IL87517A - Process for preparing an enantiomeric mixture of erythro and threo lactones - Google Patents

Process for preparing an enantiomeric mixture of erythro and threo lactones

Info

Publication number
IL87517A
IL87517A IL87517A IL8751788A IL87517A IL 87517 A IL87517 A IL 87517A IL 87517 A IL87517 A IL 87517A IL 8751788 A IL8751788 A IL 8751788A IL 87517 A IL87517 A IL 87517A
Authority
IL
Israel
Prior art keywords
erythro
preparing
enantiomeric mixture
difluoronucleosides
deoxy
Prior art date
Application number
IL87517A
Other languages
English (en)
Other versions
IL87517A0 (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Priority to IL10214488A priority Critical patent/IL102144A/en
Publication of IL87517A0 publication Critical patent/IL87517A0/xx
Priority to IL102143A priority patent/IL102143A0/xx
Priority to IL102144A priority patent/IL102144A0/xx
Publication of IL87517A publication Critical patent/IL87517A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
IL87517A 1987-08-28 1988-08-22 Process for preparing an enantiomeric mixture of erythro and threo lactones IL87517A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IL10214488A IL102144A (en) 1987-08-28 1988-08-22 Process for the preparation of '2 - deoxy -' 2, '2 - difluoro nucleosides
IL102143A IL102143A0 (en) 1987-08-28 1992-06-09 Process for selectively isolating 2-deoxy-2,2-difluoro-d-erythro-pentofuranos-1-ulose-3,5-dibenzoate
IL102144A IL102144A0 (en) 1987-08-28 1992-06-09 Process for producing 2'-deoxy-2',2'-difluoro nucleosides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9072587A 1987-08-28 1987-08-28

Publications (2)

Publication Number Publication Date
IL87517A0 IL87517A0 (en) 1989-01-31
IL87517A true IL87517A (en) 1993-05-13

Family

ID=22224017

Family Applications (1)

Application Number Title Priority Date Filing Date
IL87517A IL87517A (en) 1987-08-28 1988-08-22 Process for preparing an enantiomeric mixture of erythro and threo lactones

Country Status (11)

Country Link
EP (4) EP0688782B1 (de)
JP (5) JP2738540B2 (de)
KR (1) KR970002659B1 (de)
AT (4) ATE202113T1 (de)
CA (1) CA1324128C (de)
DE (4) DE3856158T2 (de)
ES (4) ES2157289T3 (de)
GR (1) GR3026611T3 (de)
HU (3) HU202249B (de)
IE (1) IE81131B1 (de)
IL (1) IL87517A (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2012129A1 (en) * 1989-03-20 1990-09-20 Ramakrishnan Nagarajan Recovery of difluoro sugar
US5256797A (en) * 1992-06-22 1993-10-26 Eli Lilly And Company Process for separating 2-deoxy-2,2-difluoro-D-ribofuranosyl alkylsulfonate anomers
US5401861A (en) * 1992-06-22 1995-03-28 Eli Lilly And Company Low temperature process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates
US5252756A (en) * 1992-06-22 1993-10-12 Eli Lilly And Company Process for preparing beta-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl-arylsulfonates
UA41261C2 (uk) * 1992-06-22 2001-09-17 Елі Ліллі Енд Компані Спосіб одержання збагачених бета-аномером нуклеозидів
YU43193A (sh) * 1992-06-22 1997-01-08 Eli Lilly And Company 2'-deoksi-2',2'-difluoro(4-supstituisani)pirimidinski nukleozidi antivirusnog i antikancerogenog dejstva i međuproizvodi
US5256798A (en) * 1992-06-22 1993-10-26 Eli Lilly And Company Process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates
US5559222A (en) * 1995-02-03 1996-09-24 Eli Lilly And Company Preparation of 1-(2'-deoxy-2',2'-difluoro-D-ribo-pentofuranosyl)-cytosine from 2-deoxy-2,2-difluoro-β-D-ribo-pentopyranose
JP2000501738A (ja) 1995-12-13 2000-02-15 イーライ・リリー・アンド・カンパニー α，α―ジフルオロ―β―ヒドロキシチオールエステル及びその合成
KR100578616B1 (ko) * 2004-07-23 2006-05-10 한미약품 주식회사 Ｄ-에리트로-2,2-다이플루오로-2-데옥시-1-옥소라이보스화합물의 제조방법
EP1940859A1 (de) * 2005-10-28 2008-07-09 Arch Pharmalabs Limited Verbessertes verfahren zur zubereitung von gemcitabinhydrochlorid
KR101259648B1 (ko) * 2005-12-14 2013-05-09 동아에스티 주식회사 2′,2′-디플루오로뉴클레오시드 및 중간체의 새로운 제조방법
KR100741310B1 (ko) * 2006-08-01 2007-08-01 (주) 유일팜테크 젬시타빈의 합성에 유용한 신규한나프탈렌-2-카르복실레이트 유도체와 그의 제조방법
EP2139884B1 (de) * 2007-03-23 2013-12-04 Dongwoo Syntech Co., Ltd. Verfahren zur herstellung von 2'-desoxy-2',2'-difluorcytidin
JP2011524369A (ja) 2008-06-12 2011-09-01 サイノファーム タイワン リミテッド ゲムシタビン塩基の結晶多形
GB0812895D0 (en) 2008-07-15 2008-08-20 Glycom As Crystalline carbohydrate derivative

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
EP0184365B1 (de) * 1984-12-04 1993-08-04 Eli Lilly And Company Tumorbehandlung bei Säugetieren
CA1295998C (en) * 1985-07-29 1992-02-18 Sai P. Sunkara Nucleosides and their use as antineoplastic agents

Also Published As

Publication number Publication date
IE882608L (en) 1989-02-28
DE3856158T2 (de) 1998-08-20
KR890003794A (ko) 1989-04-18
DE3856158D1 (de) 1998-05-14
ES2176279T3 (es) 2002-12-01
HU9201768D0 (en) 1992-08-28
JPH1081696A (ja) 1998-03-31
KR970002659B1 (ko) 1997-03-07
EP0630905B1 (de) 1999-05-06
CA1324128C (en) 1993-11-09
EP0688782A1 (de) 1995-12-27
EP0630905A1 (de) 1994-12-28
JP2738540B2 (ja) 1998-04-08
DE3856330D1 (de) 1999-06-10
JP2810034B2 (ja) 1998-10-15
EP0306190B1 (de) 1998-04-08
HUT47590A (en) 1989-03-28
JP2899576B2 (ja) 1999-06-02
ES2131152T3 (es) 1999-07-16
ATE202113T1 (de) 2001-06-15
GR3026611T3 (en) 1998-07-31
HU202249B (en) 1991-02-28
ES2113845T3 (es) 1998-05-16
ATE164847T1 (de) 1998-04-15
IE81131B1 (en) 2000-03-22
EP0688783B1 (de) 2001-06-13
HU906268D0 (en) 1991-03-28
JP2899577B2 (ja) 1999-06-02
JPS6471894A (en) 1989-03-16
DE3856477D1 (de) 2001-07-19
JPH1072484A (ja) 1998-03-17
DE3856330T2 (de) 1999-09-30
DE3856527D1 (de) 2002-06-06
IL87517A0 (en) 1989-01-31
EP0306190A2 (de) 1989-03-08
DE3856477T2 (de) 2001-11-08
JP2777359B2 (ja) 1998-07-16
JPH1072483A (ja) 1998-03-17
HU206886B (en) 1993-01-28
ATE217009T1 (de) 2002-05-15
JPH1072457A (ja) 1998-03-17
ES2157289T3 (es) 2001-08-16
EP0688782B1 (de) 2002-05-02
DE3856527T2 (de) 2002-10-31
EP0688783A1 (de) 1995-12-27
EP0306190A3 (de) 1991-11-21
ATE179713T1 (de) 1999-05-15

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