ATE218544T1 - Omega-zykloalkyl-prostaglandin e1 derivate - Google Patents

Omega-zykloalkyl-prostaglandin e1 derivate

Info

Publication number: ATE218544T1
Authority: AT; Austria
Prior art keywords: prostaglandin; omega; cycloalkyl; derivatives; hepatopathy
Prior art date: 1998-07-21

Application number

AT99305735T

Other languages

English (en)

Inventor

Shuichi Ohuchida

Kousuke Tani

Original Assignee

Ono Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-21

Filing date

1999-07-20

Publication date

2002-06-15

1999-07-20 Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co

2002-06-15 Application granted granted Critical

2002-06-15 Publication of ATE218544T1 publication Critical patent/ATE218544T1/de

Links

125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
208000023275 Autoimmune disease Diseases 0.000 abstract 1
125000004648 C2-C8 alkenyl group Chemical group 0.000 abstract 1
125000004649 C2-C8 alkynyl group Chemical group 0.000 abstract 1
229920000858 Cyclodextrin Polymers 0.000 abstract 1
208000010412 Glaucoma Diseases 0.000 abstract 1
208000005107 Premature Birth Diseases 0.000 abstract 1
206010036590 Premature baby Diseases 0.000 abstract 1
206010052779 Transplant rejections Diseases 0.000 abstract 1
230000002159 abnormal effect Effects 0.000 abstract 1
206010000210 abortion Diseases 0.000 abstract 1
231100000176 abortion Toxicity 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
208000026278 immune system disease Diseases 0.000 abstract 1
208000019423 liver disease Diseases 0.000 abstract 1
230000016273 neuron death Effects 0.000 abstract 1
201000001119 neuropathy Diseases 0.000 abstract 1
230000007823 neuropathy Effects 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
230000011164 ossification Effects 0.000 abstract 1
208000033808 peripheral neuropathy Diseases 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
210000001525 retina Anatomy 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 1
238000002054 transplantation Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT99305735T 1998-07-21 1999-07-20 Omega-zykloalkyl-prostaglandin e1 derivate ATE218544T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP22105498		1998-07-21

Publications (1)

Publication Number	Publication Date
ATE218544T1 true ATE218544T1 (de)	2002-06-15

Family

ID=16760781

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99305735T ATE218544T1 (de)	1998-07-21	1999-07-20	Omega-zykloalkyl-prostaglandin e1 derivate

Country Status (8)

Country	Link
US (1)	US6235780B1 (de)
EP (1)	EP0974580B1 (de)
KR (1)	KR100349964B1 (de)
AT (1)	ATE218544T1 (de)
DE (1)	DE69901658T2 (de)
DK (1)	DK0974580T3 (de)
ES (1)	ES2178352T3 (de)
PT (1)	PT974580E (de)

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JP2006021998A (ja) *	2002-07-18	2006-01-26	Ono Pharmaceut Co Ltd	Ｅｐ２アゴニストを有効成分とする月経困難症治療剤
DK1563846T3 (da)	2002-10-10	2012-12-17	Ono Pharmaceutical Co	Endogene reparationsfaktorproduktionsfremmere
WO2004078103A2 (en) *	2003-03-03	2004-09-16	Applied Research Systems Ars Holding N.V.	G-lactam derivatives as prostaglandin agonists
AU2004261397A1 (en) *	2003-07-18	2005-02-10	Laboratoires Serono Sa	Hydrazide derivatives as prostaglandin receptors modulators
WO2005009468A1 (ja)	2003-07-25	2005-02-03	Ono Pharmaceutical Co., Ltd.	軟骨関連疾患治療剤
JP4893999B2 (ja)	2004-10-22	2012-03-07	小野薬品工業株式会社	吸入用医薬組成物
MY145694A (en) *	2005-04-11	2012-03-30	Xenon Pharmaceuticals Inc	Spiroheterocyclic compounds and their uses as therapeutic agents
AR056968A1 (es) *	2005-04-11	2007-11-07	Xenon Pharmaceuticals Inc	Compuestos espiro-oxindol y composiciones farmacéuticas
CA2610692C (en)	2005-06-03	2014-11-25	Ono Pharmaceutical Co., Ltd.	Ep2 agonists which may have an ep3 agonistic effect for regeneration and/or protection of nerves
PL1976828T3 (pl)	2005-12-29	2017-07-31	Celtaxsys, Inc.	Pochodne diaminy jako inhibitory hydrolazy leukotrienu a4
WO2008060789A2 (en)	2006-10-12	2008-05-22	Xenon Pharmaceuticals Inc.	Use of spiro-oxindole compounds as therapeutic agents
RU2009117605A (ru) *	2006-10-12	2010-11-20	Ксенон Фармасьютикалз Инк. (Ca)	ПРОИЗВОДНЫЕ СПИРО-(ФУРО[3,2-c]ПИРИДИН-3-3'-ИНДОЛ)-2'(1'H)-ОНА И РОДСТВЕННЫЕ ИМ СОЕДИНЕНИЯ ДЛЯ ЛЕЧЕНИЯ ОПОСРЕДОВАННЫХ НАТРИЕВЫМИ КАНАЛАМИ ЗАБОЛЕВАНИЙ, ТАКИХ КАК БОЛЬ
JP5271272B2 (ja)	2006-11-16	2013-08-21	ジェンムスファーマインコーポレイティド	Ａ型インフルエンザウィルス感染の治療のための薬剤としてのｅｐ２およびｅｐ４作動薬
WO2010045251A2 (en)	2008-10-17	2010-04-22	Xenon Pharmaceuticals, Inc.	Spiro-oxindole compounds and their use as therapeutic agents
CA2741024A1 (en) *	2008-10-17	2010-04-22	Xenon Pharmaceuticals Inc.	Spiro-oxindole compounds and their use as therapeutic agents
AR077252A1 (es)	2009-06-29	2011-08-10	Xenon Pharmaceuticals Inc	Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
AU2010306768B2 (en)	2009-10-14	2016-08-04	Xenon Pharmaceuticals Inc.	Synthetic methods for spiro-oxindole compounds
US20110086899A1 (en) *	2009-10-14	2011-04-14	Xenon Pharmaceuticals Inc.	Pharmaceutical compositions for oral administration
MY165117A (en)	2010-02-26	2018-02-28	Xenon Pharmaceuticals Inc	Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents
AU2013246485A1 (en)	2012-04-12	2014-10-16	Xenon Pharmaceuticals Inc.	Asymmetric syntheses for spiro-oxindole compounds useful as therapeutic agents
JP6400479B2 (ja)	2012-10-29	2018-10-03	株式会社カルディオ	肺疾患特異的治療剤
EP2968264A4 (de)	2013-03-14	2016-11-02	Celtaxsys Inc	Inhibitoren der leukotrien-a4-hydrolase
JP6449166B2 (ja)	2013-10-15	2019-01-09	小野薬品工業株式会社	薬剤溶出性ステントグラフト
AR103636A1 (es)	2015-02-05	2017-05-24	Teva Pharmaceuticals Int Gmbh	Métodos de tratamiento de neuralgia postherpética con una formulación tópica de un compuesto de espiro-oxindol
WO2017218920A1 (en)	2016-06-16	2017-12-21	Teva Pharmaceuticals International Gmbh	Asymmetric synthesis of funapide
KR20190088551A (ko)	2016-12-09	2019-07-26	켈탁시스, 인코퍼레이티드	루코트리엔 a4 하이드롤라제의 저해제
CA3045887A1 (en)	2016-12-09	2018-06-14	Celtaxsys, Inc.	Pendant amines and derivatives as inhibitors of leukotriene a4 hydrolase
AU2017371353B2 (en)	2016-12-09	2022-02-03	Celltaxis, Llc	Monamine and monoamine derivatives as inhibitors of leukotriene A4 hydrolase
WO2021163400A1 (en)	2020-02-12	2021-08-19	Cytoagents, Inc.	Compositions and methods for treating coronavirus infections

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Publication number	Priority date	Publication date	Assignee	Title
US4132738A (en)	1978-02-23	1979-01-02	Miles Laboratories, Inc.	Preparation of 15-deoxy-16-hydroxyprostaglandins
DE2950027A1 (de)	1979-12-10	1981-06-11	Schering Ag Berlin Und Bergkamen, 1000 Berlin	9-chlor-prostaglandinderivate, verfahren zur herstellung und verwendung als arzneimittel
US5204371A (en)	1979-12-10	1993-04-20	Schering Aktiengesellschaft	Pharmaceutically active 9-chloroprostaglandins
DE3126924A1 (de)	1981-07-03	1983-01-20	Schering Ag, 1000 Berlin Und 4619 Bergkamen	9-fluor-prostaglandinderivate, verfahren zur herstellung und verwendung als arzneimittel
JPS5883670A (ja) *	1981-11-13	1983-05-19	Teijin Ltd	プロスタグランデインｅ↓１類の製造法
JP3502952B2 (ja) *	1992-10-20	2004-03-02	大正製薬株式会社	プロスタグランジン誘導体
EP0666256A1 (de) *	1992-10-20	1995-08-09	Taisho Pharmaceutical Co. Ltd	Prostaglandinderivate
DE4330177A1 (de) *	1993-08-31	1995-03-02	Schering Ag	Neue 9-Chlor-prostaglandin-derivate
JP3579448B2 (ja) *	1993-12-29	2004-10-20	大正製薬株式会社	プロスタグランジン誘導体、その塩およびその使用
JP3506485B2 (ja) *	1994-04-19	2004-03-15	大正製薬株式会社	プロスタグランジン誘導体
NO317155B1 (no) *	1997-02-04	2004-08-30	Ono Pharmaceutical Co	<omega>-cykloalkyl-prostagladin-E<N>2</N>-derivater
JP3162668B2 (ja) *	1997-02-04	2001-05-08	小野薬品工業株式会社	ω−シクロアルキル−プロスタグランジンＥ２誘導体
WO1999033794A1 (en) *	1997-12-25	1999-07-08	Ono Pharmaceutical Co., Ltd.	φ-CYCLOALKYL-PROSTAGLANDIN E2 DERIVATIVES

1999
- 1999-07-19 US US09/356,674 patent/US6235780B1/en not_active Expired - Fee Related
- 1999-07-20 AT AT99305735T patent/ATE218544T1/de not_active IP Right Cessation
- 1999-07-20 ES ES99305735T patent/ES2178352T3/es not_active Expired - Lifetime
- 1999-07-20 DK DK99305735T patent/DK0974580T3/da active
- 1999-07-20 EP EP99305735A patent/EP0974580B1/de not_active Expired - Lifetime
- 1999-07-20 PT PT99305735T patent/PT974580E/pt unknown
- 1999-07-20 DE DE69901658T patent/DE69901658T2/de not_active Expired - Fee Related
- 1999-07-21 KR KR1019990029480A patent/KR100349964B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR20000011866A (ko)	2000-02-25
PT974580E (pt)	2002-10-31
ES2178352T3 (es)	2002-12-16
DE69901658T2 (de)	2002-11-21
EP0974580B1 (de)	2002-06-05
DE69901658D1 (de)	2002-07-11
US6235780B1 (en)	2001-05-22
DK0974580T3 (da)	2002-09-30
EP0974580A1 (de)	2000-01-26
KR100349964B1 (ko)	2002-08-22

Legal Events

Date	Code	Title	Description
2002-11-15	UEP	Publication of translation of european patent specification
2005-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE218544T1 (de)	2002-06-15	Omega-zykloalkyl-prostaglandin e1 derivate
HU9800208D0 (en)	1998-03-30	Omega-cycloalkyl-prostaglandin e2-derivatives
ATE260254T1 (de)	2004-03-15	Omega-cycloalkyl-prostaglandin e2 derivate
ATE225770T1 (de)	2002-10-15	Difluoroprostaglandin-derivate und ihre anwendung
ZA959444B (en)	1997-08-07	Polyanionic benzylglycosides as inhibitors of smooth muscle cell proliferation.
BR0310057A (pt)	2007-04-10	melhoria do desenvolvimento de catarata e outras doenças oftálmicas
EP0366279A3 (de)	1991-12-27	Okulare hypotensive Mittel
NZ506497A (en)	2004-12-24	Indole derivatives, pharmaceuticals thereof and their use in lowering intraocular pressure or for the treatment or prevention of glaucoma or ocular hypertension
TW200716547A (en)	2007-05-01	Piperidin-4-yl-amide derivatives
ATE223411T1 (de)	2002-09-15	1-methylcarbapenem-derivate
GB2115815B (en)	1985-06-19	Benzothiazoline compounds
TR200002808T2 (tr)	2001-01-22	İlaç olarak yararlı C11 oksimil ve hidroksilamino prostaglandinleri
ES466168A1 (es)	1979-07-01	Procedimiento para la preparacion de nuevos derivados de cromonas dotados de actividad medicamentosa
ES2096800T3 (es)	1997-03-16	Benzo(b)tiofen-3-il-piperazinas, un procedimiento para su preparacion y su uso como medicamentos.
FR2714381B1 (fr)	1996-02-02	Dérivés de la benzoxazine, leurs procédés d'obtention et leur utilisation en tant que médicaments .
TW208000B (de)	1993-06-21
NO974745L (no)	1997-12-12	1-£<omega>-(3,4-dihydro-2-naftalenyl)alkyl\| cyklisk-amin-derivater, fremgangsmåte for deres fremstilling og farmasöytiske preparater som inneholder samme
AU2178099A (en)	1999-08-09	Azetidinecarboxamide derivatives for treating cns disorders
DE69806640D1 (de)	2002-08-22	17beta-aryl(arylmethyl)oxy(thio)alkyl-androstanderivative
DE69903346D1 (de)	2002-11-07	22s-hydroxycholesta-8,14-dien derivate mit meiose regulierende aktivität