ATE217875T1 - Acylphosph(on)at beta-lactamase inhibitoren - Google Patents
Acylphosph(on)at beta-lactamase inhibitorenInfo
- Publication number
- ATE217875T1 ATE217875T1 AT98965488T AT98965488T ATE217875T1 AT E217875 T1 ATE217875 T1 AT E217875T1 AT 98965488 T AT98965488 T AT 98965488T AT 98965488 T AT98965488 T AT 98965488T AT E217875 T1 ATE217875 T1 AT E217875T1
- Authority
- AT
- Austria
- Prior art keywords
- beta
- lactamase inhibitors
- inhibitors
- acylphosph
- ate
- Prior art date
Links
- 239000003781 beta lactamase inhibitor Substances 0.000 title abstract 4
- 229940126813 beta-lactamase inhibitor Drugs 0.000 title abstract 4
- 239000003112 inhibitor Substances 0.000 abstract 2
- 102000030899 Serine-Type D-Ala-D-Ala Carboxypeptidase Human genes 0.000 abstract 1
- 108010004832 Serine-Type D-Ala-D-Ala Carboxypeptidase Proteins 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 229930014626 natural product Natural products 0.000 abstract 1
- 150000003952 β-lactams Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/409—Compounds containing the structure P(=X)-X-acyl, P(=X) -X-heteroatom, P(=X)-X-CN (X = O, S, Se)
- C07F9/4093—Compounds containing the structure P(=X)-X-C(=X)- (X = O, S, Se)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/095—Compounds containing the structure P(=O)-O-acyl, P(=O)-O-heteroatom, P(=O)-O-CN
- C07F9/096—Compounds containing the structure P(=O)-O-C(=X)- (X = O, S, Se)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/098—Esters of polyphosphoric acids or anhydrides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
- C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65744—Esters of oxyacids of phosphorus condensed with carbocyclic or heterocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Pyrrole Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Cosmetics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6883797P | 1997-12-24 | 1997-12-24 | |
| PCT/US1998/027518 WO1999033850A1 (en) | 1997-12-24 | 1998-12-23 | NOVEL β-LACTAMASE AND DD-PEPTIDASE INHIBITORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE217875T1 true ATE217875T1 (de) | 2002-06-15 |
Family
ID=22085029
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98965488T ATE217875T1 (de) | 1997-12-24 | 1998-12-23 | Acylphosph(on)at beta-lactamase inhibitoren |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6608046B1 (de) |
| EP (1) | EP1042334B1 (de) |
| JP (1) | JP2002503643A (de) |
| KR (1) | KR100591572B1 (de) |
| AT (1) | ATE217875T1 (de) |
| AU (1) | AU755799B2 (de) |
| CA (1) | CA2315821A1 (de) |
| DE (1) | DE69805548T2 (de) |
| ES (1) | ES2178302T3 (de) |
| WO (1) | WO1999033850A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6599889B2 (en) * | 1997-12-24 | 2003-07-29 | Methylgere, Inc. | Acyl phosphonate inhibitors of β-lactamases |
| US6921756B2 (en) | 1999-07-06 | 2005-07-26 | Methylgene, Inc. | Inhibitors of β-lactamase |
| US6884791B2 (en) | 1999-07-06 | 2005-04-26 | Methylgene, Inc. | Inhibitors of β-lactamase |
| AU770599B2 (en) | 1999-07-06 | 2004-02-26 | Methylgene Inc. | Sulfonamidomethyl phosphonate inhibitors of beta-lactamase |
| WO2008073142A2 (en) * | 2006-05-22 | 2008-06-19 | Merck & Co., Inc. | Novel inhibitors of beta-lactamase |
| JP2009538302A (ja) * | 2006-05-22 | 2009-11-05 | メチルジーン・インコーポレイテッド | 新規なベータ−ラクタマーゼのスルホンアミドメチルホスホネート阻害剤 |
| WO2009114921A1 (en) * | 2008-03-17 | 2009-09-24 | Dmitrienko Gary I | INHIBITORS OF CLASS B AND CLASS D β-LACTAMASES |
| WO2013053953A1 (en) * | 2011-10-14 | 2013-04-18 | Université de Liège | Method for measuring beta-lactam antibiotics |
| CN104159587A (zh) * | 2012-01-06 | 2014-11-19 | 南佛罗里达大学 | 组合物、使用方法、以及治疗方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8603812D0 (sv) * | 1986-09-12 | 1986-09-12 | Draco Ab | Administration of liposomes to mammals |
| ES2082971T3 (es) * | 1990-03-14 | 1996-04-01 | Univ Toronto | Esteres de fosfato de acilo y modificacion de proteinas con los mismos. |
| US5250665A (en) * | 1991-05-31 | 1993-10-05 | The University Of Toronto Innovations Foundation | Specifically β-β cross-linked hemoglobins and method of preparation |
-
1998
- 1998-12-23 KR KR1020007007134A patent/KR100591572B1/ko not_active Expired - Fee Related
- 1998-12-23 JP JP2000526526A patent/JP2002503643A/ja active Pending
- 1998-12-23 AT AT98965488T patent/ATE217875T1/de active
- 1998-12-23 DE DE69805548T patent/DE69805548T2/de not_active Expired - Lifetime
- 1998-12-23 EP EP98965488A patent/EP1042334B1/de not_active Expired - Lifetime
- 1998-12-23 WO PCT/US1998/027518 patent/WO1999033850A1/en not_active Ceased
- 1998-12-23 CA CA002315821A patent/CA2315821A1/en not_active Abandoned
- 1998-12-23 AU AU20945/99A patent/AU755799B2/en not_active Ceased
- 1998-12-23 US US09/582,255 patent/US6608046B1/en not_active Expired - Fee Related
- 1998-12-23 ES ES98965488T patent/ES2178302T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1042334B1 (de) | 2002-05-22 |
| KR100591572B1 (ko) | 2006-06-20 |
| WO1999033850A8 (en) | 1999-09-10 |
| AU755799B2 (en) | 2002-12-19 |
| CA2315821A1 (en) | 1999-07-08 |
| DE69805548T2 (de) | 2003-01-09 |
| KR20010033621A (ko) | 2001-04-25 |
| DE69805548D1 (en) | 2002-06-27 |
| US6608046B1 (en) | 2003-08-19 |
| EP1042334A1 (de) | 2000-10-11 |
| AU2094599A (en) | 1999-07-19 |
| ES2178302T3 (es) | 2002-12-16 |
| JP2002503643A (ja) | 2002-02-05 |
| WO1999033850A1 (en) | 1999-07-08 |
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