ATE217870T1 - Verfahren zur herstell ung von baccatin iii- analogen, verbindungen mit neuen funktionellen gruppen an c2 und c4 - Google Patents

Verfahren zur herstell ung von baccatin iii- analogen, verbindungen mit neuen funktionellen gruppen an c2 und c4

Info

Publication number: ATE217870T1
Authority: AT; Austria
Prior art keywords: compounds; functional groups; baccatin iii; new functional; iii analogues
Prior art date: 1993-01-29

Application number

AT94909517T

Other languages

English (en)

Inventor

Robert A Holton

Seocchan Kim

Yukio Suzuki

Original Assignee

Univ Florida State

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-01-29

Filing date

1994-01-31

Publication date

2002-06-15

1993-01-29 Priority claimed from US08/010,798 external-priority patent/US5399726A/en

1994-01-31 Application filed by Univ Florida State filed Critical Univ Florida State

2002-06-15 Application granted granted Critical

2002-06-15 Publication of ATE217870T1 publication Critical patent/ATE217870T1/de

Links

OVMSOCFBDVBLFW-VHLOTGQHSA-N 5beta,20-epoxy-1,7beta,13alpha-trihydroxy-9-oxotax-11-ene-2alpha,4alpha,10beta-triyl 4,10-diacetate 2-benzoate Chemical class O([C@@H]1[C@@]2(C[C@H](O)C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)O)C(=O)C1=CC=CC=C1 OVMSOCFBDVBLFW-VHLOTGQHSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
125000001424 substituent group Chemical group 0.000 abstract 2
125000002252 acyl group Chemical group 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003368 amide group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
-1 nitro, amino Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Hematology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)

AT94909517T 1993-01-29 1994-01-31 Verfahren zur herstell ung von baccatin iii- analogen, verbindungen mit neuen funktionellen gruppen an c2 und c4 ATE217870T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US08/010,798 US5399726A (en)	1993-01-29	1993-01-29	Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups
US3485293A	1993-03-22	1993-03-22
US9471593A	1993-07-20	1993-07-20
PCT/US1994/001099 WO1994017051A1 (en)	1993-01-29	1994-01-31	Process for the preparation of baccatin iii analogs bearing new c2 and c4 functional groups

Publications (1)

Publication Number	Publication Date
ATE217870T1 true ATE217870T1 (de)	2002-06-15

Family

ID=27359309

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT94907959T ATE220064T1 (de)	1993-01-29	1994-01-28	C2-taxan-derivate sowie diese enthaltende arzneimittel
AT94909517T ATE217870T1 (de)	1993-01-29	1994-01-31	Verfahren zur herstell ung von baccatin iii- analogen, verbindungen mit neuen funktionellen gruppen an c2 und c4

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT94907959T ATE220064T1 (de)	1993-01-29	1994-01-28	C2-taxan-derivate sowie diese enthaltende arzneimittel

Country Status (13)

Country	Link
EP (2)	EP0681573B1 (de)
JP (2)	JP3452928B2 (de)
CN (1)	CN1125061C (de)
AT (2)	ATE220064T1 (de)
AU (2)	AU685778B2 (de)
CA (2)	CA2155013C (de)
DE (2)	DE69430902T2 (de)
DK (1)	DK0681573T3 (de)
ES (1)	ES2176237T3 (de)
IL (1)	IL108444A0 (de)
PT (1)	PT681573E (de)
TW (2)	TW360646B (de)
WO (2)	WO1994017052A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5710287A (en)	1991-09-23	1998-01-20	Florida State University	Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
IL108443A0 (en) *	1993-01-29	1994-04-12	Univ Florida State	C7 taxane derivatives and pharmaceutical compositions containing them
FR2702212B1 (fr) *	1993-03-02	1995-04-07	Rhone Poulenc Rorer Sa	Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5677470A (en) *	1994-06-28	1997-10-14	Tanabe Seiyaku Co., Ltd.	Baccatin derivatives and processes for preparing the same
FR2723094A1 (fr) *	1994-07-26	1996-02-02	Rhone Poulenc Rorer Sa	Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
CA2162759A1 (en) *	1994-11-17	1996-05-18	Kenji Tsujihara	Baccatin derivatives and processes for preparing the same
EP0868422A1 (de) *	1996-09-24	1998-10-07	Marigen S.A.	Ultramikroemulsionen aus spontan dispergierbaren konzentraten mit antitumoral und antiviral wirksamen estern von baccatin-iii-verbindungen
HUP0101457A3 (en) *	1997-12-31	2003-01-28	Bristol Myers Squibb Co	Antitumor 2-aroyl-4-acyl paclitaxel analogs and medicaments containing them , their intermediates and method for producing them
ITMI20021921A1 (it) *	2002-09-10	2004-03-11	Indena Spa	Funzionalizzazione della posizione 14 dei nuclei tassanici e sintesi di nuovi derivati antitumorali.
AU2005245396A1 (en) *	2004-05-14	2005-12-01	Immunogen, Inc.	A facile method for synthesizing baccatin III compounds
US20130090484A1 (en) *	2011-10-11	2013-04-11	Scinopharm Taiwan Ltd.	Process for making an intermediate of cabazitaxel
CN104250235B (zh) *	2014-09-24	2016-10-05	江苏红豆杉药业有限公司	一种紫杉醇的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4942184A (en) *	1988-03-07	1990-07-17	The United States Of America As Represented By The Department Of Health And Human Services	Water soluble, antineoplastic derivatives of taxol

1994
- 1994-01-26 IL IL10844494A patent/IL108444A0/xx unknown
- 1994-01-28 AU AU61327/94A patent/AU685778B2/en not_active Ceased
- 1994-01-28 CA CA002155013A patent/CA2155013C/en not_active Expired - Fee Related
- 1994-01-28 PT PT94907959T patent/PT681573E/pt unknown
- 1994-01-28 AT AT94907959T patent/ATE220064T1/de not_active IP Right Cessation
- 1994-01-28 EP EP94907959A patent/EP0681573B1/de not_active Expired - Lifetime
- 1994-01-28 DK DK94907959T patent/DK0681573T3/da active
- 1994-01-28 DE DE69430902T patent/DE69430902T2/de not_active Expired - Fee Related
- 1994-01-28 ES ES94907959T patent/ES2176237T3/es not_active Expired - Lifetime
- 1994-01-28 JP JP51740094A patent/JP3452928B2/ja not_active Expired - Fee Related
- 1994-01-28 WO PCT/US1994/001223 patent/WO1994017052A1/en not_active Ceased
- 1994-01-29 CN CN94101158A patent/CN1125061C/zh not_active Expired - Fee Related
- 1994-01-31 JP JP51738694A patent/JP3741715B2/ja not_active Expired - Fee Related
- 1994-01-31 CA CA002155014A patent/CA2155014C/en not_active Expired - Fee Related
- 1994-01-31 EP EP94909517A patent/EP0681575B1/de not_active Expired - Lifetime
- 1994-01-31 DE DE69430661T patent/DE69430661T2/de not_active Expired - Fee Related
- 1994-01-31 AU AU62340/94A patent/AU684268B2/en not_active Ceased
- 1994-01-31 AT AT94909517T patent/ATE217870T1/de not_active IP Right Cessation
- 1994-01-31 WO PCT/US1994/001099 patent/WO1994017051A1/en not_active Ceased
- 1994-04-18 TW TW083103421A patent/TW360646B/zh not_active IP Right Cessation
- 1994-05-12 TW TW083104292A patent/TW402598B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
TW360646B (en)	1999-06-11
JPH10502327A (ja)	1998-03-03
ATE220064T1 (de)	2002-07-15
DE69430902T2 (de)	2002-10-24
EP0681573B1 (de)	2002-07-03
CN1101346A (zh)	1995-04-12
JP3741715B2 (ja)	2006-02-01
CA2155013A1 (en)	1994-08-04
TW402598B (en)	2000-08-21
DE69430902D1 (de)	2002-08-08
CN1125061C (zh)	2003-10-22
WO1994017051A1 (en)	1994-08-04
AU6132794A (en)	1994-08-15
EP0681575A4 (de)	1995-12-13
AU684268B2 (en)	1997-12-11
DK0681573T3 (da)	2002-10-28
JPH08506326A (ja)	1996-07-09
DE69430661T2 (de)	2002-10-24
CA2155014A1 (en)	1994-08-04
CA2155014C (en)	2007-06-26
DE69430661D1 (de)	2002-06-27
ES2176237T3 (es)	2002-12-01
AU6234094A (en)	1994-08-15
CA2155013C (en)	2006-04-11
IL108444A0 (en)	1994-04-12
EP0681575A1 (de)	1995-11-15
AU685778B2 (en)	1998-01-29
EP0681573A1 (de)	1995-11-15
JP3452928B2 (ja)	2003-10-06
WO1994017052A1 (en)	1994-08-04
EP0681573A4 (de)	1995-12-06
EP0681575B1 (de)	2002-05-22
PT681573E (pt)	2002-11-29

Legal Events

Date	Code	Title	Description
2002-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69430611D1 (de)	2002-06-20	Phosphonooxymethyl oder Methylthiomethylether von Taxanderivaten als Antitumormittel
DE69430661D1 (de)	2002-06-27	Verfahren zur Herstell ung von Baccatin III-Analogen, Verbindungen mit neuen funktionellen Gruppen an C2 und C4
NL350077I2 (nl)	2017-07-11	Cyprosulfamide
ATE396728T1 (de)	2008-06-15	Verwendung von oestrogen antagonisten und oestrogen agonisten zur behandlung von pathologischen zuständen
DE69420564D1 (de)	1999-10-14	Immunsuppressive und antiallergische verbindungen; z.b. n-(3-oxohexanoyl)-homoserinlacton
FI952248A7 (fi)	1995-05-09	Kasvainvastaisia koostumuksia, jotka sisältävät taksaanijohdannaisia
DE69429438D1 (de)	2002-01-24	Tricyclische carbamat-derivate zur inhibierung der g-protein funktion und für die behandlung von proliferativen erkrankungen
KR927003540A (ko)	1992-12-18	3-벤질리덴-1-카르바모일-2-피롤리돈 유사체
FI970246A7 (fi)	1997-01-21	Dihydrobentsofuraanit
DE60234092D1 (de)	2009-12-03	Agonisten und antagonisten von sphingosin-1-phosphatrezeptoren
EA200201083A1 (ru)	2003-04-24	Противоопухолевые производные эктейнасцидина
CO5050366A1 (es)	2001-06-27	Compuesto fungicida correspondiente a compuesto 7-bromo-3- metil-3,4-dihidrotienol[3,2-d]pirimidin-4-ona
TR199800011T1 (xx)	1998-04-21	Benzo$g] kuinolin t�revleri
MX9306606A (es)	1994-04-29	Procedimiento para la preparacion de derivados de taxano.
DE69102936D1 (de)	1994-08-25	Bis(alkyl-substituierte-4-hydroxyphenylthio)alkan-Analoga als Inhibitoren der Kataraktentstehung.
ES8702364A1 (es)	1986-12-16	Procedimiento para preparar nuevos derivados de benzazepinas.
EA199800034A1 (ru)	1998-08-27	Способ получения n-монозамещенных и n,n'-дизамещенных асимметричных циклических мочевин
NO983691D0 (no)	1998-08-12	Forbindelser tilhörende amidiniumfamilien, farmasöytiske preparater inneholdende disse samt anvendelse derav
SE7705310L (sv)	1977-11-08	Kinazolinderivat
KR830007512A (ko)	1983-10-21	단시간 작용 β-차단제의 제조방법
DE60032827D1 (de)	2007-02-15	Verfahren und Oxazolidin Zwischenprodukt zur Herstellung von Taxanen
TR199701298T1 (xx)	1998-02-21	Tetralinler.
BR9612242A (pt)	1999-07-13	Processo para a preparação de derivados de 7-(alcoxicarboniloxi-beta-substituidos)-10-hidroxi-tax anos e os respectivos derivados
DE60031269D1 (de)	2006-11-23	Halbsynthese von paclitaxel mit hilfe von dialkyldichlorsilanen
DE69209771D1 (de)	1996-05-15	Derivate von Bis(Phenyl)Äthan