ATE218544T1 - Omega-zykloalkyl-prostaglandin e1 derivate - Google Patents
Omega-zykloalkyl-prostaglandin e1 derivateInfo
- Publication number
- ATE218544T1 ATE218544T1 AT99305735T AT99305735T ATE218544T1 AT E218544 T1 ATE218544 T1 AT E218544T1 AT 99305735 T AT99305735 T AT 99305735T AT 99305735 T AT99305735 T AT 99305735T AT E218544 T1 ATE218544 T1 AT E218544T1
- Authority
- AT
- Austria
- Prior art keywords
- prostaglandin
- omega
- cycloalkyl
- derivatives
- hepatopathy
- Prior art date
Links
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 abstract 1
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 abstract 1
- 229920000858 Cyclodextrin Polymers 0.000 abstract 1
- 208000010412 Glaucoma Diseases 0.000 abstract 1
- 208000005107 Premature Birth Diseases 0.000 abstract 1
- 206010036590 Premature baby Diseases 0.000 abstract 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 206010000210 abortion Diseases 0.000 abstract 1
- 231100000176 abortion Toxicity 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 208000019423 liver disease Diseases 0.000 abstract 1
- 230000016273 neuron death Effects 0.000 abstract 1
- 201000001119 neuropathy Diseases 0.000 abstract 1
- 230000007823 neuropathy Effects 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 230000011164 ossification Effects 0.000 abstract 1
- 208000033808 peripheral neuropathy Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 210000001525 retina Anatomy 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22105498 | 1998-07-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE218544T1 true ATE218544T1 (de) | 2002-06-15 |
Family
ID=16760781
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99305735T ATE218544T1 (de) | 1998-07-21 | 1999-07-20 | Omega-zykloalkyl-prostaglandin e1 derivate |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6235780B1 (de) |
| EP (1) | EP0974580B1 (de) |
| KR (1) | KR100349964B1 (de) |
| AT (1) | ATE218544T1 (de) |
| DE (1) | DE69901658T2 (de) |
| DK (1) | DK0974580T3 (de) |
| ES (1) | ES2178352T3 (de) |
| PT (1) | PT974580E (de) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006021998A (ja) * | 2002-07-18 | 2006-01-26 | Ono Pharmaceut Co Ltd | Ｅｐ２アゴニストを有効成分とする月経困難症治療剤 |
| HUE029417T2 (en) | 2002-10-10 | 2017-02-28 | Ono Pharmaceutical Co | Microspheres containing ONO-1301 |
| JP4662926B2 (ja) * | 2003-03-03 | 2011-03-30 | メルク セローノ ソシエテ アノニム | プロスタグランジン作動薬としてのγ−ラクタム誘導体 |
| EP1654219A2 (de) * | 2003-07-18 | 2006-05-10 | Applied Research Systems ARS Holding N.V. | Hydrazinderivate als modulatoren des prostaglandinrezeptors |
| WO2005009468A1 (ja) | 2003-07-25 | 2005-02-03 | Ono Pharmaceutical Co., Ltd. | 軟骨関連疾患治療剤 |
| EP1806148A4 (de) | 2004-10-22 | 2009-12-02 | Ono Pharmaceutical Co | Medizinische zusammensetzung zur inhalation |
| MY144968A (en) * | 2005-04-11 | 2011-11-30 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds and their uses as therapeutic agents |
| AR053710A1 (es) * | 2005-04-11 | 2007-05-16 | Xenon Pharmaceuticals Inc | Compuestos espiroheterociclicos y sus usos como agentes terapeuticos |
| JP5040650B2 (ja) | 2005-06-03 | 2012-10-03 | 小野薬品工業株式会社 | 神経再生および／または保護剤 |
| EP3205644A1 (de) | 2005-12-29 | 2017-08-16 | Celtaxsys Inc. | Diaminderivate als inhibitoren der leukotrien-a4 hydrolase |
| WO2008046049A1 (en) * | 2006-10-12 | 2008-04-17 | Xenon Pharmaceuticals Inc. | Spiro (furo [3, 2-c] pyridine-3-3 ' -indol) -2' (1'h)-one derivatives and related compounds for the treatment of sodium-channel mediated diseases, such as pain |
| EP2073806B1 (de) | 2006-10-12 | 2012-02-15 | Xenon Pharmaceuticals Inc. | Verwendung von spiro-oxindol-verbindungen als therapeutika |
| EP2269611B1 (de) * | 2006-11-16 | 2016-03-23 | Gemmus Pharma Inc. | EP2- und EP4-Agonisten als Wirkstoffe zur Behandlung von Influenza A Virusinfektionen |
| HRP20150882T1 (hr) * | 2008-10-17 | 2015-09-25 | Xenon Pharmaceuticals Inc. | Spirooksindolski spojevi i njihova upotreba kao terapijska sredstva |
| WO2010045197A1 (en) * | 2008-10-17 | 2010-04-22 | Xenon Pharmaceuticals, Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
| AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
| PE20170202A1 (es) | 2009-10-14 | 2017-03-24 | Xenon Pharmaceuticals Inc | Metodos sinteticos para compuestos espiro-oxoindol |
| US20110086899A1 (en) * | 2009-10-14 | 2011-04-14 | Xenon Pharmaceuticals Inc. | Pharmaceutical compositions for oral administration |
| RU2596488C2 (ru) | 2010-02-26 | 2016-09-10 | Ксенон Фармасьютикалз Инк. | Фармацевтические композиции спиро-оксиндольного соединения для местного введения и их применение в качестве терапевтических агентов |
| KR20150002794A (ko) | 2012-04-12 | 2015-01-07 | 제논 파마슈티칼스 인크. | 치료제로서 유용한 스파이로-옥시인돌 화합물을 위한 비대칭적 합성 |
| ES2733998T3 (es) | 2012-10-29 | 2019-12-03 | Cardio Incorporated | Agente terapéutico específico de enfermedad pulmonar |
| AU2014240042C1 (en) | 2013-03-14 | 2019-09-05 | Celltaxis, Llc | Inhibitors of leukotriene A4 hydrolase |
| US9968716B2 (en) | 2013-10-15 | 2018-05-15 | Ono Pharmaceutical Co., Ltd. | Drug-eluting stent graft |
| AR103636A1 (es) | 2015-02-05 | 2017-05-24 | Teva Pharmaceuticals Int Gmbh | Métodos de tratamiento de neuralgia postherpética con una formulación tópica de un compuesto de espiro-oxindol |
| WO2017218920A1 (en) | 2016-06-16 | 2017-12-21 | Teva Pharmaceuticals International Gmbh | Asymmetric synthesis of funapide |
| WO2018107158A1 (en) | 2016-12-09 | 2018-06-14 | Celtaxsys, Inc. | Monamine and monoamine derivatives as inhibitors of leukotriene a4 hydrolase |
| CA3045887A1 (en) | 2016-12-09 | 2018-06-14 | Celtaxsys, Inc. | Pendant amines and derivatives as inhibitors of leukotriene a4 hydrolase |
| US10202362B2 (en) | 2016-12-09 | 2019-02-12 | Celtaxsys, Inc. | Inhibitors of leukotriene A4 hydrolase |
| EP4103192A4 (de) | 2020-02-12 | 2024-02-21 | Cytoagents, Inc. | Zusammensetzungen und verfahren zur behandlung von coronavirusinfektionen |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4132738A (en) | 1978-02-23 | 1979-01-02 | Miles Laboratories, Inc. | Preparation of 15-deoxy-16-hydroxyprostaglandins |
| US5204371A (en) | 1979-12-10 | 1993-04-20 | Schering Aktiengesellschaft | Pharmaceutically active 9-chloroprostaglandins |
| DE2950027A1 (de) | 1979-12-10 | 1981-06-11 | Schering Ag Berlin Und Bergkamen, 1000 Berlin | 9-chlor-prostaglandinderivate, verfahren zur herstellung und verwendung als arzneimittel |
| DE3126924A1 (de) | 1981-07-03 | 1983-01-20 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | 9-fluor-prostaglandinderivate, verfahren zur herstellung und verwendung als arzneimittel |
| JPS5883670A (ja) * | 1981-11-13 | 1983-05-19 | Teijin Ltd | プロスタグランデインｅ↓１類の製造法 |
| WO1994008959A1 (fr) * | 1992-10-20 | 1994-04-28 | Taisho Pharmaceutical Co., Ltd. | Derive de prostaglandine |
| JP3502952B2 (ja) * | 1992-10-20 | 2004-03-02 | 大正製薬株式会社 | プロスタグランジン誘導体 |
| DE4330177A1 (de) * | 1993-08-31 | 1995-03-02 | Schering Ag | Neue 9-Chlor-prostaglandin-derivate |
| JP3579448B2 (ja) * | 1993-12-29 | 2004-10-20 | 大正製薬株式会社 | プロスタグランジン誘導体、その塩およびその使用 |
| JP3506485B2 (ja) * | 1994-04-19 | 2004-03-15 | 大正製薬株式会社 | プロスタグランジン誘導体 |
| JP3162668B2 (ja) * | 1997-02-04 | 2001-05-08 | 小野薬品工業株式会社 | ω−シクロアルキル−プロスタグランジンＥ２誘導体 |
| NO317155B1 (no) * | 1997-02-04 | 2004-08-30 | Ono Pharmaceutical Co | <omega>-cykloalkyl-prostagladin-E<N>2</N>-derivater |
| WO1999033794A1 (en) * | 1997-12-25 | 1999-07-08 | Ono Pharmaceutical Co., Ltd. | φ-CYCLOALKYL-PROSTAGLANDIN E2 DERIVATIVES |
-
1999
- 1999-07-19 US US09/356,674 patent/US6235780B1/en not_active Expired - Fee Related
- 1999-07-20 ES ES99305735T patent/ES2178352T3/es not_active Expired - Lifetime
- 1999-07-20 DE DE69901658T patent/DE69901658T2/de not_active Expired - Fee Related
- 1999-07-20 EP EP99305735A patent/EP0974580B1/de not_active Expired - Lifetime
- 1999-07-20 DK DK99305735T patent/DK0974580T3/da active
- 1999-07-20 PT PT99305735T patent/PT974580E/pt unknown
- 1999-07-20 AT AT99305735T patent/ATE218544T1/de not_active IP Right Cessation
- 1999-07-21 KR KR1019990029480A patent/KR100349964B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0974580B1 (de) | 2002-06-05 |
| ES2178352T3 (es) | 2002-12-16 |
| US6235780B1 (en) | 2001-05-22 |
| PT974580E (pt) | 2002-10-31 |
| DK0974580T3 (da) | 2002-09-30 |
| DE69901658T2 (de) | 2002-11-21 |
| KR100349964B1 (ko) | 2002-08-22 |
| DE69901658D1 (de) | 2002-07-11 |
| EP0974580A1 (de) | 2000-01-26 |
| KR20000011866A (ko) | 2000-02-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |