ATE216255T1 - Lokale abgabe von faktoren die des überlebens von transplantierten zellen verhögen - Google Patents

Lokale abgabe von faktoren die des überlebens von transplantierten zellen verhögen

Info

Publication number: ATE216255T1
Authority: AT; Austria
Prior art keywords: microspheres; egf; hepatocytes; cells; survival
Prior art date: 1994-12-16

Application number

AT95943823T

Other languages

English (en)

Inventor

David J Mooney

Robert S Langer

Joseph P Vacanti

Original Assignee

Massachusetts Inst Technology

Childrens Medical Center

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-12-16

Filing date

1995-12-14

Publication date

2002-05-15

1995-12-14 Application filed by Massachusetts Inst Technology, Childrens Medical Center filed Critical Massachusetts Inst Technology

2002-05-15 Application granted granted Critical

2002-05-15 Publication of ATE216255T1 publication Critical patent/ATE216255T1/de

Links

230000004083 survival effect Effects 0.000 title abstract 3
239000004005 microsphere Substances 0.000 abstract 5
VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 abstract 4
102000009024 Epidermal Growth Factor Human genes 0.000 abstract 3
101800003838 Epidermal growth factor Proteins 0.000 abstract 3
210000004027 cell Anatomy 0.000 abstract 3
229940116977 epidermal growth factor Drugs 0.000 abstract 3
210000003494 hepatocyte Anatomy 0.000 abstract 3
AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 abstract 2
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 abstract 2
230000006820 DNA synthesis Effects 0.000 abstract 1
241001465754 Metazoa Species 0.000 abstract 1
239000002870 angiogenesis inducing agent Substances 0.000 abstract 1
229920001577 copolymer Polymers 0.000 abstract 1
239000000839 emulsion Substances 0.000 abstract 1
239000003102 growth factor Substances 0.000 abstract 1
239000007943 implant Substances 0.000 abstract 1
238000002513 implantation Methods 0.000 abstract 1
238000000338 in vitro Methods 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
238000011694 lewis rat Methods 0.000 abstract 1
230000007774 longterm Effects 0.000 abstract 1
239000011159 matrix material Substances 0.000 abstract 1
210000000713 mesentery Anatomy 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000035755 proliferation Effects 0.000 abstract 1
239000000725 suspension Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/407—Liver; Hepatocytes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1808—Epidermal growth factor [EGF] urogastrone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0068—General culture methods using substrates
- C12N5/0075—General culture methods using substrates using microcarriers
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2531/00—Microcarriers
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/30—Synthetic polymers
- C12N2533/40—Polyhydroxyacids, e.g. polymers of glycolic or lactic acid (PGA, PLA, PLGA); Bioresorbable polymers

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Organic Chemistry (AREA)
Wood Science & Technology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Cell Biology (AREA)
General Engineering & Computer Science (AREA)
Immunology (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Nutrition Science (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Developmental Biology & Embryology (AREA)
General Chemical & Material Sciences (AREA)
Virology (AREA)
Chemical Kinetics & Catalysis (AREA)
Physiology (AREA)
Dermatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicinal Preparation (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Compounds Of Unknown Constitution (AREA)
Materials For Medical Uses (AREA)

AT95943823T 1994-12-16 1995-12-14 Lokale abgabe von faktoren die des überlebens von transplantierten zellen verhögen ATE216255T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/358,235 US6281015B1 (en)	1994-12-16	1994-12-16	Localized delivery of factors enhancing survival of transplanted cells
PCT/US1995/016356 WO1996018411A1 (en)	1994-12-16	1995-12-14	Localized delivery of factors enhancing survival of transplanted cells

Publications (1)

Publication Number	Publication Date
ATE216255T1 true ATE216255T1 (de)	2002-05-15

Family

ID=23408836

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95943823T ATE216255T1 (de)	1994-12-16	1995-12-14	Lokale abgabe von faktoren die des überlebens von transplantierten zellen verhögen

Country Status (10)

Country	Link
US (1)	US6281015B1 (de)
EP (1)	EP0794790B1 (de)
JP (2)	JP4361134B2 (de)
AT (1)	ATE216255T1 (de)
CA (1)	CA2207286C (de)
DE (1)	DE69526448T2 (de)
DK (1)	DK0794790T3 (de)
ES (1)	ES2176359T3 (de)
PT (1)	PT794790E (de)
WO (1)	WO1996018411A1 (de)

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1994
- 1994-12-16 US US08/358,235 patent/US6281015B1/en not_active Expired - Lifetime
1995
- 1995-12-14 WO PCT/US1995/016356 patent/WO1996018411A1/en not_active Ceased
- 1995-12-14 DE DE69526448T patent/DE69526448T2/de not_active Expired - Lifetime
- 1995-12-14 ES ES95943823T patent/ES2176359T3/es not_active Expired - Lifetime
- 1995-12-14 DK DK95943823T patent/DK0794790T3/da active
- 1995-12-14 PT PT95943823T patent/PT794790E/pt unknown
- 1995-12-14 CA CA002207286A patent/CA2207286C/en not_active Expired - Fee Related
- 1995-12-14 AT AT95943823T patent/ATE216255T1/de active
- 1995-12-14 EP EP95943823A patent/EP0794790B1/de not_active Expired - Lifetime
- 1995-12-14 JP JP51927596A patent/JP4361134B2/ja not_active Expired - Fee Related
2007
- 2007-08-27 JP JP2007220401A patent/JP2008011863A/ja active Pending

Also Published As

Publication number	Publication date
EP0794790A1 (de)	1997-09-17
DK0794790T3 (da)	2002-07-22
JP2008011863A (ja)	2008-01-24
DE69526448D1 (de)	2002-05-23
EP0794790B1 (de)	2002-04-17
CA2207286A1 (en)	1996-06-20
DE69526448T2 (de)	2002-11-07
PT794790E (pt)	2002-09-30
CA2207286C (en)	2003-10-07
WO1996018411A1 (en)	1996-06-20
JPH10510816A (ja)	1998-10-20
ES2176359T3 (es)	2002-12-01
US6281015B1 (en)	2001-08-28
JP4361134B2 (ja)	2009-11-11

Legal Events

Date	Code	Title	Description
2002-10-15	UEP	Publication of translation of european patent specification

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