ATE218544T1 - Omega-zykloalkyl-prostaglandin e1 derivate - Google Patents

Omega-zykloalkyl-prostaglandin e1 derivate

Info

Publication number: ATE218544T1
Authority: AT; Austria
Prior art keywords: prostaglandin; omega; cycloalkyl; derivatives; hepatopathy
Prior art date: 1998-07-21

Application number

AT99305735T

Other languages

English (en)

Inventor

Shuichi Ohuchida

Kousuke Tani

Original Assignee

Ono Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-21

Filing date

1999-07-20

Publication date

2002-06-15

1999-07-20 Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co

2002-06-15 Application granted granted Critical

2002-06-15 Publication of ATE218544T1 publication Critical patent/ATE218544T1/de

Links

125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
208000023275 Autoimmune disease Diseases 0.000 abstract 1
125000004648 C2-C8 alkenyl group Chemical group 0.000 abstract 1
125000004649 C2-C8 alkynyl group Chemical group 0.000 abstract 1
229920000858 Cyclodextrin Polymers 0.000 abstract 1
208000010412 Glaucoma Diseases 0.000 abstract 1
208000005107 Premature Birth Diseases 0.000 abstract 1
206010036590 Premature baby Diseases 0.000 abstract 1
206010052779 Transplant rejections Diseases 0.000 abstract 1
230000002159 abnormal effect Effects 0.000 abstract 1
206010000210 abortion Diseases 0.000 abstract 1
231100000176 abortion Toxicity 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
208000026278 immune system disease Diseases 0.000 abstract 1
208000019423 liver disease Diseases 0.000 abstract 1
230000016273 neuron death Effects 0.000 abstract 1
201000001119 neuropathy Diseases 0.000 abstract 1
230000007823 neuropathy Effects 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
230000011164 ossification Effects 0.000 abstract 1
208000033808 peripheral neuropathy Diseases 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
210000001525 retina Anatomy 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 1
238000002054 transplantation Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT99305735T 1998-07-21 1999-07-20 Omega-zykloalkyl-prostaglandin e1 derivate ATE218544T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP22105498		1998-07-21

Publications (1)

Publication Number	Publication Date
ATE218544T1 true ATE218544T1 (de)	2002-06-15

Family

ID=16760781

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99305735T ATE218544T1 (de)	1998-07-21	1999-07-20	Omega-zykloalkyl-prostaglandin e1 derivate

Country Status (8)

Country	Link
US (1)	US6235780B1 (de)
EP (1)	EP0974580B1 (de)
KR (1)	KR100349964B1 (de)
AT (1)	ATE218544T1 (de)
DE (1)	DE69901658T2 (de)
DK (1)	DK0974580T3 (de)
ES (1)	ES2178352T3 (de)
PT (1)	PT974580E (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2006021998A (ja) *	2002-07-18	2006-01-26	Ono Pharmaceut Co Ltd	Ｅｐ２アゴニストを有効成分とする月経困難症治療剤
ES2584606T3 (es)	2002-10-10	2016-09-28	Ono Pharmaceutical Co., Ltd.	Microesferas que comprenden ONO-1301
ATE394372T1 (de) *	2003-03-03	2008-05-15	Serono Lab	G-lactamderivate als prostaglandinagonisten
JP2006528154A (ja) *	2003-07-18	2006-12-14	アプライドリサーチシステムズエーアールエスホールディングナームロゼフェンノートシャップ	プロスタグランジン受容体のモジュレータとしてのヒドラジド誘導体
EP2422814A1 (de)	2003-07-25	2012-02-29	Ono Pharmaceutical Co., Ltd.	Heilmittel für Knorpelerkrankungen
JP4893999B2 (ja)	2004-10-22	2012-03-07	小野薬品工業株式会社	吸入用医薬組成物
AR056968A1 (es) *	2005-04-11	2007-11-07	Xenon Pharmaceuticals Inc	Compuestos espiro-oxindol y composiciones farmacéuticas
AR053710A1 (es) *	2005-04-11	2007-05-16	Xenon Pharmaceuticals Inc	Compuestos espiroheterociclicos y sus usos como agentes terapeuticos
RU2420316C2 (ru)	2005-06-03	2011-06-10	Оно Фармасьютикал Ко., Лтд.	Агент для регенерации и/или защиты нервов
LT1976828T (lt)	2005-12-29	2017-04-25	Celtaxsys, Inc.	Diamino dariniai, kaip leukotrieno a4 hidrolazės inhibitoriai
WO2008060789A2 (en)	2006-10-12	2008-05-22	Xenon Pharmaceuticals Inc.	Use of spiro-oxindole compounds as therapeutic agents
US20110294842A9 (en) *	2006-10-12	2011-12-01	Xenon Pharmaceuticals Inc.	Spiro (furo [3, 2-c] pyridine-3-3' -indol) -2' (1'h)-one derivatives and related compounds for the treatment of sodium-channel mediated diseases, such as pain
EP2269611B1 (de) *	2006-11-16	2016-03-23	Gemmus Pharma Inc.	EP2- und EP4-Agonisten als Wirkstoffe zur Behandlung von Influenza A Virusinfektionen
JO3032B1 (ar) *	2008-10-17	2016-09-05	Xenon Pharmaceuticals Inc	مركبات سبيرو – اوكسندول وإستعمالاتها كعوامل علاجية.
CA2741024A1 (en) *	2008-10-17	2010-04-22	Xenon Pharmaceuticals Inc.	Spiro-oxindole compounds and their use as therapeutic agents
AR077252A1 (es)	2009-06-29	2011-08-10	Xenon Pharmaceuticals Inc	Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
KR20120099429A (ko)	2009-10-14	2012-09-10	제논 파마슈티칼스 인크.	스피로-옥스인돌 화합물의 합성 방법
US20110086899A1 (en) *	2009-10-14	2011-04-14	Xenon Pharmaceuticals Inc.	Pharmaceutical compositions for oral administration
WO2011106729A2 (en)	2010-02-26	2011-09-01	Xenon Pharmaceuticals Inc.	Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents
HK1205114A1 (en)	2012-04-12	2015-12-11	Xenon Pharmaceuticals Inc.	Asymmetric syntheses for spiro-oxindole compounds useful as therapeutic agents
EP2913047B1 (de)	2012-10-29	2019-05-08	Cardio Incorporated	Spezifisches therapeutikum für pulmonale erkrankungen
CA2906035A1 (en)	2013-03-14	2014-09-25	Celtaxsys, Inc.	Inhibitors of leukotriene a4 hydrolase
US9968716B2 (en)	2013-10-15	2018-05-15	Ono Pharmaceutical Co., Ltd.	Drug-eluting stent graft
WO2016127068A1 (en)	2015-02-05	2016-08-11	Teva Pharmaceuticals International Gmbh	Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound
US10100060B2 (en)	2016-06-16	2018-10-16	Xenon Pharmaceuticals Inc.	Asymmetric synthesis of funapide
US10385007B2 (en)	2016-12-09	2019-08-20	Celtaxsys, Inc.	Monamine and monoamine derivatives as inhibitors of leukotriene A4 hydrolase
AU2017371348B2 (en)	2016-12-09	2022-02-03	Celltaxis, Llc	Inhibitors of leukotriene A4 hydrolase
US10202334B2 (en)	2016-12-09	2019-02-12	Celtaxsys, Inc.	Pendant amines and derivatives as inhibitors of leukotriene A4 hydrolase
WO2021163400A1 (en)	2020-02-12	2021-08-19	Cytoagents, Inc.	Compositions and methods for treating coronavirus infections

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4132738A (en)	1978-02-23	1979-01-02	Miles Laboratories, Inc.	Preparation of 15-deoxy-16-hydroxyprostaglandins
US5204371A (en)	1979-12-10	1993-04-20	Schering Aktiengesellschaft	Pharmaceutically active 9-chloroprostaglandins
DE2950027A1 (de)	1979-12-10	1981-06-11	Schering Ag Berlin Und Bergkamen, 1000 Berlin	9-chlor-prostaglandinderivate, verfahren zur herstellung und verwendung als arzneimittel
DE3126924A1 (de)	1981-07-03	1983-01-20	Schering Ag, 1000 Berlin Und 4619 Bergkamen	9-fluor-prostaglandinderivate, verfahren zur herstellung und verwendung als arzneimittel
JPS5883670A (ja) *	1981-11-13	1983-05-19	Teijin Ltd	プロスタグランデインｅ↓１類の製造法
WO1994008959A1 (fr) *	1992-10-20	1994-04-28	Taisho Pharmaceutical Co., Ltd.	Derive de prostaglandine
JP3502952B2 (ja) *	1992-10-20	2004-03-02	大正製薬株式会社	プロスタグランジン誘導体
DE4330177A1 (de) *	1993-08-31	1995-03-02	Schering Ag	Neue 9-Chlor-prostaglandin-derivate
JP3579448B2 (ja) *	1993-12-29	2004-10-20	大正製薬株式会社	プロスタグランジン誘導体、その塩およびその使用
JP3506485B2 (ja) *	1994-04-19	2004-03-15	大正製薬株式会社	プロスタグランジン誘導体
NO317155B1 (no) *	1997-02-04	2004-08-30	Ono Pharmaceutical Co	<omega>-cykloalkyl-prostagladin-E<N>2</N>-derivater
JP3162668B2 (ja) *	1997-02-04	2001-05-08	小野薬品工業株式会社	ω−シクロアルキル−プロスタグランジンＥ２誘導体
DE69821987T2 (de) *	1997-12-25	2004-12-16	Ono Pharmaceutical Co. Ltd.	Omega-cycloalkyl-prostaglandin e2 derivate

1999
- 1999-07-19 US US09/356,674 patent/US6235780B1/en not_active Expired - Fee Related
- 1999-07-20 PT PT99305735T patent/PT974580E/pt unknown
- 1999-07-20 AT AT99305735T patent/ATE218544T1/de not_active IP Right Cessation
- 1999-07-20 ES ES99305735T patent/ES2178352T3/es not_active Expired - Lifetime
- 1999-07-20 EP EP99305735A patent/EP0974580B1/de not_active Expired - Lifetime
- 1999-07-20 DK DK99305735T patent/DK0974580T3/da active
- 1999-07-20 DE DE69901658T patent/DE69901658T2/de not_active Expired - Fee Related
- 1999-07-21 KR KR1019990029480A patent/KR100349964B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DK0974580T3 (da)	2002-09-30
US6235780B1 (en)	2001-05-22
ES2178352T3 (es)	2002-12-16
EP0974580A1 (de)	2000-01-26
KR20000011866A (ko)	2000-02-25
DE69901658T2 (de)	2002-11-21
KR100349964B1 (ko)	2002-08-22
PT974580E (pt)	2002-10-31
DE69901658D1 (de)	2002-07-11
EP0974580B1 (de)	2002-06-05

Legal Events

Date	Code	Title	Description
2002-11-15	UEP	Publication of translation of european patent specification
2005-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE218544T1 (de)	2002-06-15	Omega-zykloalkyl-prostaglandin e1 derivate
HU9800208D0 (en)	1998-03-30	Omega-cycloalkyl-prostaglandin e2-derivatives
ATE260254T1 (de)	2004-03-15	Omega-cycloalkyl-prostaglandin e2 derivate
PT1213296E (pt)	2004-08-31	Derivados de glucopiranosiloxipirazole composicoes medicas que os contem e intermediarios na sua producao
ATE225770T1 (de)	2002-10-15	Difluoroprostaglandin-derivate und ihre anwendung
GR3032629T3 (en)	2000-05-31	Polyanionic benzylglycosides as inhibitors of smooth muscle cell proliferation
BR0310057A (pt)	2007-04-10	melhoria do desenvolvimento de catarata e outras doenças oftálmicas
EP0580268A3 (de)	1994-02-23
TW200716547A (en)	2007-05-01	Piperidin-4-yl-amide derivatives
PT882728E (pt)	2002-11-29	Derivados de 1-metilcarbapenem
GB2115815B (en)	1985-06-19	Benzothiazoline compounds
TR200002808T2 (tr)	2001-01-22	İlaç olarak yararlı C11 oksimil ve hidroksilamino prostaglandinleri
ATE100439T1 (de)	1994-02-15	2-(2-hydroxy-3-phenoxypropylamino)-ethoxybenzol derivate.
ES466168A1 (es)	1979-07-01	Procedimiento para la preparacion de nuevos derivados de cromonas dotados de actividad medicamentosa
BG103395A (en)	2000-02-29	Derivatives of benzenesulphonamide and medicaments containing them
ES2096800T3 (es)	1997-03-16	Benzo(b)tiofen-3-il-piperazinas, un procedimiento para su preparacion y su uso como medicamentos.
NO974745L (no)	1997-12-12	1-£<omega>-(3,4-dihydro-2-naftalenyl)alkyl\| cyklisk-amin-derivater, fremgangsmåte for deres fremstilling og farmasöytiske preparater som inneholder samme
HUT62279A (en)	1993-04-28	Process for producing new thiobenzoyl morpholide derivatives and weight increasing agents comprising such compounds
AU2178099A (en)	1999-08-09	Azetidinecarboxamide derivatives for treating cns disorders
ATE220686T1 (de)	2002-08-15	17beta-aryl(arylmethyl)oxy(thio)alkyl- androstanderivative
DE69903346D1 (de)	2002-11-07	22s-hydroxycholesta-8,14-dien derivate mit meiose regulierende aktivität