ATE218137T1 - Benzo(5,6)cyclohepta(1,2-b)pyridin derivate als farnesyl protein transferase inhibitoren - Google Patents

Benzo(5,6)cyclohepta(1,2-b)pyridin derivate als farnesyl protein transferase inhibitoren

Info

Publication number
ATE218137T1
ATE218137T1 AT98930063T AT98930063T ATE218137T1 AT E218137 T1 ATE218137 T1 AT E218137T1 AT 98930063 T AT98930063 T AT 98930063T AT 98930063 T AT98930063 T AT 98930063T AT E218137 T1 ATE218137 T1 AT E218137T1
Authority
AT
Austria
Prior art keywords
protein transferase
farnesyl protein
cyclohepta
benzo
pyridine derivatives
Prior art date
Application number
AT98930063T
Other languages
English (en)
Inventor
Timothy J Guzi
Dinanath F Rane
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE218137T1 publication Critical patent/ATE218137T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT98930063T 1997-06-17 1998-06-15 Benzo(5,6)cyclohepta(1,2-b)pyridin derivate als farnesyl protein transferase inhibitoren ATE218137T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87650797A 1997-06-17 1997-06-17
PCT/US1998/011499 WO1998057945A1 (en) 1997-06-17 1998-06-15 Benzo(5,6)cyclohepta(1,2-b)pyridine derivatives as farnesyl protein transferase inhibitors

Publications (1)

Publication Number Publication Date
ATE218137T1 true ATE218137T1 (de) 2002-06-15

Family

ID=25367883

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98930063T ATE218137T1 (de) 1997-06-17 1998-06-15 Benzo(5,6)cyclohepta(1,2-b)pyridin derivate als farnesyl protein transferase inhibitoren

Country Status (12)

Country Link
EP (1) EP0991637B1 (de)
JP (1) JP2002510308A (de)
KR (1) KR20010013829A (de)
CN (1) CN1272844A (de)
AT (1) ATE218137T1 (de)
AU (1) AU7953798A (de)
CA (1) CA2293433C (de)
DE (1) DE69805619T2 (de)
ES (1) ES2174450T3 (de)
HU (1) HUP0002659A3 (de)
IL (1) IL133448A0 (de)
WO (1) WO1998057945A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002028381A2 (en) 2000-10-05 2002-04-11 Daley George Q Methods of inducing cancer cell death and tumor regression
AU2002211427A1 (en) * 2000-10-05 2002-04-15 Whitehead Institute For Biomedical Research Effects of combined administration of farnesyl transferase inhibitors and signal transduction inhibitors
TW200418825A (en) 2002-12-16 2004-10-01 Hoffmann La Roche Novel (R)-and (S) enantiomers of thiophene hydroxamic acid derivatives
KR20240035513A (ko) 2021-07-09 2024-03-15 알리고스 테라퓨틱스 인코포레이티드 항바이러스 화합물
US12065428B2 (en) 2021-09-17 2024-08-20 Aligos Therapeutics, Inc. Anti-viral compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
JPH0676403B2 (ja) * 1991-01-18 1994-09-28 エスエス製薬株式会社 新規なベンゾ［５，６ シクロヘプタ［１，２−ｂ ピリジン誘導体及びこれを含有する抗アレルギー剤
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them

Also Published As

Publication number Publication date
WO1998057945A1 (en) 1998-12-23
EP0991637B1 (de) 2002-05-29
CA2293433C (en) 2009-09-29
CN1272844A (zh) 2000-11-08
AU7953798A (en) 1999-01-04
CA2293433A1 (en) 1998-12-23
JP2002510308A (ja) 2002-04-02
ES2174450T3 (es) 2002-11-01
DE69805619T2 (de) 2002-11-07
EP0991637A1 (de) 2000-04-12
HUP0002659A3 (en) 2002-11-28
DE69805619D1 (en) 2002-07-04
HK1024910A1 (en) 2000-10-27
HUP0002659A2 (hu) 2001-06-28
IL133448A0 (en) 2001-04-30
KR20010013829A (ko) 2001-02-26

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Legal Events

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