ATE217009T1 - Stereoselektives verfahren zur herstellung von geschützten 2',2'-difluorlactonen - Google Patents

Stereoselektives verfahren zur herstellung von geschützten 2',2'-difluorlactonen

Info

Publication number: ATE217009T1
Authority: AT; Austria
Prior art keywords: difluorolactones; difluoronucleosides; deoxy; producing; stereoselective process
Prior art date: 1987-08-28

Application number

AT95201845T

Other languages

English (en)

Inventor

Ta-Sen Chou

Perry Clark Heath

Lawrence Edward Patterson

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-08-28

Filing date

1988-08-22

Publication date

2002-05-15

1988-08-22 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2002-05-15 Application granted granted Critical

2002-05-15 Publication of ATE217009T1 publication Critical patent/ATE217009T1/de

Links

238000000034 method Methods 0.000 title abstract 3
230000000707 stereoselective effect Effects 0.000 title 1
150000002596 lactones Chemical class 0.000 abstract 3
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
239000000543 intermediate Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
150000007522 mineralic acids Chemical class 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1
239000002243 precursor Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Furan Compounds (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Epoxy Compounds (AREA)

AT95201845T 1987-08-28 1988-08-22 Stereoselektives verfahren zur herstellung von geschützten 2',2'-difluorlactonen ATE217009T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US9072587A	1987-08-28	1987-08-28

Publications (1)

Publication Number	Publication Date
ATE217009T1 true ATE217009T1 (de)	2002-05-15

Family

ID=22224017

Family Applications (4)

Application Number	Title	Priority Date	Filing Date
AT94202041T ATE179713T1 (de)	1987-08-28	1988-08-22	Verfahren zur selektiven isolierung von beta-2'- desoxy-2'2'-difluorocytidin oder seiner salze
AT88307750T ATE164847T1 (de)	1987-08-28	1988-08-22	Verfahren zur herstellung von zwischenverbindungen verwendbar in der herstellung von 2',2'-difluoronucleosiden
AT95201846T ATE202113T1 (de)	1987-08-28	1988-08-22	Verfahren zur herstellung von 2'-deoxy-2',2'- difluornukleosiden
AT95201845T ATE217009T1 (de)	1987-08-28	1988-08-22	Stereoselektives verfahren zur herstellung von geschützten 2',2'-difluorlactonen

Family Applications Before (3)

Application Number	Title	Priority Date	Filing Date
AT94202041T ATE179713T1 (de)	1987-08-28	1988-08-22	Verfahren zur selektiven isolierung von beta-2'- desoxy-2'2'-difluorocytidin oder seiner salze
AT88307750T ATE164847T1 (de)	1987-08-28	1988-08-22	Verfahren zur herstellung von zwischenverbindungen verwendbar in der herstellung von 2',2'-difluoronucleosiden
AT95201846T ATE202113T1 (de)	1987-08-28	1988-08-22	Verfahren zur herstellung von 2'-deoxy-2',2'- difluornukleosiden

Country Status (11)

Country	Link
EP (4)	EP0688783B1 (de)
JP (5)	JP2738540B2 (de)
KR (1)	KR970002659B1 (de)
AT (4)	ATE179713T1 (de)
CA (1)	CA1324128C (de)
DE (4)	DE3856527T2 (de)
ES (4)	ES2113845T3 (de)
GR (1)	GR3026611T3 (de)
HU (3)	HU202249B (de)
IE (1)	IE81131B1 (de)
IL (1)	IL87517A (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2012129A1 (en) *	1989-03-20	1990-09-20	Ramakrishnan Nagarajan	Recovery of difluoro sugar
US5256798A (en) *	1992-06-22	1993-10-26	Eli Lilly And Company	Process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates
YU43193A (sh) *	1992-06-22	1997-01-08	Eli Lilly And Company	2'-deoksi-2',2'-difluoro(4-supstituisani)pirimidinski nukleozidi antivirusnog i antikancerogenog dejstva i međuproizvodi
US5401861A (en) *	1992-06-22	1995-03-28	Eli Lilly And Company	Low temperature process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates
US5256797A (en) *	1992-06-22	1993-10-26	Eli Lilly And Company	Process for separating 2-deoxy-2,2-difluoro-D-ribofuranosyl alkylsulfonate anomers
US5252756A (en) *	1992-06-22	1993-10-12	Eli Lilly And Company	Process for preparing beta-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl-arylsulfonates
UA41261C2 (uk) *	1992-06-22	2001-09-17	Елі Ліллі Енд Компані	Спосіб одержання збагачених бета-аномером нуклеозидів
US5559222A (en) *	1995-02-03	1996-09-24	Eli Lilly And Company	Preparation of 1-(2'-deoxy-2',2'-difluoro-D-ribo-pentofuranosyl)-cytosine from 2-deoxy-2,2-difluoro-β-D-ribo-pentopyranose
WO1997021719A1 (en)	1995-12-13	1997-06-19	Eli Lilly And Company	α, α-DIFLUORO-β-HYDROXY THIOL ESTERS AND THEIR SYNTHESIS
KR100578616B1 (ko) *	2004-07-23	2006-05-10	한미약품 주식회사	Ｄ-에리트로-2,2-다이플루오로-2-데옥시-1-옥소라이보스화합물의 제조방법
US8193354B2 (en) *	2005-10-28	2012-06-05	Arch Pharmalabs Limited	Process for preparation of Gemcitabine hydrochloride
WO2007069838A1 (en) *	2005-12-14	2007-06-21	Dong-A Pharm.Co., Ltd.	A manufacturing process of 2',2'-difluoronucleoside and intermediate
KR100741310B1 (ko) *	2006-08-01	2007-08-01	(주) 유일팜테크	젬시타빈의 합성에 유용한 신규한나프탈렌-2-카르복실레이트 유도체와 그의 제조방법
US7994310B2 (en) *	2007-03-23	2011-08-09	Dongwoo Syntech Co., Ltd.	Process for preparing 2′-deoxy-2′, 2′-difluorocytidine
CA2727813A1 (en)	2008-06-12	2009-12-17	Scinopharm Taiwan, Ltd.	Crystalline polymorphs of gemcitabine base
GB0812895D0 (en) *	2008-07-15	2008-08-20	Glycom As	Crystalline carbohydrate derivative

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4526988A (en)	1983-03-10	1985-07-02	Eli Lilly And Company	Difluoro antivirals and intermediate therefor
CA1264738A (en) *	1984-12-04	1990-01-23	Eli Lilly And Company	Treatment of tumors in mammals
CA1295998C (en) *	1985-07-29	1992-02-18	Sai P. Sunkara	Nucleosides and their use as antineoplastic agents

1988
- 1988-08-22 CA CA000575329A patent/CA1324128C/en not_active Expired - Lifetime
- 1988-08-22 ES ES88307750T patent/ES2113845T3/es not_active Expired - Lifetime
- 1988-08-22 EP EP95201846A patent/EP0688783B1/de not_active Expired - Lifetime
- 1988-08-22 AT AT94202041T patent/ATE179713T1/de not_active IP Right Cessation
- 1988-08-22 DE DE3856527T patent/DE3856527T2/de not_active Expired - Lifetime
- 1988-08-22 IL IL87517A patent/IL87517A/xx not_active IP Right Cessation
- 1988-08-22 AT AT88307750T patent/ATE164847T1/de not_active IP Right Cessation
- 1988-08-22 EP EP94202041A patent/EP0630905B1/de not_active Expired - Lifetime
- 1988-08-22 EP EP88307750A patent/EP0306190B1/de not_active Expired - Lifetime
- 1988-08-22 ES ES94202041T patent/ES2131152T3/es not_active Expired - Lifetime
- 1988-08-22 AT AT95201846T patent/ATE202113T1/de not_active IP Right Cessation
- 1988-08-22 DE DE3856477T patent/DE3856477T2/de not_active Expired - Fee Related
- 1988-08-22 ES ES95201846T patent/ES2157289T3/es not_active Expired - Lifetime
- 1988-08-22 ES ES95201845T patent/ES2176279T3/es not_active Expired - Lifetime
- 1988-08-22 DE DE3856158T patent/DE3856158T2/de not_active Expired - Lifetime
- 1988-08-22 AT AT95201845T patent/ATE217009T1/de not_active IP Right Cessation
- 1988-08-22 DE DE3856330T patent/DE3856330T2/de not_active Expired - Lifetime
- 1988-08-22 EP EP95201845A patent/EP0688782B1/de not_active Expired - Lifetime
- 1988-08-26 IE IE260888A patent/IE81131B1/en not_active IP Right Cessation
- 1988-08-26 HU HU884471A patent/HU202249B/hu unknown
- 1988-08-26 HU HU906268A patent/HU206886B/hu unknown
- 1988-08-26 JP JP63213482A patent/JP2738540B2/ja not_active Expired - Lifetime
- 1988-08-27 KR KR1019880010908A patent/KR970002659B1/ko not_active Expired - Fee Related
1992
- 1992-05-27 HU HU9201768A patent/HU9201768D0/hu unknown
1997
- 1997-08-25 JP JP9227948A patent/JP2810034B2/ja not_active Expired - Lifetime
- 1997-08-25 JP JP9227954A patent/JP2899577B2/ja not_active Expired - Lifetime
- 1997-08-25 JP JP9227946A patent/JP2777359B2/ja not_active Expired - Lifetime
- 1997-08-25 JP JP9227952A patent/JP2899576B2/ja not_active Expired - Lifetime
1998
- 1998-04-10 GR GR980400807T patent/GR3026611T3/el unknown

Also Published As

Publication number	Publication date
IL87517A (en)	1993-05-13
DE3856158D1 (de)	1998-05-14
JPS6471894A (en)	1989-03-16
IE882608L (en)	1989-02-28
ATE179713T1 (de)	1999-05-15
ATE202113T1 (de)	2001-06-15
JP2899576B2 (ja)	1999-06-02
EP0688783A1 (de)	1995-12-27
EP0688782B1 (de)	2002-05-02
JPH1072457A (ja)	1998-03-17
ES2131152T3 (es)	1999-07-16
IE81131B1 (en)	2000-03-22
EP0306190A3 (de)	1991-11-21
EP0688782A1 (de)	1995-12-27
HU202249B (en)	1991-02-28
DE3856527D1 (de)	2002-06-06
EP0306190B1 (de)	1998-04-08
HUT47590A (en)	1989-03-28
DE3856330D1 (de)	1999-06-10
ES2176279T3 (es)	2002-12-01
JP2899577B2 (ja)	1999-06-02
DE3856330T2 (de)	1999-09-30
KR890003794A (ko)	1989-04-18
ATE164847T1 (de)	1998-04-15
EP0688783B1 (de)	2001-06-13
GR3026611T3 (en)	1998-07-31
IL87517A0 (en)	1989-01-31
JPH1072483A (ja)	1998-03-17
HU206886B (en)	1993-01-28
DE3856477T2 (de)	2001-11-08
JP2810034B2 (ja)	1998-10-15
JP2738540B2 (ja)	1998-04-08
EP0630905B1 (de)	1999-05-06
JP2777359B2 (ja)	1998-07-16
DE3856158T2 (de)	1998-08-20
HU906268D0 (en)	1991-03-28
EP0630905A1 (de)	1994-12-28
HU9201768D0 (en)	1992-08-28
DE3856477D1 (de)	2001-07-19
CA1324128C (en)	1993-11-09
DE3856527T2 (de)	2002-10-31
KR970002659B1 (ko)	1997-03-07
JPH1072484A (ja)	1998-03-17
ES2157289T3 (es)	2001-08-16
JPH1081696A (ja)	1998-03-31
ES2113845T3 (es)	1998-05-16
EP0306190A2 (de)	1989-03-08

Legal Events

Date	Code	Title	Description
2002-08-15	UEP	Publication of translation of european patent specification
2008-11-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
ATE217009T1 (de)	2002-05-15	Stereoselektives verfahren zur herstellung von geschützten 2',2'-difluorlactonen
DE3883408D1 (de)	1993-09-30	Verfahren zur Herstellung von Avermectinen und die verwendeten Kulturen.
DE3586017D1 (de)	1992-06-17	Stabiles glukose-isomerase-konzentrat und verfahren zu dessen herstellung.
DE3862306D1 (de)	1991-05-16	Verfahren zur elektrochemischen herstellung von carbonsaeuren.
DE3784988D1 (de)	1993-04-29	Methode fuer selektiven zuwachs des anteils der gewoenlichen hauptkomponente des antibiotischen komplexes a/16686.
DE3787773D1 (de)	1993-11-18	Zum Abbau von Glycosaminoglycan fähige Enzymzusammensetzung und Verfahren zur Herstellung dieser Zusammensetzung.
ATE38832T1 (de)	1988-12-15	Verfahren zur herstellung von pyrrolidonderivaten.
DE3768148D1 (de)	1991-04-04	Verfahren zur herstellung von carbonsaeuren.
DE3883911D1 (de)	1993-10-14	Verfahren zur Herstellung von Orotsäure durch Fermentierung.
DE3785266D1 (de)	1993-05-13	Stamm zur massenproduktion von epsilon-poly-l-lysin, methode, um diesen stamm zu gebrauchen, und methode zur herstellung von epsilon-poly-l-lysin.
ATE34176T1 (de)	1988-05-15	2'-chloropentostatin, eine diese verbindung enthaltende pharmazeutische zusammensetzung und ein mikroorganismus zur herstellung dieser verbindung.
DE3585646D1 (de)	1992-04-23	Fermentationsverfahren zur herstellung von karbonsaeurealkylestern.
ATA158484A (de)	1986-11-15	Verfahren zur herstellung von oralen retardformen des alpha-(2,5-dimethoxy-phenyl)-betaglycinamido\|thanols
DE68927132D1 (de)	1996-10-17	Verfahren zur Herstellung von Lactonen
DE3880072D1 (de)	1993-05-13	N-phenyl-2,2,6,6-tetrahalogencyclohexanimin und verfahren zur herstellung von derivaten des 2,2,6,6-tetrahalogencyclohexanimins und von derivaten des 2,6-dihalogenanilins.
ATE118551T1 (de)	1995-03-15	Verfahren zur herstellung von s-2,2-r1,r2-1,3- dioxolan-4-methanol.
DE3868160D1 (de)	1992-03-12	Verfahren zur herstellung von carbonsaeuren.
DE3583794D1 (de)	1991-09-19	Verfahren zur herstellung von bestaendigen pharmazeutischen zusammensetzungen von prostaglandin-e-derivaten und/oder ihren 15r-formen.
DE69225610D1 (de)	1998-06-25	Verfahren zur herstellung von avermectin und kulturen dafür
ATE10623T1 (de)	1984-12-15	Verfahren zur herstellung von l-prolin.
DE69122545D1 (de)	1996-11-14	Verfahren zur Herstellung von menschlichem Nervenwachstumsfaktor durch Genmanipulation
ATE91507T1 (de)	1993-07-15	Fermentationsverfahren zur herstellung von 2-keto-l-gulonsaeuren.
DE3867339D1 (de)	1992-02-13	Verfahren zur herstellung von salzen des aminomalonsaeuredinitrils.
ATE58140T1 (de)	1990-11-15	Verfahren zur herstellung eines lactons.
ATE76117T1 (de)	1992-05-15	Verfahren zur herstellung dekorativer ueberzuege auf metallen.