ATE348876T1 - Verfahren zur vermehrung von natürlichen killerzellen - Google Patents

Verfahren zur vermehrung von natürlichen killerzellen

Info

Publication number
ATE348876T1
ATE348876T1 AT00976285T AT00976285T ATE348876T1 AT E348876 T1 ATE348876 T1 AT E348876T1 AT 00976285 T AT00976285 T AT 00976285T AT 00976285 T AT00976285 T AT 00976285T AT E348876 T1 ATE348876 T1 AT E348876T1
Authority
AT
Austria
Prior art keywords
natural killer
killer cells
human
producing natural
cells
Prior art date
Application number
AT00976285T
Other languages
English (en)
Inventor
Tadao Riken Ohno
Kaoru Riken Saijoh
Original Assignee
Riken
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riken filed Critical Riken
Application granted granted Critical
Publication of ATE348876T1 publication Critical patent/ATE348876T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT00976285T 1999-11-26 2000-11-16 Verfahren zur vermehrung von natürlichen killerzellen ATE348876T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP33607999A JP3619853B2 (ja) 1999-11-26 1999-11-26 ナチュラルキラー細胞の増殖方法

Publications (1)

Publication Number Publication Date
ATE348876T1 true ATE348876T1 (de) 2007-01-15

Family

ID=18295489

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00976285T ATE348876T1 (de) 1999-11-26 2000-11-16 Verfahren zur vermehrung von natürlichen killerzellen

Country Status (10)

Country Link
EP (1) EP1233058B1 (de)
JP (1) JP3619853B2 (de)
KR (1) KR20030032905A (de)
CN (1) CN1237170C (de)
AT (1) ATE348876T1 (de)
CA (1) CA2393322A1 (de)
DE (1) DE60032508D1 (de)
HK (1) HK1048498A1 (de)
TW (1) TWI224137B (de)
WO (1) WO2001038494A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1288291A4 (de) * 2000-06-06 2004-05-12 Kirin Brewery Methode zur verfielfältigung von natürlichen killer-t-zellen
JP2002045174A (ja) * 2000-07-31 2002-02-12 Inst Of Physical & Chemical Res ナチュラルキラー細胞増殖法
CN101658678A (zh) 2004-09-15 2010-03-03 森永乳业株式会社 筛选具有自然杀伤细胞增殖作用的物质和增殖自然杀伤细胞的方法
JP3924310B2 (ja) 2004-09-29 2007-06-06 森永乳業株式会社 高血糖改善のための医薬及び飲食品
JP2008109866A (ja) * 2006-10-30 2008-05-15 Jms Co Ltd 培地添加剤、この培地添加剤を含む培地、及びこの培地を用いた細胞の培養方法
MX2007015736A (es) * 2007-12-11 2009-06-11 Val De Bio S De R L De C V Procedimiento para sensibilizar celulas y el uso de las mismas para tratamiento de tumores.
WO2014117121A1 (en) 2013-01-28 2014-07-31 St. Jude Children's Research Hospital, Inc. A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease
KR102211120B1 (ko) 2014-05-15 2021-02-03 내셔널 유니버시티 오브 싱가포르 변형된 천연 살해 세포 및 그의 용도
CN104611293B (zh) * 2014-12-30 2017-10-13 杭州特马赛生物技术有限公司 一种体外中药组合诱导扩增nk细胞的方法及其应用
CN104789527B (zh) * 2015-05-15 2018-05-29 江苏杰晟生物科技有限公司 一种自体自然杀伤细胞鸡尾酒式培养的制备方法及其试剂盒产品
CN107064085B (zh) * 2017-03-16 2021-05-11 中国人民解放军三〇七医院 自然杀伤细胞活性测定方法
WO2018182511A1 (en) 2017-03-27 2018-10-04 National University Of Singapore Stimulatory cell lines for ex vivo expansion and activation of natural killer cells
IL269553B2 (en) 2017-03-27 2025-10-01 Nat Univ Singapore Truncated NKG2D chimeric receptors and their uses in immunotherapy with natural killer cells
CN111801348A (zh) 2018-02-09 2020-10-20 新加坡国立大学 活化性嵌合受体及其在自然杀伤细胞免疫疗法中的用途
SG11202008976YA (en) 2018-04-02 2020-10-29 Nat Univ Singapore Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells
EP3844186A4 (de) 2018-08-29 2022-08-17 National University of Singapore Verfahren zur spezifischen stimulation des überlebens und der expansion von genetisch modifizierten immunzellen
CA3120563A1 (en) 2018-11-26 2020-06-04 Nkarta, Inc. Methods for the simultaneous expansion of multiple immune cell types, related compositions and uses of same in cancer immunotherapy
WO2020180882A1 (en) 2019-03-05 2020-09-10 Nkarta, Inc. Cd19-directed chimeric antigen receptors and uses thereof in immunotherapy
CN112251405A (zh) * 2020-10-15 2021-01-22 大连天星生物技术有限责任公司 一种体外高效诱导扩增nk细胞的方法
CN112285083B (zh) * 2020-10-28 2022-01-07 上海睿钰生物科技有限公司 一种细胞杀伤效力的评价方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5415874A (en) * 1989-10-31 1995-05-16 The Board Of Trustees Of The Leland Stanford Junior University Natural killer cell lines and clones with antigen specificity
JP3381224B2 (ja) * 1996-04-17 2003-02-24 ベーリンガー マンハイム ゲゼルシャフト ミット ベシュレンクテル ハフツング リンパ球を生産し、そして増加させる方法
FR2775692B1 (fr) * 1998-03-03 2000-06-16 Roussy Inst Gustave Methodes d'activation de cellules tueuses naturelles (nk) et moyens de mise en oeuvre

Also Published As

Publication number Publication date
DE60032508D1 (de) 2007-02-01
EP1233058B1 (de) 2006-12-20
WO2001038494A1 (en) 2001-05-31
JP3619853B2 (ja) 2005-02-16
JP2001149069A (ja) 2001-06-05
EP1233058A4 (de) 2003-01-15
CN1399675A (zh) 2003-02-26
KR20030032905A (ko) 2003-04-26
HK1048498A1 (en) 2003-04-04
CN1237170C (zh) 2006-01-18
CA2393322A1 (en) 2001-05-31
TWI224137B (en) 2004-11-21
EP1233058A1 (de) 2002-08-21

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