ES2178352T3 - Derivados de omega-cicloaquil-prostaglandina e1. - Google Patents

Derivados de omega-cicloaquil-prostaglandina e1.

Info

Publication number
ES2178352T3
ES2178352T3 ES99305735T ES99305735T ES2178352T3 ES 2178352 T3 ES2178352 T3 ES 2178352T3 ES 99305735 T ES99305735 T ES 99305735T ES 99305735 T ES99305735 T ES 99305735T ES 2178352 T3 ES2178352 T3 ES 2178352T3
Authority
ES
Spain
Prior art keywords
sub
derivatives
omega
cicloaquil
prostaglandina
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99305735T
Other languages
English (en)
Inventor
Shuichi Ohuchida
Kousuke Tani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2178352T3 publication Critical patent/ES2178352T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se presentan derivados de la omega-cicloalquil-prostaglandina E1 de la fórmula (1) en donde R¿sup,1} es OH, etc; X es Cl, F; R{sup,2} es H, alquilo C{sub,1-8}, alquenilo C{sub,2-8}, alquinilo C{sub,2-8} que puede estar sustituido; n es 0-4, las sales no tóxicas de los mismos o los clatratos de ciclodextrina de los mismos pueden unirse fuertemente sobre el receptor de subtipo EP{sub,2}. Por lo tanto, los derivados son útiles para la prevención y/o tratamiento de disfunciones inmunológicas (enfermedades autoinmunes, rechazos de miembros trasplantados, etc), el asma, la formación anormal del hueso, la muerte de las células neuronales, la hepatopatías, los abortos, los nacimientos prematuros o las neuropatías de retina (por ejemplo el glaucoma), etc.
ES99305735T 1998-07-21 1999-07-20 Derivados de omega-cicloaquil-prostaglandina e1. Expired - Lifetime ES2178352T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP22105498 1998-07-21

Publications (1)

Publication Number Publication Date
ES2178352T3 true ES2178352T3 (es) 2002-12-16

Family

ID=16760781

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99305735T Expired - Lifetime ES2178352T3 (es) 1998-07-21 1999-07-20 Derivados de omega-cicloaquil-prostaglandina e1.

Country Status (8)

Country Link
US (1) US6235780B1 (es)
EP (1) EP0974580B1 (es)
KR (1) KR100349964B1 (es)
AT (1) ATE218544T1 (es)
DE (1) DE69901658T2 (es)
DK (1) DK0974580T3 (es)
ES (1) ES2178352T3 (es)
PT (1) PT974580E (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006021998A (ja) * 2002-07-18 2006-01-26 Ono Pharmaceut Co Ltd Ｅｐ２アゴニストを有効成分とする月経困難症治療剤
DK1563846T3 (da) 2002-10-10 2012-12-17 Ono Pharmaceutical Co Endogene reparationsfaktorproduktionsfremmere
WO2004078103A2 (en) * 2003-03-03 2004-09-16 Applied Research Systems Ars Holding N.V. G-lactam derivatives as prostaglandin agonists
AU2004261397A1 (en) * 2003-07-18 2005-02-10 Laboratoires Serono Sa Hydrazide derivatives as prostaglandin receptors modulators
WO2005009468A1 (ja) 2003-07-25 2005-02-03 Ono Pharmaceutical Co., Ltd. 軟骨関連疾患治療剤
JP4893999B2 (ja) 2004-10-22 2012-03-07 小野薬品工業株式会社 吸入用医薬組成物
MY145694A (en) * 2005-04-11 2012-03-30 Xenon Pharmaceuticals Inc Spiroheterocyclic compounds and their uses as therapeutic agents
AR056968A1 (es) * 2005-04-11 2007-11-07 Xenon Pharmaceuticals Inc Compuestos espiro-oxindol y composiciones farmacéuticas
CA2610692C (en) 2005-06-03 2014-11-25 Ono Pharmaceutical Co., Ltd. Ep2 agonists which may have an ep3 agonistic effect for regeneration and/or protection of nerves
PL1976828T3 (pl) 2005-12-29 2017-07-31 Celtaxsys, Inc. Pochodne diaminy jako inhibitory hydrolazy leukotrienu a4
WO2008060789A2 (en) 2006-10-12 2008-05-22 Xenon Pharmaceuticals Inc. Use of spiro-oxindole compounds as therapeutic agents
RU2009117605A (ru) * 2006-10-12 2010-11-20 Ксенон Фармасьютикалз Инк. (Ca) ПРОИЗВОДНЫЕ СПИРО-(ФУРО[3,2-c]ПИРИДИН-3-3'-ИНДОЛ)-2'(1'H)-ОНА И РОДСТВЕННЫЕ ИМ СОЕДИНЕНИЯ ДЛЯ ЛЕЧЕНИЯ ОПОСРЕДОВАННЫХ НАТРИЕВЫМИ КАНАЛАМИ ЗАБОЛЕВАНИЙ, ТАКИХ КАК БОЛЬ
JP5271272B2 (ja) 2006-11-16 2013-08-21 ジェンムス ファーマ インコーポレイティド Ａ型インフルエンザウィルス感染の治療のための薬剤としてのｅｐ２およびｅｐ４作動薬
WO2010045251A2 (en) 2008-10-17 2010-04-22 Xenon Pharmaceuticals, Inc. Spiro-oxindole compounds and their use as therapeutic agents
CA2741024A1 (en) * 2008-10-17 2010-04-22 Xenon Pharmaceuticals Inc. Spiro-oxindole compounds and their use as therapeutic agents
AR077252A1 (es) 2009-06-29 2011-08-10 Xenon Pharmaceuticals Inc Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
AU2010306768B2 (en) 2009-10-14 2016-08-04 Xenon Pharmaceuticals Inc. Synthetic methods for spiro-oxindole compounds
US20110086899A1 (en) * 2009-10-14 2011-04-14 Xenon Pharmaceuticals Inc. Pharmaceutical compositions for oral administration
MY165117A (en) 2010-02-26 2018-02-28 Xenon Pharmaceuticals Inc Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents
AU2013246485A1 (en) 2012-04-12 2014-10-16 Xenon Pharmaceuticals Inc. Asymmetric syntheses for spiro-oxindole compounds useful as therapeutic agents
JP6400479B2 (ja) 2012-10-29 2018-10-03 株式会社カルディオ 肺疾患特異的治療剤
EP2968264A4 (en) 2013-03-14 2016-11-02 Celtaxsys Inc INHIBITORS OF LEUCOTRIENE A4 HYDROLASE
JP6449166B2 (ja) 2013-10-15 2019-01-09 小野薬品工業株式会社 薬剤溶出性ステントグラフト
AR103636A1 (es) 2015-02-05 2017-05-24 Teva Pharmaceuticals Int Gmbh Métodos de tratamiento de neuralgia postherpética con una formulación tópica de un compuesto de espiro-oxindol
WO2017218920A1 (en) 2016-06-16 2017-12-21 Teva Pharmaceuticals International Gmbh Asymmetric synthesis of funapide
KR20190088551A (ko) 2016-12-09 2019-07-26 켈탁시스, 인코퍼레이티드 루코트리엔 a4 하이드롤라제의 저해제
CA3045887A1 (en) 2016-12-09 2018-06-14 Celtaxsys, Inc. Pendant amines and derivatives as inhibitors of leukotriene a4 hydrolase
AU2017371353B2 (en) 2016-12-09 2022-02-03 Celltaxis, Llc Monamine and monoamine derivatives as inhibitors of leukotriene A4 hydrolase
WO2021163400A1 (en) 2020-02-12 2021-08-19 Cytoagents, Inc. Compositions and methods for treating coronavirus infections

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4132738A (en) 1978-02-23 1979-01-02 Miles Laboratories, Inc. Preparation of 15-deoxy-16-hydroxyprostaglandins
DE2950027A1 (de) 1979-12-10 1981-06-11 Schering Ag Berlin Und Bergkamen, 1000 Berlin 9-chlor-prostaglandinderivate, verfahren zur herstellung und verwendung als arzneimittel
US5204371A (en) 1979-12-10 1993-04-20 Schering Aktiengesellschaft Pharmaceutically active 9-chloroprostaglandins
DE3126924A1 (de) 1981-07-03 1983-01-20 Schering Ag, 1000 Berlin Und 4619 Bergkamen 9-fluor-prostaglandinderivate, verfahren zur herstellung und verwendung als arzneimittel
JPS5883670A (ja) * 1981-11-13 1983-05-19 Teijin Ltd プロスタグランデインｅ↓１類の製造法
JP3502952B2 (ja) * 1992-10-20 2004-03-02 大正製薬株式会社 プロスタグランジン誘導体
EP0666256A1 (en) * 1992-10-20 1995-08-09 Taisho Pharmaceutical Co. Ltd Prostaglandine derivative
DE4330177A1 (de) * 1993-08-31 1995-03-02 Schering Ag Neue 9-Chlor-prostaglandin-derivate
JP3579448B2 (ja) * 1993-12-29 2004-10-20 大正製薬株式会社 プロスタグランジン誘導体、その塩およびその使用
JP3506485B2 (ja) * 1994-04-19 2004-03-15 大正製薬株式会社 プロスタグランジン誘導体
NO317155B1 (no) * 1997-02-04 2004-08-30 Ono Pharmaceutical Co <omega>-cykloalkyl-prostagladin-E<N>2</N>-derivater
JP3162668B2 (ja) * 1997-02-04 2001-05-08 小野薬品工業株式会社 ω−シクロアルキル−プロスタグランジンＥ２誘導体
WO1999033794A1 (en) * 1997-12-25 1999-07-08 Ono Pharmaceutical Co., Ltd. φ-CYCLOALKYL-PROSTAGLANDIN E2 DERIVATIVES

Also Published As

Publication number Publication date
KR20000011866A (ko) 2000-02-25
ATE218544T1 (de) 2002-06-15
PT974580E (pt) 2002-10-31
DE69901658T2 (de) 2002-11-21
EP0974580B1 (en) 2002-06-05
DE69901658D1 (de) 2002-07-11
US6235780B1 (en) 2001-05-22
DK0974580T3 (da) 2002-09-30
EP0974580A1 (en) 2000-01-26
KR100349964B1 (ko) 2002-08-22

Similar Documents

Publication Publication Date Title
ES2178352T3 (es) Derivados de omega-cicloaquil-prostaglandina e1.
ATE260254T1 (de) Omega-cycloalkyl-prostaglandin e2 derivate
NO994485L (no) Styrt frigivelse av farmasöytiske midler i det fremre kammer i öyet
ES2116950T1 (es) Liberacion controlada de farmacos mioticos y midriaticos en la camara anterior.
AR032840A1 (es) Hoja quirurgica que se usa con un instrumento quirurgico para realizar incisiones en implantes en la esclerotica ocular
ES2193391T3 (es) Antagonistas muscarinicos.
ES2178808T3 (es) Derivados omega-cicloalquil-prostaglandina e2.
ES2075082T3 (es) Derivados de isoquinolina para el tratamiento del glaucoma o hipertension ocular.
BRPI0406879A (pt) Dispositivo de liberação sustentada e método para a liberação ocular de agentes adrenérgicos
PE20240657A1 (es) Derivados de 3-(1-oxoisoindolin-2-il)piperidina-2,6-diona y sus usos medicos
ES2123873T3 (es) Pirrolocarbazol.
ES2068955T3 (es) Derivados de 1,2,3,4-tetrahidro-9-acridinamina.
BR0208353A (pt) Compostos de diidropirimidina substituìdos com ciano e seu uso para tratar doenças
AR007997A1 (es) Un derivado de distamicina sustituida con acriloilo, sus utilizaciones, un procedimiento para producirlo y una composicion farmaceutica que lo comprende.
BR0208405A (pt) Compostos de diidropirimina substituìdos com ciano e seu uso para tratar doenças
ES2183148T3 (es) Composiciones oftalmicas que contienen un inhibidor de anhidrasa carbonica y de la goma de xantano.
BR0210238A (pt) Novos análogos de aril-amino-propano e seu uso para o tratamento de glaucoma
BRPI0416469A (pt) agente tropicalizante e métodos para fabricação e uso do mesmo
AR013273A1 (es) SISTEMA MATERIAL VISCOELÁSTICO GELIFICABLE FORMADO POR DOS PARTES CON POLíMEROS DE GALACTOMANANO Y BORATO.
NO20003786L (no) Oftalmisk sammensetning
DK0719559T3 (da) Viskøse natriumhyaluronatopløsninger til anvendelse som maskerende væsker i terapeutisk fotokeratektomi under anvendelse af
AR044720A1 (es) Una sulfonamida heterociclica, su uso, un proceso para prepararla, una composicion farmaceutica que la comprende, y compuestos utiles como intermediari0s
Hylkema et al. Treatment of ptosis by levator resection with adjustable sutures via the anterior approach.
BR0316775A (pt) Novos análogos de benzopirano e seu uso para o tratamento de glaucoma
EP1845983A4 (en) OPHTHALMIC COMPOSITIONS AND METHOD FOR THEIR USE