ATE216696T1 - Verfahren zur herstellung eines hiv-protease inhibitor - Google Patents

Verfahren zur herstellung eines hiv-protease inhibitor

Info

Publication number: ATE216696T1
Authority: AT; Austria
Prior art keywords: amino; producing; protease inhibitor; hiv protease; thiazolyl
Prior art date: 1995-06-06

Application number

AT96915755T

Other languages

English (en)

Inventor

Jien-Heh Tien

Jerome A Menzia

Arthur J Cooper

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-06

Filing date

1996-05-13

Publication date

2002-05-15

1996-05-13 Application filed by Abbott Lab filed Critical Abbott Lab

2002-05-15 Application granted granted Critical

2002-05-15 Publication of ATE216696T1 publication Critical patent/ATE216696T1/de

Links

229940122440 HIV protease inhibitor Drugs 0.000 title 1
239000004030 hiv protease inhibitor Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
239000002253 acid Substances 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
NCDNCNXCDXHOMX-OOUBJREFSA-N 1,3-thiazol-5-ylmethyl n-[(2s,3s,5s)-3-hydroxy-5-[[(2r)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate Chemical compound N([C@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-OOUBJREFSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Virology (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Tropical Medicine & Parasitology (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
AIDS & HIV (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Compounds Of Unknown Constitution (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT96915755T 1995-06-06 1996-05-13 Verfahren zur herstellung eines hiv-protease inhibitor ATE216696T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/469,965 US5567823A (en)	1995-06-06	1995-06-06	Process for the preparation of an HIV protease inhibiting compound
PCT/US1996/006812 WO1996039398A1 (en)	1995-06-06	1996-05-13	Process for the preparation of an hiv protease inhibiting compound

Publications (1)

Publication Number	Publication Date
ATE216696T1 true ATE216696T1 (de)	2002-05-15

Family

ID=23865732

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96915755T ATE216696T1 (de)	1995-06-06	1996-05-13	Verfahren zur herstellung eines hiv-protease inhibitor

Country Status (11)

Country	Link
US (1)	US5567823A (de)
EP (1)	EP0830353B1 (de)
JP (2)	JP4580044B2 (de)
AT (1)	ATE216696T1 (de)
CA (1)	CA2219983C (de)
DE (1)	DE69620882T2 (de)
DK (1)	DK0830353T3 (de)
ES (1)	ES2176456T3 (de)
MX (1)	MX9709454A (de)
PT (1)	PT830353E (de)
WO (1)	WO1996039398A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2170020C (en)	1992-12-29	2005-08-02	Dale J. Kempf	Retroviral protease inhibiting compounds
US6037157A (en)	1995-06-29	2000-03-14	Abbott Laboratories	Method for improving pharmacokinetics
US6180634B1 (en) *	1997-11-13	2001-01-30	Merck & Co., Inc.	Combination therapy for the treatment of AIDS
US6803466B1 (en) *	1997-12-08	2004-10-12	The Scripps Research Institute	HIV/FIV protease inhibitors having a small P3 residue
EP1039886A4 (de) *	1997-12-08	2001-05-16	Scripps Research Inst	Ein kleiner p3 rest aufweisende hiv/fiv protease hemmer
US6894171B1 (en) *	1998-07-20	2005-05-17	Abbott Laboratories	Polymorph of a pharmaceutical
MY121765A (en) *	1998-07-20	2006-02-28	Abbott Lab	Polymorph of ritonavir
TR200103488T2 (tr) *	1999-06-04	2002-04-22	Abbott Laboratories	Geliştirilmiş farmasötik formülasyonlar.
IT1313624B1 (it) *	1999-09-21	2002-09-09	Archimica Spa Ora Clariant Lif	Procedimento per la sintesi del ritonavir
EP1175205B1 (de) *	1999-11-12	2006-06-14	Abbott Laboratories	Feste dispersion mit ritonavir, fenofibrat oder griseofulvin
TR201809435T4 (tr)	2000-01-19	2018-07-23	Abbvie Inc	Geliştirilmiş farmasötik formülasyonlar.
DE10026698A1 (de) *	2000-05-30	2001-12-06	Basf Ag	Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
US8377952B2 (en)	2003-08-28	2013-02-19	Abbott Laboratories	Solid pharmaceutical dosage formulation
US8025899B2 (en)	2003-08-28	2011-09-27	Abbott Laboratories	Solid pharmaceutical dosage form
BRPI0401742B8 (pt) *	2004-05-13	2021-05-25	Cristalia Produtos Quim Farmaceuticos Ltda	composto análogo do ritonavir útil como inibidor de protease retroviral, preparação do composto análogo do ritonavir e composição farmacêutica do composto análogo do ritonavir
EP1976517A1 (de)	2005-12-30	2008-10-08	Gilead Sciences, Inc.	Verfahren zur verbesserung der pharmakokinetik von hiv-integrase-hemmern
PL2049506T5 (pl) *	2006-07-07	2024-09-09	Gilead Sciences, Inc.	Modulatory farmakokinetycznych właściwości leków
WO2008041176A2 (en) *	2006-10-03	2008-04-10	Ranbaxy Laboratories Limited	Process for the preparation of form i and form ii of ritonavir
CA2669938C (en) *	2006-11-15	2016-01-05	Abbott Laboratories	Solid pharmaceutical dosage formulations
MX2009008935A (es)	2007-02-23	2009-11-02	Gilead Sciences Inc	Moduladores de las propiedades farmacocineticas de productos terapeuticos.
US8759379B2 (en) *	2008-01-04	2014-06-24	Gilead Sciences, Inc.	Inhibitors of cytochrome P450
CN101967130B (zh) *	2010-07-02	2012-12-26	厦门市亨瑞生化有限公司	利托那韦中间体的合成方法
CN102786494B (zh) *	2012-07-26	2016-01-06	合肥华方医药科技有限公司	利托那韦异构体杂质的合成研究及控制方法
IN2014CH00872A (de) *	2014-02-21	2015-08-28	Mylan Lab Ltd
CN104311503B (zh) *	2014-11-03	2017-01-25	东北制药集团股份有限公司	一种制备抗hiv药物利托那韦的方法
CN111646953A (zh) *	2020-04-23	2020-09-11	厦门蔚嘉制药有限公司	一种合成利托那韦的新方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5142056A (en) *	1989-05-23	1992-08-25	Abbott Laboratories	Retroviral protease inhibiting compounds
CA2170020C (en) *	1992-12-29	2005-08-02	Dale J. Kempf	Retroviral protease inhibiting compounds

1995
- 1995-06-06 US US08/469,965 patent/US5567823A/en not_active Expired - Lifetime
1996
- 1996-05-13 JP JP50055497A patent/JP4580044B2/ja not_active Expired - Lifetime
- 1996-05-13 WO PCT/US1996/006812 patent/WO1996039398A1/en not_active Ceased
- 1996-05-13 PT PT96915755T patent/PT830353E/pt unknown
- 1996-05-13 CA CA002219983A patent/CA2219983C/en not_active Expired - Lifetime
- 1996-05-13 EP EP96915755A patent/EP0830353B1/de not_active Expired - Lifetime
- 1996-05-13 MX MX9709454A patent/MX9709454A/es active IP Right Grant
- 1996-05-13 DK DK96915755T patent/DK0830353T3/da active
- 1996-05-13 ES ES96915755T patent/ES2176456T3/es not_active Expired - Lifetime
- 1996-05-13 DE DE69620882T patent/DE69620882T2/de not_active Expired - Lifetime
- 1996-05-13 AT AT96915755T patent/ATE216696T1/de active
2010
- 2010-07-01 JP JP2010150808A patent/JP5390477B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JPH11507029A (ja)	1999-06-22
CA2219983A1 (en)	1996-12-12
JP2010270123A (ja)	2010-12-02
ES2176456T3 (es)	2002-12-01
US5567823A (en)	1996-10-22
JP5390477B2 (ja)	2014-01-15
EP0830353B1 (de)	2002-04-24
MX9709454A (es)	1998-02-28
JP4580044B2 (ja)	2010-11-10
DK0830353T3 (da)	2002-07-29
CA2219983C (en)	2007-09-18
WO1996039398A1 (en)	1996-12-12
PT830353E (pt)	2002-10-31
DE69620882T2 (de)	2002-12-12
EP0830353A1 (de)	1998-03-25
DE69620882D1 (de)	2002-05-29

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Legal Events

Date	Code	Title	Description
2002-10-15	UEP	Publication of translation of european patent specification