business Plc | Method of detecting tumour recurrence |
| US10011870B2 (en) | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
| US12084720B2 (en) | 2017-12-14 | 2024-09-10 | Natera, Inc. | Assessing graft suitability for transplantation |
| US12024738B2 (en) | 2018-04-14 | 2024-07-02 | Natera, Inc. | Methods for cancer detection and monitoring |
| US12234509B2 (en) | 2018-07-03 | 2025-02-25 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
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Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1323293C (en) * | 1987-12-11 | 1993-10-19 | Keith C. Backman | Assay using template-dependent nucleic acid probe reorganization |
| AU629845B2 (en) * | 1988-08-30 | 1992-10-15 | Abbott Laboratories | Detection and amplification of target nucleic acid sequences |
| US5389512A (en) * | 1988-10-07 | 1995-02-14 | Hoffman-La Roche Inc. | Method for determining the relative amount of a viral nucleic acid segment in a sample by the polymerase chain reaction |
| US5219727A (en) * | 1989-08-21 | 1993-06-15 | Hoffmann-Laroche Inc. | Quantitation of nucleic acids using the polymerase chain reaction |
| US5213961A (en) * | 1989-08-31 | 1993-05-25 | Brigham And Women's Hospital | Accurate quantitation of RNA and DNA by competetitive polymerase chain reaction |
| JPH04152899A (ja) * | 1990-10-17 | 1992-05-26 | Shionogi & Co Ltd | ２段階ｐｃｒ法によるｈｉｖ―１ゲノムの検出法およびオリゴヌクレオチド |
| CA2065719A1 (en) * | 1991-04-30 | 1992-10-31 | John B. Findlay | Nucleic acid amplification and detection methods using rapid polymerase chain reaction cycle |
| DE69213112T2 (de) * | 1991-06-20 | 1997-04-03 | Hoffmann La Roche | Verbesserte Methoden zur Nukleinsäure-Amplifizierung |
| AU4248193A (en) * | 1992-05-15 | 1993-12-13 | New England Deaconess Hospital | Quantitation of viral rna by competitive polymerase chain reaction |
| US5340728A (en) * | 1992-12-09 | 1994-08-23 | E. I. Du Pont De Nemours And Company | Method for amplification of targeted segments of nucleic acid using nested polymerase chain reaction |
| DE69431510T2 (de) * | 1993-07-08 | 2003-02-27 | Johnson & Johnson Clinical Diagnostics, Inc. | Verfahren zur Koamplifikation zweier unterschiedlicher Nukleinsäure-Sequenzen unter Verwendung der Polymerase-Kettenreaktion |
-
1996
- 1996-05-17 AT AT96920266T patent/ATE215993T1/de not_active IP Right Cessation
- 1996-05-17 WO PCT/US1996/007138 patent/WO1996036736A2/en not_active Ceased
- 1996-05-17 DE DE69620596T patent/DE69620596T2/de not_active Expired - Fee Related
- 1996-05-17 JP JP8535080A patent/JPH11505126A/ja active Pending
- 1996-05-17 EP EP96920266A patent/EP0826069B1/de not_active Expired - Lifetime
- 1996-05-17 CA CA002221454A patent/CA2221454A1/en not_active Abandoned
- 1996-08-23 US US08/697,404 patent/US5858732A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US5858732A (en) | 1999-01-12 |
| WO1996036736A3 (en) | 1997-04-17 |
| WO1996036736A2 (en) | 1996-11-21 |
| CA2221454A1 (en) | 1996-11-21 |
| JPH11505126A (ja) | 1999-05-18 |
| DE69620596T2 (de) | 2002-11-21 |
| EP0826069A2 (de) | 1998-03-04 |
| EP0826069B1 (de) | 2002-04-10 |
| DE69620596D1 (de) | 2002-05-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |