ATE218060T1 - Zusammenstellungen die beta-amyloid protein bedingte zytotoxizität verhindern - Google Patents

Zusammenstellungen die beta-amyloid protein bedingte zytotoxizität verhindern

Info

Publication number: ATE218060T1
Authority: AT; Austria
Prior art keywords: amyloid protein; compositions; optionally substituted; protein related; prevent beta
Prior art date: 1996-07-11

Application number

AT97930746T

Other languages

English (en)

Inventor

Masaomi Miyamoto

Keisuke Hirai

Giichi Goto

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-11

Filing date

1997-07-10

Publication date

2002-06-15

1997-07-10 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

2002-06-15 Application granted granted Critical

2002-06-15 Publication of ATE218060T1 publication Critical patent/ATE218060T1/de

Links

102000013455 Amyloid beta-Peptides Human genes 0.000 title abstract 2
108010090849 Amyloid beta-Peptides Proteins 0.000 title abstract 2
230000003013 cytotoxicity Effects 0.000 title abstract 2
231100000135 cytotoxicity Toxicity 0.000 title abstract 2
239000000203 mixture Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000005017 substituted alkenyl group Chemical group 0.000 abstract 1
125000000547 substituted alkyl group Chemical group 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT97930746T 1996-07-11 1997-07-10 Zusammenstellungen die beta-amyloid protein bedingte zytotoxizität verhindern ATE218060T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP18209596		1996-07-11
PCT/JP1997/002391 WO1998002149A2 (en)	1996-07-11	1997-07-10	Use of idebenone and analogues against beta amyloid induced cytotoxicity

Publications (1)

Publication Number	Publication Date
ATE218060T1 true ATE218060T1 (de)	2002-06-15

Family

ID=16112269

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97930746T ATE218060T1 (de)	1996-07-11	1997-07-10	Zusammenstellungen die beta-amyloid protein bedingte zytotoxizität verhindern

Country Status (7)

Country	Link
US (1)	US6271266B1 (de)
EP (1)	EP0915696B1 (de)
AT (1)	ATE218060T1 (de)
AU (1)	AU3458997A (de)
CA (1)	CA2252519A1 (de)
DE (1)	DE69712888D1 (de)
WO (1)	WO1998002149A2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2619303T3 (es)	2005-06-01	2017-06-26	Edison Pharmaceuticals, Inc.	Productos terapéuticos redox activos para el tratamiento de enfermedades mitocondriales y otras afecciones y modulación de biomarcadores energéticos
SI1933821T1 (sl) *	2005-09-15	2020-11-30	Ptc Therapeutics, Inc.	Repne variante redoks-aktivnih terapevtikov za zdravljenje mitohondrijskih bolezni in drugih bolezni ter modulacijo energijskih biooznačevalcev
WO2007100652A2 (en)	2006-02-22	2007-09-07	Edison Pharmaceuticals, Inc.	Side chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
EP1891946A1 (de) *	2006-08-14	2008-02-27	Santhera Pharmaceuticals (Schweiz) AG	Transmukosale Verabreichung von 2,3-dimethoxy-5-methyl-6-(10-hydroxydecyl)-1,4-benzoquinon
EA038941B1 (ru)	2007-11-06	2021-11-12	ПиТиСи ТЕРАПЬЮТИКС, ИНК.	ПРОИЗВОДНЫЕ 4-(п-ХИНОНИЛ)-2-ГИДРОКСИБУТАНАМИДА ДЛЯ ЛЕЧЕНИЯ МИТОХОНДРИАЛЬНЫХ ЗАБОЛЕВАНИЙ
MX363223B (es)	2008-09-10	2019-03-15	Bioelectron Tech Corp	Tratamiento de trastornos generalizados del desarrollo con terapeuticos con actividad redox.
US8263094B2 (en) *	2008-09-23	2012-09-11	Eastman Chemical Company	Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids and preparation thereof
DK2605769T3 (en) *	2010-08-16	2016-10-24	Santhera Pharmaceuticals (Schweiz) Ag	Benzoquinonderivater for the treatment of mitochondrial diseases of the eye
WO2014035356A1 (en) *	2012-08-31	2014-03-06	Mahmut Bilgic	Tablet formulations comprising a quinone derivative active agent
DK3233786T3 (da)	2014-12-16	2022-05-09	Ptc Therapeutics Inc	Polymorfe og amorfe former af (r)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6- dioxocyclohexa-1,4-dienyl)butanamid
US10703701B2 (en)	2015-12-17	2020-07-07	Ptc Therapeutics, Inc.	Fluoroalkyl, fluoroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders
JP7266304B2 (ja)	2017-04-21	2023-04-28	ユニヴァーシティーオブタスマニア	治療化合物および方法
TN2021000075A1 (en)	2018-10-17	2023-01-05	Ptc Therapeutics Inc	2,3,5-TRIMETHYL-6-NONYLCYCLOHEXA-2,5-DIENE-1,4-DIONE FOR SUPPRESSING AND TREATING α-SYNUCLEINOPATHIES, TAUOPATHIES, AND OTHER DISORDERS
MX2024000445A (es)	2021-07-08	2024-04-05	Ptc Therapeutics Inc	Composiciones farmaceuticas que comprenden 2,3,5-trimetil-6-nonilc iclohexa-2,5-dieno-1,4-diona.
CN119792259A (zh) *	2024-10-14	2025-04-11	中国农业大学	艾地苯醌在制备朊病毒病药物中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH08768B2 (ja)	1989-08-24	1996-01-10	武田薬品工業株式会社	神経成長因子分泌誘導剤
JP2849286B2 (ja) *	1992-07-09	1999-01-20	三菱電機株式会社	半導体装置の製造方法
DE69420776T2 (de)	1993-06-18	2000-05-18	Takeda Chemical Industries, Ltd.	Idebenone-haltige Zusammensetzungen zur Behandlung von M. Alzheimer

1997
- 1997-07-10 CA CA002252519A patent/CA2252519A1/en not_active Abandoned
- 1997-07-10 WO PCT/JP1997/002391 patent/WO1998002149A2/en not_active Ceased
- 1997-07-10 AT AT97930746T patent/ATE218060T1/de not_active IP Right Cessation
- 1997-07-10 EP EP97930746A patent/EP0915696B1/de not_active Expired - Lifetime
- 1997-07-10 US US09/180,463 patent/US6271266B1/en not_active Expired - Fee Related
- 1997-07-10 AU AU34589/97A patent/AU3458997A/en not_active Abandoned
- 1997-07-10 DE DE69712888T patent/DE69712888D1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
WO1998002149A3 (en)	1998-06-04
CA2252519A1 (en)	1998-01-22
WO1998002149A2 (en)	1998-01-22
US6271266B1 (en)	2001-08-07
EP0915696B1 (de)	2002-05-29
AU3458997A (en)	1998-02-09
DE69712888D1 (de)	2002-07-04
EP0915696A2 (de)	1999-05-19

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Legal Events

Date	Code	Title	Description
2002-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties