ATE217799T1 - Behandlung von akuter intermittierender porphyria oder anderen porphyrischen krankheiten - Google Patents

Behandlung von akuter intermittierender porphyria oder anderen porphyrischen krankheiten

Info

Publication number: ATE217799T1
Authority: AT; Austria
Prior art keywords: porphyria; enzyme; treatment; pbgd; analogue
Prior art date: 1998-01-27

Application number

AT99906067T

Other languages

English (en)

Inventor

Jens Fogh

Paer Gellerfors

Original Assignee

Hemebiotech As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-01-27

Filing date

1999-01-27

Publication date

2002-06-15

1999-01-27 Application filed by Hemebiotech As filed Critical Hemebiotech As

2002-06-15 Application granted granted Critical

2002-06-15 Publication of ATE217799T1 publication Critical patent/ATE217799T1/de

Links

206010036182 Porphyria acute Diseases 0.000 title abstract 5
208000005452 Acute intermittent porphyria Diseases 0.000 title abstract 3
201000010099 disease Diseases 0.000 title abstract 3
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
238000011282 treatment Methods 0.000 title abstract 2
206010036186 Porphyria non-acute Diseases 0.000 abstract 4
102000004190 Enzymes Human genes 0.000 abstract 3
108090000790 Enzymes Proteins 0.000 abstract 3
108010056651 Hydroxymethylbilane synthase Proteins 0.000 abstract 3
102100034391 Porphobilinogen deaminase Human genes 0.000 abstract 3
238000000034 method Methods 0.000 abstract 3
208000034958 Congenital erythropoietic porphyria Diseases 0.000 abstract 2
208000007209 Erythropoietic Porphyria Diseases 0.000 abstract 2
208000003591 Hepatoerythropoietic Porphyria Diseases 0.000 abstract 2
208000000627 Hereditary Coproporphyria Diseases 0.000 abstract 2
101001067100 Homo sapiens Uroporphyrinogen-III synthase Proteins 0.000 abstract 2
241000097929 Porphyria Species 0.000 abstract 2
201000010273 Porphyria Cutanea Tarda Diseases 0.000 abstract 2
208000010642 Porphyrias Diseases 0.000 abstract 2
102000015437 Uroporphyrinogen decarboxylase Human genes 0.000 abstract 2
108010064762 Uroporphyrinogen decarboxylase Proteins 0.000 abstract 2
102100034397 Uroporphyrinogen-III synthase Human genes 0.000 abstract 2
239000003054 catalyst Substances 0.000 abstract 2
230000007812 deficiency Effects 0.000 abstract 2
201000008220 erythropoietic protoporphyria Diseases 0.000 abstract 2
208000000070 harderoporphyria Diseases 0.000 abstract 2
108010094074 Coproporphyrinogen oxidase Proteins 0.000 abstract 1
102000003875 Ferrochelatase Human genes 0.000 abstract 1
108010057394 Ferrochelatase Proteins 0.000 abstract 1
102000004867 Hydro-Lyases Human genes 0.000 abstract 1
108090001042 Hydro-Lyases Proteins 0.000 abstract 1
102100036201 Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial Human genes 0.000 abstract 1
108020001991 Protoporphyrinogen Oxidase Proteins 0.000 abstract 1
102000005135 Protoporphyrinogen oxidase Human genes 0.000 abstract 1
108020000963 Uroporphyrinogen-III synthase Proteins 0.000 abstract 1
230000006696 biosynthetic metabolic pathway Effects 0.000 abstract 1
NIUVHXTXUXOFEB-UHFFFAOYSA-N coproporphyrinogen III Chemical compound C1C(=C(C=2C)CCC(O)=O)NC=2CC(=C(C=2C)CCC(O)=O)NC=2CC(N2)=C(CCC(O)=O)C(C)=C2CC2=C(C)C(CCC(O)=O)=C1N2 NIUVHXTXUXOFEB-UHFFFAOYSA-N 0.000 abstract 1
238000001415 gene therapy Methods 0.000 abstract 1
150000003278 haem Chemical class 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
102000003643 uroporphyrinogen-III synthase Human genes 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/51—Lyases (4)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Genetics & Genomics (AREA)
Hematology (AREA)
Diabetes (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Microbiology (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Biotechnology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

AT99906067T 1998-01-27 1999-01-27 Behandlung von akuter intermittierender porphyria oder anderen porphyrischen krankheiten ATE217799T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DK11298		1998-01-27
DKPA199801748		1998-12-30
PCT/DK1999/000040 WO1999037325A2 (en)	1998-01-27	1999-01-27	Method for treating acute intermittent porphyria (aip) and other porphyric diseases

Publications (1)

Publication Number	Publication Date
ATE217799T1 true ATE217799T1 (de)	2002-06-15

Family

ID=26063333

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99906067T ATE217799T1 (de)	1998-01-27	1999-01-27	Behandlung von akuter intermittierender porphyria oder anderen porphyrischen krankheiten

Country Status (11)

Country	Link
EP (1)	EP1049487B1 (de)
JP (1)	JP2002501032A (de)
AT (1)	ATE217799T1 (de)
AU (1)	AU750143B2 (de)
CA (1)	CA2319096C (de)
DE (1)	DE69901536T2 (de)
DK (1)	DK1049487T3 (de)
ES (1)	ES2177240T3 (de)
NO (1)	NO327241B1 (de)
PT (1)	PT1049487E (de)
WO (1)	WO1999037325A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6537777B1 (en)	1998-07-27	2003-03-25	Hemebiotech A/S	Human porphobilinogen deaminase sequences
AU774603B2 (en) *	1999-07-27	2004-07-01	Zymenex A/S	Production of rhPBGD and new therapeutic methods for treating patients with acute intermittent porphyria (AIP) and other porphyric diseases
NZ576986A (en)	2004-01-30	2010-12-24	Shire Pharmaceuticals Ireland Ltd	Production and purification of recombinant arylsulfatase A
NO347673B1 (no)	2006-04-04	2024-02-19	Takeda Pharmaceuticals Co	En sammensetning som omfatter konsentrert polypeptide og bruk derav.
KR20110086553A (ko) *	2008-09-29	2011-07-28	암스테르담 몰레큘러 테라퓨틱스 비. 브이.	포르포빌리노겐 디아미나아제 유전자 치료
US10336992B2 (en)	2011-07-08	2019-07-02	Shire Human Genetic Therapies, Inc.	Methods for purification of arylsulfatase A
SG10201604810UA (en)	2012-02-07	2016-08-30	Global Bio Therapeutics Inc	Compartmentalized method of nucleic acid delivery and compositions and uses thereof
WO2014110246A1 (en)	2013-01-09	2014-07-17	Shire Human Genetic Therapies, Inc.	Methods for purification of arylsulfatase a
CN105813579B (zh)	2013-08-08	2019-05-07	全球生物疗法有限公司	用于微创手术过程的夹具装置和其应用
JP2019519601A (ja)	2016-05-18	2019-07-11	モダーナティエックス・インコーポレイテッドＭｏｄｅｒｎａＴＸ，Ｉｎｃ．	急性間欠性ポルフィリン症の治療のためのポルホビリノゲン脱アミノ酵素をコードするポリヌクレオチド
CA3024624A1 (en) *	2016-05-18	2017-11-23	Modernatx, Inc.	Polynucleotides encoding porphobilinogen deaminase for the treatment of acute intermittent porphyria
WO2018206125A1 (en) *	2017-05-09	2018-11-15	Fundacion Para La Investigacion Medica Aplicada	Human porphobilinogen deaminase derived proteins and polynucleotides and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2657345B2 (ja) *	1992-04-17	1997-09-24	新日本製鐵株式会社	医療用診断装置および疾患判断方法

1999
- 1999-01-27 AT AT99906067T patent/ATE217799T1/de active
- 1999-01-27 ES ES99906067T patent/ES2177240T3/es not_active Expired - Lifetime
- 1999-01-27 CA CA002319096A patent/CA2319096C/en not_active Expired - Lifetime
- 1999-01-27 PT PT99906067T patent/PT1049487E/pt unknown
- 1999-01-27 AU AU26097/99A patent/AU750143B2/en not_active Expired
- 1999-01-27 DK DK99906067T patent/DK1049487T3/da active
- 1999-01-27 JP JP2000528305A patent/JP2002501032A/ja active Pending
- 1999-01-27 EP EP99906067A patent/EP1049487B1/de not_active Expired - Lifetime
- 1999-01-27 DE DE69901536T patent/DE69901536T2/de not_active Expired - Lifetime
- 1999-01-27 WO PCT/DK1999/000040 patent/WO1999037325A2/en not_active Ceased
2000
- 2000-07-26 NO NO20003830A patent/NO327241B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
WO1999037325A2 (en)	1999-07-29
NO20003830D0 (no)	2000-07-26
ES2177240T3 (es)	2002-12-01
CA2319096A1 (en)	1999-07-29
NO20003830L (no)	2000-09-27
DK1049487T3 (da)	2002-09-16
NO327241B1 (no)	2009-05-18
CA2319096C (en)	2007-07-03
WO1999037325A3 (en)	1999-09-30
AU2609799A (en)	1999-08-09
PT1049487E (pt)	2002-10-31
EP1049487B1 (de)	2002-05-22
EP1049487A2 (de)	2000-11-08
DE69901536T2 (de)	2003-01-16
AU750143B2 (en)	2002-07-11
DE69901536D1 (de)	2002-06-27
JP2002501032A (ja)	2002-01-15

Legal Events

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2003-03-15

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Ref document number: 1049487

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2005-08-15

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Publication	Publication Date	Title
DE69901536D1 (de)	2002-06-27	Behandlung von akuter intermittierender porphyria oder anderen porphyrischen krankheiten
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