ATE217631T1 - Neue phospholipid-saccharid-konjugate - Google Patents

Neue phospholipid-saccharid-konjugate

Info

Publication number
ATE217631T1
ATE217631T1 AT94912202T AT94912202T ATE217631T1 AT E217631 T1 ATE217631 T1 AT E217631T1 AT 94912202 T AT94912202 T AT 94912202T AT 94912202 T AT94912202 T AT 94912202T AT E217631 T1 ATE217631 T1 AT E217631T1
Authority
AT
Austria
Prior art keywords
phospholipide
new
saccharide conjugates
saccharide
conjugates
Prior art date
Application number
AT94912202T
Other languages
English (en)
Inventor
Barbara Y F Wan
Mark M Staveski
Alan E Walts
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Application granted granted Critical
Publication of ATE217631T1 publication Critical patent/ATE217631T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT94912202T 1993-03-12 1994-03-09 Neue phospholipid-saccharid-konjugate ATE217631T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/030,793 US5354853A (en) 1993-03-12 1993-03-12 Phospholipid-saccharide conjugates
PCT/US1994/002535 WO1994021656A2 (en) 1993-03-12 1994-03-09 Novel phospholipid-saccharide conjugates

Publications (1)

Publication Number Publication Date
ATE217631T1 true ATE217631T1 (de) 2002-06-15

Family

ID=21856073

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94912202T ATE217631T1 (de) 1993-03-12 1994-03-09 Neue phospholipid-saccharid-konjugate

Country Status (7)

Country Link
US (1) US5354853A (de)
EP (1) EP0688329B1 (de)
JP (1) JPH08507544A (de)
AT (1) ATE217631T1 (de)
CA (1) CA2158055A1 (de)
DE (1) DE69430626T2 (de)
WO (1) WO1994021656A2 (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
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AU705644B2 (en) * 1995-08-01 1999-05-27 Novartis Ag Liposomal oligonucleotide compositions
AU5571196A (en) * 1996-04-24 1997-11-12 Sdg, Inc. Improved masking of liposomes from res recognition
PT939647E (pt) * 1996-08-27 2002-04-29 Chiron Corp Glicpconjugados do serogrupo b de neisseria meningitidis e metodos de utilizacao dos mesmos
US6071532A (en) * 1996-10-15 2000-06-06 Emory University Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof
US6096291A (en) * 1996-12-27 2000-08-01 Biovector Therapeutics, S.A. Mucosal administration of substances to mammals
US6204254B1 (en) 1997-09-12 2001-03-20 Baxter International, Inc. Biocompatible surfaces and a method for their preparation
US20070141181A1 (en) * 1998-02-13 2007-06-21 Nutramax Laboratories, Inc. Use of anabolic agents, anti-catabolic agents, antioxidant agents, and analgesics for protection, treatment and repair of connective tissues in humans and animals
US6451771B1 (en) 1999-02-12 2002-09-17 Nutramax Laboratories, Inc. Use of anabolic agents anti-catabolic agents and antioxidant agents for protection treatment and repair of connective tissues in humans and animals
US6797289B2 (en) * 1998-02-13 2004-09-28 Nutramax Laboratories, Inc. Use of anabolic agents, anti-catabolic agents, antioxidant agents, and analgesics for protection, treatment and repair of connective tissues in humans and animals
JP3861133B2 (ja) * 1999-12-07 2006-12-20 独立行政法人産業技術総合研究所 グルコシルフォスファチジルグリセロール誘導体の製造方法
US20090325876A1 (en) * 2004-09-29 2009-12-31 Saul Yedgar Use of lipid conjugates in the treatment of diseases associated with vasculature
US8304395B2 (en) * 2000-01-10 2012-11-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Lipid conjugates in the treatment of disease
US7393938B2 (en) * 2000-01-10 2008-07-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of diseases
US7772196B2 (en) 2000-01-10 2010-08-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of diseases
US20060189568A1 (en) * 2000-01-10 2006-08-24 Saul Yedgar Use of lipid conjugates in the treatment of infection
US7811999B2 (en) 2000-01-10 2010-10-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Use of lipid conjugates in the treatment of diseases
US7608598B2 (en) * 2000-01-10 2009-10-27 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of conjunctivitis
US7893226B2 (en) 2004-09-29 2011-02-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Use of lipid conjugates in the treatment of diseases
US8076312B2 (en) * 2000-01-10 2011-12-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Use of lipid conjugates in the treatment of disease
US8916539B2 (en) * 2000-01-10 2014-12-23 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of disease
US9040078B2 (en) 2000-01-10 2015-05-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of diseases of the nervous system
US8501701B2 (en) * 2000-01-10 2013-08-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Use of lipid conjugates in the treatment of disease
US6749865B2 (en) 2000-02-15 2004-06-15 Genzyme Corporation Modification of biopolymers for improved drug delivery
WO2001060412A2 (en) 2000-02-15 2001-08-23 Genzyme Corporation Modification of biopolymers for improved drug delivery
EP1356291B1 (de) * 2000-12-06 2011-05-04 Ecole Polytechnique Fédérale de Lausanne (EPFL) Verfahren zur herstellung eines bioanalytischen reagenzes, nachweisverfahren beruhend auf der verwendung des bioanalytischen reagenz, sowie dessen verwendung
US8883761B2 (en) * 2001-01-10 2014-11-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of diseases associated with vasculature
WO2002090510A2 (en) * 2001-05-08 2002-11-14 Emory University Regulating immine responses using dendritic cells
US20060193906A1 (en) * 2002-01-30 2006-08-31 National Institute Of Advanced Industrial Science And Technology Sugar-modified liposome and products comprising the liposome
US7070801B2 (en) * 2002-01-30 2006-07-04 National Institute Of Advanced Industrial Science And Technology Sugar-modified liposome and products comprising the liposome
DE10207177A1 (de) * 2002-02-19 2003-09-04 Novosom Ag Fakultativ kationische Lipide
US7299805B2 (en) * 2002-06-07 2007-11-27 Marctec, Llc Scaffold and method for implanting cells
US20040131631A1 (en) * 2002-11-22 2004-07-08 Alexander Andrianov Polyphosphazene immunostimulants
DE60319872T2 (de) * 2002-12-12 2009-03-05 Novozymes A/S Verfahren zur auswahl eines lipolytischen enzyms
WO2005011632A1 (ja) * 2003-08-01 2005-02-10 National Institute Of Advanced Industrial Science And Technology 糖鎖を有する標的指向性および腸管吸収制御性リポソームならびにそれを含む癌治療薬および診断薬
WO2005049631A1 (en) * 2003-11-18 2005-06-02 The Malaghan Institute Of Medical Research Synthetic molecules having immune activity
WO2005090370A1 (en) 2004-02-05 2005-09-29 The Regents Of The University Of California Pharmacologically active agents containing esterified phosphonates and methods for use thereof
DE102004038443A1 (de) * 2004-08-07 2006-03-16 Bioghurt Biogarde Gmbh & Co. Kg Verfahren zur enzymatischen Herstellung und/oder Modifikation von Phospholipiden
JP5339905B2 (ja) * 2005-08-03 2013-11-13 モリア バイオファーマスーティカルズ 嚢胞性線維症における脂質複合体の使用及びその適用
JP4744973B2 (ja) * 2005-08-05 2011-08-10 株式会社トプコン 眼底カメラ
US8859524B2 (en) 2005-11-17 2014-10-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Lipid conjugates in the treatment of chronic rhinosinusitis
US8906882B2 (en) 2005-11-17 2014-12-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Lipid conjugates in the treatment of allergic rhinitis
US20080183282A1 (en) * 2006-03-09 2008-07-31 Saul Yedgar Use of lipid conjugates for the coating of stents and catheters
CA2705785A1 (en) * 2006-11-14 2008-05-22 Saul Yedgar Use of lipid conjugates in the treatment of diseases or disorders of the eye
KR100829595B1 (ko) 2006-12-11 2008-05-14 한국화학연구원 당이 결합된 인지질로 수식된 리포솜 및 이의 제조방법
AU2010247814B2 (en) 2009-05-11 2015-08-13 Celsus Therapeutics Plc Lipid-polymer conjugates, their preparation and uses thereof
US20140255317A1 (en) * 2011-09-07 2014-09-11 Kyoto University Preparation comprising hexose-6-phosphate-modified cholesterol derivative
EP3058940A1 (de) * 2015-02-23 2016-08-24 Abivax Chinolin-Derivate zur Behandlung oder Vorbeugung von viralen Infektionen
EP3059236A1 (de) * 2015-02-23 2016-08-24 Abivax Neue Chinolinderivate zur Verwendung bei der Behandlung und Prävention von Virusinfektionen
CN105153251B (zh) * 2015-09-29 2018-03-20 浙江合糖科技有限公司 一种单糖甲苷的苄基化方法
US12503482B2 (en) * 2019-01-08 2025-12-23 The Brigham And Women's Hospital, Inc. Compositions and methods for trehalose phospholipids

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4585762A (en) * 1982-07-30 1986-04-29 Fujisawa Pharmaceutical Co., Ltd. Phospholipid derivatives, processes for use thereof and pharmaceutical composition of the same
JPS59187792A (ja) * 1983-04-11 1984-10-24 Meito Sangyo Kk 酵素法リン脂質糖類誘導体の製法
US4873322A (en) * 1986-01-24 1989-10-10 Ciba-Geigy Corporation Saccharide derivatives and processes for their manufacture
FR2596651B1 (fr) * 1986-04-08 1989-11-10 Centre Nat Rech Scient Nouveaux liposomes a base de phosphatidylinositolmannosides, et compositions pharmaceutiques les contenant
WO1989008499A1 (fr) * 1988-03-17 1989-09-21 Nippon Fine Chemical Co., Ltd. Liposome
GB8825290D0 (en) * 1988-10-28 1988-11-30 Hounsell E F Characterisation of glycoproteins

Also Published As

Publication number Publication date
WO1994021656A3 (en) 1994-11-10
DE69430626D1 (de) 2002-06-20
EP0688329A1 (de) 1995-12-27
CA2158055A1 (en) 1994-09-29
JPH08507544A (ja) 1996-08-13
WO1994021656A2 (en) 1994-09-29
US5354853A (en) 1994-10-11
DE69430626T2 (de) 2002-12-19
EP0688329B1 (de) 2002-05-15

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