TR200401012T4 - Mide tedavisinde kullanılan aktif olmayan ilaçlar. - Google Patents

Mide tedavisinde kullanılan aktif olmayan ilaçlar.

Info

Publication number
TR200401012T4
TR200401012T4 TR2004/01012T TR200401012T TR200401012T4 TR 200401012 T4 TR200401012 T4 TR 200401012T4 TR 2004/01012 T TR2004/01012 T TR 2004/01012T TR 200401012 T TR200401012 T TR 200401012T TR 200401012 T4 TR200401012 T4 TR 200401012T4
Authority
TR
Turkey
Prior art keywords
treatment
disclosed
stomach
hydrophilic group
drugs used
Prior art date
Application number
TR2004/01012T
Other languages
English (en)
Inventor
Samuel Tremont J.
Paul Collins W.
Fenton L.Ricky
Original Assignee
Pharmacia Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corporation filed Critical Pharmacia Corporation
Publication of TR200401012T4 publication Critical patent/TR200401012T4/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Bu bulus AW-SiRIR2R3 formülünün bir bilesenini saglamakta olup,içerisindeki RI ve RZ bagimsiz olarak alkil, sikloalkil, alkenil, alkinil, aril, aralkil, alkaril veya bir hidrofilik gruptur;R3 bir hidrofilik gruptur ve AW, AWH ilacinin esdegerli olarak baglanmis sekli olup, içerisindeki W;0,CO2,NH,S veya bir enolat gruptur.Elbette R1,R veya R3'den her biri veya tümü bagimsiz olarak hidrofilik gruplari ihtiva edebilir. Hidrofilik grup nötr olmayabilir veya bir poliol olabilir.En tercih edilen bir yapilanmada hidrofilik grup bir üçüncül amin veya polietilen glikoldur.Bu bilesen, AWH ilaci için bir aktif olmayan ilaç vazifesi görür. Bu bulus ayni zamanda,ilkin AWH ilacini YSiRIR2R7 formülüne sahip bir bilesenle tepkimeye sokarak bu bilesenleri hazirlamak için bir yöntem saglamakta olup, içerisindeki Y;halo veya bir alkil-, haloalkil-, aril-, alkaril-, aralkil-veya haloaril-sülfonat esterdir;R1 ve R2 önceden açiklandigi gibidir;R7,bir halo grubun ikame ettigi bir gruptur. DEVAMI VAR...
TR2004/01012T 2000-02-28 2001-02-16 Mide tedavisinde kullanılan aktif olmayan ilaçlar. TR200401012T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/514,819 US6413945B1 (en) 1997-04-04 2000-02-28 Gastro-specific prodrugs

Publications (1)

Publication Number Publication Date
TR200401012T4 true TR200401012T4 (tr) 2004-10-21

Family

ID=24048822

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2004/01012T TR200401012T4 (tr) 2000-02-28 2001-02-16 Mide tedavisinde kullanılan aktif olmayan ilaçlar.

Country Status (11)

Country Link
US (1) US6413945B1 (tr)
EP (1) EP1261613B1 (tr)
JP (1) JP2003525301A (tr)
AT (1) ATE266034T1 (tr)
AU (1) AU2001237033A1 (tr)
DE (1) DE60103134T2 (tr)
DK (1) DK1261613T3 (tr)
ES (1) ES2215880T3 (tr)
PT (1) PT1261613E (tr)
TR (1) TR200401012T4 (tr)
WO (1) WO2001064690A1 (tr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1744785A1 (en) * 2004-04-30 2007-01-24 Kopran Research Laboratories Limited Hydroxyalkyl derivatives of biologically active compounds
WO2009132265A2 (en) * 2008-04-25 2009-10-29 The University Of North Carolina At Chapel Hill Degradable compounds and methods of use thereof, particularly with particle replication in non-wetting templates
US20110212986A1 (en) * 2008-08-21 2011-09-01 Health Research, Inc. Anti-flavivirus therapeutic
EP2616103A1 (en) 2010-09-16 2013-07-24 The University of North Carolina At Chapel Hill Asymmetric bifunctional silyl monomers and particles thereof as prodrugs and delivery vehicles for pharmaceutical, chemical and biological agents
WO2016057828A1 (en) 2014-10-08 2016-04-14 Epigenetics Pharma Llc Silylated pyrimidine prodrugs and methods of their use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5055604A (en) * 1990-04-17 1991-10-08 G. D. Searle & Co. Process for preparing prostaglandin analogs using organozirconium compounds
WO1992001477A1 (en) * 1990-07-26 1992-02-06 G.D. Searle & Co. Polymeric drug delivery system
JPH08165301A (ja) * 1994-12-15 1996-06-25 Mitsubishi Chem Corp 環状イヌロオリゴ糖のシリル化誘導体およびその製造方法
US5618959A (en) * 1995-03-10 1997-04-08 Vivus Incorporated Process for preparing prostaglandin E1, E2 and analogs thereof using furylcopper reagents
US6030959A (en) * 1997-04-04 2000-02-29 Monsanto Company Gastro-specific prodrugs

Also Published As

Publication number Publication date
DE60103134D1 (de) 2004-06-09
PT1261613E (pt) 2004-08-31
EP1261613A1 (en) 2002-12-04
EP1261613B1 (en) 2004-05-06
ES2215880T3 (es) 2004-10-16
AU2001237033A1 (en) 2001-09-12
ATE266034T1 (de) 2004-05-15
DK1261613T3 (da) 2004-08-09
JP2003525301A (ja) 2003-08-26
WO2001064690A1 (en) 2001-09-07
DE60103134T2 (de) 2005-04-28
US6413945B1 (en) 2002-07-02

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