ATE356816T1 - Trizyklische keto amid derivative als farnesyl protein transferase inhibitoren - Google Patents

Trizyklische keto amid derivative als farnesyl protein transferase inhibitoren

Info

Publication number
ATE356816T1
ATE356816T1 AT98928891T AT98928891T ATE356816T1 AT E356816 T1 ATE356816 T1 AT E356816T1 AT 98928891 T AT98928891 T AT 98928891T AT 98928891 T AT98928891 T AT 98928891T AT E356816 T1 ATE356816 T1 AT E356816T1
Authority
AT
Austria
Prior art keywords
aralkyl
lower alkyl
amide derivatives
protein transferase
transferase inhibitors
Prior art date
Application number
AT98928891T
Other languages
English (en)
Inventor
Ronald J Doll
Tarik Lalwani
Carmen Alvarez
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE356816T1 publication Critical patent/ATE356816T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
AT98928891T 1997-06-17 1998-06-15 Trizyklische keto amid derivative als farnesyl protein transferase inhibitoren ATE356816T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/877,677 US5925639A (en) 1997-06-17 1997-06-17 Keto amide derivatives useful as farnesyl protein transferase inhibitors

Publications (1)

Publication Number Publication Date
ATE356816T1 true ATE356816T1 (de) 2007-04-15

Family

ID=25370491

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98928891T ATE356816T1 (de) 1997-06-17 1998-06-15 Trizyklische keto amid derivative als farnesyl protein transferase inhibitoren

Country Status (10)

Country Link
US (1) US5925639A (de)
EP (1) EP0989978B1 (de)
JP (1) JP3269636B2 (de)
CN (1) CN1267288A (de)
AT (1) ATE356816T1 (de)
AU (1) AU8058598A (de)
CA (1) CA2293672C (de)
DE (1) DE69837331T2 (de)
ES (1) ES2284206T3 (de)
WO (1) WO1998057947A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6524832B1 (en) 1994-02-04 2003-02-25 Arch Development Corporation DNA damaging agents in combination with tyrosine kinase inhibitors
US6632455B2 (en) 1997-12-22 2003-10-14 Schering Corporation Molecular dispersion composition with enhanced bioavailability
US6271378B1 (en) 1998-12-18 2001-08-07 Schering Corporation Process for preparing tricyclic compounds having antihistaminic activity
US6316462B1 (en) 1999-04-09 2001-11-13 Schering Corporation Methods of inducing cancer cell death and tumor regression
EP1255537B1 (de) * 2000-02-04 2006-04-19 Janssen Pharmaceutica N.V. Farnesyl protein transferase inhibitoren zur behandlung von brustkrebs
AR035660A1 (es) 2000-11-29 2004-06-23 Schering Corp Compuestos 3,10-dibromo-8-cloro-11h-benzo[5,6]ciclohepta[1,2-b]piridin-11-il-4-piperidinilos o sus sales farmaceuticamente aceptables, composiciones farmaceuticas que los comprenden, usos de los mismos para preparar medicamentos, y un procedimiento para producir un compuesto intermediario para produ
US20070148660A1 (en) * 2005-06-16 2007-06-28 The Regents Of The University Of California Treatment of maladaptive substance use with H-ras antagonists
US20110230428A1 (en) * 2008-07-22 2011-09-22 John Wityak Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
US9981918B2 (en) 2011-08-30 2018-05-29 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
JP2014525443A (ja) 2011-08-30 2014-09-29 シーエイチディーアイ ファウンデーション，インコーポレーテッド キヌレニン−３−モノオキシゲナーゼインヒビター、医薬組成物、およびこれらの使用方法
KR20170026633A (ko) 2014-07-17 2017-03-08 씨에이치디아이 파운데이션, 인코포레이티드 Hiv-관련 장애의 치료 방법 및 치료용 조성물

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4758577A (en) * 1984-04-05 1988-07-19 Merck & Co., Inc. 4-(5H-dibenzo[a,d]cyclohepten-5-yl)piperidine compounds for treating cardiovascular disorders
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
ATE210652T1 (de) * 1993-10-15 2001-12-15 Schering Corp Tricyclische carbamat-derivate zur inhibierung der g-protein funktion und für die behandlung von proliferativen erkrankungen
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
US5684013A (en) * 1995-03-24 1997-11-04 Schering Corporation Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US5700806A (en) * 1995-03-24 1997-12-23 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL117797A0 (en) * 1995-04-07 1996-08-04 Pharmacopeia Inc Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL117798A (en) 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
KR20000036111A (ko) * 1996-09-13 2000-06-26 둘락 노먼 씨. 파네실 단백질 트랜스페라제 억제제인 트리사이클릭 항종양성화합물

Also Published As

Publication number Publication date
DE69837331D1 (en) 2007-04-26
JP2000514841A (ja) 2000-11-07
EP0989978A1 (de) 2000-04-05
EP0989978B1 (de) 2007-03-14
US5925639A (en) 1999-07-20
CA2293672A1 (en) 1998-12-23
CA2293672C (en) 2004-04-06
JP3269636B2 (ja) 2002-03-25
ES2284206T3 (es) 2007-11-01
AU8058598A (en) 1999-01-04
CN1267288A (zh) 2000-09-20
DE69837331T2 (de) 2007-11-15
WO1998057947A1 (en) 1998-12-23

Similar Documents

Publication Publication Date Title
ATE242231T1 (de) Carbonyl-piperaznyl und piperidinyl derivate zur hemmung farnesyl protein transferase
GB1589933A (en) Amino acid derivatives
AR047339A1 (es) Derivados de difenilazetidona.proceso de obtencion.
PL334915A1 (en) Pyrrolidine derivatives exhibiting phospholipase a2 inhibiting activity
EA200300982A1 (ru) Гетероциклические производные для лечения рака и других пролиферативных заболеваний
ATE356816T1 (de) Trizyklische keto amid derivative als farnesyl protein transferase inhibitoren
GB1447599A (en) Derivatives of alpha-methyldopa
PL309874A1 (en) Novel derivatives of pyrrolocarbasol, method of obtaining them and pharmaceutical composition containing such derivatives
NO160297C (no) Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-oksoazetidinderivater
NO305515B1 (no) 5-amino-8-metyl-7-pyrrolidinylkinolin-3-karboksylsyrederivater og farmas°ytiske preparater inneholdende disse
ATE223411T1 (de) 1-methylcarbapenem-derivate
ATE215555T1 (de) 17-beta.-allyloxy(thio)alkyl-androstan derivative zur modulation von meiose
IL133414A0 (en) Benzo (5, 6) cycloheptapyridine cyclic ureas and lactams useful as farnesyl protein transferase inhibitors
DK0643061T3 (da) Nye cephalosporin-antibitotika
NZ240272A (en) Piperazine derivatives; pharmaceutical compositions and preparatory processes
AU686642B2 (en) Cyclohexane derivatives
DE69826281D1 (de) Benzo[5,6]cyclohepta[1,2b]pyridine derivate anwendbar als farnesyl protein transferase inhibitoren
EP0590681A3 (en) A process for the preparation of aminothiadiazolylacetyl halide derivatives
HU9503718D0 (en) Serotoninergic abeo-ergoline derivatives
EP0573659A4 (en) Pyrazolothiazolopyrimidine derivative
DE69303847D1 (de) Indolderivate
EA200000922A1 (ru) Производные аминоантрациклинона и их применение в лечении амилоидоза
ES8600762A1 (es) Un procedimiento para la preparacion de nuevos compuestos de beta-lactama.
TW326439B (en) Octahydornaphthalene oxime derivatives for cholesterol biosynthesis inhibition, their preparation and use

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties