ATE315084T1 - Herstellung von rhpbgd - Google Patents

Herstellung von rhpbgd

Info

Publication number: ATE315084T1
Authority: AT; Austria
Prior art keywords: porphyria; rhpbgd; catalyst; production; delta
Prior art date: 1999-07-27

Application number

AT00951266T

Other languages

English (en)

Inventor

Paer Gellerfors

Jens Fogh

Original Assignee

Zymenex As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-07-27

Filing date

2000-07-27

Publication date

2006-02-15

2000-07-27 Application filed by Zymenex As filed Critical Zymenex As

2006-02-15 Application granted granted Critical

2006-02-15 Publication of ATE315084T1 publication Critical patent/ATE315084T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 3
206010036182 Porphyria acute Diseases 0.000 abstract 4
206010036186 Porphyria non-acute Diseases 0.000 abstract 4
102000004190 Enzymes Human genes 0.000 abstract 3
108090000790 Enzymes Proteins 0.000 abstract 3
239000003054 catalyst Substances 0.000 abstract 3
208000005452 Acute intermittent porphyria Diseases 0.000 abstract 2
208000034958 Congenital erythropoietic porphyria Diseases 0.000 abstract 2
208000007209 Erythropoietic Porphyria Diseases 0.000 abstract 2
208000003591 Hepatoerythropoietic Porphyria Diseases 0.000 abstract 2
208000000627 Hereditary Coproporphyria Diseases 0.000 abstract 2
101001067100 Homo sapiens Uroporphyrinogen-III synthase Proteins 0.000 abstract 2
108010056651 Hydroxymethylbilane synthase Proteins 0.000 abstract 2
102100034391 Porphobilinogen deaminase Human genes 0.000 abstract 2
241000097929 Porphyria Species 0.000 abstract 2
201000010273 Porphyria Cutanea Tarda Diseases 0.000 abstract 2
208000010642 Porphyrias Diseases 0.000 abstract 2
102100034397 Uroporphyrinogen-III synthase Human genes 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 2
230000007812 deficiency Effects 0.000 abstract 2
201000010099 disease Diseases 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
201000008220 erythropoietic protoporphyria Diseases 0.000 abstract 2
239000012634 fragment Substances 0.000 abstract 2
208000000070 harderoporphyria Diseases 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
102000010553 ALAD Human genes 0.000 abstract 1
101150082527 ALAD gene Proteins 0.000 abstract 1
108010094074 Coproporphyrinogen oxidase Proteins 0.000 abstract 1
241000588724 Escherichia coli Species 0.000 abstract 1
102000003875 Ferrochelatase Human genes 0.000 abstract 1
108010057394 Ferrochelatase Proteins 0.000 abstract 1
102000004867 Hydro-Lyases Human genes 0.000 abstract 1
108090001042 Hydro-Lyases Proteins 0.000 abstract 1
102000003960 Ligases Human genes 0.000 abstract 1
108090000364 Ligases Proteins 0.000 abstract 1
102100036201 Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial Human genes 0.000 abstract 1
108020001991 Protoporphyrinogen Oxidase Proteins 0.000 abstract 1
102000005135 Protoporphyrinogen oxidase Human genes 0.000 abstract 1
101000702488 Rattus norvegicus High affinity cationic amino acid transporter 1 Proteins 0.000 abstract 1
102000015437 Uroporphyrinogen decarboxylase Human genes 0.000 abstract 1
108010064762 Uroporphyrinogen decarboxylase Proteins 0.000 abstract 1
230000006696 biosynthetic metabolic pathway Effects 0.000 abstract 1
239000013613 expression plasmid Substances 0.000 abstract 1
238000001415 gene therapy Methods 0.000 abstract 1
150000003278 haem Chemical class 0.000 abstract 1
101150055960 hemB gene Proteins 0.000 abstract 1
101150107144 hemC gene Proteins 0.000 abstract 1
230000035772 mutation Effects 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
230000009466 transformation Effects 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1
HUHWZXWWOFSFKF-UHFFFAOYSA-N uroporphyrinogen-III Chemical compound C1C(=C(C=2CCC(O)=O)CC(O)=O)NC=2CC(=C(C=2CCC(O)=O)CC(O)=O)NC=2CC(N2)=C(CC(O)=O)C(CCC(=O)O)=C2CC2=C(CCC(O)=O)C(CC(O)=O)=C1N2 HUHWZXWWOFSFKF-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/51—Lyases (4)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Microbiology (AREA)
Gastroenterology & Hepatology (AREA)
Hematology (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Immunology (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Enzymes And Modification Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT00951266T 1999-07-27 2000-07-27 Herstellung von rhpbgd ATE315084T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DKPA199901071		1999-07-27
DKPA200000667		2000-04-19

Publications (1)

Publication Number	Publication Date
ATE315084T1 true ATE315084T1 (de)	2006-02-15

Family

ID=26065173

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00951266T ATE315084T1 (de)	1999-07-27	2000-07-27	Herstellung von rhpbgd

Country Status (7)

Country	Link
EP (1)	EP1202744B1 (de)
JP (1)	JP2003505057A (de)
AT (1)	ATE315084T1 (de)
AU (1)	AU774603B2 (de)
CA (1)	CA2378373C (de)
NO (1)	NO328463B1 (de)
WO (1)	WO2001007065A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2003002731A1 (en)	2001-06-29	2003-01-09	Hemebiotech A/S	A PROCESS FOR PURIFICATION OF RECOMBINANT PORPHOBILINOGEN DEAMINASE (rhPBGD)
JP4586027B2 (ja)	2004-01-30	2010-11-24	シャイアファーマシューティカルズアイルランドリミテッド	組換えアリールスルファターゼａの製造及び精製
MX2008012748A (es)	2006-04-04	2009-01-07	Shire Pharmaceuticals Ireland	Un proceso para la concentracion de un polipeptido.
AU2013202948B2 (en) *	2006-04-04	2015-11-26	Chiesi Farmaceutici S.P.A.	A process for concentration of a polypeptide
EP2729566B1 (de)	2011-07-08	2017-03-15	Shire Human Genetic Therapies, Inc.	Verfahren zur reinigung von arylsulfatase a
EP2943568B1 (de)	2013-01-09	2019-11-20	Shire Human Genetic Therapies, Inc.	Verfahren zur reinigung von arylsulfatase a
AU2017266948B2 (en) *	2016-05-18	2024-07-04	Fundacion Para La Investigacion Medica Aplicada	Polynucleotides encoding porphobilinogen deaminase for the treatment of acute intermittent porphyria
MA45032A (fr)	2016-05-18	2019-03-27	Fundacion Para La Investig Medica Aplicada	Polynucléotides codant pour la porphobilinogène désaminase destinés au traitement de la porphyrie intermittente aiguë

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE217799T1 (de) *	1998-01-27	2002-06-15	Hemebiotech As	Behandlung von akuter intermittierender porphyria oder anderen porphyrischen krankheiten

2000
- 2000-07-27 JP JP2001511948A patent/JP2003505057A/ja active Pending
- 2000-07-27 AT AT00951266T patent/ATE315084T1/de not_active IP Right Cessation
- 2000-07-27 WO PCT/DK2000/000425 patent/WO2001007065A2/en not_active Ceased
- 2000-07-27 CA CA2378373A patent/CA2378373C/en not_active Expired - Fee Related
- 2000-07-27 AU AU64262/00A patent/AU774603B2/en not_active Ceased
- 2000-07-27 EP EP00951266A patent/EP1202744B1/de not_active Expired - Lifetime
2002
- 2002-01-24 NO NO20020375A patent/NO328463B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU774603B2 (en)	2004-07-01
NO20020375L (no)	2002-03-22
NO20020375D0 (no)	2002-01-24
EP1202744A2 (de)	2002-05-08
WO2001007065A3 (en)	2001-08-02
NO328463B1 (no)	2010-02-22
CA2378373A1 (en)	2001-02-01
AU6426200A (en)	2001-02-13
EP1202744B1 (de)	2006-01-04
WO2001007065B1 (en)	2001-09-20
WO2001007065A2 (en)	2001-02-01
CA2378373C (en)	2011-12-13
JP2003505057A (ja)	2003-02-12

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Legal Events

Date	Code	Title	Description
2006-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties